PubMed:11781834 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11781834","sourcedb":"PubMed","sourceid":"11781834","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11781834","text":"Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells.\nCellular senescence has been proposed to be an in vitro and in vivo block that cells must overcome in order to immortalize and become tumorigenic. To characterize these pathways, we focused on changes in the cyclin-dependent kinase inhibitors and their binding partners that underlie the cell cycle arrest at senescence. As a model, we utilized normal human prostate epithelial cell (HPEC) and human uroepithelial cell (HUC) cultures. After 30-40 population doublings cells became growth-arrested in G0/1 with a threefold decrease in Cdk2-associated activity, a point defined as pre-senescence. Temporally following this growth arrest, the cells develop a senescence morphology and express senescence-associated beta-galactosidase (SA-beta-gal). Levels of p16(INK4a) and p57(KIP2) rise in HUCs during progressive passages, whereas only p16 increases in HPEC cultures. The induced expression of p57, similar to p16, produces a senescent-like phenotype. pRB, cyclin D, p19(INK4d) and p27(KIP1) decrease in both cell types. We find that p53, p21(CIP1) and p15(INK4b) are transiently elevated in HPECs and HUCs at the pre-senescent growth arrest, then return to low proliferating levels at terminal senescence. Analysis of p53, p21(CIP1), p15(INK4b), p16(INK4a), and p57(KIP2) reveals altered expression in immortalized, non-tumorigenic HPV16 E6 and E7 prostate lines and in tumorigenic prostate cancer cells. These results indicate: (i) the existence of a subset of growth inhibiting genes elevated at the onset of the senescence, (ii) a distinct class of genes involved in the maintenance of senescence, and (iii) the frequent inactivation of these pathways during immortalization.","tracks":[{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":666,"end":670},"obj":"protein"},{"id":"T2","span":{"begin":822,"end":862},"obj":"protein"},{"id":"T3","span":{"begin":864,"end":875},"obj":"protein"},{"id":"T4","span":{"begin":888,"end":891},"obj":"protein"},{"id":"T5","span":{"begin":892,"end":897},"obj":"protein"},{"id":"T6","span":{"begin":903,"end":906},"obj":"protein"},{"id":"T7","span":{"begin":907,"end":911},"obj":"protein"},{"id":"T8","span":{"begin":968,"end":971},"obj":"protein"},{"id":"T9","span":{"begin":1026,"end":1029},"obj":"protein"},{"id":"T10","span":{"begin":1042,"end":1045},"obj":"protein"},{"id":"T11","span":{"begin":1084,"end":1087},"obj":"protein"},{"id":"T12","span":{"begin":1089,"end":1097},"obj":"protein"},{"id":"T13","span":{"begin":1099,"end":1102},"obj":"protein"},{"id":"T14","span":{"begin":1103,"end":1108},"obj":"protein"},{"id":"T15","span":{"begin":1114,"end":1117},"obj":"protein"},{"id":"T16","span":{"begin":1118,"end":1122},"obj":"protein"},{"id":"T17","span":{"begin":1166,"end":1169},"obj":"protein"},{"id":"T18","span":{"begin":1171,"end":1174},"obj":"protein"},{"id":"T19","span":{"begin":1175,"end":1179},"obj":"protein"},{"id":"T20","span":{"begin":1185,"end":1188},"obj":"protein"},{"id":"T21","span":{"begin":1189,"end":1194},"obj":"protein"},{"id":"T22","span":{"begin":1351,"end":1354},"obj":"protein"},{"id":"T23","span":{"begin":1356,"end":1359},"obj":"protein"},{"id":"T24","span":{"begin":1360,"end":1364},"obj":"protein"},{"id":"T25","span":{"begin":1367,"end":1370},"obj":"protein"},{"id":"T26","span":{"begin":1371,"end":1376},"obj":"protein"},{"id":"T27","span":{"begin":1379,"end":1382},"obj":"protein"},{"id":"T28","span":{"begin":1383,"end":1388},"obj":"protein"},{"id":"T29","span":{"begin":1395,"end":1398},"obj":"protein"},{"id":"T30","span":{"begin":1399,"end":1403},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"AIMed"},{"subj":"T2","pred":"source","obj":"AIMed"},{"subj":"T3","pred":"source","obj":"AIMed"},{"subj":"T4","pred":"source","obj":"AIMed"},{"subj":"T5","pred":"source","obj":"AIMed"},{"subj":"T6","pred":"source","obj":"AIMed"},{"subj":"T7","pred":"source","obj":"AIMed"},{"subj":"T8","pred":"source","obj":"AIMed"},{"subj":"T9","pred":"source","obj":"AIMed"},{"subj":"T10","pred":"source","obj":"AIMed"},{"subj":"T11","pred":"source","obj":"AIMed"},{"subj":"T12","pred":"source","obj":"AIMed"},{"subj":"T13","pred":"source","obj":"AIMed"},{"subj":"T14","pred":"source","obj":"AIMed"},{"subj":"T15","pred":"source","obj":"AIMed"},{"subj":"T16","pred":"source","obj":"AIMed"},{"subj":"T17","pred":"source","obj":"AIMed"},{"subj":"T18","pred":"source","obj":"AIMed"},{"subj":"T19","pred":"source","obj":"AIMed"},{"subj":"T20","pred":"source","obj":"AIMed"},{"subj":"T21","pred":"source","obj":"AIMed"},{"subj":"T22","pred":"source","obj":"AIMed"},{"subj":"T23","pred":"source","obj":"AIMed"},{"subj":"T24","pred":"source","obj":"AIMed"},{"subj":"T25","pred":"source","obj":"AIMed"},{"subj":"T26","pred":"source","obj":"AIMed"},{"subj":"T27","pred":"source","obj":"AIMed"},{"subj":"T28","pred":"source","obj":"AIMed"},{"subj":"T29","pred":"source","obj":"AIMed"},{"subj":"T30","pred":"source","obj":"AIMed"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":1399,"end":1403},"obj":"gene:10518"},{"id":"T1","span":{"begin":1515,"end":1530},"obj":"disease:C0376358"},{"id":"T2","span":{"begin":1399,"end":1403},"obj":"gene:10518"},{"id":"T3","span":{"begin":1515,"end":1530},"obj":"disease:C0600139"},{"id":"T4","span":{"begin":1399,"end":1403},"obj":"gene:1028"},{"id":"T5","span":{"begin":1515,"end":1530},"obj":"disease:C0376358"},{"id":"T6","span":{"begin":1399,"end":1403},"obj":"gene:1028"},{"id":"T7","span":{"begin":1515,"end":1530},"obj":"disease:C0600139"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":8,"end":31},"obj":"protein"},{"id":"T2","span":{"begin":340,"end":363},"obj":"protein"},{"id":"T3","span":{"begin":632,"end":636},"obj":"protein"},{"id":"T4","span":{"begin":666,"end":670},"obj":"protein"},{"id":"T5","span":{"begin":844,"end":862},"obj":"protein"},{"id":"T6","span":{"begin":888,"end":898},"obj":"protein"},{"id":"T7","span":{"begin":903,"end":912},"obj":"protein"},{"id":"T8","span":{"begin":968,"end":971},"obj":"protein"},{"id":"T9","span":{"begin":1026,"end":1029},"obj":"protein"},{"id":"T10","span":{"begin":1042,"end":1045},"obj":"protein"},{"id":"T11","span":{"begin":1084,"end":1087},"obj":"protein"},{"id":"T12","span":{"begin":1089,"end":1097},"obj":"protein"},{"id":"T13","span":{"begin":1099,"end":1109},"obj":"protein"},{"id":"T14","span":{"begin":1114,"end":1123},"obj":"protein"},{"id":"T15","span":{"begin":1166,"end":1169},"obj":"protein"},{"id":"T16","span":{"begin":1171,"end":1180},"obj":"protein"},{"id":"T17","span":{"begin":1185,"end":1195},"obj":"protein"},{"id":"T18","span":{"begin":1351,"end":1354},"obj":"protein"},{"id":"T19","span":{"begin":1356,"end":1365},"obj":"protein"},{"id":"T20","span":{"begin":1367,"end":1377},"obj":"protein"},{"id":"T21","span":{"begin":1379,"end":1389},"obj":"protein"},{"id":"T22","span":{"begin":1395,"end":1404},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"FSU-PRGE"},{"subj":"T2","pred":"source","obj":"FSU-PRGE"},{"subj":"T3","pred":"source","obj":"FSU-PRGE"},{"subj":"T4","pred":"source","obj":"FSU-PRGE"},{"subj":"T5","pred":"source","obj":"FSU-PRGE"},{"subj":"T6","pred":"source","obj":"FSU-PRGE"},{"subj":"T7","pred":"source","obj":"FSU-PRGE"},{"subj":"T8","pred":"source","obj":"FSU-PRGE"},{"subj":"T9","pred":"source","obj":"FSU-PRGE"},{"subj":"T10","pred":"source","obj":"FSU-PRGE"},{"subj":"T11","pred":"source","obj":"FSU-PRGE"},{"subj":"T12","pred":"source","obj":"FSU-PRGE"},{"subj":"T13","pred":"source","obj":"FSU-PRGE"},{"subj":"T14","pred":"source","obj":"FSU-PRGE"},{"subj":"T15","pred":"source","obj":"FSU-PRGE"},{"subj":"T16","pred":"source","obj":"FSU-PRGE"},{"subj":"T17","pred":"source","obj":"FSU-PRGE"},{"subj":"T18","pred":"source","obj":"FSU-PRGE"},{"subj":"T19","pred":"source","obj":"FSU-PRGE"},{"subj":"T20","pred":"source","obj":"FSU-PRGE"},{"subj":"T21","pred":"source","obj":"FSU-PRGE"},{"subj":"T22","pred":"source","obj":"FSU-PRGE"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11781834-9#21#25#gene1026","span":{"begin":1360,"end":1364},"obj":"gene1026"},{"id":"11781834-9#21#25#gene56996","span":{"begin":1360,"end":1364},"obj":"gene56996"},{"id":"11781834-9#28#37#gene1030","span":{"begin":1367,"end":1376},"obj":"gene1030"},{"id":"11781834-9#60#64#gene1028","span":{"begin":1399,"end":1403},"obj":"gene1028"},{"id":"11781834-9#60#64#gene10518","span":{"begin":1399,"end":1403},"obj":"gene10518"},{"id":"11781834-9#176#191#diseaseC0376358","span":{"begin":1515,"end":1530},"obj":"diseaseC0376358"},{"id":"11781834-9#176#191#diseaseC0600139","span":{"begin":1515,"end":1530},"obj":"diseaseC0600139"},{"id":"11781834-9#176#191#diseaseC0376358","span":{"begin":1515,"end":1530},"obj":"diseaseC0376358"},{"id":"11781834-9#176#191#diseaseC0600139","span":{"begin":1515,"end":1530},"obj":"diseaseC0600139"},{"id":"11781834-9#176#191#diseaseC0376358","span":{"begin":1515,"end":1530},"obj":"diseaseC0376358"},{"id":"11781834-9#176#191#diseaseC0600139","span":{"begin":1515,"end":1530},"obj":"diseaseC0600139"},{"id":"11781834-9#176#191#diseaseC0376358","span":{"begin":1515,"end":1530},"obj":"diseaseC0376358"},{"id":"11781834-9#176#191#diseaseC0600139","span":{"begin":1515,"end":1530},"obj":"diseaseC0600139"},{"id":"11781834-9#176#191#diseaseC0376358","span":{"begin":1515,"end":1530},"obj":"diseaseC0376358"},{"id":"11781834-9#176#191#diseaseC0600139","span":{"begin":1515,"end":1530},"obj":"diseaseC0600139"}],"relations":[{"id":"21#25#gene1026176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene1026176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene1026176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene1026176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene1026176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene1026176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene1026176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene1026176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene1026176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene1026176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene1026","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene56996176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene56996176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene56996176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene56996176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene56996176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene56996176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene56996176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene56996176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"21#25#gene56996176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"21#25#gene56996176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#21#25#gene56996","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"28#37#gene1030176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"28#37#gene1030176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"28#37#gene1030176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"28#37#gene1030176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"28#37#gene1030176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"28#37#gene1030176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"28#37#gene1030176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"28#37#gene1030176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"28#37#gene1030176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"28#37#gene1030176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#28#37#gene1030","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene1028176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene1028176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene1028176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene1028176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene1028176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene1028176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene1028176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene1028176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene1028176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene1028176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene1028","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene10518176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene10518176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene10518176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene10518176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene10518176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene10518176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene10518176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene10518176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0600139"},{"id":"60#64#gene10518176#191#diseaseC0376358","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0376358"},{"id":"60#64#gene10518176#191#diseaseC0600139","pred":"associated_with","subj":"11781834-9#60#64#gene10518","obj":"11781834-9#176#191#diseaseC0600139"}],"attributes":[{"subj":"11781834-9#21#25#gene1026","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#21#25#gene56996","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#28#37#gene1030","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#60#64#gene1028","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#60#64#gene10518","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0376358","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"11781834-9#176#191#diseaseC0600139","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AIMed","color":"#b5ec93","default":true},{"id":"DisGeNET","color":"#ec93cf"},{"id":"FSU-PRGE","color":"#93e9ec"},{"id":"DisGeNET5_gene_disease","color":"#ecd493"}]}]}}