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PubMed:11726653 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 17-36 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T2 142-161 Glycan_Motif denotes N-Acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T3 713-719 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T4 918-924 Glycan_Motif denotes core 3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00035MO
T5 979-985 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T6 1088-1094 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T7 1404-1410 Glycan_Motif denotes core 3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00035MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.
T2 142-322 Sentence denotes N-Acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) catalyzes the transfer of sulfate from adenosine 3'-phosphate,5'-phosphosulfate to the C-6 position of the non-reducing GlcNAc.
T3 323-566 Sentence denotes Three human GlcNAc6STs, namely GlcNAc6ST-1, GlcNAc6ST-2 (HEC-GlcNAc6ST), and GlcNAc6ST-3 (I-GlcNAc6ST), were produced as fusion proteins to protein A, and their substrate specificities as well as their enzymological properties were determined.
T4 567-675 Sentence denotes Both GlcNAc6ST-1 and GlcNAc6ST-2 efficiently utilized the following oligosaccharide structures as acceptors:
T5 676-764 Sentence denotes GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe, and GlcNAcbeta1-2Man.
T6 765-867 Sentence denotes The ratios of activities to these substrates were not significantly different between the two enzymes.
T7 868-952 Sentence denotes However, GlcNAc6ST-2 but not GlcNAc6ST-1 acted on core 3 of GlcNAcbeta1-3GalNAc-pNP.
T8 953-1049 Sentence denotes GlcNAc6ST-3 used only the core 2 structure among the above mentioned oligosaccharide structures.
T9 1050-1235 Sentence denotes The ability of GlcNAc6ST-1 to sulfate core 2 structure as efficiently as GlcNAc6ST-2 is consistent with the view that GlcNAc6ST-1 is also involved in the synthesis of l-selectin ligand.
T10 1236-1372 Sentence denotes Indeed, cells doubly transfected with GlcNAc6ST-1 and fucosyltransferase VII cDNAs supported the rolling of L-selectin-expressing cells.
T11 1373-1680 Sentence denotes The activity of GlcNAc6ST-2 on core 3 and its expression in mucinous adenocarcinoma suggested that this enzyme corresponds to the sulfotransferase, which is specifically expressed in mucinous adenocarcinoma (Seko, A., Sumiya, J., Yonezawa, S., Nagata, K., and Yamashita, K. (2000) Glycobiology 10, 919-929).

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 17-36 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T2 142-161 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-Acetylglucosamine

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 17-36 chem:24139 denotes N-acetylglucosamine
PD-NGLY1-deficiency-B_T2 144-161 chem:24139 denotes Acetylglucosamine
PD-NGLY1-deficiency-B_T3 315-321 chem:24139 denotes GlcNAc

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11726653-9#16#27#gene10164 1389-1400 gene10164 denotes GlcNAc6ST-2
11726653-9#60#83#diseaseC0007130 1433-1456 diseaseC0007130 denotes mucinous adenocarcinoma
11726653-9#183#206#diseaseC0007130 1556-1579 diseaseC0007130 denotes mucinous adenocarcinoma
16#27#gene1016460#83#diseaseC0007130 11726653-9#16#27#gene10164 11726653-9#60#83#diseaseC0007130 associated_with GlcNAc6ST-2,mucinous adenocarcinoma
16#27#gene10164183#206#diseaseC0007130 11726653-9#16#27#gene10164 11726653-9#183#206#diseaseC0007130 associated_with GlcNAc6ST-2,mucinous adenocarcinoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1389-1400 gene:10164 denotes GlcNAc6ST-2
T1 1433-1456 disease:C0007130 denotes mucinous adenocarcinoma
T2 1389-1400 gene:10164 denotes GlcNAc6ST-2
T3 1556-1579 disease:C0007130 denotes mucinous adenocarcinoma
R1 T0 T1 associated_with GlcNAc6ST-2,mucinous adenocarcinoma
R2 T2 T3 associated_with GlcNAc6ST-2,mucinous adenocarcinoma

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 701-707 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 713-719 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 918-924 Glycan denotes core 3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00035MO
T4 979-985 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T5 1088-1094 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T6 1404-1410 Glycan denotes core 3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00035MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 106-111 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 1433-1456 Disease denotes mucinous adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004957
T3 1556-1579 Disease denotes mucinous adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004957

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 701-707 Glycan denotes GalNAc https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL
T2 713-719 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 918-924 Glycan denotes core 3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00035MO
T4 979-985 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T5 1088-1094 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T6 1404-1410 Glycan denotes core 3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00035MO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 106-111 Phenotype denotes tumor HP:0002664

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 106-111 Disease denotes tumor MONDO:0005070
T2 1433-1456 Disease denotes mucinous adenocarcinoma MONDO:0004957
T3 1556-1579 Disease denotes mucinous adenocarcinoma MONDO:0004957

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 329-334 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.
T2 142-322 Sentence denotes N-Acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) catalyzes the transfer of sulfate from adenosine 3'-phosphate,5'-phosphosulfate to the C-6 position of the non-reducing GlcNAc.
T3 323-566 Sentence denotes Three human GlcNAc6STs, namely GlcNAc6ST-1, GlcNAc6ST-2 (HEC-GlcNAc6ST), and GlcNAc6ST-3 (I-GlcNAc6ST), were produced as fusion proteins to protein A, and their substrate specificities as well as their enzymological properties were determined.
T4 567-675 Sentence denotes Both GlcNAc6ST-1 and GlcNAc6ST-2 efficiently utilized the following oligosaccharide structures as acceptors:
T5 676-764 Sentence denotes GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe, and GlcNAcbeta1-2Man.
T6 765-867 Sentence denotes The ratios of activities to these substrates were not significantly different between the two enzymes.
T7 868-952 Sentence denotes However, GlcNAc6ST-2 but not GlcNAc6ST-1 acted on core 3 of GlcNAcbeta1-3GalNAc-pNP.
T8 953-1049 Sentence denotes GlcNAc6ST-3 used only the core 2 structure among the above mentioned oligosaccharide structures.
T9 1050-1235 Sentence denotes The ability of GlcNAc6ST-1 to sulfate core 2 structure as efficiently as GlcNAc6ST-2 is consistent with the view that GlcNAc6ST-1 is also involved in the synthesis of l-selectin ligand.
T10 1236-1372 Sentence denotes Indeed, cells doubly transfected with GlcNAc6ST-1 and fucosyltransferase VII cDNAs supported the rolling of L-selectin-expressing cells.
T11 1373-1680 Sentence denotes The activity of GlcNAc6ST-2 on core 3 and its expression in mucinous adenocarcinoma suggested that this enzyme corresponds to the sulfotransferase, which is specifically expressed in mucinous adenocarcinoma (Seko, A., Sumiya, J., Yonezawa, S., Nagata, K., and Yamashita, K. (2000) Glycobiology 10, 919-929).

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 329-334 OrganismTaxon denotes human 9606

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 106-111 Phenotype denotes tumor HP:0002664