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PubMed:11836257 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-111 Sentence denotes Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.
T2 112-225 Sentence denotes Recent studies have initiated a paradigm shift in the understanding of the function of heat shock proteins (HSP).
T3 226-361 Sentence denotes It is now clear that HSP can and do exit mammalian cells, interact with cells of the immune system, and exert immunoregulatory effects.
T4 362-662 Sentence denotes We recently demonstrated that exogenously added HSP70 possesses potent cytokine activity, with the ability to bind with high affinity to the plasma membrane, elicit a rapid intracellular Ca(2+) flux, activate NF-kappaB, and up-regulate the expression of pro-inflammatory cytokines in human monocytes.
T5 663-1009 Sentence denotes Here for the first time, we report that HSP70-induced proinflammatory cytokine production is mediated via the MyD88/IRAK/NF-kappaB signal transduction pathway and that HSP70 utilizes both TLR2 (receptor for Gram-positive bacteria) and TLR4 (receptor for Gram-negative bacteria) to transduce its proinflammatory signal in a CD14-dependent fashion.
T6 1010-1320 Sentence denotes These studies now pave the way for the development of highly effective pharmacological or molecular tools that will either up-regulate or suppress HSP70-induced functions in conditions where HSP70 effects are desirable (cancer) or disorders where HSP70 effects are undesirable (arthritis and arteriosclerosis).

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 46-59 Cellular_component denotes extracellular
T2 60-65 Gene_or_gene_product denotes HSP70
T3 75-101 Gene_or_gene_product denotes toll-like receptor (TLR) 2
T4 106-110 Gene_or_gene_product denotes TLR4
T5 199-218 Gene_or_gene_product denotes heat shock proteins
T6 220-223 Gene_or_gene_product denotes HSP
T7 247-250 Gene_or_gene_product denotes HSP
T8 410-415 Gene_or_gene_product denotes HSP70
T9 503-518 Cellular_component denotes plasma membrane
T10 535-548 Cellular_component denotes intracellular
T11 549-555 Simple_chemical denotes Ca(2+)
T12 571-580 Complex denotes NF-kappaB
T13 703-708 Gene_or_gene_product denotes HSP70
T14 773-778 Gene_or_gene_product denotes MyD88
T15 779-783 Gene_or_gene_product denotes IRAK
T16 784-793 Complex denotes NF-kappaB
T17 831-836 Gene_or_gene_product denotes HSP70
T18 851-855 Gene_or_gene_product denotes TLR2
T19 898-902 Gene_or_gene_product denotes TLR4
T20 986-990 Gene_or_gene_product denotes CD14
T21 1157-1162 Gene_or_gene_product denotes HSP70
T22 1201-1206 Gene_or_gene_product denotes HSP70
T23 1257-1262 Gene_or_gene_product denotes HSP70

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 220-223 Disease denotes HSP http://purl.obolibrary.org/obo/MONDO_0006785|http://purl.obolibrary.org/obo/MONDO_0019064
T3 247-250 Disease denotes HSP http://purl.obolibrary.org/obo/MONDO_0006785|http://purl.obolibrary.org/obo/MONDO_0019064
T5 1230-1236 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T6 1288-1297 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T7 1302-1318 Disease denotes arteriosclerosis http://purl.obolibrary.org/obo/MONDO_0002277

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 204-209 Phenotype denotes shock HP:0031273
T2 1230-1236 Phenotype denotes cancer HP:0002664
T3 1288-1297 Phenotype denotes arthritis HP:0001369
T4 1302-1318 Phenotype denotes arteriosclerosis HP:0002634

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 646-651 OrganismTaxon denotes human 9606
T2 884-892 OrganismTaxon denotes bacteria 2|629395
T4 931-939 OrganismTaxon denotes bacteria 2|629395

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 46-59 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 311-324 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T3 503-518 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T4 535-548 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 652-661 Body_part denotes monocytes http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 652-661 Cell denotes monocytes http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054