PubMed:11819307 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11819307","sourcedb":"PubMed","sourceid":"11819307","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/11819307","text":"Phase tissue intercellular adhesion molecule-1 expression in nude mice human liver cancer metastasis model.\nAIM:To study the phase cancer tissue intercellular adhesion molecule-1 (ICAM-1) expression of human cancer metastasis model in nude mice, and to analyze the relationship between ICAM-1 expression and the metastasis and recurrence of hepatocellular cancinoma (HCC).METHODS:HCC tissues from liver cancer metastasis model in nude mice (LCI-D20) was orthotopically implanted, and ICAM-1 expression in HCC tissues at different growing time were detected by immunodot blot.Tumor size, intrahepatic and extrahepatic metastasis foci were observed by naked eyes and under light microscope.RESULTS:ICAM-1 was positively correlated to the tumor growing time (r = 0.88, P \u003c 0.01) and tumor size r =0.5, P \u003c 0.05). It was higher in metastatic HCC than in nonmetastatic HCC (8.24 ± 0.95 vs 3.03 ± 0.51, P \u003c 0.01). ICAM-1 content in cancer tissues increased suddenly after metastasis occurred and then maintained in a high level. ICAM-1 was also higher in multimetastasis group than in monometastasis group (10.05 ± 1.17 vs 5.48 ± 0.49, P \u003c0.05 =.CONCLUSION:Tissue ICAM-1 could predict not only the metastasis of human liver cancer metastasis model in nude mice early and sensitively, but also the metastasis degree. So tissue ICAM-1 may be a potential index indicating the status of metastasis of HCC patients.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":77,"end":89},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":367,"end":370},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":397,"end":409},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T8","span":{"begin":505,"end":508},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":736,"end":741},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T10","span":{"begin":780,"end":785},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":838,"end":841},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T12","span":{"begin":864,"end":867},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":1212,"end":1224},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T16","span":{"begin":1391,"end":1394},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0002691"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"0007256"},{"id":"A3","pred":"mondo_id","subj":"T1","obj":"0018531"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0007256"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0002691"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"0007256"},{"id":"A7","pred":"mondo_id","subj":"T5","obj":"0018531"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"0007256"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005070"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"0005070"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0007256"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"0007256"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0002691"},{"id":"A14","pred":"mondo_id","subj":"T13","obj":"0007256"},{"id":"A15","pred":"mondo_id","subj":"T13","obj":"0018531"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"0007256"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T4","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T8","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T10","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T11","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T12","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T13","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T16","pred":"source","obj":"PMID_GLOBAL"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PMID_GLOBAL","color":"#ecd393","default":true}]}]}}