> top > docs > PubMed:11591122 > annotations

PubMed:11591122 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-153 Sentence denotes A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians.
TextSentencer_T2 154-255 Sentence denotes The poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that detects and binds DNA strand breaks.
TextSentencer_T3 256-364 Sentence denotes Excessive PARP activation leads to the death of mice islet beta-cells by depleting cellular energy reserves.
TextSentencer_T4 365-660 Sentence denotes On the other hand, PARP-mutant mice are resistant to streptozotocine-induced diabetes, and in the non-obese diabetic (NOD) mouse model, treatment with nicotinamide, a PARP inhibitor, protects islet cells against cytotoxic actions in vitro and results in a decreased incidence of type 1 diabetes.
TextSentencer_T5 661-854 Sentence denotes PARP gene in human is located within a recently identified type 1 diabetes-susceptibility region on chromosome 1q41-42, and contains a polymorphic CA dinucleotide repeat in the promoter region.
TextSentencer_T6 855-1137 Sentence denotes To consider the putative involvement of PARP polymorphism in predisposition to type 1 diabetes, we performed genotyping for the various alleles of the CA dinucleotide repeat in 158 unrelated French Caucasian patients with type 1 diabetes and 193 ethnically-matched healthy controls.
TextSentencer_T7 1138-1337 Sentence denotes We found no significant difference of PARP alleles distribution between patients and controls, even after stratification of the patients according to HLA class II genotype or to age at disease onset.
TextSentencer_T8 1338-1460 Sentence denotes Our results suggest that this PARP polymorphism does not influence susceptibility to type 1 diabetes in French Caucasians.
T1 0-153 Sentence denotes A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians.
T2 154-255 Sentence denotes The poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that detects and binds DNA strand breaks.
T3 256-364 Sentence denotes Excessive PARP activation leads to the death of mice islet beta-cells by depleting cellular energy reserves.
T4 365-660 Sentence denotes On the other hand, PARP-mutant mice are resistant to streptozotocine-induced diabetes, and in the non-obese diabetic (NOD) mouse model, treatment with nicotinamide, a PARP inhibitor, protects islet cells against cytotoxic actions in vitro and results in a decreased incidence of type 1 diabetes.
T5 661-854 Sentence denotes PARP gene in human is located within a recently identified type 1 diabetes-susceptibility region on chromosome 1q41-42, and contains a polymorphic CA dinucleotide repeat in the promoter region.
T6 855-1137 Sentence denotes To consider the putative involvement of PARP polymorphism in predisposition to type 1 diabetes, we performed genotyping for the various alleles of the CA dinucleotide repeat in 158 unrelated French Caucasian patients with type 1 diabetes and 193 ethnically-matched healthy controls.
T7 1138-1337 Sentence denotes We found no significant difference of PARP alleles distribution between patients and controls, even after stratification of the patients according to HLA class II genotype or to age at disease onset.
T8 1338-1460 Sentence denotes Our results suggest that this PARP polymorphism does not influence susceptibility to type 1 diabetes in French Caucasians.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11591122-0#59#69#gene100616102 59-69 gene100616102 denotes polymerase
11591122-0#59#69#gene100862688 59-69 gene100862688 denotes polymerase
11591122-0#59#69#gene100862685 59-69 gene100862685 denotes polymerase
11591122-0#47#50#gene23038 47-50 gene23038 denotes ADP
11591122-0#116#131#diseaseC0011854 116-131 diseaseC0011854 denotes type 1 diabetes
11591122-0#116#131#diseaseC0011854 116-131 diseaseC0011854 denotes type 1 diabetes
11591122-4#0#4#gene1302 661-665 gene1302 denotes PARP
11591122-4#0#4#gene142 661-665 gene142 denotes PARP
11591122-4#59#74#diseaseC0011854 720-735 diseaseC0011854 denotes type 1 diabetes
59#69#gene100616102116#131#diseaseC0011854 11591122-0#59#69#gene100616102 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
59#69#gene100616102116#131#diseaseC0011854 11591122-0#59#69#gene100616102 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
59#69#gene100862688116#131#diseaseC0011854 11591122-0#59#69#gene100862688 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
59#69#gene100862688116#131#diseaseC0011854 11591122-0#59#69#gene100862688 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
59#69#gene100862685116#131#diseaseC0011854 11591122-0#59#69#gene100862685 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
59#69#gene100862685116#131#diseaseC0011854 11591122-0#59#69#gene100862685 11591122-0#116#131#diseaseC0011854 associated_with polymerase,type 1 diabetes
47#50#gene23038116#131#diseaseC0011854 11591122-0#47#50#gene23038 11591122-0#116#131#diseaseC0011854 associated_with ADP,type 1 diabetes
47#50#gene23038116#131#diseaseC0011854 11591122-0#47#50#gene23038 11591122-0#116#131#diseaseC0011854 associated_with ADP,type 1 diabetes
0#4#gene130259#74#diseaseC0011854 11591122-4#0#4#gene1302 11591122-4#59#74#diseaseC0011854 associated_with PARP,type 1 diabetes
0#4#gene14259#74#diseaseC0011854 11591122-4#0#4#gene142 11591122-4#59#74#diseaseC0011854 associated_with PARP,type 1 diabetes

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2034 59-69 gene:100616102 denotes polymerase
T2035 116-131 disease:C0011854 denotes type 1 diabetes
R1 T2034 T2035 associated_with polymerase,type 1 diabetes
R2 T2034 T2035 associated_with polymerase,type 1 diabetes
R3 T2034 T2035 associated_with polymerase,type 1 diabetes

DisGeNET

Id Subject Object Predicate Lexical cue
T0 42-69 gene:142 denotes poly(ADP-ribose) polymerase
T1 116-131 disease:C0011854 denotes type 1 diabetes
T2 532-536 gene:142 denotes PARP
T3 644-659 disease:C0011854 denotes type 1 diabetes
T4 532-536 gene:142 denotes PARP
T5 442-450 disease:C0011849 denotes diabetes
T6 532-536 gene:142 denotes PARP
T7 442-450 disease:C0011847 denotes diabetes
T8 384-388 gene:142 denotes PARP
T9 644-659 disease:C0011854 denotes type 1 diabetes
T10 384-388 gene:142 denotes PARP
T11 442-450 disease:C0011847 denotes diabetes
T12 384-388 gene:142 denotes PARP
T13 442-450 disease:C0011849 denotes diabetes
T14 661-665 gene:1302 denotes PARP
T15 720-735 disease:C0011854 denotes type 1 diabetes
T16 661-665 gene:142 denotes PARP
T17 720-735 disease:C0011854 denotes type 1 diabetes
T18 895-899 gene:142 denotes PARP
T19 934-949 disease:C0011854 denotes type 1 diabetes
T20 895-899 gene:142 denotes PARP
T21 1077-1092 disease:C0011854 denotes type 1 diabetes
T22 1368-1372 gene:142 denotes PARP
T23 1423-1438 disease:C0011854 denotes type 1 diabetes
R1 T0 T1 associated_with poly(ADP-ribose) polymerase,type 1 diabetes
R2 T2 T3 associated_with PARP,type 1 diabetes
R3 T4 T5 associated_with PARP,diabetes
R4 T6 T7 associated_with PARP,diabetes
R5 T8 T9 associated_with PARP,type 1 diabetes
R6 T10 T11 associated_with PARP,diabetes
R7 T12 T13 associated_with PARP,diabetes
R8 T14 T15 associated_with PARP,type 1 diabetes
R9 T16 T17 associated_with PARP,type 1 diabetes
R10 T18 T19 associated_with PARP,type 1 diabetes
R11 T20 T21 associated_with PARP,type 1 diabetes
R12 T22 T23 associated_with PARP,type 1 diabetes