PubMed:11789762 JSONTXT

{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":32,"end":71},"obj":"protein"},{"id":"T2","span":{"begin":187,"end":226},"obj":"protein"},{"id":"T3","span":{"begin":236,"end":242},"obj":"protein"},{"id":"T4","span":{"begin":244,"end":247},"obj":"protein"},{"id":"T5","span":{"begin":248,"end":254},"obj":"protein"},{"id":"T6","span":{"begin":256,"end":262},"obj":"protein"},{"id":"T7","span":{"begin":268,"end":274},"obj":"protein"},{"id":"T8","span":{"begin":370,"end":409},"obj":"protein"},{"id":"T9","span":{"begin":687,"end":693},"obj":"protein"},{"id":"T10","span":{"begin":698,"end":704},"obj":"protein"},{"id":"T11","span":{"begin":756,"end":767},"obj":"protein"},{"id":"T12","span":{"begin":801,"end":840},"obj":"protein"},{"id":"T13","span":{"begin":1130,"end":1136},"obj":"protein"},{"id":"T14","span":{"begin":1227,"end":1233},"obj":"protein"},{"id":"T15","span":{"begin":1331,"end":1337},"obj":"protein"}],"text":"Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer.\nBACKGROUND: To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence.\nMETHODS: We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer.\nRESULTS: Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence.\nCONCLUSIONS: The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":236,"end":242},"obj":"protein"},{"id":"T2","span":{"begin":248,"end":254},"obj":"protein"},{"id":"T3","span":{"begin":256,"end":262},"obj":"protein"},{"id":"T4","span":{"begin":268,"end":274},"obj":"protein"},{"id":"T5","span":{"begin":687,"end":693},"obj":"protein"},{"id":"T6","span":{"begin":698,"end":704},"obj":"protein"},{"id":"T7","span":{"begin":756,"end":762},"obj":"protein"},{"id":"T8","span":{"begin":1130,"end":1136},"obj":"protein"},{"id":"T9","span":{"begin":1227,"end":1233},"obj":"protein"},{"id":"T10","span":{"begin":1331,"end":1337},"obj":"protein"}],"text":"Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer.\nBACKGROUND: To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence.\nMETHODS: We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer.\nRESULTS: Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence.\nCONCLUSIONS: The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good."}