> top > docs > PubMed:11481323 > annotations

PubMed:11481323 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.
T2 103-236 Sentence denotes Nuclear hormone receptors (NRs) are transcription factors whose activity is regulated by ligands and by coactivators or corepressors.
T3 237-440 Sentence denotes We report the characterization of a new NR coregulator: proline-, glutamic acid-, leucine-rich protein 1 (PELP1), a novel human protein that comprises 1,282 amino acids and is localized on chromosome 17.
T4 441-653 Sentence denotes The primary structure of PELP1 consists of several motifs present in most transcriptional regulators including nine NR-interacting boxes (LXXLL motifs), a zinc finger, and glutamic acid- and proline-rich regions.
T5 654-734 Sentence denotes We demonstrate that PELP1 is a coactivator of estrogen receptor alpha (ERalpha).
T6 735-866 Sentence denotes PELP1 enhances 17beta-estradiol-dependent transcriptional activation from the estrogen response element in a dose-dependent manner.
T7 867-1010 Sentence denotes PELP1 interacts with ERalpha and also with general transcriptional coactivators p300 and cAMP response element-binding protein-binding protein.
T8 1011-1158 Sentence denotes PELP1 was differentially expressed in various human and murine tissues with the highest expression levels in the testes, mammary glands, and brain.
T9 1159-1401 Sentence denotes We also provide evidence supporting the developmental regulation of PELP1 expression in murine mammary glands, the detectable expression of PELP1 in human mammary cancer cell lines, and the enhanced expression of PELP1 in human breast tumors.
T10 1402-1521 Sentence denotes These findings suggest that PELP1 is a novel coregulator of ERalpha and may have a role in breast cancer tumorigenesis.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1132-1151 http://purl.obolibrary.org/obo/MAT_0000073 denotes mammary glands, and
T2 1152-1157 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 1254-1268 http://purl.obolibrary.org/obo/MAT_0000073 denotes mammary glands

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11481323-8#68#73#gene27043 1227-1232 gene27043 denotes PELP1
11481323-8#140#145#gene27043 1299-1304 gene27043 denotes PELP1
11481323-8#213#218#gene27043 1372-1377 gene27043 denotes PELP1
11481323-8#228#241#diseaseC1458155 1387-1400 diseaseC1458155 denotes breast tumors
11481323-9#28#33#gene27043 1430-1435 gene27043 denotes PELP1
11481323-9#28#33#gene27043 1430-1435 gene27043 denotes PELP1
11481323-9#91#104#diseaseC0006142 1493-1506 diseaseC0006142 denotes breast cancer
11481323-9#91#104#diseaseC0678222 1493-1506 diseaseC0678222 denotes breast cancer
11481323-9#105#118#diseaseC0596263 1507-1520 diseaseC0596263 denotes tumorigenesis
68#73#gene27043228#241#diseaseC1458155 11481323-8#68#73#gene27043 11481323-8#228#241#diseaseC1458155 associated_with PELP1,breast tumors
140#145#gene27043228#241#diseaseC1458155 11481323-8#140#145#gene27043 11481323-8#228#241#diseaseC1458155 associated_with PELP1,breast tumors
213#218#gene27043228#241#diseaseC1458155 11481323-8#213#218#gene27043 11481323-8#228#241#diseaseC1458155 associated_with PELP1,breast tumors
28#33#gene2704391#104#diseaseC0006142 11481323-9#28#33#gene27043 11481323-9#91#104#diseaseC0006142 associated_with PELP1,breast cancer
28#33#gene2704391#104#diseaseC0678222 11481323-9#28#33#gene27043 11481323-9#91#104#diseaseC0678222 associated_with PELP1,breast cancer
28#33#gene27043105#118#diseaseC0596263 11481323-9#28#33#gene27043 11481323-9#105#118#diseaseC0596263 associated_with PELP1,tumorigenesis
28#33#gene2704391#104#diseaseC0006142 11481323-9#28#33#gene27043 11481323-9#91#104#diseaseC0006142 associated_with PELP1,breast cancer
28#33#gene2704391#104#diseaseC0678222 11481323-9#28#33#gene27043 11481323-9#91#104#diseaseC0678222 associated_with PELP1,breast cancer
28#33#gene27043105#118#diseaseC0596263 11481323-9#28#33#gene27043 11481323-9#105#118#diseaseC0596263 associated_with PELP1,tumorigenesis

LocText

Id Subject Object Predicate Lexical cue
T1 42-47 uniprot:Q8IZL8 denotes PELP1
T2 57-62 taxonomy:9606 denotes human
T3 78-101 uniprot:P03372 denotes estrogen receptor alpha
T4 293-341 uniprot:Q8IZL8 denotes proline-, glutamic acid-, leucine-rich protein 1
T5 343-348 uniprot:Q8IZL8 denotes PELP1
T6 359-364 taxonomy:9606 denotes human
T7 426-436 go:GO:0005694 denotes chromosome
T8 466-471 uniprot:Q8IZL8 denotes PELP1
T9 674-679 uniprot:Q8IZL8 denotes PELP1
T10 700-723 uniprot:P03372 denotes estrogen receptor alpha
T11 725-732 uniprot:P03372 denotes ERalpha
T12 735-740 uniprot:Q8IZL8 denotes PELP1
T13 867-872 uniprot:Q8IZL8 denotes PELP1
T14 888-895 uniprot:P03372 denotes ERalpha
T15 947-951 uniprot:Q09472 denotes p300
T16 1011-1016 uniprot:Q8IZL8 denotes PELP1
T17 1057-1062 taxonomy:9606 denotes human
T18 1067-1073 taxonomy:10090 denotes murine
T19 1227-1232 uniprot:Q8IZL8 denotes PELP1
T20 1247-1253 taxonomy:10090 denotes murine
T21 1299-1304 uniprot:Q8IZL8 denotes PELP1
T22 1308-1313 taxonomy:9606 denotes human
T23 1372-1377 uniprot:Q8IZL8 denotes PELP1
T24 1381-1386 taxonomy:9606 denotes human
T25 1430-1435 uniprot:Q8IZL8 denotes PELP1
T26 1462-1469 uniprot:P03372 denotes ERalpha

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1430-1435 gene:27043 denotes PELP1
T1 1493-1506 disease:C0006142 denotes breast cancer
T2 1430-1435 gene:27043 denotes PELP1
T3 1493-1506 disease:C0678222 denotes breast cancer
T4 1430-1435 gene:27043 denotes PELP1
T5 1507-1520 disease:C0596263 denotes tumorigenesis
R1 T0 T1 associated_with PELP1,breast cancer
R2 T2 T3 associated_with PELP1,breast cancer
R3 T4 T5 associated_with PELP1,tumorigenesis

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1132-1146 Body_part denotes mammary glands http://purl.obolibrary.org/obo/MAT_0000073
T2 1152-1157 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1254-1268 Body_part denotes mammary glands http://purl.obolibrary.org/obo/MAT_0000073

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1314-1328 Disease denotes mammary cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 1387-1400 Disease denotes breast tumors http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100
T4 1493-1506 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 57-62 OrganismTaxon denotes human 9606
T2 359-364 OrganismTaxon denotes human 9606
T3 1057-1062 OrganismTaxon denotes human 9606
T4 1308-1313 OrganismTaxon denotes human 9606
T5 1381-1386 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 426-436 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T2 601-607 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T3 1132-1146 Body_part denotes mammary glands http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200
T5 1152-1157 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T7 1254-1268 Body_part denotes mammary glands http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200
T9 1387-1393 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T10 1493-1499 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1322-1328 Phenotype denotes cancer HP:0002664
T2 1387-1400 Phenotype denotes breast tumors HP:0100013
T3 1493-1506 Phenotype denotes breast cancer HP:0003002

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1322-1333 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064