PubMed:11829604
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1726-1730 | Disease | denotes | mole | http://purl.obolibrary.org/obo/MONDO_0005073 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1726-1730 | Phenotype | denotes | mole | HP:0003764 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 252-268 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 270-276 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 310-328 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T4 | 330-336 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T5 | 804-810 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T6 | 851-857 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T7 | 1497-1503 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T8 | 1544-1550 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T9 | 1643-1661 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T10 | 1696-1702 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 252-268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 270-276 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T3 | 310-328 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
| T4 | 330-336 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T5 | 804-810 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T6 | 851-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T7 | 1497-1503 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T8 | 1544-1550 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T9 | 1643-1661 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
| T10 | 1696-1702 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1726-1730 | Phenotype | denotes | mole | HP:0003764 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1726-1730 | Disease | denotes | mole | http://purl.obolibrary.org/obo/MONDO_0005073 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 621-625 | Body_part | denotes | POPC | http://purl.obolibrary.org/obo/UBERON_0034889 |
| T2 | 1437-1446 | Body_part | denotes | membranes | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T5 | 1726-1730 | Body_part | denotes | mole | http://purl.obolibrary.org/obo/UBERON_1000010 |
| T6 | 1757-1761 | Body_part | denotes | POPC | http://purl.obolibrary.org/obo/UBERON_0034889 |
| T7 | 2390-2398 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-153 | Sentence | denotes | Quantitative measurements of recombinant HIV surface glycoprotein 120 binding to several glycosphingolipids expressed in planar supported lipid bilayers. |
| T2 | 154-465 | Sentence | denotes | The interaction of recombinant HIV-1 surface glycoprotein gp120 (rgp120) with natural isolates of lactosylceramide (LacCer), glucosylceramide (GlcCer), and galactosylceramide (GalCer) has been quantitatively measured under equilibrium conditions using total internal reflection fluorescence (TIRF) spectroscopy. |
| T3 | 466-633 | Sentence | denotes | The binding affinity (K(a)) of rgp120 to these glycosphingolipids (GSLs), reconstituted at 5 mol % in supported planar lipid bilayers composed of 95 mol % POPC, is ca. |
| T4 | 634-701 | Sentence | denotes | 10(6) M(-1) for dissolved rgp120 concentrations greater than 25 nM. |
| T5 | 702-906 | Sentence | denotes | In contrast, at concentrations of rgp120 between 0.2 and 15 nM, rgp120 does not bind significantly to LacCer and GlcCer, but has a high affinity for GalCer with a measured K(a) value of 1.6 x 10(9) M(-1). |
| T6 | 907-1091 | Sentence | denotes | However, protein surface coverage measurements show that this strong binding process accounts for very little of the total protein adsorbed over the entire concentration range studied. |
| T7 | 1092-1125 | Sentence | denotes | At a protein concentration of ca. |
| T8 | 1126-1249 | Sentence | denotes | 20 nM, the surface coverage is only 3% of that achieved at apparent saturation (i.e., when the protein concentration is ca. |
| T9 | 1250-1258 | Sentence | denotes | 220 nM). |
| T10 | 1259-1366 | Sentence | denotes | Thus the "high affinity" binding sites comprise only a small fraction of the total number of binding sites. |
| T11 | 1367-1409 | Sentence | denotes | Several other variables were investigated. |
| T12 | 1410-1674 | Sentence | denotes | Rgp120 binding behavior at membranes doped with alpha-hydroxygalactosylceramide (alpha-GalCer) was very similar to that observed with GalCer, showing that the presence/absence of an alpha-hydroxy moiety does not significantly affect galactosylceramide recognition. |
| T13 | 1675-1781 | Sentence | denotes | Phase segregation of GalCer, which occurs when the mole fraction of this GSL in a POPC bilayer exceeds ca. |
| T14 | 1782-1879 | Sentence | denotes | 0.1, was also investigated and showed no effect on binding affinity at low rgp120 concentrations. |
| T15 | 1880-2106 | Sentence | denotes | To investigate the influence of fatty acid chain length, GSLs with monodisperse C(18) and C(24) chain lengths, both with and without an alpha-hydroxy moiety, were synthesized, and their binding affinity to rgp120 was examined. |
| T16 | 2107-2308 | Sentence | denotes | Relative to the natural isolates (which contain a mixture of chain lengths), minimal differences were observed; thus among the compounds tested, fatty acid chain length does not affect GSL recognition. |
| T17 | 2309-2449 | Sentence | denotes | The results of this work should aid efforts to design anti-HIV-1 agents based on membrane-tethered, carbohydrate-based receptors for rgp120. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 252-268 | Glycan | denotes | lactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T2 | 270-276 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T3 | 310-328 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T4 | 330-336 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T5 | 804-810 | Glycan | denotes | LacCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
| T6 | 851-857 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T7 | 1497-1503 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T8 | 1544-1550 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T9 | 1643-1661 | Glycan | denotes | galactosylceramide | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
| T10 | 1696-1702 | Glycan | denotes | GalCer | https://api.glycosmos.org/wurcs2image/latest/png/binary/G65889KE |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 252-268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosylceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 270-276 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T3 | 310-328 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
| T4 | 330-336 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T5 | 804-810 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | LacCer | http://www.glycoepitope.jp/epitopes/EP0078 |
| T6 | 851-857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T7 | 1497-1503 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T8 | 1544-1550 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
| T9 | 1643-1661 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | galactosylceramide | http://www.glycoepitope.jp/epitopes/EP0074 |
| T10 | 1696-1702 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GalCer | http://www.glycoepitope.jp/epitopes/EP0074 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 621-625 | Body_part | denotes | POPC | http://purl.obolibrary.org/obo/UBERON_0034889 |
| T2 | 1437-1446 | Body_part | denotes | membranes | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T5 | 1726-1730 | Body_part | denotes | mole | http://purl.obolibrary.org/obo/UBERON_1000010 |
| T6 | 1757-1761 | Body_part | denotes | POPC | http://purl.obolibrary.org/obo/UBERON_0034889 |
| T7 | 2390-2398 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |