PubMed:11815625
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1058-1065 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-51 | Sentence | denotes | Cytokine signaling: STATS in plasma membrane rafts. |
| T2 | 52-170 | Sentence | denotes | STAT transcription factors signal from the plasma membrane to the nucleus in response to growth factors and cytokines. |
| T3 | 171-274 | Sentence | denotes | We have investigated whether plasma membrane "rafts" are involved in cytokine-activated STAT signaling. |
| T4 | 275-637 | Sentence | denotes | Cytokine-free human hepatoma Hep3B cells or cells treated with interleukin-6 (IL-6) or orthovanadate (a general activator of STATs) were fractionated, and plasma membrane raft fractions were obtained by equilibrium sedimentation or flotation through discontinuous sucrose gradients using either non-detergent or detergent-based (saponin or Triton X-100) methods. |
| T5 | 638-1107 | Sentence | denotes | By Western blotting the plasma membrane raft fractions obtained using either non-detergent or detergent-based methods contained significant amounts of STAT1 and STAT3 (up to approximately 10% of the total cytoplasmic amount) as well as the integral raft proteins caveolin-1 and flotillin-1, the IL-6-receptor signal transducing chain gp130, the interferon-gamma receptor alpha chain (IFN-gammaRalpha), and the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57). |
| T6 | 1108-1301 | Sentence | denotes | Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT species were now also observed in the membrane raft fraction but in a form deficient in DNA binding. |
| T7 | 1302-1572 | Sentence | denotes | The data show pre-association of STATs with plasma membrane rafts in flotation fractions, which also contained caveolin-1 and flotillin-1, and suggest that Tyr phosphorylation may not in itself be sufficient to cause the departure of PY-STATs from plasma membrane rafts. |
| T8 | 1573-1726 | Sentence | denotes | Methyl-beta-cyclodextrin, which sequesters cholesterol and disrupts plasma membrane rafts, markedly inhibited IL-6- and IFN-gamma-induced STAT signaling. |
| T9 | 1727-1952 | Sentence | denotes | Signaling through specialized raft microdomains may be a general mechanism operating at the level of the plasma membrane through which cytokines and growth factors activate STAT species (the "raft-STAT signaling hypothesis"). |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1058-1065 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | protein | denotes | Cytokine |
| T2 | 20-25 | protein | denotes | STATS |
| T3 | 52-56 | protein | denotes | STAT |
| T4 | 57-78 | protein | denotes | transcription factors |
| T5 | 141-155 | protein | denotes | growth factors |
| T6 | 160-169 | protein | denotes | cytokines |
| T7 | 240-248 | protein | denotes | cytokine |
| T8 | 259-263 | protein | denotes | STAT |
| T9 | 275-283 | protein | denotes | Cytokine |
| T10 | 338-351 | protein | denotes | interleukin-6 |
| T11 | 353-357 | protein | denotes | IL-6 |
| T12 | 400-405 | protein | denotes | STATs |
| T13 | 789-794 | protein | denotes | STAT1 |
| T14 | 799-804 | protein | denotes | STAT3 |
| T15 | 901-911 | protein | denotes | caveolin-1 |
| T16 | 916-927 | protein | denotes | flotillin-1 |
| T17 | 933-971 | protein | denotes | IL-6-receptor signal transducing chain |
| T18 | 972-977 | protein | denotes | gp130 |
| T19 | 983-1020 | protein | denotes | interferon-gamma receptor alpha chain |
| T20 | 1022-1037 | protein | denotes | IFN-gammaRalpha |
| T21 | 1048-1057 | protein | denotes | chaperone |
| T22 | 1058-1086 | protein | denotes | glucose-regulated protein 58 |
| T23 | 1088-1093 | protein | denotes | GRP58 |
| T24 | 1094-1099 | protein | denotes | ER-60 |
| T25 | 1100-1105 | protein | denotes | ERp57 |
| T26 | 1140-1144 | protein | denotes | IL-6 |
| T27 | 1196-1200 | protein | denotes | STAT |
| T28 | 1335-1340 | protein | denotes | STATs |
| T29 | 1413-1423 | protein | denotes | caveolin-1 |
| T30 | 1428-1439 | protein | denotes | flotillin-1 |
| T31 | 1539-1544 | protein | denotes | STATs |
| T32 | 1683-1687 | protein | denotes | IL-6 |
| T33 | 1693-1702 | protein | denotes | IFN-gamma |
| T34 | 1711-1715 | protein | denotes | STAT |
| T35 | 1862-1871 | protein | denotes | cytokines |
| T36 | 1876-1890 | protein | denotes | growth factors |
| T37 | 1900-1904 | protein | denotes | STAT |
| T38 | 1924-1928 | protein | denotes | STAT |
PIR-corpus2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | protein | denotes | Cytokine |
| T2 | 20-25 | protein | denotes | STATS |
| T3 | 52-78 | protein | denotes | STAT transcription factors |
| T4 | 141-155 | protein | denotes | growth factors |
| T5 | 160-169 | protein | denotes | cytokines |
| T6 | 240-248 | protein | denotes | cytokine |
| T7 | 259-263 | protein | denotes | STAT |
| T8 | 275-283 | protein | denotes | Cytokine |
| T9 | 338-358 | protein | denotes | interleukin-6 (IL-6) |
| T10 | 400-405 | protein | denotes | STATs |
| T11 | 789-794 | protein | denotes | STAT1 |
| T12 | 799-804 | protein | denotes | STAT3 |
| T13 | 878-911 | protein | denotes | integral raft proteins caveolin-1 |
| T14 | 916-927 | protein | denotes | flotillin-1 |
| T15 | 933-946 | protein | denotes | IL-6-receptor |
| T16 | 972-977 | protein | denotes | gp130 |
| T17 | 983-1038 | protein | denotes | interferon-gamma receptor alpha chain (IFN-gammaRalpha) |
| T18 | 1048-1057 | protein | denotes | chaperone |
| T19 | 1088-1093 | protein | denotes | GRP58 |
| T20 | 1094-1099 | protein | denotes | ER-60 |
| T21 | 1100-1105 | protein | denotes | ERp57 |
| T22 | 1140-1144 | protein | denotes | IL-6 |
| T23 | 1196-1200 | protein | denotes | STAT |
| T24 | 1335-1340 | protein | denotes | STATs |
| T25 | 1413-1423 | protein | denotes | caveolin-1 |
| T26 | 1428-1439 | protein | denotes | flotillin-1 |
| T27 | 1539-1544 | protein | denotes | STATs |
| T28 | 1683-1687 | protein | denotes | IL-6 |
| T29 | 1693-1702 | protein | denotes | IFN-gamma |
| T30 | 1711-1715 | protein | denotes | STAT |
| T31 | 1862-1871 | protein | denotes | cytokines |
| T32 | 1876-1890 | protein | denotes | growth factors |
| T33 | 1900-1904 | protein | denotes | STAT |
| T34 | 1924-1928 | protein | denotes | STAT |
PIR-corpus1
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | protein | denotes | Cytokine |
| T2 | 20-25 | protein | denotes | STATS |
| T3 | 52-78 | protein | denotes | STAT transcription factors |
| T4 | 141-155 | protein | denotes | growth factors |
| T5 | 160-169 | protein | denotes | cytokines |
| T6 | 240-248 | protein | denotes | cytokine |
| T7 | 259-263 | protein | denotes | STAT |
| T8 | 275-283 | protein | denotes | Cytokine |
| T9 | 338-351 | protein | denotes | interleukin-6 |
| T10 | 353-357 | acronym | denotes | IL-6 |
| T11 | 400-405 | protein | denotes | STATs |
| T12 | 789-794 | protein | denotes | STAT1 |
| T13 | 799-804 | protein | denotes | STAT3 |
| T14 | 892-900 | protein | denotes | proteins |
| T15 | 901-911 | protein | denotes | caveolin-1 |
| T16 | 916-927 | protein | denotes | flotillin-1 |
| T17 | 933-946 | protein | denotes | IL-6-receptor |
| T18 | 972-977 | protein | denotes | gp130 |
| T19 | 983-1020 | protein | denotes | interferon-gamma receptor alpha chain |
| T20 | 1022-1037 | acronym | denotes | IFN-gammaRalpha |
| T21 | 1048-1057 | protein | denotes | chaperone |
| T22 | 1088-1105 | protein | denotes | GRP58/ER-60/ERp57 |
| T23 | 1140-1144 | protein | denotes | IL-6 |
| T24 | 1196-1200 | protein | denotes | STAT |
| T25 | 1335-1340 | protein | denotes | STATs |
| T26 | 1413-1423 | protein | denotes | caveolin-1 |
| T27 | 1428-1439 | protein | denotes | flotillin-1 |
| T28 | 1536-1544 | protein | denotes | PY-STATs |
| T29 | 1573-1597 | protein | denotes | Methyl-beta-cyclodextrin |
| T30 | 1683-1687 | protein | denotes | IL-6 |
| T31 | 1693-1702 | protein | denotes | IFN-gamma |
| T32 | 1711-1715 | protein | denotes | STAT |
| T33 | 1862-1871 | protein | denotes | cytokines |
| T34 | 1876-1890 | protein | denotes | growth factors |
| T35 | 1900-1904 | protein | denotes | STAT |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 295-303 | Disease | denotes | hepatoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 289-294 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 29-44 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T2 | 95-110 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T3 | 118-125 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
| T5 | 200-215 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T6 | 430-445 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T7 | 662-677 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T8 | 843-854 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T9 | 1239-1247 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T12 | 1346-1361 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T13 | 1550-1565 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T14 | 1641-1656 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |
| T15 | 1832-1847 | Body_part | denotes | plasma membrane | http://purl.obolibrary.org/obo/GO_0005886 |