PubMed:11805072 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11805072","sourcedb":"PubMed","sourceid":"11805072","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11805072","text":"Update and perspectives on congenital disorders of glycosylation.\nDefects in nine genes of the N-linked glycosylation pathway cause congenital disorders of glycosylation (CDGs) and serious medical consequences. Although glycobiology is seldom featured in a general medical education, an increasing number of physicians are becoming acquainted with the field because it directly impacts patient diagnosis and care. Medical practice and attitudes will change in the postgenomic era, and glycobiology has an opportunity to be a cornerstone of part of that new perspective. This review of recent developments in the CDG field describes the biochemical and molecular basis of these disorders, describes successful experimental approaches, and points out a few perspectives on current problems. The broad, multisystemic presentations of these patients emphasize that glycobiology is very much a general medical science, cutting across many traditional medical specialties. The glycobiology community is well poised to provide novel perspectives for the dedicated clinicians treating both well-known and emerging human 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