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PubMed:11773079 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
T2 86-265 Sentence denotes Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation.
T3 266-390 Sentence denotes Following tyrosine phosphorylation, STAT3 proteins dimerize, translocate to the nucleus, and activate specific target genes.
T4 391-539 Sentence denotes This transcriptional activation by STAT3 proteins has been shown to require the recruitment of coactivators such as CREB-binding protein (CBP)/p300.
T5 540-726 Sentence denotes In the present study, we show that steroid receptor coactivator 1, NcoA/SRC1a, originally identified as a nuclear receptor coactivator, also functions as a coactivator of STAT3 proteins.
T6 727-850 Sentence denotes In coimmunoprecipitations, NcoA/SRC1a was found to associate with STAT3 following IL-6 stimulation of HepG2 hepatoma cells.
T7 851-969 Sentence denotes Pull-down experiments indicated that the N-terminal part of NcoA/SRC1a associates with the activation domain of STAT3.
T8 970-1112 Sentence denotes Overexpression of NcoA/SRC1a or its SRC1e isoform enhanced transcriptional activation by STAT3 proteins in transient transfection experiments.
T9 1113-1248 Sentence denotes This ability of NcoA/SRC1a to enhance STAT3 activity is dependent upon the presence of the CBP-interacting domain, activation domain 1.
T10 1249-1430 Sentence denotes Using chromatin immunoprecipitation assays, we found that STAT3, NcoA/SRC1a, and CBP/p300 are simultaneously recruited to the p21(waf1) promoter following interleukin-6 stimulation.
T11 1431-1571 Sentence denotes Taken together, these data suggest that CBP/p300 and NcoA/SRC1a may function in a common pathway to regulate STAT3 transcriptional activity.

relna

Id Subject Object Predicate Lexical cue
T1 26-31 DNA denotes STAT3
T2 86-136 DNA denotes Signal transducer and activator of transcription 3
T3 138-143 DNA denotes STAT3
T4 302-307 DNA denotes STAT3
T5 426-431 DNA denotes STAT3
T6 507-527 DNA denotes CREB-binding protein
T7 529-532 DNA denotes CBP
T8 534-538 DNA denotes p300
T9 575-605 Protein denotes steroid receptor coactivator 1
T10 711-716 DNA denotes STAT3
T11 793-798 DNA denotes STAT3
T12 809-813 Protein denotes IL-6
T13 963-968 DNA denotes STAT3
T14 1059-1064 DNA denotes STAT3
T15 1151-1156 DNA denotes STAT3
T16 1307-1312 DNA denotes STAT3
T17 1330-1338 DNA denotes CBP/p300
T18 1375-1378 Protein denotes p21
T19 1379-1383 Protein denotes waf1
T20 1404-1417 Protein denotes interleukin-6
T21 1471-1479 DNA denotes CBP/p300
T22 1540-1545 DNA denotes STAT3
R0 T9 T10 linked steroid receptor coactivator 1,STAT3

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 26-31 protein denotes STAT3
T2 32-52 protein denotes transcription factor
T3 74-78 protein denotes NcoA
T4 79-84 protein denotes SRC1a
T5 86-136 protein denotes Signal transducer and activator of transcription 3
T6 138-143 protein denotes STAT3
T7 145-166 protein denotes transcription factors
T8 235-252 protein denotes cytokine receptor
T9 302-307 protein denotes STAT3
T10 426-431 protein denotes STAT3
T11 507-533 protein denotes CREB-binding protein (CBP)
T12 534-538 protein denotes p300
T13 575-605 protein denotes steroid receptor coactivator 1
T14 607-611 protein denotes NcoA
T15 612-617 protein denotes SRC1a
T16 711-716 protein denotes STAT3
T17 754-758 protein denotes NcoA
T18 759-764 protein denotes SRC1a
T19 793-798 protein denotes STAT3
T20 809-813 protein denotes IL-6
T21 911-915 protein denotes NcoA
T22 916-921 protein denotes SRC1a
T23 963-968 protein denotes STAT3
T24 988-992 protein denotes NcoA
T25 993-998 protein denotes SRC1a
T26 1006-1011 protein denotes SRC1e
T27 1059-1064 protein denotes STAT3
T28 1129-1133 protein denotes NcoA
T29 1134-1139 protein denotes SRC1a
T30 1151-1156 protein denotes STAT3
T31 1204-1207 protein denotes CBP
T32 1307-1312 protein denotes STAT3
T33 1314-1318 protein denotes NcoA
T34 1319-1324 protein denotes SRC1a
T35 1330-1333 protein denotes CBP
T36 1334-1338 protein denotes p300
T37 1375-1384 protein denotes p21(waf1)
T38 1404-1417 protein denotes interleukin-6
T39 1471-1474 protein denotes CBP
T40 1475-1479 protein denotes p300
T41 1484-1488 protein denotes NcoA
T42 1489-1494 protein denotes SRC1a
T43 1540-1545 protein denotes STAT3

PIR-corpus2

Id Subject Object Predicate Lexical cue
T1 26-52 protein denotes STAT3 transcription factor
T2 62-73 protein denotes coactivator
T3 79-84 protein denotes SRC1a
T4 86-158 protein denotes Signal transducer and activator of transcription 3 (STAT3) transcription
T5 171-191 protein denotes cytoplasmic proteins
T6 235-252 protein denotes cytokine receptor
T7 302-316 protein denotes STAT3 proteins
T8 426-440 protein denotes STAT3 proteins
T9 507-519 protein denotes CREB-binding
T10 534-538 protein denotes p300
T11 575-591 protein denotes steroid receptor
T12 607-611 protein denotes NcoA
T13 612-617 protein denotes SRC1a
T14 646-662 protein denotes nuclear receptor
T15 696-725 protein denotes coactivator of STAT3 proteins
T16 754-758 protein denotes NcoA
T17 759-764 protein denotes SRC1a
T18 793-798 protein denotes STAT3
T19 809-813 protein denotes IL-6
T20 911-915 protein denotes NcoA
T21 916-921 protein denotes SRC1a
T22 963-968 protein denotes STAT3
T23 988-992 protein denotes NcoA
T24 993-998 protein denotes SRC1a
T25 1006-1011 protein denotes SRC1e
T26 1059-1073 protein denotes STAT3 proteins
T27 1129-1133 protein denotes NcoA
T28 1134-1139 protein denotes SRC1a
T29 1151-1156 protein denotes STAT3
T30 1204-1207 protein denotes CBP
T31 1307-1312 protein denotes STAT3
T32 1314-1318 protein denotes NcoA
T33 1319-1324 protein denotes SRC1a
T34 1330-1333 protein denotes CBP
T35 1334-1338 protein denotes p300
T36 1375-1378 protein denotes p21
T37 1379-1383 protein denotes waf1
T38 1404-1417 protein denotes interleukin-6
T39 1471-1474 protein denotes CBP
T40 1475-1479 protein denotes p300
T41 1484-1488 protein denotes NcoA
T42 1489-1494 protein denotes SRC1a
T43 1540-1545 protein denotes STAT3

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 26-52 protein denotes STAT3 transcription factor
T2 62-73 protein denotes coactivator
T3 86-136 protein denotes Signal transducer and activator of transcription 3
T4 138-143 acronym denotes STAT3
T5 145-158 protein denotes transcription
T6 183-191 protein denotes proteins
T7 235-252 protein denotes cytokine receptor
T8 302-316 protein denotes STAT3 proteins
T9 426-440 protein denotes STAT3 proteins
T10 486-498 protein denotes coactivators
T11 507-519 protein denotes CREB-binding
T12 575-591 protein denotes steroid receptor
T13 607-617 protein denotes NcoA/SRC1a
T14 646-662 protein denotes nuclear receptor
T15 696-725 protein denotes coactivator of STAT3 proteins
T16 754-764 protein denotes NcoA/SRC1a
T17 793-798 protein denotes STAT3
T18 809-813 protein denotes IL-6
T19 911-921 protein denotes NcoA/SRC1a
T20 963-968 protein denotes STAT3
T21 988-998 protein denotes NcoA/SRC1a
T22 1006-1011 protein denotes SRC1e
T23 1059-1073 protein denotes STAT3 proteins
T24 1129-1139 protein denotes NcoA/SRC1a
T25 1151-1156 protein denotes STAT3
T26 1307-1312 protein denotes STAT3
T27 1314-1324 protein denotes NcoA/SRC1a
T28 1330-1338 protein denotes CBP/p300
T29 1404-1417 protein denotes interleukin-6
T30 1471-1479 protein denotes CBP/p300
T31 1484-1494 protein denotes NcoA/SRC1a
T32 1540-1545 protein denotes STAT3

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 529-532 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T2 835-843 Disease denotes hepatoma http://purl.obolibrary.org/obo/MONDO_0007256
T3 1204-1207 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T4 1330-1333 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T5 1471-1474 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 171-182 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T2 346-353 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125