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PubMed:11751499 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 591-594 gene:1048 denotes CEA
T1 690-707 disease:C0014859 denotes esophageal cancer
T2 591-594 gene:1048 denotes CEA
T3 690-707 disease:C0152018 denotes esophageal cancer
T4 591-594 gene:1048 denotes CEA
T5 690-707 disease:C0546837 denotes esophageal cancer
T6 739-742 gene:1087 denotes CEA
T7 828-838 disease:C1458156 denotes recurrence
T8 739-742 gene:5670 denotes CEA
T9 828-838 disease:C1458156 denotes recurrence
T10 739-742 gene:1084 denotes CEA
T11 828-838 disease:C1458156 denotes recurrence
T12 739-742 gene:1048 denotes CEA
T13 828-838 disease:C1458156 denotes recurrence
R1 T0 T1 associated_with CEA,esophageal cancer
R2 T2 T3 associated_with CEA,esophageal cancer
R3 T4 T5 associated_with CEA,esophageal cancer
R4 T6 T7 associated_with CEA,recurrence
R5 T8 T9 associated_with CEA,recurrence
R6 T10 T11 associated_with CEA,recurrence
R7 T12 T13 associated_with CEA,recurrence

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11751499-10#10#13#gene1048 1376-1379 gene1048 denotes CEA
11751499-10#39#44#diseaseC0043194 1405-1410 diseaseC0043194 denotes was 1
11751499-4#128#152#gene1048 565-589 gene1048 denotes carcinoembryonic antigen
11751499-4#154#157#gene1048 591-594 gene1048 denotes CEA
11751499-4#253#270#diseaseC0014859 690-707 diseaseC0014859 denotes esophageal cancer
11751499-4#253#270#diseaseC0152018 690-707 diseaseC0152018 denotes esophageal cancer
11751499-4#253#270#diseaseC0546837 690-707 diseaseC0546837 denotes esophageal cancer
11751499-4#253#270#diseaseC0014859 690-707 diseaseC0014859 denotes esophageal cancer
11751499-4#253#270#diseaseC0152018 690-707 diseaseC0152018 denotes esophageal cancer
11751499-4#253#270#diseaseC0546837 690-707 diseaseC0546837 denotes esophageal cancer
10#13#gene104839#44#diseaseC0043194 11751499-10#10#13#gene1048 11751499-10#39#44#diseaseC0043194 associated_with CEA,was 1
128#152#gene1048253#270#diseaseC0014859 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0014859 associated_with carcinoembryonic antigen,esophageal cancer
128#152#gene1048253#270#diseaseC0152018 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0152018 associated_with carcinoembryonic antigen,esophageal cancer
128#152#gene1048253#270#diseaseC0546837 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0546837 associated_with carcinoembryonic antigen,esophageal cancer
128#152#gene1048253#270#diseaseC0014859 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0014859 associated_with carcinoembryonic antigen,esophageal cancer
128#152#gene1048253#270#diseaseC0152018 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0152018 associated_with carcinoembryonic antigen,esophageal cancer
128#152#gene1048253#270#diseaseC0546837 11751499-4#128#152#gene1048 11751499-4#253#270#diseaseC0546837 associated_with carcinoembryonic antigen,esophageal cancer
154#157#gene1048253#270#diseaseC0014859 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0014859 associated_with CEA,esophageal cancer
154#157#gene1048253#270#diseaseC0152018 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0152018 associated_with CEA,esophageal cancer
154#157#gene1048253#270#diseaseC0546837 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0546837 associated_with CEA,esophageal cancer
154#157#gene1048253#270#diseaseC0014859 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0014859 associated_with CEA,esophageal cancer
154#157#gene1048253#270#diseaseC0152018 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0152018 associated_with CEA,esophageal cancer
154#157#gene1048253#270#diseaseC0546837 11751499-4#154#157#gene1048 11751499-4#253#270#diseaseC0546837 associated_with CEA,esophageal cancer

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 141-717 OBJECTIVE denotes In esophageal cancer, lymph node metastases are the strongest predictor of recurrence and poor outcome. However, many node-negative patients still recur despite a potentially curative resection. This is probably the result of microscopically occult metastases missed by histological examination. In this study, we used both standard, gel-based reverse transcription-PCR (RT-PCR) and Taqman quantitative RT-PCR (QRT-PCR) for carcinoembryonic antigen (CEA) mRNA to detect occult micrometastases in 387 lymph nodes from 30 histologically node-negative esophageal cancer patients.
T2 739-1140 METHODS denotes CEA expression was compared with clinical outcomes to determine correlation with disease recurrence. For quantitative data, an optimum CEA expression level cutoff value was defined as the value that most accurately classified patients on the basis of disease recurrence. Kaplan-Meier survival curves were generated, and multivariate analyses were performed to evaluate the prognostic value of QRT-PCR.
T3 1150-1858 RESULTS denotes CEA expression levels were above the optimum cutoff level in 12 tissue blocks, resulting in the identification of 11 CEA-positive patients. Of these patients, 9 suffered disease recurrence and 2 remain disease free. Of the 19 CEA-negative patients, there was 1 disease recurrence. The sensitivity and specificity for predicting disease recurrence were 90 and 90%, respectively. Kaplan-Meier analysis showed that CEA positivity resulted in significantly lower disease-free and overall survival (P <0.0001 and 0.0006 respectively). In multivariate analyses, CEA positivity measured by QRT-PCR was the strongest independent predictor of disease recurrence among other clinical and pathological factors examined.
T4 1872-1995 CONCLUSIONS denotes QRT-PCR offers significant benefits over standard RT-PCR and identifies node-negative patients at high risk for recurrence.