PubMed:11790779
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 16-26 | Glycan_Motif | denotes | hyaluronan | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T2 | 499-509 | Glycan_Motif | denotes | hyaluronan | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T3 | 511-513 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T4 | 568-570 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T5 | 660-662 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T6 | 829-831 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T7 | 954-956 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T8 | 1316-1318 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
| T9 | 1404-1406 | Glycan_Motif | denotes | HA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00017MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-163 | Sentence | denotes | Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells. |
| T2 | 164-342 | Sentence | denotes | Prostate cancer metastasis to bone marrow involves initial adhesion of tumor cells to the bone marrow endothelium, followed by transmigration and proliferation within the marrow. |
| T3 | 343-597 | Sentence | denotes | Rapid, specific adhesion of highly metastatic prostate adenocarcinoma cells (PC3M-LN4) to bone marrow endothelial cell (BMEC) lines requires a pericellular hyaluronan (HA) matrix and correlates with dramatically up-regulated HA synthase (HAS) expression. |
| T4 | 598-728 | Sentence | denotes | Non-metastatic prostate tumor cells (LNCaP) do not assemble a HA matrix, adhere poorly to BMECs, and express normal levels of HAS. |
| T5 | 729-845 | Sentence | denotes | Preferential bone metastasis of prostate carcinoma cells may therefore be facilitated by tumor cell HA biosynthesis. |
| T6 | 846-989 | Sentence | denotes | In this report, HAS gene expression was manipulated to investigate the direct impact of prostate tumor cell HA production on adhesion to BMECs. |
| T7 | 990-1090 | Sentence | denotes | PC3M-LN4 cells stably transfected with antisense HAS2 and HAS3 failed to form pericellular matrices. |
| T8 | 1091-1215 | Sentence | denotes | Adhesion of these transfectants to BMECs was significantly diminished, comparable to the low level exhibited by LNCaP cells. |
| T9 | 1216-1340 | Sentence | denotes | Upon transfection with full-length HAS2 or HAS3, the non-adherent LNCaP cells retained pericellular HA and adhered to BMECs. |
| T10 | 1341-1496 | Sentence | denotes | The results of this study are consistent with a model in which HA matrix formation, BMEC adhesion, and metastatic potential are mediated by HAS expression. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-26 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | hyaluronan |
| T2 | 499-509 | https://glytoucan.org/Structures/Glycans/G00017MO | denotes | hyaluronan |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 50-58 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T2 | 133-144 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
| T3 | 133-137 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
| T4 | 164-172 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | Prostate |
| T5 | 194-205 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
| T6 | 194-198 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
| T7 | 254-265 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
| T8 | 254-258 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
| T9 | 389-397 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T10 | 433-444 | http://purl.obolibrary.org/obo/MAT_0000084 | denotes | bone marrow |
| T11 | 433-437 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
| T12 | 613-621 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T13 | 742-746 | http://purl.obolibrary.org/obo/MAT_0000299 | denotes | bone |
| T14 | 761-769 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
| T15 | 934-942 | http://purl.obolibrary.org/obo/MAT_0000078 | denotes | prostate |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-35 | protein | denotes | hyaluronan synthase |
| T2 | 568-579 | protein | denotes | HA synthase |
| T3 | 581-584 | protein | denotes | HAS |
| T4 | 724-727 | protein | denotes | HAS |
| T5 | 862-865 | protein | denotes | HAS |
| T6 | 1039-1043 | protein | denotes | HAS2 |
| T7 | 1048-1052 | protein | denotes | HAS3 |
| T8 | 1251-1255 | protein | denotes | HAS2 |
| T9 | 1259-1263 | protein | denotes | HAS3 |
| T10 | 1481-1484 | protein | denotes | HAS |
PIR-corpus2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-35 | protein | denotes | hyaluronan synthase |
| T2 | 568-585 | protein | denotes | HA synthase (HAS) |
| T3 | 724-727 | protein | denotes | HAS |
| T4 | 862-865 | protein | denotes | HAS |
| T5 | 1039-1043 | protein | denotes | HAS2 |
| T6 | 1048-1052 | protein | denotes | HAS3 |
| T7 | 1251-1255 | protein | denotes | HAS2 |
| T8 | 1259-1263 | protein | denotes | HAS3 |
| T9 | 1481-1484 | protein | denotes | HAS |
PIR-corpus1
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 16-35 | protein | denotes | hyaluronan synthase |
| T2 | 568-579 | protein | denotes | HA synthase |
| T3 | 581-584 | acronym | denotes | HAS |
| T4 | 724-727 | protein | denotes | HAS |
| T5 | 1251-1255 | protein | denotes | HAS2 |
| T6 | 1259-1263 | protein | denotes | HAS3 |
| T7 | 1481-1484 | protein | denotes | HAS |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 50-58 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T2 | 133-144 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
| T3 | 164-172 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T4 | 194-205 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
| T5 | 254-265 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
| T6 | 389-397 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T7 | 433-444 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/MAT_0000084 |
| T8 | 613-621 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T9 | 742-746 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/MAT_0000299 |
| T10 | 761-769 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
| T11 | 934-942 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/MAT_0000078 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 164-179 | Phenotype | denotes | Prostate cancer | HP:0012125 |
| T2 | 235-240 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 622-627 | Phenotype | denotes | tumor | HP:0002664 |
| T4 | 770-779 | Phenotype | denotes | carcinoma | HP:0030731 |
| T5 | 818-823 | Phenotype | denotes | tumor | HP:0002664 |
| T6 | 943-948 | Phenotype | denotes | tumor | HP:0002664 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 50-73 | Disease | denotes | prostate adenocarcinoma | http://purl.obolibrary.org/obo/MONDO_0005082 |
| T2 | 164-179 | Disease | denotes | Prostate cancer | http://purl.obolibrary.org/obo/MONDO_0008315 |
| T3 | 235-240 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 389-412 | Disease | denotes | prostate adenocarcinoma | http://purl.obolibrary.org/obo/MONDO_0005082 |
| T5 | 581-584 | Disease | denotes | HAS | http://purl.obolibrary.org/obo/MONDO_0019395 |
| T6 | 613-627 | Disease | denotes | prostate tumor | http://purl.obolibrary.org/obo/MONDO_0021259 |
| T7 | 724-727 | Disease | denotes | HAS | http://purl.obolibrary.org/obo/MONDO_0019395 |
| T8 | 761-779 | Disease | denotes | prostate carcinoma | http://purl.obolibrary.org/obo/MONDO_0005159 |
| T9 | 818-823 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T10 | 862-865 | Disease | denotes | HAS | http://purl.obolibrary.org/obo/MONDO_0019395 |
| T11 | 934-948 | Disease | denotes | prostate tumor | http://purl.obolibrary.org/obo/MONDO_0021259 |
| T12 | 1481-1484 | Disease | denotes | HAS | http://purl.obolibrary.org/obo/MONDO_0019395 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 50-58 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T2 | 133-144 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T3 | 145-162 | Body_part | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL_0000115 |
| T4 | 164-172 | Body_part | denotes | Prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T5 | 194-205 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T6 | 254-265 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T7 | 266-277 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
| T8 | 389-397 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T9 | 433-444 | Body_part | denotes | bone marrow | http://purl.obolibrary.org/obo/UBERON_0002371 |
| T10 | 445-461 | Body_part | denotes | endothelial cell | http://purl.obolibrary.org/obo/CL_0000115 |
| T11 | 613-621 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T12 | 742-746 | Body_part | denotes | bone | http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481 |
| T14 | 761-769 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
| T15 | 934-942 | Body_part | denotes | prostate | http://purl.obolibrary.org/obo/UBERON_0002367 |
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 145-162 | Cell | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL:0000115 |
| T2 | 235-246 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T3 | 445-461 | Cell | denotes | endothelial cell | http://purl.obolibrary.org/obo/CL:0000115 |
| T4 | 622-633 | Cell | denotes | tumor cells | http://purl.obolibrary.org/obo/CL:0001063 |
| T5 | 818-828 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T6 | 943-953 | Cell | denotes | tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |