
PubMed:11703582
Annnotations
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 1178-1187 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
PD-UBERON-AE-B_T2 | 1374-1383 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
11703582-1#9#28#gene80350 | 110-129 | gene80350 | denotes | apolipoprotein A-II |
11703582-1#9#28#gene336 | 110-129 | gene336 | denotes | apolipoprotein A-II |
11703582-1#30#37#gene80350 | 131-138 | gene80350 | denotes | apoA-II |
11703582-1#30#37#gene336 | 131-138 | gene336 | denotes | apoA-II |
11703582-1#179#186#gene80350 | 280-287 | gene80350 | denotes | apoA-II |
11703582-1#179#186#gene336 | 280-287 | gene336 | denotes | apoA-II |
11703582-1#298#305#gene80350 | 399-406 | gene80350 | denotes | apoA-II |
11703582-1#298#305#gene336 | 399-406 | gene336 | denotes | apoA-II |
11703582-1#229#246#diseaseC0268382 | 330-347 | diseaseC0268382 | denotes | renal amyloidosis |
11703582-10#26#33#gene80350 | 1448-1455 | gene80350 | denotes | apoA-II |
11703582-10#26#33#gene336 | 1448-1455 | gene336 | denotes | apoA-II |
11703582-10#34#45#diseaseC0002726 | 1456-1467 | diseaseC0002726 | denotes | amyloidosis |
9#28#gene80350229#246#diseaseC0268382 | 11703582-1#9#28#gene80350 | 11703582-1#229#246#diseaseC0268382 | associated_with | apolipoprotein A-II,renal amyloidosis |
9#28#gene336229#246#diseaseC0268382 | 11703582-1#9#28#gene336 | 11703582-1#229#246#diseaseC0268382 | associated_with | apolipoprotein A-II,renal amyloidosis |
30#37#gene80350229#246#diseaseC0268382 | 11703582-1#30#37#gene80350 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
30#37#gene336229#246#diseaseC0268382 | 11703582-1#30#37#gene336 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
179#186#gene80350229#246#diseaseC0268382 | 11703582-1#179#186#gene80350 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
179#186#gene336229#246#diseaseC0268382 | 11703582-1#179#186#gene336 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
298#305#gene80350229#246#diseaseC0268382 | 11703582-1#298#305#gene80350 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
298#305#gene336229#246#diseaseC0268382 | 11703582-1#298#305#gene336 | 11703582-1#229#246#diseaseC0268382 | associated_with | apoA-II,renal amyloidosis |
26#33#gene8035034#45#diseaseC0002726 | 11703582-10#26#33#gene80350 | 11703582-10#34#45#diseaseC0002726 | associated_with | apoA-II,amyloidosis |
26#33#gene33634#45#diseaseC0002726 | 11703582-10#26#33#gene336 | 11703582-10#34#45#diseaseC0002726 | associated_with | apoA-II,amyloidosis |
PubCasesHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TI1 | 0-17 | HP:0001917 | denotes | Renal amyloidosis |
AB1 | 151-162 | HP:0011034 | denotes | amyloidosis |
AB2 | 288-299 | HP:0011034 | denotes | amyloidosis |
AB3 | 330-347 | HP:0001917 | denotes | renal amyloidosis |
AB4 | 461-472 | HP:0011034 | denotes | amyloidosis |
AB5 | 531-542 | HP:0000093 | denotes | proteinuria |
AB6 | 697-714 | HP:0001917 | denotes | renal amyloidosis |
AB7 | 771-782 | HP:0011034 | denotes | amyloidosis |
AB8 | 1456-1467 | HP:0011034 | denotes | amyloidosis |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-88 | Sentence | denotes | Renal amyloidosis caused by a novel stop-codon mutation in the apolipoprotein A-II gene. |
TextSentencer_T2 | 89-100 | Sentence | denotes | BACKGROUND: |
TextSentencer_T3 | 101-407 | Sentence | denotes | Although apolipoprotein A-II (apoA-II) associated amyloidosis has been described in the senescent accelerated mouse (SAM) model of aging, so far there has been no report of human apoA-II amyloidosis except for a recent report of renal amyloidosis resulting from a stop-codon to glycine mutation of apoA-II. |
TextSentencer_T4 | 408-487 | Sentence | denotes | The mechanisms of amyloid formation in human apoA-II amyloidosis are not clear. |
TextSentencer_T5 | 488-496 | Sentence | denotes | METHODS: |
TextSentencer_T6 | 497-580 | Sentence | denotes | A 46-year-old Caucasian male with proteinuria noted at 42 years of age was studied. |
TextSentencer_T7 | 581-635 | Sentence | denotes | Renal biopsy revealed amyloid deposition in glomeruli. |
TextSentencer_T8 | 636-741 | Sentence | denotes | DNA analysis of genes known to be associated with hereditary renal amyloidosis revealed no abnormalities. |
TextSentencer_T9 | 742-830 | Sentence | denotes | To elucidate the type of his amyloidosis, apoA-II gene and plasma apoA-II were examined. |
TextSentencer_T10 | 831-1014 | Sentence | denotes | RESULTS: DNA analysis revealed heterozygosity for a G to C transversion at the second position of the stop-codon of apoA-II gene, suggesting a stop to serine substitution at codon 78. |
TextSentencer_T11 | 1015-1206 | Sentence | denotes | Western blot analysis and amino acid sequence analysis of the patient's plasma apoA-II showed both normal apoA-II and variant apoA-II with a 21-amino acid residue extension at the C-terminus. |
TextSentencer_T12 | 1207-1219 | Sentence | denotes | CONCLUSIONS: |
TextSentencer_T13 | 1220-1421 | Sentence | denotes | These results indicate that the patient's amyloid fibrils were derived from apoA-II and the amyloidogenesis is likely to be closely linked to the peptide extension at the C-terminus of variant apoA-II. |
TextSentencer_T14 | 1422-1498 | Sentence | denotes | The pathogenesis of human apoA-II amyloidosis is different from that of SAM. |
T1 | 0-88 | Sentence | denotes | Renal amyloidosis caused by a novel stop-codon mutation in the apolipoprotein A-II gene. |
T2 | 89-100 | Sentence | denotes | BACKGROUND: |
T3 | 101-407 | Sentence | denotes | Although apolipoprotein A-II (apoA-II) associated amyloidosis has been described in the senescent accelerated mouse (SAM) model of aging, so far there has been no report of human apoA-II amyloidosis except for a recent report of renal amyloidosis resulting from a stop-codon to glycine mutation of apoA-II. |
T4 | 408-487 | Sentence | denotes | The mechanisms of amyloid formation in human apoA-II amyloidosis are not clear. |
T5 | 488-496 | Sentence | denotes | METHODS: |
T6 | 497-580 | Sentence | denotes | A 46-year-old Caucasian male with proteinuria noted at 42 years of age was studied. |
T7 | 581-635 | Sentence | denotes | Renal biopsy revealed amyloid deposition in glomeruli. |
T8 | 636-741 | Sentence | denotes | DNA analysis of genes known to be associated with hereditary renal amyloidosis revealed no abnormalities. |
T9 | 742-830 | Sentence | denotes | To elucidate the type of his amyloidosis, apoA-II gene and plasma apoA-II were examined. |
T10 | 831-1014 | Sentence | denotes | RESULTS: DNA analysis revealed heterozygosity for a G to C transversion at the second position of the stop-codon of apoA-II gene, suggesting a stop to serine substitution at codon 78. |
T11 | 1015-1206 | Sentence | denotes | Western blot analysis and amino acid sequence analysis of the patient's plasma apoA-II showed both normal apoA-II and variant apoA-II with a 21-amino acid residue extension at the C-terminus. |
T12 | 1207-1219 | Sentence | denotes | CONCLUSIONS: |
T13 | 1220-1421 | Sentence | denotes | These results indicate that the patient's amyloid fibrils were derived from apoA-II and the amyloidogenesis is likely to be closely linked to the peptide extension at the C-terminus of variant apoA-II. |
T14 | 1422-1498 | Sentence | denotes | The pathogenesis of human apoA-II amyloidosis is different from that of SAM. |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 1178-1187 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
PD-UBERON-AE-B_T2 | 1374-1383 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
PubCasesORDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
AB1 | 686-714 | ORDO:85450 | denotes | hereditary renal amyloidosis |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 1448-1455 | gene:80350 | denotes | apoA-II |
T1 | 1456-1467 | disease:C0002726 | denotes | amyloidosis |
T2 | 1448-1455 | gene:336 | denotes | apoA-II |
T3 | 1456-1467 | disease:C0002726 | denotes | amyloidosis |
R1 | T0 | T1 | associated_with | apoA-II,amyloidosis |
R2 | T2 | T3 | associated_with | apoA-II,amyloidosis |