PubMed:11518717
Annnotations
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 436-439 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T2 | 515-518 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T3 | 568-571 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T4 | 630-633 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T5 | 819-822 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T6 | 924-927 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T7 | 1167-1170 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T8 | 1522-1525 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T9 | 1633-1636 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
T10 | 1698-1701 | Glycan_Motif | denotes | cad | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-120 | Sentence | denotes | IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1. |
T2 | 121-299 | Sentence | denotes | Hyperactivation of the insulin-like growth factor I receptor (IGF-IR) contributes to primary breast cancer development, but the role of the IGF-IR in tumor metastasis is unclear. |
T3 | 300-441 | Sentence | denotes | Here we studied the effects of the IGF-IR on intercellular connections mediated by the major epithelial adhesion protein, E-cadherin (E-cad). |
T4 | 442-598 | Sentence | denotes | We found that IGF-IR overexpression markedly stimulated aggregation in E-cad-positive MCF-7 breast cancer cells, but not in E-cad-negative MDA-MB-231 cells. |
T5 | 599-720 | Sentence | denotes | However, when the IGF-IR and E-cad were co-expressed in MDA-MB-231 cells, cell-cell adhesion was substantially increased. |
T6 | 721-963 | Sentence | denotes | The IGF-IR-dependent cell-cell adhesion of MCF-7 cells was not related to altered expression of E-cad or alpha-, beta-, or gamma-catenins but coincided with the up-regulation of another element of the E-cad complex, zonula occludens-1 (ZO-1). |
T7 | 964-1098 | Sentence | denotes | ZO-1 expression (mRNA and protein) was induced by IGF-I and was blocked in MCF-7 cells with a tyrosine kinase-defective IGF-IR mutant. |
T8 | 1099-1194 | Sentence | denotes | By co-immunoprecipitation, we found that ZO-1 associates with the E-cad complex and the IGF-IR. |
T9 | 1195-1430 | Sentence | denotes | High levels of ZO-1 coincided with an increased IGF-IR/alpha-catenin/ZO-1-binding and improved ZO-1/actin association, whereas down-regulation of ZO-1 by the expression of an anti-ZO-1 RNA inhibited IGF-IR-dependent cell-cell adhesion. |
T10 | 1431-1672 | Sentence | denotes | The results suggested that one of the mechanisms by which the activated IGF-IR regulates E-cad-mediated cell-cell adhesion is overexpression of ZO-1 and the resulting stronger connections between the E-cad complex and the actin cytoskeleton. |
T11 | 1673-1764 | Sentence | denotes | We hypothesize that in E-cad-positive cells, the IGF-IR may produce antimetastatic effects. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 436-439 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T2 | 515-518 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T3 | 568-571 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T4 | 630-633 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T5 | 819-822 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T6 | 924-927 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T7 | 1167-1170 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T8 | 1522-1525 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T9 | 1633-1636 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
T10 | 1698-1701 | https://glytoucan.org/Structures/Glycans/G00063MO | denotes | cad |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
11518717-0#0#14#gene3480 | 0-14 | gene3480 | denotes | IGF-I receptor |
11518717-0#51#64#diseaseC0006142 | 51-64 | diseaseC0006142 | denotes | breast cancer |
11518717-0#51#64#diseaseC0678222 | 51-64 | diseaseC0678222 | denotes | breast cancer |
11518717-1#62#68#gene3480 | 183-189 | gene3480 | denotes | IGF-IR |
11518717-1#140#146#gene3480 | 261-267 | gene3480 | denotes | IGF-IR |
11518717-1#150#166#diseaseC0027627 | 271-287 | diseaseC0027627 | denotes | tumor metastasis |
0#14#gene348051#64#diseaseC0006142 | 11518717-0#0#14#gene3480 | 11518717-0#51#64#diseaseC0006142 | associated_with | IGF-I receptor,breast cancer |
0#14#gene348051#64#diseaseC0678222 | 11518717-0#0#14#gene3480 | 11518717-0#51#64#diseaseC0678222 | associated_with | IGF-I receptor,breast cancer |
62#68#gene3480150#166#diseaseC0027627 | 11518717-1#62#68#gene3480 | 11518717-1#150#166#diseaseC0027627 | associated_with | IGF-IR,tumor metastasis |
140#146#gene3480150#166#diseaseC0027627 | 11518717-1#140#146#gene3480 | 11518717-1#150#166#diseaseC0027627 | associated_with | IGF-IR,tumor metastasis |
CoMAGC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 456-462 | Gene | denotes | IGF-IR |
E1 | 463-477 | Gene_expression | denotes | overexpression |
E2 | 463-477 | Positive_regulation | denotes | overexpression |
T2 | 534-547 | breast cancer | denotes | breast cancer |
T3 | 581-591 | breast cancer | denotes | MDA-MB-231 |
T4 | 528-533 | breast cancer | denotes | MCF-7 |
R1 | T1 | E1 | themeOf | IGF-IR,overexpression |
R2 | E1 | E2 | themeOf | overexpression,overexpression |
R3 | T1 | T2 | CGE-increased | IGF-IR,breast cancer |
R4 | T1 | T2 | CCS-unidentifiable | IGF-IR,breast cancer |
R5 | T1 | T2 | PT- | IGF-IR,breast cancer |
R3 | T1 | T2 | IGE- | IGF-IR,breast cancer |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 144-181 | gene:3480 | denotes | insulin-like growth factor I receptor |
T1 | 214-227 | disease:C0006142 | denotes | breast cancer |
T2 | 144-181 | gene:3480 | denotes | insulin-like growth factor I receptor |
T3 | 214-227 | disease:C0678222 | denotes | breast cancer |
T4 | 183-189 | gene:3480 | denotes | IGF-IR |
T5 | 214-227 | disease:C0006142 | denotes | breast cancer |
T6 | 183-189 | gene:3480 | denotes | IGF-IR |
T7 | 214-227 | disease:C0678222 | denotes | breast cancer |
T8 | 183-189 | gene:3480 | denotes | IGF-IR |
T9 | 271-287 | disease:C0027627 | denotes | tumor metastasis |
T10 | 183-189 | gene:3480 | denotes | IGF-IR |
T11 | 271-287 | disease:C2939419 | denotes | tumor metastasis |
T12 | 261-267 | gene:3480 | denotes | IGF-IR |
T13 | 271-287 | disease:C0027627 | denotes | tumor metastasis |
T14 | 261-267 | gene:3480 | denotes | IGF-IR |
T15 | 271-287 | disease:C2939419 | denotes | tumor metastasis |
R1 | T0 | T1 | associated_with | insulin-like growth factor I receptor,breast cancer |
R2 | T2 | T3 | associated_with | insulin-like growth factor I receptor,breast cancer |
R3 | T4 | T5 | associated_with | IGF-IR,breast cancer |
R4 | T6 | T7 | associated_with | IGF-IR,breast cancer |
R5 | T8 | T9 | associated_with | IGF-IR,tumor metastasis |
R6 | T10 | T11 | associated_with | IGF-IR,tumor metastasis |
R7 | T12 | T13 | associated_with | IGF-IR,tumor metastasis |
R8 | T14 | T15 | associated_with | IGF-IR,tumor metastasis |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 51-64 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T2 | 206-227 | Disease | denotes | primary breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
T3 | 271-276 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
T4 | 534-547 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 51-57 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T2 | 98-106 | Body_part | denotes | junction | http://purl.obolibrary.org/obo/UBERON_0007651 |
T3 | 214-220 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T4 | 534-540 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
T5 | 937-953 | Body_part | denotes | zonula occludens | http://purl.obolibrary.org/obo/GO_0005923 |
T6 | 1653-1671 | Body_part | denotes | actin cytoskeleton | http://purl.obolibrary.org/obo/GO_0015629 |