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Id Subject Object Predicate Lexical cue
T1 0-5 uniprot:Q06218 denotes Dbp9p
T2 119-124 uniprot:P53734 denotes Dbp6p
T3 469-493 taxonomy:4932 denotes Saccharomyces cerevisiae
T4 513-520 uniprot:Q06218 denotes YLR276C
T5 538-542 uniprot:Q06218 denotes DBP9
T6 544-562 uniprot:Q06218 denotes DEAD-box protein 9
T7 586-595 go:GO:0005730 denotes nucleolar
T8 671-676 uniprot:Q06218 denotes Dbp9p
T9 1009-1014 uniprot:Q06218 denotes Dbp9p
T10 1064-1069 uniprot:Q06218 denotes Dbp9p
T11 1108-1112 uniprot:P53734 denotes dbp6
T12 1130-1134 uniprot:P53734 denotes dbp6
T13 1135-1139 uniprot:Q06218 denotes dbp9
T14 1194-1199 uniprot:P53734 denotes Dbp6p
T15 1204-1209 uniprot:Q06218 denotes Dbp9p
T16 1231-1236 taxonomy:4932 denotes yeast
T17 1332-1337 uniprot:P53734 denotes Dbp6p
T18 1342-1347 uniprot:Q06218 denotes Dbp9p
R1 T4 T7 localizeTo YLR276C,nucleolar
R2 T5 T7 localizeTo DBP9,nucleolar
R3 T6 T7 localizeTo DEAD-box protein 9,nucleolar
R4 T8 T7 localizeTo Dbp9p,nucleolar

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p.
T2 126-215 Sentence denotes Ribosome synthesis is a highly complex process and constitutes a major cellular activity.
T3 216-419 Sentence denotes The biogenesis of this ribonucleoprotein assembly requires a multitude of protein trans-acting factors including several putative ATP-dependent RNA helicases of the DEAD-box and related protein families.
T4 420-649 Sentence denotes Here we show that the previously uncharacterized Saccharomyces cerevisiae open reading frame YLR276C, hereafter named DBP9 (DEAD-box protein 9), encodes an essential nucleolar protein involved in 60S-ribosomal-subunit biogenesis.
T5 650-765 Sentence denotes Genetic depletion of Dbp9p results in a deficit in 60S ribosomal subunits and the appearance of half-mer polysomes.
T6 766-980 Sentence denotes This terminal phenotype is likely due to the instability of early pre-ribosomal particles, as evidenced by the low steady-state levels and the decreased synthesis of the 27S precursors to mature 25S and 5.8S rRNAs.
T7 981-1180 Sentence denotes In agreement with a role of Dbp9p in 60S subunit synthesis, we find that increased Dbp9p dosage efficiently suppresses certain dbp6 alleles and that dbp6/dbp9 double mutants show synthetic lethality.
T8 1181-1254 Sentence denotes Furthermore, Dbp6p and Dbp9p weakly interact in a yeast two-hybrid assay.
T9 1255-1401 Sentence denotes Altogether, our findings indicate an intimate functional interaction between Dbp6p and Dbp9p during the process of 60S-ribosomal-subunit assembly.