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Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 169-177 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 1035-1051 Cell denotes cortical neurons http://purl.obolibrary.org/obo/CL:0010012
T3 1159-1175 Cell denotes cortical neurons http://purl.obolibrary.org/obo/CL:0010012

sentences

Id Subject Object Predicate Lexical cue
T1 0-80 Sentence denotes Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.
T2 81-201 Sentence denotes The activity of cyclin-dependent kinase-5 (Cdk5) is tightly regulated by binding of its neuronal activators p35 and p39.
T3 202-471 Sentence denotes Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5.
T4 472-626 Sentence denotes It is unknown whether p39, which is expressed throughout the adult rat brain, is cleaved by calpain, and whether this contributes to deregulation of Cdk5.
T5 627-729 Sentence denotes Here, we show that calpain cleaved p39 in vitro, resulting in generation of a C-terminal p29 fragment.
T6 730-819 Sentence denotes In vivo, p29 was generated in ischemic brain concomitant with increased calpain activity.
T7 820-932 Sentence denotes In fresh brain lysates, generation of p29 was Ca(2+)-dependent, and calpain inhibitors abolished p29 production.
T8 933-1082 Sentence denotes The Ca(2+) ionophore ionomycin and the excitotoxin glutamate induced production of p29 in cultures of cortical neurons in a calpain-dependent manner.
T9 1083-1176 Sentence denotes Like p25, p29 was more stable than p39 and caused redistribution of Cdk5 in cortical neurons.
T10 1177-1316 Sentence denotes Our data suggest that neurotoxic insults lead to calpain-mediated conversion of p39 to p29, which might contribute to deregulation of Cdk5.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 322-328 http://purl.obolibrary.org/obo/MAT_0000098 denotes brains
T2 336-342 http://purl.obolibrary.org/obo/MAT_0000098 denotes brains
T3 543-548 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 769-774 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T5 829-834 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-7 protein denotes Calpain
T2 33-72 protein denotes cyclin-dependent kinase-5 activator p39
T3 97-122 protein denotes cyclin-dependent kinase-5
T4 124-128 protein denotes Cdk5
T5 189-192 protein denotes p35
T6 197-200 protein denotes p39
T7 227-230 protein denotes p35
T8 245-248 protein denotes p25
T9 273-281 protein denotes protease
T10 282-289 protein denotes calpain
T11 291-294 protein denotes p25
T12 381-384 protein denotes p25
T13 397-401 protein denotes Cdk5
T14 466-470 protein denotes Cdk5
T15 494-497 protein denotes p39
T16 564-571 protein denotes calpain
T17 621-625 protein denotes Cdk5
T18 646-653 protein denotes calpain
T19 662-665 protein denotes p39
T20 802-809 protein denotes calpain
T21 1057-1064 protein denotes calpain
T22 1088-1091 protein denotes p25
T23 1118-1121 protein denotes p39
T24 1151-1155 protein denotes Cdk5
T25 1226-1233 protein denotes calpain
T26 1257-1260 protein denotes p39
T27 1264-1267 protein denotes p29
T28 1311-1315 protein denotes Cdk5

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 0-7 protein denotes Calpain
T2 33-72 protein denotes cyclin-dependent kinase-5 activator p39
T3 76-79 protein denotes p29
T4 97-129 protein denotes cyclin-dependent kinase-5 (Cdk5)
T5 169-192 protein denotes neuronal activators p35
T6 197-200 protein denotes p39
T7 227-230 protein denotes p35
T8 245-248 protein denotes p25
T9 256-289 protein denotes Ca(2+)-dependent protease calpain
T10 291-294 protein denotes p25
T11 381-384 protein denotes p25
T12 397-401 protein denotes Cdk5
T13 466-470 protein denotes Cdk5
T14 494-497 protein denotes p39
T15 564-571 protein denotes calpain
T16 621-625 protein denotes Cdk5
T17 646-653 protein denotes calpain
T18 662-665 protein denotes p39
T19 716-719 protein denotes p29
T20 739-742 protein denotes p29
T21 802-809 protein denotes calpain
T22 858-861 protein denotes p29
T23 888-895 protein denotes calpain
T24 917-920 protein denotes p29
T25 1016-1019 protein denotes p29
T26 1057-1064 protein denotes calpain
T27 1088-1091 protein denotes p25
T28 1093-1096 protein denotes p29
T29 1118-1121 protein denotes p39
T30 1151-1155 protein denotes Cdk5
T31 1226-1233 protein denotes calpain
T32 1257-1260 protein denotes p39
T33 1264-1267 protein denotes p29
T34 1311-1315 protein denotes Cdk5

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 0-7 protein denotes Calpain
T2 33-72 protein denotes cyclin-dependent kinase-5 activator p39
T3 97-122 protein denotes cyclin-dependent kinase-5
T4 124-128 acronym denotes Cdk5
T5 178-192 protein denotes activators p35
T6 197-200 protein denotes p39
T7 227-230 protein denotes p35
T8 256-281 protein denotes Ca(2+)-dependent protease
T9 282-289 protein denotes calpain
T10 291-294 protein denotes p25
T11 397-401 protein denotes Cdk5
T12 466-470 protein denotes Cdk5
T13 494-497 protein denotes p39
T14 564-571 protein denotes calpain
T15 621-625 protein denotes Cdk5
T16 646-653 protein denotes calpain
T17 662-665 protein denotes p39
T18 802-809 protein denotes calpain
T19 1118-1121 protein denotes p39
T20 1151-1155 protein denotes Cdk5
T21 1257-1260 protein denotes p39
T22 1311-1315 protein denotes Cdk5

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 322-328 Body_part denotes brains http://purl.obolibrary.org/obo/MAT_0000098
T2 336-342 Body_part denotes brains http://purl.obolibrary.org/obo/MAT_0000098
T3 543-548 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T4 769-774 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T5 829-834 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 360-379 Phenotype denotes Alzheimer's disease HP:0002511

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 207-217 Disease denotes neurotoxic http://purl.obolibrary.org/obo/MONDO_0005527
T2 360-379 Disease denotes Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0004975
T3 1199-1209 Disease denotes neurotoxic http://purl.obolibrary.org/obo/MONDO_0005527

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 539-542 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 543-548 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 769-774 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T5 829-834 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T7 1035-1051 Body_part denotes cortical neurons http://purl.obolibrary.org/obo/CL_0010012
T8 1159-1175 Body_part denotes cortical neurons http://purl.obolibrary.org/obo/CL_0010012