PubMed:11592852
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 117-247 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) degrade the extracellular matrix and carry out key functions during development and after injury. |
| T2 | 248-411 | DRI_Background | denotes | By means of zymography, Western blot and immunohistochemistry, we studied MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in rat brain after focal cerebral ischemia. |
| T3 | 412-533 | DRI_Background | denotes | The control rat brain showed constitutive MMP-2 and, to a lesser extent, MMP-9, which were mainly present as prozymogens. |
| T4 | 534-680 | DRI_Background | denotes | MMP-2 protein was located in the cell body of neurons, glia, and endothelium, whereas MMP-9 was associated to neurons and myelinated fibre tracts. |
| T5 | 1055-1111 | DRI_Outcome | denotes | Our results are compatible with progressive induction of |
| T6 | 1125-1169 | DRI_Outcome | denotes | , likely in neurons, shortly after ischemia. |
| T7 | 1170-1439 | DRI_Outcome | denotes | For MMP-2, the results suggest a discrete production immediately after reperfusion, while a very enhanced expression and activation of MMP-2 attributable to microglia/macrophages occurs on day 4, and it might contribute to the phagocytic action of these reactive cells. |
c_corpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 29-35 | UBERON:0027368 | denotes | matrix |
| T2 | 29-55 | Q9GLE5 | denotes | matrix metalloproteinase-2 |
| T3 | 29-55 | P08253 | denotes | matrix metalloproteinase-2 |
| T4 | 29-55 | Q8MPP3 | denotes | matrix metalloproteinase-2 |
| T5 | 29-55 | Q90611 | denotes | matrix metalloproteinase-2 |
| T7 | 29-55 | PR:000010479 | denotes | matrix metalloproteinase-2 |
| T8 | 29-55 | P33436 | denotes | matrix metalloproteinase-2 |
| T9 | 29-55 | P33434 | denotes | matrix metalloproteinase-2 |
| T10 | 29-55 | P50757 | denotes | matrix metalloproteinase-2 |
| T6 | 29-55 | D020778 | denotes | matrix metalloproteinase-2 |
| T13 | 66-69 | PR:P63003-1 | denotes | rat |
| T14 | 66-69 | PR:Q2G0B1 | denotes | rat |
| T15 | 66-69 | PR:Q8VHJ4 | denotes | rat |
| T12 | 66-69 | 10116 | denotes | rat |
| T16 | 66-69 | D051381 | denotes | rat |
| T17 | 70-75 | UBERON:6110636 | denotes | brain |
| T18 | 70-75 | UBERON:0000955 | denotes | brain |
| T19 | 98-115 | D002545 | denotes | cerebral ischemia |
| T20 | 98-115 | D002545 | denotes | cerebral ischemia |
| T23 | 124-142 | D045726 | denotes | metalloproteinases |
| T24 | 144-148 | D020782 | denotes | MMPs |
| T26 | 162-182 | GO:0031012 | denotes | extracellular matrix |
| T27 | 176-182 | UBERON:0027368 | denotes | matrix |
| T28 | 322-325 | CHEBI:340824 | denotes | MMP |
| T31 | 322-325 | CHEBI:59761 | denotes | MMP |
| T32 | 322-327 | PR:P08253 | denotes | MMP-2 |
| T33 | 322-327 | Q9GLE5 | denotes | MMP-2 |
| T34 | 322-327 | P08253 | denotes | MMP-2 |
| T35 | 322-327 | Q90611 | denotes | MMP-2 |
| T37 | 322-327 | PR:Q8MPP3 | denotes | MMP-2 |
| T38 | 322-327 | P33436 | denotes | MMP-2 |
| T39 | 322-327 | PR:Q90611 | denotes | MMP-2 |
| T40 | 322-327 | PR:P33436 | denotes | MMP-2 |
| T41 | 322-327 | PR:000010479 | denotes | MMP-2 |
| T42 | 322-327 | PR:P33434 | denotes | MMP-2 |
| T43 | 322-327 | P33434 | denotes | MMP-2 |
| T44 | 322-327 | P50757 | denotes | MMP-2 |
| T36 | 322-327 | GO:0004228 | denotes | MMP-2 |
| T47 | 329-341 | P08253 | denotes | gelatinase A |
| T48 | 329-341 | Q90611 | denotes | gelatinase A |
| T50 | 329-341 | PR:000010479 | denotes | gelatinase A |
| T51 | 329-341 | P33436 | denotes | gelatinase A |
| T52 | 329-341 | P33434 | denotes | gelatinase A |
| T53 | 329-341 | P50757 | denotes | gelatinase A |
| T49 | 329-341 | D020778 | denotes | gelatinase A |
| T54 | 347-350 | CHEBI:340824 | denotes | MMP |
| T57 | 347-350 | CHEBI:59761 | denotes | MMP |
| T58 | 347-352 | PR:P50282 | denotes | MMP-9 |
| T59 | 347-352 | PR:P14780 | denotes | MMP-9 |
| T60 | 347-352 | P14780 | denotes | MMP-9 |
| T61 | 347-352 | PR:P41245 | denotes | MMP-9 |
| T62 | 347-352 | P41246 | denotes | MMP-9 |
| T63 | 347-352 | P41245 | denotes | MMP-9 |
| T64 | 347-352 | PR:P52176 | denotes | MMP-9 |
| T65 | 347-352 | P50282 | denotes | MMP-9 |
| T67 | 347-352 | PR:000010491 | denotes | MMP-9 |
| T68 | 347-352 | P52176 | denotes | MMP-9 |
| T69 | 347-352 | O18733 | denotes | MMP-9 |
| T66 | 347-352 | GO:0004229 | denotes | MMP-9 |
| T73 | 354-366 | P14780 | denotes | gelatinase B |
| T74 | 354-366 | P41246 | denotes | gelatinase B |
| T75 | 354-366 | P41245 | denotes | gelatinase B |
| T76 | 354-366 | P50282 | denotes | gelatinase B |
| T77 | 354-366 | PR:000010491 | denotes | gelatinase B |
| T78 | 354-366 | P52176 | denotes | gelatinase B |
| T79 | 354-366 | O18733 | denotes | gelatinase B |
| T72 | 354-366 | D020780 | denotes | gelatinase B |
| T81 | 371-374 | PR:P63003-1 | denotes | rat |
| T82 | 371-374 | PR:Q2G0B1 | denotes | rat |
| T83 | 371-374 | PR:Q8VHJ4 | denotes | rat |
| T80 | 371-374 | 10116 | denotes | rat |
| T84 | 371-374 | D051381 | denotes | rat |
| T85 | 375-380 | UBERON:6110636 | denotes | brain |
| T86 | 375-380 | UBERON:0000955 | denotes | brain |
| T87 | 393-410 | D002545 | denotes | cerebral ischemia |
| T88 | 393-410 | D002545 | denotes | cerebral ischemia |
| T92 | 424-427 | PR:P63003-1 | denotes | rat |
| T93 | 424-427 | PR:Q2G0B1 | denotes | rat |
| T94 | 424-427 | PR:Q8VHJ4 | denotes | rat |
| T91 | 424-427 | 10116 | denotes | rat |
| T95 | 424-427 | D051381 | denotes | rat |
| T96 | 428-433 | UBERON:6110636 | denotes | brain |
| T97 | 428-433 | UBERON:0000955 | denotes | brain |
| T98 | 454-457 | CHEBI:340824 | denotes | MMP |
| T101 | 454-457 | CHEBI:59761 | denotes | MMP |
| T102 | 454-459 | PR:P08253 | denotes | MMP-2 |
| T103 | 454-459 | Q9GLE5 | denotes | MMP-2 |
| T104 | 454-459 | P08253 | denotes | MMP-2 |
| T105 | 454-459 | Q90611 | denotes | MMP-2 |
| T107 | 454-459 | PR:Q8MPP3 | denotes | MMP-2 |
| T108 | 454-459 | P33436 | denotes | MMP-2 |
| T109 | 454-459 | PR:Q90611 | denotes | MMP-2 |
| T110 | 454-459 | PR:P33436 | denotes | MMP-2 |
| T111 | 454-459 | PR:000010479 | denotes | MMP-2 |
| T112 | 454-459 | PR:P33434 | denotes | MMP-2 |
| T113 | 454-459 | P33434 | denotes | MMP-2 |
| T114 | 454-459 | P50757 | denotes | MMP-2 |
| T106 | 454-459 | GO:0004228 | denotes | MMP-2 |
| T116 | 485-488 | CHEBI:340824 | denotes | MMP |
| T119 | 485-488 | CHEBI:59761 | denotes | MMP |
| T120 | 485-490 | PR:P50282 | denotes | MMP-9 |
| T121 | 485-490 | PR:P14780 | denotes | MMP-9 |
| T122 | 485-490 | P14780 | denotes | MMP-9 |
| T123 | 485-490 | PR:P41245 | denotes | MMP-9 |
| T124 | 485-490 | P41246 | denotes | MMP-9 |
| T125 | 485-490 | P41245 | denotes | MMP-9 |
| T126 | 485-490 | PR:P52176 | denotes | MMP-9 |
| T127 | 485-490 | P50282 | denotes | MMP-9 |
| T129 | 485-490 | PR:000010491 | denotes | MMP-9 |
| T130 | 485-490 | P52176 | denotes | MMP-9 |
| T131 | 485-490 | O18733 | denotes | MMP-9 |
| T128 | 485-490 | GO:0004229 | denotes | MMP-9 |
| T132 | 534-537 | CHEBI:340824 | denotes | MMP |
| T135 | 534-537 | CHEBI:59761 | denotes | MMP |
| T136 | 534-539 | PR:P08253 | denotes | MMP-2 |
| T137 | 534-539 | Q9GLE5 | denotes | MMP-2 |
| T138 | 534-539 | P08253 | denotes | MMP-2 |
| T139 | 534-539 | Q90611 | denotes | MMP-2 |
| T141 | 534-539 | PR:Q8MPP3 | denotes | MMP-2 |
| T142 | 534-539 | P33436 | denotes | MMP-2 |
| T143 | 534-539 | PR:Q90611 | denotes | MMP-2 |
| T144 | 534-539 | PR:P33436 | denotes | MMP-2 |
| T145 | 534-539 | PR:000010479 | denotes | MMP-2 |
| T146 | 534-539 | PR:P33434 | denotes | MMP-2 |
| T147 | 534-539 | P33434 | denotes | MMP-2 |
| T148 | 534-539 | P50757 | denotes | MMP-2 |
| T140 | 534-539 | GO:0004228 | denotes | MMP-2 |
| T153 | 540-547 | SO:0000104 | denotes | protein |
| T152 | 540-547 | PR:000000001 | denotes | protein |
| T150 | 540-547 | CHEBI:36080 | denotes | protein |
| T151 | 540-547 | CHEBI:11122 | denotes | protein |
| T149 | 540-547 | GO:0003675 | denotes | protein |
| T154 | 567-576 | GO:0044297 | denotes | cell body |
| T155 | 599-610 | UBERON:0001986 | denotes | endothelium |
| T156 | 620-623 | CHEBI:340824 | denotes | MMP |
| T159 | 620-623 | CHEBI:59761 | denotes | MMP |
| T160 | 620-625 | PR:P50282 | denotes | MMP-9 |
| T161 | 620-625 | PR:P14780 | denotes | MMP-9 |
| T162 | 620-625 | P14780 | denotes | MMP-9 |
| T163 | 620-625 | PR:P41245 | denotes | MMP-9 |
| T164 | 620-625 | P41246 | denotes | MMP-9 |
| T165 | 620-625 | P41245 | denotes | MMP-9 |
| T166 | 620-625 | PR:P52176 | denotes | MMP-9 |
| T167 | 620-625 | P50282 | denotes | MMP-9 |
| T169 | 620-625 | PR:000010491 | denotes | MMP-9 |
| T170 | 620-625 | P52176 | denotes | MMP-9 |
| T171 | 620-625 | O18733 | denotes | MMP-9 |
| T168 | 620-625 | GO:0004229 | denotes | MMP-9 |
| T172 | 681-689 | D007511 | denotes | Ischemia |
| T173 | 681-689 | D007511 | denotes | Ischemia |
| T176 | 708-711 | PR:O04529 | denotes | MMP |
| T174 | 708-711 | CHEBI:340824 | denotes | MMP |
| T177 | 708-711 | CHEBI:59761 | denotes | MMP |
| T175 | 708-711 | GO:0004235 | denotes | MMP |
| T178 | 764-767 | CHEBI:340824 | denotes | MMP |
| T181 | 764-767 | CHEBI:59761 | denotes | MMP |
| T182 | 764-769 | PR:P50282 | denotes | MMP-9 |
| T183 | 764-769 | PR:P14780 | denotes | MMP-9 |
| T184 | 764-769 | P14780 | denotes | MMP-9 |
| T185 | 764-769 | PR:P41245 | denotes | MMP-9 |
| T186 | 764-769 | P41246 | denotes | MMP-9 |
| T187 | 764-769 | P41245 | denotes | MMP-9 |
| T188 | 764-769 | PR:P52176 | denotes | MMP-9 |
| T189 | 764-769 | P50282 | denotes | MMP-9 |
| T191 | 764-769 | PR:000010491 | denotes | MMP-9 |
| T192 | 764-769 | P52176 | denotes | MMP-9 |
| T193 | 764-769 | O18733 | denotes | MMP-9 |
| T190 | 764-769 | GO:0004229 | denotes | MMP-9 |
| T198 | 770-777 | SO:0000104 | denotes | protein |
| T197 | 770-777 | PR:000000001 | denotes | protein |
| T195 | 770-777 | CHEBI:36080 | denotes | protein |
| T196 | 770-777 | CHEBI:11122 | denotes | protein |
| T194 | 770-777 | GO:0003675 | denotes | protein |
| T199 | 857-860 | CHEBI:340824 | denotes | MMP |
| T202 | 857-860 | CHEBI:59761 | denotes | MMP |
| T203 | 857-862 | PR:P08253 | denotes | MMP-2 |
| T204 | 857-862 | Q9GLE5 | denotes | MMP-2 |
| T205 | 857-862 | P08253 | denotes | MMP-2 |
| T206 | 857-862 | Q90611 | denotes | MMP-2 |
| T208 | 857-862 | PR:Q8MPP3 | denotes | MMP-2 |
| T209 | 857-862 | P33436 | denotes | MMP-2 |
| T210 | 857-862 | PR:Q90611 | denotes | MMP-2 |
| T211 | 857-862 | PR:P33436 | denotes | MMP-2 |
| T212 | 857-862 | PR:000010479 | denotes | MMP-2 |
| T213 | 857-862 | PR:P33434 | denotes | MMP-2 |
| T214 | 857-862 | P33434 | denotes | MMP-2 |
| T215 | 857-862 | P50757 | denotes | MMP-2 |
| T207 | 857-862 | GO:0004228 | denotes | MMP-2 |
| T219 | 929-932 | CHEBI:340824 | denotes | MMP |
| T222 | 929-932 | CHEBI:59761 | denotes | MMP |
| T223 | 929-934 | PR:P08253 | denotes | MMP-2 |
| T224 | 929-934 | Q9GLE5 | denotes | MMP-2 |
| T225 | 929-934 | P08253 | denotes | MMP-2 |
| T226 | 929-934 | Q90611 | denotes | MMP-2 |
| T228 | 929-934 | PR:Q8MPP3 | denotes | MMP-2 |
| T229 | 929-934 | P33436 | denotes | MMP-2 |
| T230 | 929-934 | PR:Q90611 | denotes | MMP-2 |
| T231 | 929-934 | PR:P33436 | denotes | MMP-2 |
| T232 | 929-934 | PR:000010479 | denotes | MMP-2 |
| T233 | 929-934 | PR:P33434 | denotes | MMP-2 |
| T234 | 929-934 | P33434 | denotes | MMP-2 |
| T235 | 929-934 | P50757 | denotes | MMP-2 |
| T227 | 929-934 | GO:0004228 | denotes | MMP-2 |
| T240 | 935-942 | SO:0000104 | denotes | protein |
| T239 | 935-942 | PR:000000001 | denotes | protein |
| T237 | 935-942 | CHEBI:36080 | denotes | protein |
| T238 | 935-942 | CHEBI:11122 | denotes | protein |
| T236 | 935-942 | GO:0003675 | denotes | protein |
| T241 | 1014-1017 | CHEBI:340824 | denotes | MMP |
| T244 | 1014-1017 | CHEBI:59761 | denotes | MMP |
| T245 | 1014-1019 | PR:P08253 | denotes | MMP-2 |
| T246 | 1014-1019 | Q9GLE5 | denotes | MMP-2 |
| T247 | 1014-1019 | P08253 | denotes | MMP-2 |
| T248 | 1014-1019 | Q90611 | denotes | MMP-2 |
| T250 | 1014-1019 | PR:Q8MPP3 | denotes | MMP-2 |
| T251 | 1014-1019 | P33436 | denotes | MMP-2 |
| T252 | 1014-1019 | PR:Q90611 | denotes | MMP-2 |
| T253 | 1014-1019 | PR:P33436 | denotes | MMP-2 |
| T254 | 1014-1019 | PR:000010479 | denotes | MMP-2 |
| T255 | 1014-1019 | PR:P33434 | denotes | MMP-2 |
| T256 | 1014-1019 | P33434 | denotes | MMP-2 |
| T257 | 1014-1019 | P50757 | denotes | MMP-2 |
| T249 | 1014-1019 | GO:0004228 | denotes | MMP-2 |
| T258 | 1023-1041 | CL:0002629 | denotes | reactive microglia |
| T260 | 1112-1115 | CHEBI:340824 | denotes | MMP |
| T263 | 1112-1115 | CHEBI:59761 | denotes | MMP |
| T264 | 1112-1117 | PR:P50282 | denotes | MMP-9 |
| T265 | 1112-1117 | PR:P14780 | denotes | MMP-9 |
| T266 | 1112-1117 | P14780 | denotes | MMP-9 |
| T267 | 1112-1117 | PR:P41245 | denotes | MMP-9 |
| T268 | 1112-1117 | P41246 | denotes | MMP-9 |
| T269 | 1112-1117 | P41245 | denotes | MMP-9 |
| T270 | 1112-1117 | PR:P52176 | denotes | MMP-9 |
| T271 | 1112-1117 | P50282 | denotes | MMP-9 |
| T273 | 1112-1117 | PR:000010491 | denotes | MMP-9 |
| T274 | 1112-1117 | P52176 | denotes | MMP-9 |
| T275 | 1112-1117 | O18733 | denotes | MMP-9 |
| T272 | 1112-1117 | GO:0004229 | denotes | MMP-9 |
| T276 | 1160-1168 | D007511 | denotes | ischemia |
| T277 | 1160-1168 | D007511 | denotes | ischemia |
| T278 | 1174-1177 | CHEBI:340824 | denotes | MMP |
| T281 | 1174-1177 | CHEBI:59761 | denotes | MMP |
| T282 | 1174-1179 | PR:P08253 | denotes | MMP-2 |
| T283 | 1174-1179 | Q9GLE5 | denotes | MMP-2 |
| T284 | 1174-1179 | P08253 | denotes | MMP-2 |
| T285 | 1174-1179 | Q90611 | denotes | MMP-2 |
| T287 | 1174-1179 | PR:Q8MPP3 | denotes | MMP-2 |
| T288 | 1174-1179 | P33436 | denotes | MMP-2 |
| T289 | 1174-1179 | PR:Q90611 | denotes | MMP-2 |
| T290 | 1174-1179 | PR:P33436 | denotes | MMP-2 |
| T291 | 1174-1179 | PR:000010479 | denotes | MMP-2 |
| T292 | 1174-1179 | PR:P33434 | denotes | MMP-2 |
| T293 | 1174-1179 | P33434 | denotes | MMP-2 |
| T294 | 1174-1179 | P50757 | denotes | MMP-2 |
| T286 | 1174-1179 | GO:0004228 | denotes | MMP-2 |
| T295 | 1305-1308 | CHEBI:340824 | denotes | MMP |
| T298 | 1305-1308 | CHEBI:59761 | denotes | MMP |
| T299 | 1305-1310 | PR:P08253 | denotes | MMP-2 |
| T300 | 1305-1310 | Q9GLE5 | denotes | MMP-2 |
| T301 | 1305-1310 | P08253 | denotes | MMP-2 |
| T302 | 1305-1310 | Q90611 | denotes | MMP-2 |
| T304 | 1305-1310 | PR:Q8MPP3 | denotes | MMP-2 |
| T305 | 1305-1310 | P33436 | denotes | MMP-2 |
| T306 | 1305-1310 | PR:Q90611 | denotes | MMP-2 |
| T307 | 1305-1310 | PR:P33436 | denotes | MMP-2 |
| T308 | 1305-1310 | PR:000010479 | denotes | MMP-2 |
| T309 | 1305-1310 | PR:P33434 | denotes | MMP-2 |
| T310 | 1305-1310 | P33434 | denotes | MMP-2 |
| T311 | 1305-1310 | P50757 | denotes | MMP-2 |
| T303 | 1305-1310 | GO:0004228 | denotes | MMP-2 |
| T312 | 1327-1336 | CL:0000129 | denotes | microglia |
UseCases_ArguminSci_Discourse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-116 | DRI_Approach | denotes | Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. |
| T2 | 117-247 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) degrade the extracellular matrix and carry out key functions during development and after injury. |
| T3 | 248-411 | DRI_Background | denotes | By means of zymography, Western blot and immunohistochemistry, we studied MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in rat brain after focal cerebral ischemia. |
| T4 | 412-533 | DRI_Background | denotes | The control rat brain showed constitutive MMP-2 and, to a lesser extent, MMP-9, which were mainly present as prozymogens. |
| T5 | 534-680 | DRI_Background | denotes | MMP-2 protein was located in the cell body of neurons, glia, and endothelium, whereas MMP-9 was associated to neurons and myelinated fibre tracts. |
| T6 | 681-1054 | DRI_Unspecified | denotes | Ischemia greatly increased MMP activation in two temporal waves, in the first one, MMP-9 protein was induced from 4 h to 4 days, and also a small and short-lasting increase in MMP-2 was detected at 4 h. The second wave showed a massive increase in MMP-2 protein expression and activation by day 4, which was compatible with abundant MMP-2 in reactive microglia/macrophages. |
| T7 | 1055-1111 | DRI_Outcome | denotes | Our results are compatible with progressive induction of |
| T8 | 1112-1125 | Token_Label.OUTSIDE | denotes | MMP-9 proform |
| T9 | 1125-1169 | DRI_Outcome | denotes | , likely in neurons, shortly after ischemia. |
| T10 | 1170-1439 | DRI_Outcome | denotes | For MMP-2, the results suggest a discrete production immediately after reperfusion, while a very enhanced expression and activation of MMP-2 attributable to microglia/macrophages occurs on day 4, and it might contribute to the phagocytic action of these reactive cells. |