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c_corpus

Id Subject Object Predicate Lexical cue
T1 11-17 UBERON:0027368 denotes matrix
T3 11-37 P14780 denotes matrix metalloproteinase-9
T4 11-37 P41246 denotes matrix metalloproteinase-9
T5 11-37 P41245 denotes matrix metalloproteinase-9
T6 11-37 P50282 denotes matrix metalloproteinase-9
T7 11-37 PR:000010491 denotes matrix metalloproteinase-9
T8 11-37 P52176 denotes matrix metalloproteinase-9
T9 11-37 O18733 denotes matrix metalloproteinase-9
T2 11-37 D020780 denotes matrix metalloproteinase-9
T10 38-42 SO:0000704 denotes gene
T11 60-71 GO:0006508 denotes proteolysis
T12 75-94 UBERON:0000120 denotes blood-brain barrier
T17 99-111 UBERON:0002316 denotes white matter
T15 99-111 D056784 denotes white matter
T16 99-111 D056784 denotes white matter
T18 129-146 D002545 denotes cerebral ischemia
T19 129-146 D002545 denotes cerebral ischemia
T22 160-169 UBERON:0004529 denotes processes
T23 173-186 GO:0005576 denotes extracellular
T24 187-198 GO:0006508 denotes proteolysis
T25 236-242 UBERON:0000479 denotes tissue
T26 256-274 D001930 denotes acute brain injury
T27 256-274 D001930 denotes acute brain injury
T28 262-267 UBERON:6110636 denotes brain
T29 262-267 UBERON:0000955 denotes brain
T32 300-306 UBERON:0027368 denotes matrix
T34 300-326 P14780 denotes matrix metalloproteinase-9
T35 300-326 P41246 denotes matrix metalloproteinase-9
T36 300-326 P41245 denotes matrix metalloproteinase-9
T37 300-326 P50282 denotes matrix metalloproteinase-9
T38 300-326 PR:000010491 denotes matrix metalloproteinase-9
T39 300-326 P52176 denotes matrix metalloproteinase-9
T40 300-326 O18733 denotes matrix metalloproteinase-9
T33 300-326 D020780 denotes matrix metalloproteinase-9
T41 328-331 CHEBI:340824 denotes MMP
T44 328-331 CHEBI:59761 denotes MMP
T45 328-333 PR:P50282 denotes MMP-9
T46 328-333 PR:P14780 denotes MMP-9
T47 328-333 P14780 denotes MMP-9
T48 328-333 PR:P41245 denotes MMP-9
T49 328-333 P41246 denotes MMP-9
T50 328-333 P41245 denotes MMP-9
T51 328-333 PR:P52176 denotes MMP-9
T52 328-333 P50282 denotes MMP-9
T54 328-333 PR:000010491 denotes MMP-9
T55 328-333 P52176 denotes MMP-9
T56 328-333 O18733 denotes MMP-9
T53 328-333 GO:0004229 denotes MMP-9
T57 335-349 D018345 denotes knock-out mice
T58 345-349 PR:000005054 denotes mice
T60 345-349 O89094 denotes mice
T62 386-408 D000070642 denotes traumatic brain injury
T63 386-408 D000070642 denotes traumatic brain injury
T64 396-401 UBERON:6110636 denotes brain
T65 396-401 UBERON:0000955 denotes brain
T68 485-488 CHEBI:340824 denotes MMP
T71 485-488 CHEBI:59761 denotes MMP
T72 485-490 PR:P50282 denotes MMP-9
T73 485-490 PR:P14780 denotes MMP-9
T74 485-490 P14780 denotes MMP-9
T75 485-490 PR:P41245 denotes MMP-9
T76 485-490 P41246 denotes MMP-9
T77 485-490 P41245 denotes MMP-9
T78 485-490 PR:P52176 denotes MMP-9
T79 485-490 P50282 denotes MMP-9
T81 485-490 PR:000010491 denotes MMP-9
T82 485-490 P52176 denotes MMP-9
T83 485-490 O18733 denotes MMP-9
T80 485-490 GO:0004229 denotes MMP-9
T84 505-524 UBERON:0000120 denotes blood-brain barrier
T87 526-532 UBERON:0027368 denotes matrix
T90 538-550 UBERON:0002316 denotes white matter
T88 538-550 D056784 denotes white matter
T89 538-550 D056784 denotes white matter
T91 552-555 CHEBI:340824 denotes MMP
T94 552-555 CHEBI:59761 denotes MMP
T95 552-557 PR:P50282 denotes MMP-9
T96 552-557 PR:P14780 denotes MMP-9
T97 552-557 P14780 denotes MMP-9
T98 552-557 PR:P41245 denotes MMP-9
T99 552-557 P41246 denotes MMP-9
T100 552-557 P41245 denotes MMP-9
T101 552-557 PR:P52176 denotes MMP-9
T102 552-557 P50282 denotes MMP-9
T104 552-557 PR:000010491 denotes MMP-9
T105 552-557 P52176 denotes MMP-9
T106 552-557 O18733 denotes MMP-9
T103 552-557 GO:0004229 denotes MMP-9
T107 572-581 SO:0000817 denotes wild-type
T108 582-586 PR:000005054 denotes mice
T110 582-586 O89094 denotes mice
T109 582-586 D051379 denotes mice
T111 582-586 10095 denotes mice
T112 621-629 D007511 denotes ischemia
T113 621-629 D007511 denotes ischemia
T114 631-634 CHEBI:340824 denotes MMP
T117 631-634 CHEBI:59761 denotes MMP
T118 631-636 PR:P50282 denotes MMP-9
T119 631-636 PR:P14780 denotes MMP-9
T120 631-636 P14780 denotes MMP-9
T121 631-636 PR:P41245 denotes MMP-9
T122 631-636 P41246 denotes MMP-9
T123 631-636 P41245 denotes MMP-9
T124 631-636 PR:P52176 denotes MMP-9
T125 631-636 P50282 denotes MMP-9
T127 631-636 PR:000010491 denotes MMP-9
T128 631-636 P52176 denotes MMP-9
T129 631-636 O18733 denotes MMP-9
T126 631-636 GO:0004229 denotes MMP-9
T130 660-668 D007511 denotes ischemia
T131 660-668 D007511 denotes ischemia
T132 672-681 SO:0000817 denotes wild-type
T133 682-687 UBERON:6110636 denotes brain
T134 682-687 UBERON:0000955 denotes brain
T135 735-746 UBERON:0001986 denotes endothelium
T136 778-797 UBERON:0000120 denotes blood-brain barrier
T143 809-816 SO:0000104 denotes protein
T142 809-816 PR:000000001 denotes protein
T139 809-816 GO:0003675 denotes protein
T140 809-816 CHEBI:36080 denotes protein
T141 809-816 CHEBI:11122 denotes protein
T144 821-824 CHEBI:340824 denotes MMP
T147 821-824 CHEBI:59761 denotes MMP
T148 821-826 PR:P50282 denotes MMP-9
T149 821-826 PR:P14780 denotes MMP-9
T150 821-826 P14780 denotes MMP-9
T151 821-826 PR:P41245 denotes MMP-9
T152 821-826 P41246 denotes MMP-9
T153 821-826 P41245 denotes MMP-9
T154 821-826 PR:P52176 denotes MMP-9
T155 821-826 P50282 denotes MMP-9
T157 821-826 PR:000010491 denotes MMP-9
T158 821-826 P52176 denotes MMP-9
T159 821-826 O18733 denotes MMP-9
T156 821-826 GO:0004229 denotes MMP-9
T160 874-882 D007511 denotes ischemia
T161 874-882 D007511 denotes ischemia
T162 908-922 D018345 denotes knock-out mice
T163 918-922 PR:000005054 denotes mice
T165 918-922 O89094 denotes mice
T167 968-987 UBERON:0000120 denotes blood-brain barrier
T173 999-1006 PR:000000001 denotes protein
T171 999-1006 CHEBI:36080 denotes protein
T172 999-1006 CHEBI:11122 denotes protein
T174 999-1006 SO:0000104 denotes protein
T170 999-1006 GO:0003675 denotes protein
T176 1008-1016 Q91049 denotes occludin
T177 1008-1016 Q6P6T5 denotes occludin
T178 1008-1016 Q9PUN1 denotes occludin
T179 1008-1016 Q16625 denotes occludin
T180 1008-1016 PR:000002207 denotes occludin
T181 1008-1016 Q61146 denotes occludin
T182 1008-1016 Q28269 denotes occludin
T183 1008-1016 Q28793 denotes occludin
T184 1008-1016 Q5RFS5 denotes occludin
T175 1008-1016 D062793 denotes occludin
T185 1035-1054 UBERON:0000120 denotes blood-brain barrier
T188 1079-1089 D005070 denotes Evans Blue
T189 1079-1089 D005070 denotes Evans Blue
T190 1079-1089 CHEBI:82467 denotes Evans Blue
T191 1130-1133 CHEBI:340824 denotes MMP
T194 1130-1133 CHEBI:59761 denotes MMP
T195 1130-1135 PR:P50282 denotes MMP-9
T196 1130-1135 PR:P14780 denotes MMP-9
T197 1130-1135 P14780 denotes MMP-9
T198 1130-1135 PR:P41245 denotes MMP-9
T199 1130-1135 P41246 denotes MMP-9
T200 1130-1135 P41245 denotes MMP-9
T201 1130-1135 PR:P52176 denotes MMP-9
T202 1130-1135 P50282 denotes MMP-9
T204 1130-1135 PR:000010491 denotes MMP-9
T205 1130-1135 P52176 denotes MMP-9
T206 1130-1135 O18733 denotes MMP-9
T203 1130-1135 GO:0004229 denotes MMP-9
T207 1136-1150 D018345 denotes knock-out mice
T208 1146-1150 PR:000005054 denotes mice
T210 1146-1150 O89094 denotes mice
T214 1180-1192 UBERON:0002316 denotes white matter
T212 1180-1192 D056784 denotes white matter
T213 1180-1192 D056784 denotes white matter
T215 1203-1214 GO:0009056 denotes degradation
T216 1222-1225 CHEBI:340824 denotes MMP
T219 1222-1225 CHEBI:59761 denotes MMP
T220 1222-1227 PR:P50282 denotes MMP-9
T221 1222-1227 PR:P14780 denotes MMP-9
T222 1222-1227 P14780 denotes MMP-9
T223 1222-1227 PR:P41245 denotes MMP-9
T224 1222-1227 P41246 denotes MMP-9
T225 1222-1227 P41245 denotes MMP-9
T226 1222-1227 PR:P52176 denotes MMP-9
T227 1222-1227 P50282 denotes MMP-9
T229 1222-1227 PR:000010491 denotes MMP-9
T230 1222-1227 P52176 denotes MMP-9
T231 1222-1227 O18733 denotes MMP-9
T228 1222-1227 GO:0004229 denotes MMP-9
T232 1238-1244 UBERON:0000345 denotes myelin
T233 1238-1258 P83487 denotes myelin basic protein
T235 1238-1258 PR:000010228 denotes myelin basic protein
T236 1238-1258 P20939 denotes myelin basic protein
T237 1238-1258 P98190 denotes myelin basic protein
T238 1238-1258 Q91439 denotes myelin basic protein
T239 1238-1258 P87346 denotes myelin basic protein
T240 1238-1258 P81558 denotes myelin basic protein
T241 1238-1258 P06906 denotes myelin basic protein
T242 1238-1258 P02686 denotes myelin basic protein
T243 1238-1258 P25274 denotes myelin basic protein
T244 1238-1258 P15720 denotes myelin basic protein
T245 1238-1258 P02688 denotes myelin basic protein
T246 1238-1258 P02687 denotes myelin basic protein
T247 1238-1258 Q91325 denotes myelin basic protein
T248 1238-1258 P25188 denotes myelin basic protein
T249 1238-1258 P04370 denotes myelin basic protein
T234 1238-1258 D004676 denotes myelin basic protein
T258 1251-1258 SO:0000104 denotes protein
T254 1251-1258 GO:0003675 denotes protein
T259 1288-1302 D018345 denotes knock-out mice
T260 1298-1302 PR:000005054 denotes mice
T262 1298-1302 O89094 denotes mice
T264 1350-1361 GO:0009056 denotes degradation
T265 1371-1377 UBERON:0000345 denotes myelin
T266 1371-1386 D009185 denotes myelin proteins
T270 1400-1403 PR:O04529 denotes MMP
T268 1400-1403 CHEBI:340824 denotes MMP
T271 1400-1403 CHEBI:59761 denotes MMP
T269 1400-1403 GO:0004235 denotes MMP
T276 1428-1435 SO:0000104 denotes protein
T275 1428-1435 PR:000000001 denotes protein
T272 1428-1435 GO:0003675 denotes protein
T273 1428-1435 CHEBI:36080 denotes protein
T274 1428-1435 CHEBI:11122 denotes protein
T277 1440-1444 CVCL_YL22 denotes DM20
T278 1440-1444 P79826 denotes DM20
T279 1498-1516 Q04766 denotes structural protein
T280 1498-1516 Q04765 denotes structural protein
T282 1509-1516 CHEBI:36080 denotes protein
T283 1509-1516 CHEBI:11122 denotes protein
T285 1509-1516 SO:0000104 denotes protein
T281 1509-1516 GO:0003675 denotes protein
T286 1517-1522 P53491 denotes actin
T287 1517-1522 P45520 denotes actin
T288 1517-1522 O00937 denotes actin
T289 1517-1522 Q05214 denotes actin
T290 1517-1522 P13363 denotes actin
T291 1517-1522 Q39596 denotes actin
T292 1517-1522 P30161 denotes actin
T293 1517-1522 P53476 denotes actin
T294 1517-1522 P51775 denotes actin
T295 1517-1522 P60011 denotes actin
T296 1517-1522 Q9P4D1 denotes actin
T297 1517-1522 P50138 denotes actin
T298 1517-1522 O65314 denotes actin
T299 1517-1522 P26183 denotes actin
T300 1517-1522 Q75D00 denotes actin
T301 1517-1522 P53502 denotes actin
T302 1517-1522 P11426 denotes actin
T303 1517-1522 P80709 denotes actin
T304 1517-1522 Q8X119 denotes actin
T305 1517-1522 Q6TCF2 denotes actin
T306 1517-1522 Q99023 denotes actin
T307 1517-1522 A5DQP9 denotes actin
T308 1517-1522 P60009 denotes actin
T309 1517-1522 O65315 denotes actin
T310 1517-1522 P26182 denotes actin
T311 1517-1522 Q9UVF3 denotes actin
T312 1517-1522 Q2U7A3 denotes actin
T313 1517-1522 Q92192 denotes actin
T314 1517-1522 Q9UVZ8 denotes actin
T315 1517-1522 P53689 denotes actin
T316 1517-1522 P68555 denotes actin
T317 1517-1522 P53455 denotes actin
T318 1517-1522 O13419 denotes actin
T319 1517-1522 P60010 denotes actin
T320 1517-1522 Q39758 denotes actin
T321 1517-1522 P81085 denotes actin
T322 1517-1522 P48465 denotes actin
T323 1517-1522 P78711 denotes actin
T324 1517-1522 P17128 denotes actin
T325 1517-1522 P91754 denotes actin
T326 1517-1522 Q24733 denotes actin
T327 1517-1522 P14235 denotes actin
T328 1517-1522 Q92193 denotes actin
T329 1517-1522 Q11212 denotes actin
T330 1517-1522 P45521 denotes actin
T331 1517-1522 P53477 denotes actin
T332 1517-1522 P53499 denotes actin
T333 1517-1522 P24902 denotes actin
T334 1517-1522 Q8SWN8 denotes actin
T335 1517-1522 O17320 denotes actin
T336 1517-1522 P10365 denotes actin
T338 1517-1522 O16808 denotes actin
T339 1517-1522 P53498 denotes actin
T340 1517-1522 Q9UVX4 denotes actin
T341 1517-1522 O81221 denotes actin
T342 1517-1522 P20904 denotes actin
T343 1517-1522 O65316 denotes actin
T344 1517-1522 O74258 denotes actin
T345 1517-1522 P53500 denotes actin
T346 1517-1522 P10989 denotes actin
T347 1517-1522 P90689 denotes actin
T337 1517-1522 D000199 denotes actin
T349 1530-1550 GO:0031012 denotes extracellular matrix
T350 1544-1550 UBERON:0027368 denotes matrix
T351 1544-1558 P87577 denotes matrix protein
T352 1544-1558 Q9E7N9 denotes matrix protein
T353 1544-1558 Q5VKP4 denotes matrix protein
T354 1544-1558 Q8B0H2 denotes matrix protein
T355 1544-1558 P16628 denotes matrix protein
T356 1544-1558 Q91B74 denotes matrix protein
T357 1544-1558 P07873 denotes matrix protein
T358 1544-1558 P27663 denotes matrix protein
T359 1544-1558 P36355 denotes matrix protein
T360 1544-1558 P0C571 denotes matrix protein
T361 1544-1558 O42049 denotes matrix protein
T362 1544-1558 P04876 denotes matrix protein
T363 1544-1558 P06503 denotes matrix protein
T364 1544-1558 P16629 denotes matrix protein
T365 1544-1558 Q98664 denotes matrix protein
T366 1544-1558 P0C795 denotes matrix protein
T367 1544-1558 Q5MKM5 denotes matrix protein
T368 1544-1558 P31620 denotes matrix protein
T369 1544-1558 D8V072 denotes matrix protein
T370 1544-1558 P36356 denotes matrix protein
T371 1544-1558 P35947 denotes matrix protein
T372 1544-1558 Q6X1D6 denotes matrix protein
T373 1544-1558 P24266 denotes matrix protein
T374 1544-1558 Q8JTH1 denotes matrix protein
T375 1544-1558 P25224 denotes matrix protein
T376 1544-1558 O12705 denotes matrix protein
T377 1544-1558 Q82038 denotes matrix protein
T378 1544-1558 P27287 denotes matrix protein
T379 1544-1558 C1JJY2 denotes matrix protein
T380 1544-1558 P0C794 denotes matrix protein
T381 1544-1558 P03519 denotes matrix protein
T382 1544-1558 Q9W850 denotes matrix protein
T383 1544-1558 Q84131 denotes matrix protein
T384 1544-1558 P26034 denotes matrix protein
T385 1544-1558 P17748 denotes matrix protein
T386 1544-1558 A4UHQ0 denotes matrix protein
T387 1544-1558 Q85212 denotes matrix protein
T388 1544-1558 P06157 denotes matrix protein
T389 1544-1558 P11206 denotes matrix protein
T390 1544-1558 P06502 denotes matrix protein
T391 1544-1558 Q82682 denotes matrix protein
T392 1544-1558 P06446 denotes matrix protein
T393 1544-1558 O89341 denotes matrix protein
T394 1544-1558 Q9IK90 denotes matrix protein
T395 1544-1558 Q9E785 denotes matrix protein
T396 1544-1558 Q9DLD5 denotes matrix protein
T397 1544-1558 P0DOE7 denotes matrix protein
T398 1544-1558 Q6E0W8 denotes matrix protein
T399 1544-1558 Q9JGT5 denotes matrix protein
T400 1544-1558 P33482 denotes matrix protein
T401 1544-1558 Q88266 denotes matrix protein
T402 1544-1558 O57299 denotes matrix protein
T403 1544-1558 Q77D96 denotes matrix protein
T404 1544-1558 Q5GA87 denotes matrix protein
T405 1544-1558 P25182 denotes matrix protein
T406 1544-1558 Q0GBX7 denotes matrix protein
T407 1544-1558 Q6WB99 denotes matrix protein
T408 1544-1558 Q5VKP0 denotes matrix protein
T409 1544-1558 P35976 denotes matrix protein
T410 1544-1558 A7WNB1 denotes matrix protein
T411 1544-1558 P15200 denotes matrix protein
T412 1544-1558 P08325 denotes matrix protein
T413 1544-1558 Q6X1D2 denotes matrix protein
T414 1544-1558 Q6JAM6 denotes matrix protein
T415 1544-1558 Q9QJT7 denotes matrix protein
T416 1544-1558 P19718 denotes matrix protein
T417 1544-1558 Q88428 denotes matrix protein
T418 1544-1558 P06942 denotes matrix protein
T419 1544-1558 Q2Y2M4 denotes matrix protein
T420 1544-1558 Q9JG20 denotes matrix protein
T421 1544-1558 Q01427 denotes matrix protein
T422 1544-1558 O18559 denotes matrix protein
T423 1544-1558 P41358 denotes matrix protein
T424 1544-1558 P08671 denotes matrix protein
T425 1544-1558 Q08453 denotes matrix protein
T426 1544-1558 A4UHQ5 denotes matrix protein
T427 1544-1558 Q0GBY2 denotes matrix protein
T428 1544-1558 Q66T63 denotes matrix protein
T429 1544-1558 Q8B0H7 denotes matrix protein
T430 1544-1558 P13844 denotes matrix protein
T431 1544-1558 Q9WH76 denotes matrix protein
T432 1544-1558 P31035 denotes matrix protein
T433 1544-1558 Q8B6J7 denotes matrix protein
T434 1544-1558 P19692 denotes matrix protein
T435 1544-1558 Q4VKV5 denotes matrix protein
T436 1544-1558 P06943 denotes matrix protein
T437 1544-1558 P27020 denotes matrix protein
T438 1544-1558 Q8B0I2 denotes matrix protein
T439 1544-1558 A3RM21 denotes matrix protein
T440 1544-1558 P24615 denotes matrix protein
T441 1544-1558 P0DOE6 denotes matrix protein
T442 1544-1558 P27019 denotes matrix protein
T443 1544-1558 Q66112 denotes matrix protein
T444 1544-1558 Q9JAF2 denotes matrix protein
T445 1544-1558 P18611 denotes matrix protein
T446 1544-1558 P04888 denotes matrix protein
T447 1544-1558 Q5K2K5 denotes matrix protein
T448 1544-1558 P06166 denotes matrix protein
T449 1544-1558 P03426 denotes matrix protein
T450 1544-1558 P0DOF2 denotes matrix protein
T451 1544-1558 P16287 denotes matrix protein
T452 1544-1558 P22046 denotes matrix protein
T453 1544-1558 Q9QSP2 denotes matrix protein
T454 1544-1558 P25223 denotes matrix protein
T456 1551-1558 CHEBI:36080 denotes protein
T457 1551-1558 CHEBI:11122 denotes protein
T459 1551-1558 SO:0000104 denotes protein
T455 1551-1558 GO:0003675 denotes protein
T460 1559-1566 D007797 denotes laminin
T461 1628-1642 D018345 denotes knock-out mice
T462 1638-1642 PR:000005054 denotes mice
T464 1638-1642 O89094 denotes mice
T466 1723-1726 CHEBI:340824 denotes MMP
T469 1723-1726 CHEBI:59761 denotes MMP
T470 1723-1728 PR:P50282 denotes MMP-9
T471 1723-1728 PR:P14780 denotes MMP-9
T472 1723-1728 P14780 denotes MMP-9
T473 1723-1728 PR:P41245 denotes MMP-9
T474 1723-1728 P41246 denotes MMP-9
T475 1723-1728 P41245 denotes MMP-9
T476 1723-1728 PR:P52176 denotes MMP-9
T477 1723-1728 P50282 denotes MMP-9
T479 1723-1728 PR:000010491 denotes MMP-9
T480 1723-1728 P52176 denotes MMP-9
T481 1723-1728 O18733 denotes MMP-9
T478 1723-1728 GO:0004229 denotes MMP-9
T482 1729-1733 SO:0000704 denotes gene
T483 1766-1774 D007511 denotes ischemia
T484 1766-1774 D007511 denotes ischemia
T485 1814-1825 GO:0009056 denotes degradation
T486 1838-1857 UBERON:0000120 denotes blood-brain barrier
T491 1862-1874 UBERON:0002316 denotes white matter
T489 1862-1874 D056784 denotes white matter
T490 1862-1874 D056784 denotes white matter

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 129-146 DiseaseOrPhenotypicFeature denotes cerebral ischemia 0002679
T2 262-274 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T3 396-408 DiseaseOrPhenotypicFeature denotes brain injury 0043510
T4 621-629 DiseaseOrPhenotypicFeature denotes ischemia 0005053
T5 660-668 DiseaseOrPhenotypicFeature denotes ischemia 0005053
T6 874-882 DiseaseOrPhenotypicFeature denotes ischemia 0005053
T7 1766-1774 DiseaseOrPhenotypicFeature denotes ischemia 0005053

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-147 DRI_Background denotes Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.
T2 148-275 DRI_Challenge denotes Deleterious processes of extracellular proteolysis may contribute to the progression of tissue damage after acute brain injury.
T3 276-409 DRI_Approach denotes We recently showed that matrix metalloproteinase-9 (MMP-9) knock-out mice were protected against ischemic and traumatic brain injury.
T4 410-551 DRI_Approach denotes In this study, we examined the mechanisms involved by focusing on relevant MMP-9 substrates in blood-brain barrier, matrix, and white matter.
T5 552-630 DRI_Background denotes MMP-9 knock-out and wild-type mice were subjected to transient focal ischemia.
T6 631-747 DRI_Background denotes MMP-9 levels increased after ischemia in wild-type brain, with expression primarily present in vascular endothelium.
T7 748-836 DRI_Outcome denotes Western blots showed that the blood-brain barrier-associated protein and MMP-9 substrate
T8 837-854 Token_Label.OUTSIDE denotes zonae occludens-1
T9 855-923 DRI_Outcome denotes was degraded after ischemia, but this was reduced in knock-out mice.
T10 924-1017 DRI_Background denotes There were no detectable changes in another blood-brain barrier-associated protein, occludin.
T11 1018-1176 DRI_Outcome denotes Correspondingly, blood-brain barrier disruption assessed via Evans Blue leakage was significantly attenuated in MMP-9 knock-out mice compared with wild types.
T12 1177-1446 DRI_Outcome denotes In white matter, ischemic degradation of the MMP-9 substrate myelin basic protein was significantly reduced in knock-out mice compared with wild types, whereas there was no degradation of other myelin proteins that are not MMP substrates (proteolipid protein and DM20).
T13 1447-1567 DRI_Background denotes There were no detectable changes in the ubiquitous structural protein actin or the extracellular matrix protein laminin.
T14 1568-1668 DRI_Outcome denotes Finally, 24 hr lesion volumes were significantly reduced in knock-out mice compared with wild types.
T15 1669-1886 DRI_Challenge denotes These data demonstrate that the protective effects of MMP-9 gene knock-out after transient focal ischemia may be mediated by reduced proteolytic degradation of critical blood-brain barrier and white matter components.