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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill.
T2 124-135 Sentence denotes BACKGROUND:
T3 136-390 Sentence denotes For many years, the intensivists are searching for an easily measurable and available parameter which might reflect the intensity of stress and/or systemic inflammation in critically ill patients following shock, multiple trauma, major surgery or sepsis.
T4 391-527 Sentence denotes Recently, some authors have described the onset of significant lymphocytopenia after polytrauma, major surgery, endotoxaemia and sepsis.
T5 528-688 Sentence denotes We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients.
T6 689-694 Sentence denotes GOAL:
T7 695-893 Sentence denotes We have designed a prospective longitudinal observational study to investigate serial changes in circulating neutrophil and lymphocyte counts following major surgery, unscheduled surgery and sepsis.
T8 894-902 Sentence denotes METHODS:
T9 903-1020 Sentence denotes We have investigated the differential white blood cell counts and the clinical course in 90 oncological ICU patients.
T10 1021-1313 Sentence denotes We compared three groups: group A consisting of 62 patients who underwent scheduled colorectal surgery, group B consisting of 18 patients who underwent unscheduled surgery for abdominal sepsis, group C consisting of 10 medical ICU patients who were treated for severe sepsis and septic shock.
T11 1314-1570 Sentence denotes The severity of clinical course was expressed by means of SOFA score (group A 0.3-1-1.3 point, group B 2.2-2.9-2.6 point, group C 7.4-8.3-7.7 point) and APACHE II score (group A 3.7-7.6-8.1 point, group B 8.6-11.1-10.5 point, group C 16.3-15.2-14.3 point).
T12 1571-1688 Sentence denotes Differential white blood cell counts were investigated on blood cell counter SYSMEX SF 3000 in 4 consecutive periods:
T13 1689-1848 Sentence denotes 1 day one before surgery, 0 the day of surgery or ICU admittance, 1 day one after surgery (or the 1st ICU day), 2nd day following surgery (or the 2nd ICU day).
T14 1849-1983 Sentence denotes The measured values of neutrophils and lymphocytes were expressed as relative counts (%) of the whole all white blood cell population.
T15 1984-1992 Sentence denotes RESULTS:
T16 1993-2258 Sentence denotes The physiologic response of circulating leukocytes to surgical stress in group A is characterized by the onset of marked neutrophilia (62.5% before surgery up to 84.4% after surgery) and significant lymphocytopenia (28.1% before surgery to 10.3% following surgery).
T17 2259-2376 Sentence denotes We observed a slow decline in neutrophil counts and an increase in lymphocyte counts since the 1st postoperative day.
T18 2377-2534 Sentence denotes The patients with abdominal infection (group B) had elevated counts of neutrophils already before surgery (83.2%) and low values of lymphocyte counts (9.5%).
T19 2535-2668 Sentence denotes A further increase in neutrophil counts (89.9%) and marked lymphopenia (7%) were recorded during the post-surgical period in group B.
T20 2669-2932 Sentence denotes Critically ill patients with severe sepsis or septic shock (group C) had significantly highest values of neutrophil relative counts (94%-93.1%-92.5%, p < 0.05 against group A) and marked lowest values of lymphocyte counts (3.8%-4%-3.7%, p < 0.05 against group A).
T21 2933-3138 Sentence denotes The severity of clinical course (according SOFA and APACHE II score) correlated with the divergence of neutrophil and lymphocyte counts in the white blood picture (marked neutrophilia and lymphocytopenia).
T22 3139-3150 Sentence denotes CONCLUSION:
T23 3151-3354 Sentence denotes In the population of 90 ICU oncological patients, we observed rapid serial changes in white blood cell populations, as a response of the immune system to surgical stress, systemic inflammation or sepsis.
T24 3355-3486 Sentence denotes Preliminary results show the correlation between the severity of clinical course and the grade of neutrophilia and lymphocytopenia.
T25 3487-3651 Sentence denotes The ratio of neutrophil and lymphocyte counts (in absolute and/or relative % values) is an easily measurable parameter which may express the severity of affliction.
T26 3652-3844 Sentence denotes We suggest the term: neutrophil-lymphocyte stress factor, as a ratio of neutrophil to lymphocyte counts, which can be routinely used in clinical ICU practice in intervals of 6-12 and 24 hours.
T27 3845-3950 Sentence denotes The prognostic value of neutrophil-lymphocyte stress factor should be evaluated in further studies. (Tab.
T28 3951-3966 Sentence denotes 6, Fig. 5, Ref.
T29 3967-3971 Sentence denotes 12.)
T1 0-123 Sentence denotes Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill.
T2 124-135 Sentence denotes BACKGROUND:
T3 136-390 Sentence denotes For many years, the intensivists are searching for an easily measurable and available parameter which might reflect the intensity of stress and/or systemic inflammation in critically ill patients following shock, multiple trauma, major surgery or sepsis.
T4 391-527 Sentence denotes Recently, some authors have described the onset of significant lymphocytopenia after polytrauma, major surgery, endotoxaemia and sepsis.
T5 528-688 Sentence denotes We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients.
T6 689-694 Sentence denotes GOAL:
T7 695-893 Sentence denotes We have designed a prospective longitudinal observational study to investigate serial changes in circulating neutrophil and lymphocyte counts following major surgery, unscheduled surgery and sepsis.
T8 894-902 Sentence denotes METHODS:
T9 903-1020 Sentence denotes We have investigated the differential white blood cell counts and the clinical course in 90 oncological ICU patients.
T10 1021-1313 Sentence denotes We compared three groups: group A consisting of 62 patients who underwent scheduled colorectal surgery, group B consisting of 18 patients who underwent unscheduled surgery for abdominal sepsis, group C consisting of 10 medical ICU patients who were treated for severe sepsis and septic shock.
T11 1314-1570 Sentence denotes The severity of clinical course was expressed by means of SOFA score (group A 0.3-1-1.3 point, group B 2.2-2.9-2.6 point, group C 7.4-8.3-7.7 point) and APACHE II score (group A 3.7-7.6-8.1 point, group B 8.6-11.1-10.5 point, group C 16.3-15.2-14.3 point).
T12 1571-1688 Sentence denotes Differential white blood cell counts were investigated on blood cell counter SYSMEX SF 3000 in 4 consecutive periods:
T13 1689-1848 Sentence denotes 1 day one before surgery, 0 the day of surgery or ICU admittance, 1 day one after surgery (or the 1st ICU day), 2nd day following surgery (or the 2nd ICU day).
T14 1849-1983 Sentence denotes The measured values of neutrophils and lymphocytes were expressed as relative counts (%) of the whole all white blood cell population.
T15 1984-1992 Sentence denotes RESULTS:
T16 1993-2258 Sentence denotes The physiologic response of circulating leukocytes to surgical stress in group A is characterized by the onset of marked neutrophilia (62.5% before surgery up to 84.4% after surgery) and significant lymphocytopenia (28.1% before surgery to 10.3% following surgery).
T17 2259-2376 Sentence denotes We observed a slow decline in neutrophil counts and an increase in lymphocyte counts since the 1st postoperative day.
T18 2377-2534 Sentence denotes The patients with abdominal infection (group B) had elevated counts of neutrophils already before surgery (83.2%) and low values of lymphocyte counts (9.5%).
T19 2535-2668 Sentence denotes A further increase in neutrophil counts (89.9%) and marked lymphopenia (7%) were recorded during the post-surgical period in group B.
T20 2669-2932 Sentence denotes Critically ill patients with severe sepsis or septic shock (group C) had significantly highest values of neutrophil relative counts (94%-93.1%-92.5%, p < 0.05 against group A) and marked lowest values of lymphocyte counts (3.8%-4%-3.7%, p < 0.05 against group A).
T21 2933-3138 Sentence denotes The severity of clinical course (according SOFA and APACHE II score) correlated with the divergence of neutrophil and lymphocyte counts in the white blood picture (marked neutrophilia and lymphocytopenia).
T22 3139-3150 Sentence denotes CONCLUSION:
T23 3151-3354 Sentence denotes In the population of 90 ICU oncological patients, we observed rapid serial changes in white blood cell populations, as a response of the immune system to surgical stress, systemic inflammation or sepsis.
T24 3355-3486 Sentence denotes Preliminary results show the correlation between the severity of clinical course and the grade of neutrophilia and lymphocytopenia.
T25 3487-3651 Sentence denotes The ratio of neutrophil and lymphocyte counts (in absolute and/or relative % values) is an easily measurable parameter which may express the severity of affliction.
T26 3652-3844 Sentence denotes We suggest the term: neutrophil-lymphocyte stress factor, as a ratio of neutrophil to lymphocyte counts, which can be routinely used in clinical ICU practice in intervals of 6-12 and 24 hours.
T27 3845-3950 Sentence denotes The prognostic value of neutrophil-lymphocyte stress factor should be evaluated in further studies. (Tab.
T28 3951-3966 Sentence denotes 6, Fig. 5, Ref.
T29 3967-3971 Sentence denotes 12.)