
PubMed:11773079
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-85 | Sentence | denotes | Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. |
T2 | 86-265 | Sentence | denotes | Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. |
T3 | 266-390 | Sentence | denotes | Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes. |
T4 | 391-539 | Sentence | denotes | This transcriptional activation by STAT3 proteins has been shown to require the recruitment of coactivators such as CREB-binding protein (CBP)/p300. |
T5 | 540-726 | Sentence | denotes | In the present study, we show that steroid receptor coactivator 1, NcoA/SRC1a, originally identified as a nuclear receptor coactivator, also functions as a coactivator of STAT3 proteins. |
T6 | 727-850 | Sentence | denotes | In coimmunoprecipitations, NcoA/SRC1a was found to associate with STAT3 following IL-6 stimulation of HepG2 hepatoma cells. |
T7 | 851-969 | Sentence | denotes | Pull-down experiments indicated that the N-terminal part of NcoA/SRC1a associates with the activation domain of STAT3. |
T8 | 970-1112 | Sentence | denotes | Overexpression of NcoA/SRC1a or its SRC1e isoform enhanced transcriptional activation by STAT3 proteins in transient transfection experiments. |
T9 | 1113-1248 | Sentence | denotes | This ability of NcoA/SRC1a to enhance STAT3 activity is dependent upon the presence of the CBP-interacting domain, activation domain 1. |
T10 | 1249-1430 | Sentence | denotes | Using chromatin immunoprecipitation assays, we found that STAT3, NcoA/SRC1a, and CBP/p300 are simultaneously recruited to the p21(waf1) promoter following interleukin-6 stimulation. |
T11 | 1431-1571 | Sentence | denotes | Taken together, these data suggest that CBP/p300 and NcoA/SRC1a may function in a common pathway to regulate STAT3 transcriptional activity. |
relna
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 26-31 | DNA | denotes | STAT3 |
T2 | 86-136 | DNA | denotes | Signal transducer and activator of transcription 3 |
T3 | 138-143 | DNA | denotes | STAT3 |
T4 | 302-307 | DNA | denotes | STAT3 |
T5 | 426-431 | DNA | denotes | STAT3 |
T6 | 507-527 | DNA | denotes | CREB-binding protein |
T7 | 529-532 | DNA | denotes | CBP |
T8 | 534-538 | DNA | denotes | p300 |
T9 | 575-605 | Protein | denotes | steroid receptor coactivator 1 |
T10 | 711-716 | DNA | denotes | STAT3 |
T11 | 793-798 | DNA | denotes | STAT3 |
T12 | 809-813 | Protein | denotes | IL-6 |
T13 | 963-968 | DNA | denotes | STAT3 |
T14 | 1059-1064 | DNA | denotes | STAT3 |
T15 | 1151-1156 | DNA | denotes | STAT3 |
T16 | 1307-1312 | DNA | denotes | STAT3 |
T17 | 1330-1338 | DNA | denotes | CBP/p300 |
T18 | 1375-1378 | Protein | denotes | p21 |
T19 | 1379-1383 | Protein | denotes | waf1 |
T20 | 1404-1417 | Protein | denotes | interleukin-6 |
T21 | 1471-1479 | DNA | denotes | CBP/p300 |
T22 | 1540-1545 | DNA | denotes | STAT3 |
R0 | T9 | T10 | linked | steroid receptor coactivator 1,STAT3 |
FSU-PRGE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 26-31 | protein | denotes | STAT3 |
T2 | 32-52 | protein | denotes | transcription factor |
T3 | 74-78 | protein | denotes | NcoA |
T4 | 79-84 | protein | denotes | SRC1a |
T5 | 86-136 | protein | denotes | Signal transducer and activator of transcription 3 |
T6 | 138-143 | protein | denotes | STAT3 |
T7 | 145-166 | protein | denotes | transcription factors |
T8 | 235-252 | protein | denotes | cytokine receptor |
T9 | 302-307 | protein | denotes | STAT3 |
T10 | 426-431 | protein | denotes | STAT3 |
T11 | 507-533 | protein | denotes | CREB-binding protein (CBP) |
T12 | 534-538 | protein | denotes | p300 |
T13 | 575-605 | protein | denotes | steroid receptor coactivator 1 |
T14 | 607-611 | protein | denotes | NcoA |
T15 | 612-617 | protein | denotes | SRC1a |
T16 | 711-716 | protein | denotes | STAT3 |
T17 | 754-758 | protein | denotes | NcoA |
T18 | 759-764 | protein | denotes | SRC1a |
T19 | 793-798 | protein | denotes | STAT3 |
T20 | 809-813 | protein | denotes | IL-6 |
T21 | 911-915 | protein | denotes | NcoA |
T22 | 916-921 | protein | denotes | SRC1a |
T23 | 963-968 | protein | denotes | STAT3 |
T24 | 988-992 | protein | denotes | NcoA |
T25 | 993-998 | protein | denotes | SRC1a |
T26 | 1006-1011 | protein | denotes | SRC1e |
T27 | 1059-1064 | protein | denotes | STAT3 |
T28 | 1129-1133 | protein | denotes | NcoA |
T29 | 1134-1139 | protein | denotes | SRC1a |
T30 | 1151-1156 | protein | denotes | STAT3 |
T31 | 1204-1207 | protein | denotes | CBP |
T32 | 1307-1312 | protein | denotes | STAT3 |
T33 | 1314-1318 | protein | denotes | NcoA |
T34 | 1319-1324 | protein | denotes | SRC1a |
T35 | 1330-1333 | protein | denotes | CBP |
T36 | 1334-1338 | protein | denotes | p300 |
T37 | 1375-1384 | protein | denotes | p21(waf1) |
T38 | 1404-1417 | protein | denotes | interleukin-6 |
T39 | 1471-1474 | protein | denotes | CBP |
T40 | 1475-1479 | protein | denotes | p300 |
T41 | 1484-1488 | protein | denotes | NcoA |
T42 | 1489-1494 | protein | denotes | SRC1a |
T43 | 1540-1545 | protein | denotes | STAT3 |
PIR-corpus2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 26-52 | protein | denotes | STAT3 transcription factor |
T2 | 62-73 | protein | denotes | coactivator |
T3 | 79-84 | protein | denotes | SRC1a |
T4 | 86-158 | protein | denotes | Signal transducer and activator of transcription 3 (STAT3) transcription |
T5 | 171-191 | protein | denotes | cytoplasmic proteins |
T6 | 235-252 | protein | denotes | cytokine receptor |
T7 | 302-316 | protein | denotes | STAT3 proteins |
T8 | 426-440 | protein | denotes | STAT3 proteins |
T9 | 507-519 | protein | denotes | CREB-binding |
T10 | 534-538 | protein | denotes | p300 |
T11 | 575-591 | protein | denotes | steroid receptor |
T12 | 607-611 | protein | denotes | NcoA |
T13 | 612-617 | protein | denotes | SRC1a |
T14 | 646-662 | protein | denotes | nuclear receptor |
T15 | 696-725 | protein | denotes | coactivator of STAT3 proteins |
T16 | 754-758 | protein | denotes | NcoA |
T17 | 759-764 | protein | denotes | SRC1a |
T18 | 793-798 | protein | denotes | STAT3 |
T19 | 809-813 | protein | denotes | IL-6 |
T20 | 911-915 | protein | denotes | NcoA |
T21 | 916-921 | protein | denotes | SRC1a |
T22 | 963-968 | protein | denotes | STAT3 |
T23 | 988-992 | protein | denotes | NcoA |
T24 | 993-998 | protein | denotes | SRC1a |
T25 | 1006-1011 | protein | denotes | SRC1e |
T26 | 1059-1073 | protein | denotes | STAT3 proteins |
T27 | 1129-1133 | protein | denotes | NcoA |
T28 | 1134-1139 | protein | denotes | SRC1a |
T29 | 1151-1156 | protein | denotes | STAT3 |
T30 | 1204-1207 | protein | denotes | CBP |
T31 | 1307-1312 | protein | denotes | STAT3 |
T32 | 1314-1318 | protein | denotes | NcoA |
T33 | 1319-1324 | protein | denotes | SRC1a |
T34 | 1330-1333 | protein | denotes | CBP |
T35 | 1334-1338 | protein | denotes | p300 |
T36 | 1375-1378 | protein | denotes | p21 |
T37 | 1379-1383 | protein | denotes | waf1 |
T38 | 1404-1417 | protein | denotes | interleukin-6 |
T39 | 1471-1474 | protein | denotes | CBP |
T40 | 1475-1479 | protein | denotes | p300 |
T41 | 1484-1488 | protein | denotes | NcoA |
T42 | 1489-1494 | protein | denotes | SRC1a |
T43 | 1540-1545 | protein | denotes | STAT3 |
PIR-corpus1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 26-52 | protein | denotes | STAT3 transcription factor |
T2 | 62-73 | protein | denotes | coactivator |
T3 | 86-136 | protein | denotes | Signal transducer and activator of transcription 3 |
T4 | 138-143 | acronym | denotes | STAT3 |
T5 | 145-158 | protein | denotes | transcription |
T6 | 183-191 | protein | denotes | proteins |
T7 | 235-252 | protein | denotes | cytokine receptor |
T8 | 302-316 | protein | denotes | STAT3 proteins |
T9 | 426-440 | protein | denotes | STAT3 proteins |
T10 | 486-498 | protein | denotes | coactivators |
T11 | 507-519 | protein | denotes | CREB-binding |
T12 | 575-591 | protein | denotes | steroid receptor |
T13 | 607-617 | protein | denotes | NcoA/SRC1a |
T14 | 646-662 | protein | denotes | nuclear receptor |
T15 | 696-725 | protein | denotes | coactivator of STAT3 proteins |
T16 | 754-764 | protein | denotes | NcoA/SRC1a |
T17 | 793-798 | protein | denotes | STAT3 |
T18 | 809-813 | protein | denotes | IL-6 |
T19 | 911-921 | protein | denotes | NcoA/SRC1a |
T20 | 963-968 | protein | denotes | STAT3 |
T21 | 988-998 | protein | denotes | NcoA/SRC1a |
T22 | 1006-1011 | protein | denotes | SRC1e |
T23 | 1059-1073 | protein | denotes | STAT3 proteins |
T24 | 1129-1139 | protein | denotes | NcoA/SRC1a |
T25 | 1151-1156 | protein | denotes | STAT3 |
T26 | 1307-1312 | protein | denotes | STAT3 |
T27 | 1314-1324 | protein | denotes | NcoA/SRC1a |
T28 | 1330-1338 | protein | denotes | CBP/p300 |
T29 | 1404-1417 | protein | denotes | interleukin-6 |
T30 | 1471-1479 | protein | denotes | CBP/p300 |
T31 | 1484-1494 | protein | denotes | NcoA/SRC1a |
T32 | 1540-1545 | protein | denotes | STAT3 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 529-532 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
T2 | 835-843 | Disease | denotes | hepatoma | http://purl.obolibrary.org/obo/MONDO_0007256 |
T3 | 1204-1207 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
T4 | 1330-1333 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
T5 | 1471-1474 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 171-182 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
T2 | 346-353 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |