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PubMed:11494364 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 18-24 UBERON:0000479 denotes tissue
T2 34-37 CVCL_D569 denotes CAG
T3 38-44 SO:0001068 denotes repeat
T4 67-72 10090 denotes mouse
T5 67-72 D051379 denotes mouse
T10 95-115 D006816 denotes Huntington's disease
T11 95-115 D006816 denotes Huntington's disease
T14 116-120 SO:0000704 denotes gene
T15 135-142 D004194 denotes disease
T16 135-142 D004194 denotes disease
T19 153-179 D019636 denotes neurodegenerative disorder
T20 153-179 D019636 denotes neurodegenerative disorder
T21 214-217 CVCL_D569 denotes CAG
T23 229-233 SO:0000147 denotes exon
T22 229-233 PR:P33696 denotes exon
T24 246-250 SO:0000704 denotes gene
T25 291-294 CVCL_D569 denotes CAG
T26 331-336 10090 denotes mouse
T27 331-336 D051379 denotes mouse
T28 359-363 SO:0000704 denotes gene
T29 381-386 D006801 denotes human
T30 387-391 PR:P33696 denotes exon
T31 387-391 SO:0000147 denotes exon
T32 404-408 SO:0000704 denotes gene
T33 430-433 CVCL_D569 denotes CAG
T34 452-460 CHEBI:36080 denotes proteins
T35 473-478 D006801 denotes human
T36 487-491 PR:P33696 denotes exon
T37 487-491 SO:0000147 denotes exon
T38 498-503 10090 denotes mouse
T39 498-503 D051379 denotes mouse
T40 504-514 P42858 denotes huntingtin
T41 504-514 P42859 denotes huntingtin
T42 504-514 P51111 denotes huntingtin
T43 504-514 PR:000008840 denotes huntingtin
T44 504-514 P51112 denotes huntingtin
T45 545-550 UBERON:6110636 denotes brain
T46 545-550 UBERON:0000955 denotes brain
T47 586-589 CVCL_D569 denotes CAG
T48 590-596 SO:0001068 denotes repeat
T49 679-682 CVCL_D569 denotes CAG
T50 683-689 SO:0001068 denotes repeat
T51 753-757 PR:000005054 denotes mice
T53 753-757 O89094 denotes mice
T52 753-757 D051379 denotes mice
T54 753-757 10095 denotes mice
T55 771-774 CVCL_D569 denotes CAG
T56 775-781 SO:0001068 denotes repeat
T57 807-811 PR:000005054 denotes mice
T59 807-811 O89094 denotes mice
T58 807-811 D051379 denotes mice
T60 807-811 10095 denotes mice
T61 862-865 CVCL_D569 denotes CAG
T62 866-872 SO:0001068 denotes repeat
T63 873-878 10090 denotes mouse
T64 873-878 D051379 denotes mouse
T65 888-891 CVCL_D569 denotes CAG
T66 892-898 SO:0001068 denotes repeat
T67 945-950 UBERON:0002107 denotes liver
T68 952-958 UBERON:0002113 denotes kidney
T69 960-967 UBERON:0000945 denotes stomach
T70 973-978 UBERON:6110636 denotes brain
T71 973-978 UBERON:0000955 denotes brain
T72 994-1004 UBERON:0002037 denotes cerebellum
T73 1021-1025 PR:000005054 denotes mice
T75 1021-1025 O89094 denotes mice
T74 1021-1025 D051379 denotes mice
T76 1021-1025 10095 denotes mice
T77 1056-1059 CVCL_D569 denotes CAG
T78 1060-1066 SO:0001068 denotes repeat
T79 1108-1113 10090 denotes mouse
T80 1108-1113 D051379 denotes mouse
T81 1136-1141 D006801 denotes human
T82 1142-1147 UBERON:6110636 denotes brain
T83 1142-1147 UBERON:0000955 denotes brain
T84 1164-1195 P47819 denotes Glial fibrillary acidic protein
T86 1164-1195 P14136 denotes Glial fibrillary acidic protein
T87 1164-1195 PR:000007939 denotes Glial fibrillary acidic protein
T88 1164-1195 Q28115 denotes Glial fibrillary acidic protein
T89 1164-1195 Q58EE9 denotes Glial fibrillary acidic protein
T90 1164-1195 Q5RA72 denotes Glial fibrillary acidic protein
T92 1164-1195 P03995 denotes Glial fibrillary acidic protein
T93 1164-1195 P48677 denotes Glial fibrillary acidic protein
T85 1164-1195 GO:0045101 denotes Glial fibrillary acidic protein
T94 1164-1195 GO:0045098 denotes Glial fibrillary acidic protein
T91 1164-1195 D005904 denotes Glial fibrillary acidic protein
T99 1188-1195 SO:0000104 denotes protein
T100 1197-1201 P47819 denotes GFAP
T102 1197-1201 P14136 denotes GFAP
T103 1197-1201 PR:P03995 denotes GFAP
T104 1197-1201 PR:000007939 denotes GFAP
T105 1197-1201 PR:P47819 denotes GFAP
T106 1197-1201 Q28115 denotes GFAP
T107 1197-1201 Q58EE9 denotes GFAP
T108 1197-1201 PR:P14136 denotes GFAP
T109 1197-1201 Q5RA72 denotes GFAP
T110 1197-1201 P03995 denotes GFAP
T111 1197-1201 P48677 denotes GFAP
T112 1197-1201 PR:Q58EE9 denotes GFAP
T101 1197-1201 GO:0045101 denotes GFAP
T113 1257-1273 UBERON:0002038 denotes substantia nigra
T114 1280-1295 UBERON:0001875 denotes globus pallidus
T115 1306-1314 UBERON:0002435 denotes striatum
T116 1306-1314 UBERON:0005383 denotes striatum
T118 1358-1362 D051379 denotes mice
T120 1358-1362 10095 denotes mice
T117 1358-1362 PR:000005054 denotes mice
T119 1358-1362 O89094 denotes mice
T121 1381-1400 GO:0070997 denotes neuronal cell death
T123 1406-1409 CVCL_D569 denotes CAG
T124 1410-1416 SO:0001068 denotes repeat
T125 1445-1449 P47819 denotes GFAP
T127 1445-1449 P14136 denotes GFAP
T128 1445-1449 PR:P03995 denotes GFAP
T129 1445-1449 PR:000007939 denotes GFAP
T130 1445-1449 PR:P47819 denotes GFAP
T131 1445-1449 Q28115 denotes GFAP
T132 1445-1449 Q58EE9 denotes GFAP
T133 1445-1449 PR:P14136 denotes GFAP
T134 1445-1449 Q5RA72 denotes GFAP
T135 1445-1449 P03995 denotes GFAP
T136 1445-1449 P48677 denotes GFAP
T137 1445-1449 PR:Q58EE9 denotes GFAP
T126 1445-1449 GO:0045101 denotes GFAP
T138 1473-1478 10090 denotes mouse
T139 1473-1478 D051379 denotes mouse
T140 1549-1554 10090 denotes mouse
T141 1549-1554 D051379 denotes mouse
T142 1654-1657 CVCL_D569 denotes CAG

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-121 DRI_Outcome denotes Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.
T2 122-251 DRI_Challenge denotes Huntington's disease (HD) is a neurodegenerative disorder characterized by the expansion of CAG repeats in exon 1 of the HD gene.
T3 252-442 DRI_Outcome denotes To clarify the instability of expanded CAG repeats in HD patients, an HD model mouse has been generated by gene replacement with human exon 1 of the HD gene with expansion to 77 CAG repeats.
T4 443-574 DRI_Background denotes Chimeric proteins composed of human mutated exon 1 and mouse huntingtin are expressed ubiquitously in brain and peripheral tissues.
T5 575-744 DRI_Outcome denotes One or two CAG repeat expansion was found in litters from paternal transmission, whereas contraction of CAG repeat in litters was observed through maternal transmission.
T6 745-879 DRI_Outcome denotes Elderly mice show greater CAG repeat instability than younger mice, and a unique case was observed of an expanded 97 CAG repeat mouse.
T7 880-1026 DRI_Challenge denotes Somatic CAG repeat instability is particularly pronounced in the liver, kidney, stomach, and brain but not in the cerebellum of 100-week-old mice.
T8 1027-1163 DRI_Outcome denotes The same results of expanded CAG repeat instability as observed in this HD model mouse were confirmed in the human brain of HD patients.
T9 1164-1401 DRI_Background denotes Glial fibrillary acidic protein (GFAP)-positive cells have been found to be increased in the substantia nigra (SN), globus pallidus (GP), and striatum (St) in the brains of 40-week-old affected mice, although without neuronal cell death.
T10 1402-1535 DRI_Outcome denotes The CAG repeat instability and increase in GFAP-positive cells in this mouse model appear to mirror the abnormalities in HD patients.
T11 1536-1666 DRI_Outcome denotes The HD model mouse may therefore have advantages for investigations of molecular mechanisms underlying instability of CAG repeats.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11494364-9#43#47#gene2670 1445-1449 gene2670 denotes GFAP
11494364-9#121#123#diseaseC0020179 1523-1525 diseaseC0020179 denotes HD
43#47#gene2670121#123#diseaseC0020179 11494364-9#43#47#gene2670 11494364-9#121#123#diseaseC0020179 associated_with GFAP,HD