PubMed:11479299
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 901-915 | Cell | denotes | cultured cells | http://purl.obolibrary.org/obo/CL:0000010 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-67 | Sentence | denotes | Hormone-mediated dephosphorylation of specific histone H1 isoforms. |
| T2 | 68-243 | Sentence | denotes | We have previously shown a connection between histone H1 phosphorylation and the transcriptional competence of the hormone inducible mouse mammary tumor virus (MMTV) promoter. |
| T3 | 244-449 | Sentence | denotes | Prolonged exposure of mouse cells to dexamethasone concurrently dephosphorylated histone H1 and rendered the MMTV promoter refractory to hormonal stimulation and, therefore, transcriptionally unresponsive. |
| T4 | 450-625 | Sentence | denotes | Using electrospray mass spectrometry, we demonstrate here that prolonged dexamethasone treatment differentially effects a subset of the six somatic H1 isoforms in mouse cells. |
| T5 | 626-794 | Sentence | denotes | H1 isoforms H1.0, H1.1, and H1.2 are non-responsive to hormone whereas prolonged dexamethasone treatment effectively dephosphorylated the H1.3, H1.4, and H1.5 isoforms. |
| T6 | 795-977 | Sentence | denotes | The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform. |
| T7 | 978-1203 | Sentence | denotes | These results suggest that dephosphorylation of specific histone H1 isoforms may contribute to the previously observed decrease in transcriptional competence of the MMTV promoter through the modulation of chromatin structure. |
| T8 | 1204-1409 | Sentence | denotes | In a broader sense, this work advances the hypothesis that post-translational modifications of individual histone H1 isoforms directly influence the transcriptional activation/repression of specific genes. |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 795-976 | a(CHEBI:staurosporine) decreases p(MGI:Hist1h1d,pmod(P)) | denotes | The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000352 | 795-976 | a(CHEBI:staurosporine) decreases p(MGI:Hist1h1d,pmod(P)) | denotes | The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform |
| BEL:20025176 | 795-976 | a(CHEBI:staurosporine) decreases p(MGI:Hist1h1d,pmod(P)) | denotes | The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 207-220 | Disease | denotes | mammary tumor | http://purl.obolibrary.org/obo/MONDO_0007254 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 201-226 | OrganismTaxon | denotes | mouse mammary tumor virus | 11757 |
| T2 | 228-232 | OrganismTaxon | denotes | MMTV | 11757 |
| T3 | 266-271 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T5 | 353-357 | OrganismTaxon | denotes | MMTV | 11757 |
| T6 | 613-618 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T8 | 893-897 | OrganismTaxon | denotes | MMTV | 11757 |
| T9 | 1143-1147 | OrganismTaxon | denotes | MMTV | 11757 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 215-220 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 436-448 | Phenotype | denotes | unresponsive | HP:0025237 |