PubMed:11795260
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11795260","sourcedb":"PubMed","sourceid":"11795260","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11795260","text":"Genetic studies on the role of proteinases and growth factors in atherosclerosis and aneurysm formation.\nExpression analysis and epidemiologic studies have provided indirect evidence that proteinases and growth factors play a role in the development of atherosclerosis and complications such as aneurysm formation and plaque rupture. Studies using genetically altered mice have proven to be an elegant tool to study the causal involvement of these factors in atherogenesis and to gain insight into the underlying mechanisms. Recently, proteinases of the plasminogen and matrix metalloproteinase (MMP) systems as well as their inhibitors have received much attention, and these studies together have emphasized the complexity of their role in vascular disease. This overview summarizes the current knowledge on plasminogen activator inhibitor-1 (PAI-1) in the progression of atherosclerosis and the influence of MMPs in aneurysm formation. In addition, a possible role for Gas6, the product of growth arrest-specific gene 6, in atherosclerotic lesion development is put into perspective.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":810,"end":843},"obj":"protein"},{"id":"T2","span":{"begin":845,"end":850},"obj":"protein"},{"id":"T3","span":{"begin":972,"end":976},"obj":"protein"},{"id":"T4","span":{"begin":993,"end":1022},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":554,"end":565},"obj":"gene:5340"},{"id":"T1","span":{"begin":742,"end":758},"obj":"disease:C0042373"},{"id":"T2","span":{"begin":845,"end":850},"obj":"gene:5054"},{"id":"T3","span":{"begin":874,"end":889},"obj":"disease:C0003850"},{"id":"T4","span":{"begin":810,"end":843},"obj":"gene:5054"},{"id":"T5","span":{"begin":919,"end":927},"obj":"disease:C0002940"},{"id":"T6","span":{"begin":810,"end":843},"obj":"gene:5054"},{"id":"T7","span":{"begin":874,"end":889},"obj":"disease:C0004153"},{"id":"T8","span":{"begin":845,"end":850},"obj":"gene:5054"},{"id":"T9","span":{"begin":874,"end":889},"obj":"disease:C0004153"},{"id":"T10","span":{"begin":845,"end":850},"obj":"gene:5054"},{"id":"T11","span":{"begin":919,"end":927},"obj":"disease:C0002940"},{"id":"T12","span":{"begin":810,"end":843},"obj":"gene:5054"},{"id":"T13","span":{"begin":874,"end":889},"obj":"disease:C0003850"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"}]},{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":31,"end":42},"obj":"protein"},{"id":"T2","span":{"begin":47,"end":61},"obj":"protein"},{"id":"T3","span":{"begin":188,"end":199},"obj":"protein"},{"id":"T4","span":{"begin":204,"end":218},"obj":"protein"},{"id":"T5","span":{"begin":535,"end":546},"obj":"protein"},{"id":"T6","span":{"begin":554,"end":565},"obj":"protein"},{"id":"T7","span":{"begin":570,"end":594},"obj":"protein"},{"id":"T8","span":{"begin":596,"end":599},"obj":"protein"},{"id":"T9","span":{"begin":810,"end":843},"obj":"protein"},{"id":"T10","span":{"begin":845,"end":850},"obj":"protein"},{"id":"T11","span":{"begin":911,"end":915},"obj":"protein"},{"id":"T12","span":{"begin":972,"end":976},"obj":"protein"},{"id":"T13","span":{"begin":993,"end":1022},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11795260-3#29#40#gene5340","span":{"begin":554,"end":565},"obj":"gene5340"},{"id":"11795260-3#217#233#diseaseC0042373","span":{"begin":742,"end":758},"obj":"diseaseC0042373"},{"id":"11795260-4#50#83#gene5054","span":{"begin":810,"end":843},"obj":"gene5054"},{"id":"11795260-4#85#90#gene5054","span":{"begin":845,"end":850},"obj":"gene5054"},{"id":"11795260-4#50#83#gene5054","span":{"begin":810,"end":843},"obj":"gene5054"},{"id":"11795260-4#85#90#gene5054","span":{"begin":845,"end":850},"obj":"gene5054"},{"id":"11795260-4#114#129#diseaseC0003850","span":{"begin":874,"end":889},"obj":"diseaseC0003850"},{"id":"11795260-4#114#129#diseaseC0004153","span":{"begin":874,"end":889},"obj":"diseaseC0004153"},{"id":"11795260-4#114#129#diseaseC0003850","span":{"begin":874,"end":889},"obj":"diseaseC0003850"},{"id":"11795260-4#114#129#diseaseC0004153","span":{"begin":874,"end":889},"obj":"diseaseC0004153"},{"id":"11795260-4#159#167#diseaseC0002940","span":{"begin":919,"end":927},"obj":"diseaseC0002940"}],"relations":[{"id":"29#40#gene5340217#233#diseaseC0042373","pred":"associated_with","subj":"11795260-3#29#40#gene5340","obj":"11795260-3#217#233#diseaseC0042373"},{"id":"50#83#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"50#83#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"50#83#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"50#83#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"50#83#gene5054159#167#diseaseC0002940","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#159#167#diseaseC0002940"},{"id":"85#90#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"85#90#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"85#90#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"85#90#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"85#90#gene5054159#167#diseaseC0002940","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#159#167#diseaseC0002940"},{"id":"50#83#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"50#83#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"50#83#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"50#83#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"50#83#gene5054159#167#diseaseC0002940","pred":"associated_with","subj":"11795260-4#50#83#gene5054","obj":"11795260-4#159#167#diseaseC0002940"},{"id":"85#90#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"85#90#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"85#90#gene5054114#129#diseaseC0003850","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0003850"},{"id":"85#90#gene5054114#129#diseaseC0004153","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#114#129#diseaseC0004153"},{"id":"85#90#gene5054159#167#diseaseC0002940","pred":"associated_with","subj":"11795260-4#85#90#gene5054","obj":"11795260-4#159#167#diseaseC0002940"}],"attributes":[{"subj":"11795260-3#29#40#gene5340","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-3#217#233#diseaseC0042373","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#50#83#gene5054","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#85#90#gene5054","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#50#83#gene5054","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#85#90#gene5054","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#114#129#diseaseC0003850","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#114#129#diseaseC0004153","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#114#129#diseaseC0003850","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#114#129#diseaseC0004153","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11795260-4#159#167#diseaseC0002940","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#ecd393","default":true},{"id":"DisGeNET","color":"#b993ec"},{"id":"FSU-PRGE","color":"#93ec9f"},{"id":"DisGeNET5_gene_disease","color":"#ec93a1"}]}]}}