| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-135 |
Sentence |
denotes |
Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis. |
| TextSentencer_T2 |
136-295 |
Sentence |
denotes |
To elucidate the molecular mechanism of colorectal carcinogenesis, we have been attempting to isolate genes involved in the beta-catenin/T-cell factor pathway. |
| TextSentencer_T3 |
296-516 |
Sentence |
denotes |
In the experiments reported here, analysis by cDNA microarray indicated that AF17, a fusion partner of the MLL gene in acute leukemias with t(11;17)(q23;q21), was transactivated according to accumulation of beta-catenin. |
| TextSentencer_T4 |
517-613 |
Sentence |
denotes |
Expression of AF17 was significantly enhanced in 8 of the 12 colorectal cancer tissues examined. |
| TextSentencer_T5 |
614-855 |
Sentence |
denotes |
Introduction of a plasmid designed to express AF17 stimulated growth of NIH3T3 cells, and fluorescence-activated cell sorter analysis indicated that the AF17 regulation of cell-cycle progression was occurring mainly at the G(2)-M transition. |
| TextSentencer_T6 |
856-1062 |
Sentence |
denotes |
Our results suggest that the AF17 gene product is likely to be involved in the beta-catenin-T-cell factor/lymphoid enhancer factor signaling pathway and to function as a growth-promoting, oncogenic protein. |
| TextSentencer_T7 |
1063-1248 |
Sentence |
denotes |
These findings should aid development of new strategies for diagnosis, treatment, and prevention of colon cancers and acute leukemias by clarifying the pathogenesis of these conditions. |
| T1 |
0-135 |
Sentence |
denotes |
Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis. |
| T2 |
136-295 |
Sentence |
denotes |
To elucidate the molecular mechanism of colorectal carcinogenesis, we have been attempting to isolate genes involved in the beta-catenin/T-cell factor pathway. |
| T3 |
296-516 |
Sentence |
denotes |
In the experiments reported here, analysis by cDNA microarray indicated that AF17, a fusion partner of the MLL gene in acute leukemias with t(11;17)(q23;q21), was transactivated according to accumulation of beta-catenin. |
| T4 |
517-613 |
Sentence |
denotes |
Expression of AF17 was significantly enhanced in 8 of the 12 colorectal cancer tissues examined. |
| T5 |
614-855 |
Sentence |
denotes |
Introduction of a plasmid designed to express AF17 stimulated growth of NIH3T3 cells, and fluorescence-activated cell sorter analysis indicated that the AF17 regulation of cell-cycle progression was occurring mainly at the G(2)-M transition. |
| T6 |
856-1062 |
Sentence |
denotes |
Our results suggest that the AF17 gene product is likely to be involved in the beta-catenin-T-cell factor/lymphoid enhancer factor signaling pathway and to function as a growth-promoting, oncogenic protein. |
| T7 |
1063-1248 |
Sentence |
denotes |
These findings should aid development of new strategies for diagnosis, treatment, and prevention of colon cancers and acute leukemias by clarifying the pathogenesis of these conditions. |
