PubMed:11701123
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11701123","sourcedb":"PubMed","sourceid":"11701123","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11701123","text":"Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.\nHistone H3 lysine 9 methylation has been proposed to provide a major \"switch\" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone methyltransferases (HMTases) govern H3-K9 methylation at pericentric heterochromatin and induce a specialized histone methylation pattern that differs from the broad H3-K9 methylation present at other chromosomal regions. Suv39h-deficient mice display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis. These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development.","tracks":[{"project":"2015-BEL-Sample","denotations":[{"id":"T1","span":{"begin":506,"end":700},"obj":"cat(p(MGI:Suv39h2)) decreases path(MESHD:Neoplasms)"}],"attributes":[{"subj":"T1","pred":"source","obj":"2015-BEL-Sample"}]},{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20000382","span":{"begin":506,"end":700},"obj":"cat(p(MGI:Suv39h1)) decreases path(MESHD:Neoplasms)"},{"id":"BEL:20000384","span":{"begin":506,"end":700},"obj":"cat(p(MGI:Suv39h2)) decreases path(MESHD:Neoplasms)"}],"attributes":[{"subj":"BEL:20000382","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20000384","pred":"source","obj":"2015-BEL-Sample-2"}]},{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":632,"end":637},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002664"},{"subj":"T1","pred":"source","obj":"GlyCosmos15-HP"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":632,"end":637},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"subj":"T1","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":523,"end":527},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"10088"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":688,"end":692},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000029"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":657,"end":667},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005694"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2015-BEL-Sample","color":"#9399ec","default":true},{"id":"2015-BEL-Sample-2","color":"#b3ec93"},{"id":"GlyCosmos15-HP","color":"#ec93cd"},{"id":"mondo_disease","color":"#93e7ec"},{"id":"NCBITAXON","color":"#ecd793"},{"id":"Anatomy-MAT","color":"#bd93ec"},{"id":"Anatomy-UBERON","color":"#93eca3"}]}]}}