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PubMed:11809755 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 895-903 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 912-920 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540

sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).
T2 105-247 Sentence denotes The intramembranous gamma-secretase cleavage of the beta-amyloid precursor protein (APP) is dependent on biologically active presenilins (PS).
T3 248-631 Sentence denotes Notch also undergoes a similar PS-dependent gamma-secretase-like cleavage, resulting in the liberation of the Notch intracellular domain (NICD), which is critically required for developmental signal transduction. gamma-Secretase processing of APP results in the production of a similar fragment called AICD (APP intracellular domain), which may function in nuclear signaling as well.
T4 632-668 Sentence denotes AICD, like NICD, is rapidly removed.
T5 669-803 Sentence denotes By using a battery of protease inhibitors we demonstrate that AICD, in contrast to NICD, is degraded by a cytoplasmic metalloprotease.
T6 804-927 Sentence denotes In vitro degradation of AICD can be reconstituted with cytoplasmic fractions obtained from neuronal and non-neuronal cells.
T7 928-1218 Sentence denotes Taking into account the inhibition profile and the cytoplasmic localization, we identified three candidate enzymes (neurolysin, thimet oligopeptidase, and insulin-degrading enzyme (IDE), also known as insulysin), which all are involved in the degradation of bioactive peptides in the brain.
T8 1219-1357 Sentence denotes When insulin, a well characterized substrate of IDE, was added to the in vitro degradation assay, removal of AICD was efficiently blocked.
T9 1358-1520 Sentence denotes Moreover, overexpression of IDE resulted in enhanced degradation of AICD, whereas overexpression of the inactive IDE E111Q mutant did not affect AICD degradation.
T10 1521-1603 Sentence denotes Finally, immunodepletion of IDE significantly reduced the AICD degrading activity.
T11 1604-1793 Sentence denotes Therefore our data demonstrate that IDE, which is one of the proteases implicated in the removal of extracellular Abeta, also removes the cytoplasmic product of gamma-secretase cleaved APP.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1212-1217 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-24 protein denotes Insulin-degrading enzyme
T2 45-96 protein denotes beta-amyloid precursor protein intracellular domain
T3 98-102 protein denotes AICD
T4 125-140 protein denotes gamma-secretase
T5 157-187 protein denotes beta-amyloid precursor protein
T6 189-192 protein denotes APP
T7 230-241 protein denotes presenilins
T8 243-245 protein denotes PS
T9 248-253 protein denotes Notch
T10 279-281 protein denotes PS
T11 292-307 protein denotes gamma-secretase
T12 358-384 protein denotes Notch intracellular domain
T13 386-390 protein denotes NICD
T14 461-476 protein denotes gamma-Secretase
T15 491-494 protein denotes APP
T16 550-554 protein denotes AICD
T17 556-580 protein denotes APP intracellular domain
T18 632-636 protein denotes AICD
T19 643-647 protein denotes NICD
T20 691-699 protein denotes protease
T21 731-735 protein denotes AICD
T22 752-756 protein denotes NICD
T23 787-802 protein denotes metalloprotease
T24 828-832 protein denotes AICD
T25 1044-1054 protein denotes neurolysin
T26 1056-1077 protein denotes thimet oligopeptidase
T27 1083-1107 protein denotes insulin-degrading enzyme
T28 1109-1112 protein denotes IDE
T29 1129-1138 protein denotes insulysin
T30 1224-1231 protein denotes insulin
T31 1267-1270 protein denotes IDE
T32 1328-1332 protein denotes AICD
T33 1386-1389 protein denotes IDE
T34 1426-1430 protein denotes AICD
T35 1471-1474 protein denotes IDE
T36 1503-1507 protein denotes AICD
T37 1549-1552 protein denotes IDE
T38 1579-1583 protein denotes AICD
T39 1640-1643 protein denotes IDE
T40 1665-1674 protein denotes proteases
T41 1718-1723 protein denotes Abeta
T42 1765-1780 protein denotes gamma-secretase
T43 1789-1792 protein denotes APP

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 0-24 protein denotes Insulin-degrading enzyme
T2 45-67 protein denotes beta-amyloid precursor
T3 109-140 protein denotes intramembranous gamma-secretase
T4 157-179 protein denotes beta-amyloid precursor
T5 230-246 protein denotes presenilins (PS)
T6 248-253 protein denotes Notch
T7 279-281 protein denotes PS
T8 292-307 protein denotes gamma-secretase
T9 358-363 protein denotes Notch
T10 461-476 protein denotes gamma-Secretase
T11 491-494 protein denotes APP
T12 556-559 protein denotes APP
T13 691-699 protein denotes protease
T14 775-802 protein denotes cytoplasmic metalloprotease
T15 1044-1054 protein denotes neurolysin
T16 1056-1077 protein denotes thimet oligopeptidase
T17 1083-1107 protein denotes insulin-degrading enzyme
T18 1129-1138 protein denotes insulysin
T19 1224-1231 protein denotes insulin
T20 1267-1270 protein denotes IDE
T21 1386-1389 protein denotes IDE
T22 1471-1474 protein denotes IDE
T23 1549-1552 protein denotes IDE
T24 1640-1643 protein denotes IDE
T25 1665-1674 protein denotes proteases
T26 1765-1780 protein denotes gamma-secretase
T27 1789-1792 protein denotes APP

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 0-24 protein denotes Insulin-degrading enzyme
T2 125-140 protein denotes gamma-secretase
T3 157-179 protein denotes beta-amyloid precursor
T4 189-192 acronym denotes APP
T5 230-241 protein denotes presenilins
T6 243-245 acronym denotes PS
T7 279-307 protein denotes PS-dependent gamma-secretase
T8 461-476 protein denotes gamma-Secretase
T9 491-494 protein denotes APP
T10 787-802 protein denotes metalloprotease
T11 1035-1042 protein denotes enzymes
T12 1044-1054 protein denotes neurolysin
T13 1056-1077 protein denotes thimet oligopeptidase
T14 1083-1107 protein denotes insulin-degrading enzyme
T15 1109-1112 acronym denotes IDE
T16 1129-1138 protein denotes insulysin
T17 1224-1231 protein denotes insulin
T18 1267-1270 protein denotes IDE
T19 1386-1389 protein denotes IDE
T20 1471-1474 protein denotes IDE
T21 1549-1552 protein denotes IDE
T22 1640-1643 protein denotes IDE
T23 1665-1674 protein denotes proteases
T24 1718-1723 protein denotes Abeta
T25 1765-1780 protein denotes gamma-secretase
T26 1789-1792 protein denotes APP

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1212-1217 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 50-57 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 162-169 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 76-89 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T2 364-377 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 560-573 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T4 775-786 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T5 859-870 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T6 979-990 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T7 1212-1217 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T9 1704-1717 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T10 1742-1753 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737