PubMed:11711205 JSONTXT

Annnotations TAB JSON ListView MergeView

    sonoma2

    {"project":"sonoma2","denotations":[{"id":"T0","span":{"begin":0,"end":11},"obj":"GENE"},{"id":"T1","span":{"begin":12,"end":22},"obj":"MPA"},{"id":"T2","span":{"begin":26,"end":50},"obj":"DISEASE"},{"id":"T3","span":{"begin":41,"end":50},"obj":"DISEASE"},{"id":"T4","span":{"begin":68,"end":91},"obj":"DISEASE"},{"id":"T5","span":{"begin":122,"end":130},"obj":"DISEASE"},{"id":"T6","span":{"begin":131,"end":141},"obj":"REG"},{"id":"T7","span":{"begin":147,"end":157},"obj":"CPA"},{"id":"T8","span":{"begin":162,"end":184},"obj":"CPA"},{"id":"T9","span":{"begin":162,"end":184},"obj":"DISEASE"},{"id":"T10","span":{"begin":190,"end":200},"obj":"MPA"},{"id":"T11","span":{"begin":208,"end":242},"obj":"GENE"},{"id":"T12","span":{"begin":208,"end":242},"obj":"GENE"},{"id":"T13","span":{"begin":311,"end":325},"obj":"DISEASE"},{"id":"T14","span":{"begin":311,"end":315},"obj":"GENE"},{"id":"T15","span":{"begin":337,"end":345},"obj":"DISEASE"},{"id":"T16","span":{"begin":376,"end":396},"obj":"DISEASE"},{"id":"T17","span":{"begin":481,"end":489},"obj":"MPA"},{"id":"T18","span":{"begin":493,"end":504},"obj":"GENE"},{"id":"T19","span":{"begin":580,"end":612},"obj":"DISEASE"},{"id":"T20","span":{"begin":595,"end":612},"obj":"DISEASE"},{"id":"T21","span":{"begin":636,"end":650},"obj":"DISEASE"},{"id":"T22","span":{"begin":636,"end":640},"obj":"GENE"},{"id":"T23","span":{"begin":660,"end":668},"obj":"DISEASE"},{"id":"T24","span":{"begin":749,"end":758},"obj":"NEGREG"},{"id":"T25","span":{"begin":759,"end":769},"obj":"MPA"},{"id":"T26","span":{"begin":773,"end":784},"obj":"GENE"},{"id":"T27","span":{"begin":788,"end":820},"obj":"DISEASE"},{"id":"T28","span":{"begin":803,"end":820},"obj":"DISEASE"},{"id":"T29","span":{"begin":832,"end":842},"obj":"REG"},{"id":"T30","span":{"begin":843,"end":852},"obj":"REG"},{"id":"T31","span":{"begin":856,"end":873},"obj":"DISEASE"},{"id":"T32","span":{"begin":874,"end":884},"obj":"REG"},{"id":"T33","span":{"begin":919,"end":928},"obj":"DISEASE"}],"relations":[{"id":"R12","pred":"ThemeOf","subj":"T25","obj":"T24"},{"id":"R13","pred":"ThemeOf","subj":"T26","obj":"T24"},{"id":"R14","pred":"ThemeOf","subj":"T26","obj":"T25"},{"id":"R15","pred":"ThemeOf","subj":"T27","obj":"T24"},{"id":"R16","pred":"ThemeOf","subj":"T27","obj":"T25"},{"id":"R17","pred":"ThemeOf","subj":"T27","obj":"T29"},{"id":"R0","pred":"ThemeOf","subj":"T0","obj":"T1"},{"id":"R1","pred":"ThemeOf","subj":"T2","obj":"T1"},{"id":"R2","pred":"ThemeOf","subj":"T4","obj":"T5"},{"id":"R3","pred":"ThemeOf","subj":"T4","obj":"T6"},{"id":"R4","pred":"ThemeOf","subj":"T5","obj":"T6"},{"id":"R5","pred":"ThemeOf","subj":"T7","obj":"T6"},{"id":"R6","pred":"ThemeOf","subj":"T8","obj":"T5"},{"id":"R7","pred":"ThemeOf","subj":"T8","obj":"T6"},{"id":"R8","pred":"ThemeOf","subj":"T11","obj":"T10"},{"id":"R9","pred":"ThemeOf","subj":"T18","obj":"T17"},{"id":"R10","pred":"CauseOf","subj":"T24","obj":"T29"},{"id":"R11","pred":"CauseOf","subj":"T24","obj":"T30"},{"id":"R18","pred":"ThemeOf","subj":"T27","obj":"T30"},{"id":"R19","pred":"ThemeOf","subj":"T29","obj":"T30"},{"id":"R20","pred":"ThemeOf","subj":"T31","obj":"T24"},{"id":"R21","pred":"ThemeOf","subj":"T31","obj":"T29"},{"id":"R22","pred":"ThemeOf","subj":"T31","obj":"T30"},{"id":"R23","pred":"ThemeOf","subj":"T31","obj":"T32"},{"id":"R24","pred":"ThemeOf","subj":"T33","obj":"T24"},{"id":"R25","pred":"ThemeOf","subj":"T33","obj":"T29"},{"id":"R26","pred":"ThemeOf","subj":"T33","obj":"T30"},{"id":"R27","pred":"ThemeOf","subj":"T33","obj":"T32"}],"text":"Tau protein expression in frontotemporal dementias.\nThe syndrome of frontotemporal dementia represents a diverse group of diseases presenting with behavioral and cognitive disturbances. The expression of the microtubule-associated protein tau was studied in postmortem samples of frontal cortex of 19 cases (12 Pick's disease A, B, C; 4 dementia lacking distinct histology; 3 motor neuron disease type) by Western blotting with a phosphorylation-independent anti-tau antibody. The presence of tau protein was detected in all cases evaluated, including the 11 brains classified as frontotemporal lobe degeneration (diagnostic categories Pick's disease B, C and dementia lacking distinct histology). These findings indicate that the recently reported decreased expression of tau protein in frontotemporal lobe degeneration represents pathogenic mechanism of neurodegeneration detectable only in a special subset of these disorders."}

    sonoma

    {"project":"sonoma","denotations":[{"id":"T-8","span":{"begin":68,"end":91},"obj":"DISEASE"},{"id":"T-0","span":{"begin":12,"end":22},"obj":"MPA"},{"id":"T-1","span":{"begin":26,"end":50},"obj":"DISEASE"},{"id":"T-2","span":{"begin":580,"end":612},"obj":"DISEASE"},{"id":"T-3","span":{"begin":660,"end":668},"obj":"DISEASE"},{"id":"T-4","span":{"begin":749,"end":758},"obj":"NEGREG"},{"id":"T-5","span":{"begin":759,"end":769},"obj":"MPA"},{"id":"T-6","span":{"begin":773,"end":784},"obj":"GENE"},{"id":"T-7","span":{"begin":788,"end":820},"obj":"DISEASE"},{"id":"T-9","span":{"begin":856,"end":873},"obj":"DISEASE"},{"id":"T-10","span":{"begin":131,"end":141},"obj":"REG"},{"id":"T-11","span":{"begin":190,"end":200},"obj":"MPA"},{"id":"T-12","span":{"begin":337,"end":345},"obj":"DISEASE"},{"id":"T-13","span":{"begin":376,"end":396},"obj":"DISEASE"},{"id":"T-14","span":{"begin":493,"end":504},"obj":"GENE"},{"id":"T-15","span":{"begin":0,"end":11},"obj":"GENE"},{"id":"T-16","span":{"begin":147,"end":185},"obj":"DISEASE"},{"id":"T-17","span":{"begin":208,"end":242},"obj":"GENE"},{"id":"T-18","span":{"begin":832,"end":852},"obj":"REG"},{"id":"T-19","span":{"begin":311,"end":333},"obj":"DISEASE"},{"id":"T-20","span":{"begin":636,"end":655},"obj":"DISEASE"}],"relations":[{"id":"R-0","pred":"ThemeOf","subj":"T-1","obj":"T-0"},{"id":"R-1","pred":"ThemeOf","subj":"T-1","obj":"T-10"},{"id":"R-2","pred":"ThemeOf","subj":"T-8","obj":"T-10"},{"id":"R-3","pred":"ThemeOf","subj":"T-5","obj":"T-4"},{"id":"R-4","pred":"ThemeOf","subj":"T-5","obj":"T-9"},{"id":"R-5","pred":"ThemeOf","subj":"T-6","obj":"T-5"},{"id":"R-6","pred":"ThemeOf","subj":"T-6","obj":"T-7"},{"id":"R-7","pred":"ThemeOf","subj":"T-6","obj":"T-9"},{"id":"R-8","pred":"ThemeOf","subj":"T-7","obj":"T-4"},{"id":"R-9","pred":"ThemeOf","subj":"T-7","obj":"T-5"},{"id":"R-10","pred":"ThemeOf","subj":"T-15","obj":"T-1"},{"id":"R-11","pred":"ThemeOf","subj":"T-15","obj":"T-0"},{"id":"R-12","pred":"ThemeOf","subj":"T-11","obj":"T-16"},{"id":"R-13","pred":"ThemeOf","subj":"T-10","obj":"T-16"},{"id":"R-14","pred":"ThemeOf","subj":"T-17","obj":"T-16"},{"id":"R-15","pred":"ThemeOf","subj":"T-17","obj":"T-19"},{"id":"R-16","pred":"ThemeOf","subj":"T-17","obj":"T-12"},{"id":"R-17","pred":"ThemeOf","subj":"T-17","obj":"T-13"},{"id":"R-18","pred":"ThemeOf","subj":"T-14","obj":"T-2"},{"id":"R-19","pred":"ThemeOf","subj":"T-14","obj":"T-20"},{"id":"R-20","pred":"ThemeOf","subj":"T-14","obj":"T-3"},{"id":"R-21","pred":"ThemeOf","subj":"T-18","obj":"T-7"},{"id":"R-22","pred":"ThemeOf","subj":"T-4","obj":"T-9"}],"text":"Tau protein expression in frontotemporal dementias.\nThe syndrome of frontotemporal dementia represents a diverse group of diseases presenting with behavioral and cognitive disturbances. The expression of the microtubule-associated protein tau was studied in postmortem samples of frontal cortex of 19 cases (12 Pick's disease A, B, C; 4 dementia lacking distinct histology; 3 motor neuron disease type) by Western blotting with a phosphorylation-independent anti-tau antibody. The presence of tau protein was detected in all cases evaluated, including the 11 brains classified as frontotemporal lobe degeneration (diagnostic categories Pick's disease B, C and dementia lacking distinct histology). These findings indicate that the recently reported decreased expression of tau protein in frontotemporal lobe degeneration represents pathogenic mechanism of neurodegeneration detectable only in a special subset of these disorders."}