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PubMed:11827497 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-47 Sentence denotes Delayed-onset heparin-induced thrombocytopenia.
TextSentencer_T2 48-59 Sentence denotes BACKGROUND:
TextSentencer_T3 60-188 Sentence denotes Heparin-induced thrombocytopenia presents 5 to 12 days after heparin exposure, with or without arterial or venous thromboemboli.
TextSentencer_T4 189-295 Sentence denotes Delayed recognition and treatment of heparin-induced thrombocytopenia contribute to poor patient outcomes.
TextSentencer_T5 296-306 Sentence denotes OBJECTIVE:
TextSentencer_T6 307-450 Sentence denotes To describe and increase awareness of a clinical scenario in which the onset or manifestations of heparin-induced thrombocytopenia are delayed.
TextSentencer_T7 451-458 Sentence denotes DESIGN:
TextSentencer_T8 459-485 Sentence denotes Retrospective case series.
TextSentencer_T9 486-494 Sentence denotes SETTING:
TextSentencer_T10 495-569 Sentence denotes Three large urban hospitals (with active cardiovascular surgery programs).
TextSentencer_T11 570-579 Sentence denotes PATIENTS:
TextSentencer_T12 580-733 Sentence denotes 14 patients seen over a 3-year period in whom heparin-induced thrombocytopenia became apparent on delayed presentation with thromboembolic complications.
TextSentencer_T13 734-747 Sentence denotes MEASUREMENTS:
TextSentencer_T14 748-888 Sentence denotes Platelet counts, onset of objectively determined thromboembolism, results of heparin-induced platelet factor 4 antibody tests, and outcomes.
TextSentencer_T15 889-897 Sentence denotes RESULTS:
TextSentencer_T16 898-1110 Sentence denotes Patients went home after hospitalizations that had included heparin exposure--in most cases, with no thrombocytopenia recognized--only to return to the hospital (median, day 14) with thromboembolic complications.
TextSentencer_T17 1111-1209 Sentence denotes Thromboemboli were venous (12 patients, 7 with pulmonary emboli) or arterial (4 patients) or both.
TextSentencer_T18 1210-1293 Sentence denotes Platelet counts were mildly decreased in all but 2 patients on second presentation.
TextSentencer_T19 1294-1552 Sentence denotes On readmission, 11 patients received therapeutic heparin, which worsened the patients' clinical condition and, in all 11 cases, decreased the platelet count (mean at readmission, 143 x 10(9) cells/L; mean nadir after heparin re-exposure, 39 x 10(9) cells/L).
TextSentencer_T20 1553-1641 Sentence denotes Results of serologic tests for heparin-induced antibodies were positive in all patients.
TextSentencer_T21 1642-1828 Sentence denotes Subsequent treatments included alternative anticoagulants (11 patients), thrombolytic drugs (3 patients), inferior vena cava filters (3 patients) and, eventually, warfarin (11 patients).
TextSentencer_T22 1829-1849 Sentence denotes Three patients died.
TextSentencer_T23 1850-1862 Sentence denotes CONCLUSIONS:
TextSentencer_T24 1863-1943 Sentence denotes Delayed-onset heparin-induced thrombocytopenia is increasingly being recognized.
TextSentencer_T25 1944-2177 Sentence denotes To avoid disastrous outcomes, physicians must consider heparin-induced thrombocytopenia whenever a recently hospitalized patient returns with thromboembolism; therapy with alternative anticoagulants, not heparin, should be initiated.
T1 0-47 Sentence denotes Delayed-onset heparin-induced thrombocytopenia.
T2 48-59 Sentence denotes BACKGROUND:
T3 60-188 Sentence denotes Heparin-induced thrombocytopenia presents 5 to 12 days after heparin exposure, with or without arterial or venous thromboemboli.
T4 189-295 Sentence denotes Delayed recognition and treatment of heparin-induced thrombocytopenia contribute to poor patient outcomes.
T5 296-306 Sentence denotes OBJECTIVE:
T6 307-450 Sentence denotes To describe and increase awareness of a clinical scenario in which the onset or manifestations of heparin-induced thrombocytopenia are delayed.
T7 451-458 Sentence denotes DESIGN:
T8 459-485 Sentence denotes Retrospective case series.
T9 486-494 Sentence denotes SETTING:
T10 495-569 Sentence denotes Three large urban hospitals (with active cardiovascular surgery programs).
T11 570-579 Sentence denotes PATIENTS:
T12 580-733 Sentence denotes 14 patients seen over a 3-year period in whom heparin-induced thrombocytopenia became apparent on delayed presentation with thromboembolic complications.
T13 734-747 Sentence denotes MEASUREMENTS:
T14 748-888 Sentence denotes Platelet counts, onset of objectively determined thromboembolism, results of heparin-induced platelet factor 4 antibody tests, and outcomes.
T15 889-897 Sentence denotes RESULTS:
T16 898-1110 Sentence denotes Patients went home after hospitalizations that had included heparin exposure--in most cases, with no thrombocytopenia recognized--only to return to the hospital (median, day 14) with thromboembolic complications.
T17 1111-1209 Sentence denotes Thromboemboli were venous (12 patients, 7 with pulmonary emboli) or arterial (4 patients) or both.
T18 1210-1293 Sentence denotes Platelet counts were mildly decreased in all but 2 patients on second presentation.
T19 1294-1552 Sentence denotes On readmission, 11 patients received therapeutic heparin, which worsened the patients' clinical condition and, in all 11 cases, decreased the platelet count (mean at readmission, 143 x 10(9) cells/L; mean nadir after heparin re-exposure, 39 x 10(9) cells/L).
T20 1553-1641 Sentence denotes Results of serologic tests for heparin-induced antibodies were positive in all patients.
T21 1642-1828 Sentence denotes Subsequent treatments included alternative anticoagulants (11 patients), thrombolytic drugs (3 patients), inferior vena cava filters (3 patients) and, eventually, warfarin (11 patients).
T22 1829-1849 Sentence denotes Three patients died.
T23 1850-1862 Sentence denotes CONCLUSIONS:
T24 1863-1943 Sentence denotes Delayed-onset heparin-induced thrombocytopenia is increasingly being recognized.
T25 1944-2177 Sentence denotes To avoid disastrous outcomes, physicians must consider heparin-induced thrombocytopenia whenever a recently hospitalized patient returns with thromboembolism; therapy with alternative anticoagulants, not heparin, should be initiated.

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 60-92 HP:0011874 denotes Heparin-induced thrombocytopenia
TI1 14-46 HP:0011874 denotes heparin-induced thrombocytopenia
AB2 226-258 HP:0011874 denotes heparin-induced thrombocytopenia
AB3 405-437 HP:0011874 denotes heparin-induced thrombocytopenia
AB4 626-658 HP:0011874 denotes heparin-induced thrombocytopenia
AB5 797-812 HP:0001907 denotes thromboembolism
AB6 999-1015 HP:0001873 denotes thrombocytopenia
AB7 1877-1909 HP:0011874 denotes heparin-induced thrombocytopenia
AB8 1999-2031 HP:0011874 denotes heparin-induced thrombocytopenia
AB9 2086-2101 HP:0001907 denotes thromboembolism

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 155-163 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T2 1179-1187 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 1757-1766 http://purl.obolibrary.org/obo/UBERON_0004087 denotes vena cava

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 60-92 ORDO:3325 denotes Heparin-induced thrombocytopenia
TI1 14-46 ORDO:3325 denotes heparin-induced thrombocytopenia
AB2 226-258 ORDO:3325 denotes heparin-induced thrombocytopenia
AB3 405-437 ORDO:3325 denotes heparin-induced thrombocytopenia
AB4 626-658 ORDO:3325 denotes heparin-induced thrombocytopenia
AB5 1877-1909 ORDO:3325 denotes heparin-induced thrombocytopenia
AB6 1999-2031 ORDO:3325 denotes heparin-induced thrombocytopenia

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 155-163 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T2 1179-1187 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 1757-1766 http://purl.obolibrary.org/obo/UBERON_0004087 denotes vena cava

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 14-21 Chemical denotes heparin
T2 30-46 Disease denotes thrombocytopenia
T3 60-67 Chemical denotes Heparin
T4 76-92 Disease denotes thrombocytopenia
T5 121-128 Chemical denotes heparin
T6 155-163 Disease denotes arterial
T7 155-187 Disease denotes arterial or venous thromboemboli
T8 167-187 Disease denotes venous thromboemboli
T9 174-187 Disease denotes thromboemboli
T10 226-233 Chemical denotes heparin
T11 242-258 Disease denotes thrombocytopenia
T12 405-412 Chemical denotes heparin
T13 421-437 Disease denotes thrombocytopenia
T14 626-633 Chemical denotes heparin
T15 642-658 Disease denotes thrombocytopenia
T16 704-718 Disease denotes thromboembolic
T17 797-812 Disease denotes thromboembolism
T18 825-832 Chemical denotes heparin
T19 958-965 Chemical denotes heparin
T20 999-1015 Disease denotes thrombocytopenia
T21 1081-1095 Disease denotes thromboembolic
T22 1111-1124 Disease denotes Thromboemboli
T23 1158-1174 Disease denotes pulmonary emboli
T24 1343-1350 Chemical denotes heparin
T25 1511-1518 Chemical denotes heparin
T26 1584-1591 Chemical denotes heparin
T27 1805-1813 Chemical denotes warfarin
T28 1877-1884 Chemical denotes heparin
T29 1893-1909 Disease denotes thrombocytopenia
T30 1999-2006 Chemical denotes heparin
T31 2015-2031 Disease denotes thrombocytopenia
T32 2086-2101 Disease denotes thromboembolism
T33 2148-2155 Chemical denotes heparin