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PubMed:11518717 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 436-439 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T2 515-518 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T3 568-571 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T4 630-633 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T5 819-822 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T6 924-927 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T7 1167-1170 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T8 1522-1525 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T9 1633-1636 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T10 1698-1701 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1.
T2 121-299 Sentence denotes Hyperactivation of the insulin-like growth factor I receptor (IGF-IR) contributes to primary breast cancer development, but the role of the IGF-IR in tumor metastasis is unclear.
T3 300-441 Sentence denotes Here we studied the effects of the IGF-IR on intercellular connections mediated by the major epithelial adhesion protein, E-cadherin (E-cad).
T4 442-598 Sentence denotes We found that IGF-IR overexpression markedly stimulated aggregation in E-cad-positive MCF-7 breast cancer cells, but not in E-cad-negative MDA-MB-231 cells.
T5 599-720 Sentence denotes However, when the IGF-IR and E-cad were co-expressed in MDA-MB-231 cells, cell-cell adhesion was substantially increased.
T6 721-963 Sentence denotes The IGF-IR-dependent cell-cell adhesion of MCF-7 cells was not related to altered expression of E-cad or alpha-, beta-, or gamma-catenins but coincided with the up-regulation of another element of the E-cad complex, zonula occludens-1 (ZO-1).
T7 964-1098 Sentence denotes ZO-1 expression (mRNA and protein) was induced by IGF-I and was blocked in MCF-7 cells with a tyrosine kinase-defective IGF-IR mutant.
T8 1099-1194 Sentence denotes By co-immunoprecipitation, we found that ZO-1 associates with the E-cad complex and the IGF-IR.
T9 1195-1430 Sentence denotes High levels of ZO-1 coincided with an increased IGF-IR/alpha-catenin/ZO-1-binding and improved ZO-1/actin association, whereas down-regulation of ZO-1 by the expression of an anti-ZO-1 RNA inhibited IGF-IR-dependent cell-cell adhesion.
T10 1431-1672 Sentence denotes The results suggested that one of the mechanisms by which the activated IGF-IR regulates E-cad-mediated cell-cell adhesion is overexpression of ZO-1 and the resulting stronger connections between the E-cad complex and the actin cytoskeleton.
T11 1673-1764 Sentence denotes We hypothesize that in E-cad-positive cells, the IGF-IR may produce antimetastatic effects.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 436-439 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T2 515-518 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T3 568-571 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T4 630-633 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T5 819-822 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T6 924-927 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T7 1167-1170 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T8 1522-1525 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T9 1633-1636 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T10 1698-1701 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11518717-0#0#14#gene3480 0-14 gene3480 denotes IGF-I receptor
11518717-0#51#64#diseaseC0006142 51-64 diseaseC0006142 denotes breast cancer
11518717-0#51#64#diseaseC0678222 51-64 diseaseC0678222 denotes breast cancer
11518717-1#62#68#gene3480 183-189 gene3480 denotes IGF-IR
11518717-1#140#146#gene3480 261-267 gene3480 denotes IGF-IR
11518717-1#150#166#diseaseC0027627 271-287 diseaseC0027627 denotes tumor metastasis
0#14#gene348051#64#diseaseC0006142 11518717-0#0#14#gene3480 11518717-0#51#64#diseaseC0006142 associated_with IGF-I receptor,breast cancer
0#14#gene348051#64#diseaseC0678222 11518717-0#0#14#gene3480 11518717-0#51#64#diseaseC0678222 associated_with IGF-I receptor,breast cancer
62#68#gene3480150#166#diseaseC0027627 11518717-1#62#68#gene3480 11518717-1#150#166#diseaseC0027627 associated_with IGF-IR,tumor metastasis
140#146#gene3480150#166#diseaseC0027627 11518717-1#140#146#gene3480 11518717-1#150#166#diseaseC0027627 associated_with IGF-IR,tumor metastasis

CoMAGC

Id Subject Object Predicate Lexical cue
T1 456-462 Gene denotes IGF-IR
E1 463-477 Gene_expression denotes overexpression
E2 463-477 Positive_regulation denotes overexpression
T2 534-547 breast cancer denotes breast cancer
T3 581-591 breast cancer denotes MDA-MB-231
T4 528-533 breast cancer denotes MCF-7
R1 T1 E1 themeOf IGF-IR,overexpression
R2 E1 E2 themeOf overexpression,overexpression
R3 T1 T2 CGE-increased IGF-IR,breast cancer
R4 T1 T2 CCS-unidentifiable IGF-IR,breast cancer
R5 T1 T2 PT- IGF-IR,breast cancer
R3 T1 T2 IGE- IGF-IR,breast cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 144-181 gene:3480 denotes insulin-like growth factor I receptor
T1 214-227 disease:C0006142 denotes breast cancer
T2 144-181 gene:3480 denotes insulin-like growth factor I receptor
T3 214-227 disease:C0678222 denotes breast cancer
T4 183-189 gene:3480 denotes IGF-IR
T5 214-227 disease:C0006142 denotes breast cancer
T6 183-189 gene:3480 denotes IGF-IR
T7 214-227 disease:C0678222 denotes breast cancer
T8 183-189 gene:3480 denotes IGF-IR
T9 271-287 disease:C0027627 denotes tumor metastasis
T10 183-189 gene:3480 denotes IGF-IR
T11 271-287 disease:C2939419 denotes tumor metastasis
T12 261-267 gene:3480 denotes IGF-IR
T13 271-287 disease:C0027627 denotes tumor metastasis
T14 261-267 gene:3480 denotes IGF-IR
T15 271-287 disease:C2939419 denotes tumor metastasis
R1 T0 T1 associated_with insulin-like growth factor I receptor,breast cancer
R2 T2 T3 associated_with insulin-like growth factor I receptor,breast cancer
R3 T4 T5 associated_with IGF-IR,breast cancer
R4 T6 T7 associated_with IGF-IR,breast cancer
R5 T8 T9 associated_with IGF-IR,tumor metastasis
R6 T10 T11 associated_with IGF-IR,tumor metastasis
R7 T12 T13 associated_with IGF-IR,tumor metastasis
R8 T14 T15 associated_with IGF-IR,tumor metastasis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 51-64 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 206-227 Disease denotes primary breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T3 271-276 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 534-547 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 51-57 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 98-106 Body_part denotes junction http://purl.obolibrary.org/obo/UBERON_0007651
T3 214-220 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 534-540 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T5 937-953 Body_part denotes zonula occludens http://purl.obolibrary.org/obo/GO_0005923
T6 1653-1671 Body_part denotes actin cytoskeleton http://purl.obolibrary.org/obo/GO_0015629