PubMed:11470797
Annnotations
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 62-104 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine 4-O-sulfotransferase |
| T2 | 146-188 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T3 | 200-229 | https://acgg.asia/db/ggdb/info/gg040 | denotes | dermatan-4-sulfotransferase-1 |
| T4 | 231-237 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T5 | 304-326 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| T6 | 554-560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T7 | 602-624 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| T8 | 634-676 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T9 | 680-692 | https://acgg.asia/db/ggdb/info/gg045 | denotes | GalNAc-4-ST1 |
| T10 | 703-747 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine-4-O-sulfotransferase 2 |
| T11 | 703-745 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T12 | 864-870 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T13 | 1018-1024 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T14 | 1258-1264 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T15 | 1419-1425 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T16 | 1554-1560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T17 | 1713-1719 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 62-83 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T2 | 146-167 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T3 | 304-309 | Glycan_Motif | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54406UD |
| T4 | 602-607 | Glycan_Motif | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54406UD |
| T5 | 634-655 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T6 | 703-724 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T7 | 772-783 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T8 | 820-831 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 62-104 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine 4-O-sulfotransferase |
| T2 | 146-188 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T3 | 200-229 | https://acgg.asia/db/ggdb/info/gg040 | denotes | dermatan-4-sulfotransferase-1 |
| T4 | 231-237 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T5 | 304-326 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| T6 | 554-560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T7 | 602-624 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| T8 | 634-676 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T9 | 680-692 | https://acgg.asia/db/ggdb/info/gg045 | denotes | GalNAc-4-ST1 |
| T10 | 703-747 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine-4-O-sulfotransferase 2 |
| T11 | 703-745 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T12 | 864-870 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T13 | 1018-1024 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T14 | 1258-1264 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T15 | 1419-1425 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T16 | 1554-1560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| T17 | 1713-1719 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-105 | Sentence | denotes | Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. |
| T2 | 106-327 | Sentence | denotes | We have identified and characterized an N-acetylgalactosamine-4-O-sulfotransferase designated dermatan-4-sulfotransferase-1 (D4ST-1) (GenBank(TM) accession number AF401222) based on its homology to HNK-1 sulfotransferase. |
| T3 | 328-553 | Sentence | denotes | The cDNA predicts an open reading frame encoding a type II membrane protein of 376 amino acids with a 43-amino acid cytoplasmic domain and a 316-amino acid luminal domain containing two potential N-linked glycosylation sites. |
| T4 | 554-863 | Sentence | denotes | D4ST-1 has significant amino acid identity with HNK-1 sulfotransferase (21.4%), N-acetylgalactosamine-4-O-sulfotransferase 1 (GalNAc-4-ST1) (24.7%), N-acetylgalactosamine-4-O-sulfotransferase 2 (GalNAc-4-ST2) (21.0%), chondroitin-4-O-sulfotransferase 1 (27.3%), and chondroitin-4-O-sulfotransferase 2 (22.8%). |
| T5 | 864-1017 | Sentence | denotes | D4ST-1 transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. |
| T6 | 1018-1238 | Sentence | denotes | D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha1,3GalNAcbeta1,4 that is flanked by GlcUAbeta1,3GalNAcbeta1,4 as compared with IdoUAalpha1,3GalNAcbeta1,4 flanked by IdoUAalpha1,3GalNAcbeta1,4. |
| T7 | 1239-1392 | Sentence | denotes | The specificity of D4ST-1 when assayed in vitro suggests that the addition of sulfate to GalNAc occurs immediately after epimerization of GlcUA to IdoUA. |
| T8 | 1393-1488 | Sentence | denotes | The open reading frame of D4ST-1 is encoded by a single exon located on human chromosome 15q14. |
| T9 | 1489-1553 | Sentence | denotes | Northern blot analysis reveals a single 2.4-kilobase transcript. |
| T10 | 1554-1694 | Sentence | denotes | D4ST-1 message is expressed in virtually all tissues at some level but is most highly expressed in pituitary, placenta, uterus, and thyroid. |
| T11 | 1695-1886 | Sentence | denotes | The properties of D4ST-1 indicate that sulfation of the GalNAc moieties in dermatan is mediated by a distinct GalNAc-4-O-sulfotransferase and occurs following epimerization of GlcUA to IdoUA. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 62-83 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T2 | 146-167 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T3 | 304-309 | https://glytoucan.org/Structures/Glycans/G54406UD | denotes | HNK-1 |
| T4 | 602-607 | https://glytoucan.org/Structures/Glycans/G54406UD | denotes | HNK-1 |
| T5 | 634-655 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T6 | 703-724 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T7 | 772-783 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T8 | 820-831 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1653-1662 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
| T2 | 1664-1672 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
| T3 | 1674-1680 | http://purl.obolibrary.org/obo/MAT_0000127 | denotes | uterus |
| T4 | 1686-1693 | http://purl.obolibrary.org/obo/MAT_0000081 | denotes | thyroid |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 304-309 | http://www.glycoepitope.jp/epitopes/EP0001 | denotes | HNK-1 |
| T2 | 602-607 | http://www.glycoepitope.jp/epitopes/EP0001 | denotes | HNK-1 |
| T3 | 772-783 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T4 | 820-831 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 44-104 | protein | denotes | dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase |
| T2 | 146-188 | protein | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| T3 | 200-229 | protein | denotes | dermatan-4-sulfotransferase-1 |
| T4 | 231-237 | protein | denotes | D4ST-1 |
| T5 | 304-326 | protein | denotes | HNK-1 sulfotransferase |
| T6 | 554-560 | protein | denotes | D4ST-1 |
| T7 | 602-624 | protein | denotes | HNK-1 sulfotransferase |
| T8 | 634-678 | protein | denotes | N-acetylgalactosamine-4-O-sulfotransferase 1 |
| T9 | 680-692 | protein | denotes | GalNAc-4-ST1 |
| T10 | 703-747 | protein | denotes | N-acetylgalactosamine-4-O-sulfotransferase 2 |
| T11 | 749-761 | protein | denotes | GalNAc-4-ST2 |
| T12 | 772-806 | protein | denotes | chondroitin-4-O-sulfotransferase 1 |
| T13 | 820-854 | protein | denotes | chondroitin-4-O-sulfotransferase 2 |
| T14 | 864-870 | protein | denotes | D4ST-1 |
| T15 | 1018-1024 | protein | denotes | D4ST-1 |
| T16 | 1258-1264 | protein | denotes | D4ST-1 |
| T17 | 1419-1425 | protein | denotes | D4ST-1 |
| T18 | 1554-1560 | protein | denotes | D4ST-1 |
| T19 | 1713-1719 | protein | denotes | D4ST-1 |
| T20 | 1805-1832 | protein | denotes | GalNAc-4-O-sulfotransferase |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 62-104 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine 4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T2 | 62-104 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine 4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T3 | 146-188 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T4 | 146-188 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T5 | 189-199 | url | denotes | designated |
| PD-GlycoGenes20190927-B_T6 | 200-229 | https://acgg.asia/db/ggdb/info/gg040 | denotes | dermatan-4-sulfotransferase-1 |
| PD-GlycoGenes20190927-B_T7 | 231-237 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T8 | 304-326 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| PD-GlycoGenes20190927-B_T9 | 384-386 | https://acgg.asia/db/ggdb/info/gg111 | denotes | II |
| PD-GlycoGenes20190927-B_T10 | 554-560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T11 | 561-564 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |
| PD-GlycoGenes20190927-B_T12 | 602-624 | https://acgg.asia/db/ggdb/info/gg035 | denotes | HNK-1 sulfotransferase |
| PD-GlycoGenes20190927-B_T13 | 634-676 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T14 | 634-676 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T15 | 680-692 | https://acgg.asia/db/ggdb/info/gg045 | denotes | GalNAc-4-ST1 |
| PD-GlycoGenes20190927-B_T16 | 703-745 | https://acgg.asia/db/ggdb/info/gg046 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T17 | 703-745 | https://acgg.asia/db/ggdb/info/gg045 | denotes | N-acetylgalactosamine-4-O-sulfotransferase |
| PD-GlycoGenes20190927-B_T18 | 749-761 | https://acgg.asia/db/ggdb/info/gg046 | denotes | GalNAc-4-ST2 |
| PD-GlycoGenes20190927-B_T19 | 864-870 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T20 | 1018-1024 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T21 | 1258-1264 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T22 | 1419-1425 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T23 | 1554-1560 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
| PD-GlycoGenes20190927-B_T24 | 1713-1719 | https://acgg.asia/db/ggdb/info/gg040 | denotes | D4ST-1 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 304-309 | Glycan | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54406UD |
| T2 | 602-607 | Glycan | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54406UD |
| T3 | 680-686 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 749-755 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 772-783 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 820-831 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 927-933 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1328-1334 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T9 | 1751-1757 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1805-1811 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1653-1662 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1653-1662 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 1664-1672 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T3 | 1674-1680 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/MAT_0000127 |
| T4 | 1686-1693 | Body_part | denotes | thyroid | http://purl.obolibrary.org/obo/MAT_0000081 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 304-309 | Glycan | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54406UD |
| T2 | 602-607 | Glycan | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54406UD |
| T3 | 680-686 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 749-755 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 772-783 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 820-831 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 927-933 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T8 | 1328-1334 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T9 | 1751-1757 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1805-1811 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 304-309 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HNK-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
| T2 | 602-607 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HNK-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
| T3 | 772-783 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 820-831 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 387-395 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/UBERON_0000094 |
| T2 | 444-455 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T3 | 1471-1481 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T4 | 1653-1662 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T5 | 1664-1672 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T6 | 1674-1680 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/UBERON_0000995|http://purl.obolibrary.org/obo/UBERON_0006834 |
| T8 | 1686-1693 | Body_part | denotes | thyroid | http://purl.obolibrary.org/obo/UBERON_0002046 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1465-1470 | Organism | denotes | human | 9606 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 304-309 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HNK-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
| T2 | 602-607 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HNK-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
| T3 | 772-783 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 820-831 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-105 | Sentence | denotes | Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. |
| T2 | 106-327 | Sentence | denotes | We have identified and characterized an N-acetylgalactosamine-4-O-sulfotransferase designated dermatan-4-sulfotransferase-1 (D4ST-1) (GenBank(TM) accession number AF401222) based on its homology to HNK-1 sulfotransferase. |
| T3 | 328-553 | Sentence | denotes | The cDNA predicts an open reading frame encoding a type II membrane protein of 376 amino acids with a 43-amino acid cytoplasmic domain and a 316-amino acid luminal domain containing two potential N-linked glycosylation sites. |
| T4 | 554-863 | Sentence | denotes | D4ST-1 has significant amino acid identity with HNK-1 sulfotransferase (21.4%), N-acetylgalactosamine-4-O-sulfotransferase 1 (GalNAc-4-ST1) (24.7%), N-acetylgalactosamine-4-O-sulfotransferase 2 (GalNAc-4-ST2) (21.0%), chondroitin-4-O-sulfotransferase 1 (27.3%), and chondroitin-4-O-sulfotransferase 2 (22.8%). |
| T5 | 864-1017 | Sentence | denotes | D4ST-1 transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. |
| T6 | 1018-1238 | Sentence | denotes | D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha1,3GalNAcbeta1,4 that is flanked by GlcUAbeta1,3GalNAcbeta1,4 as compared with IdoUAalpha1,3GalNAcbeta1,4 flanked by IdoUAalpha1,3GalNAcbeta1,4. |
| T7 | 1239-1392 | Sentence | denotes | The specificity of D4ST-1 when assayed in vitro suggests that the addition of sulfate to GalNAc occurs immediately after epimerization of GlcUA to IdoUA. |
| T8 | 1393-1488 | Sentence | denotes | The open reading frame of D4ST-1 is encoded by a single exon located on human chromosome 15q14. |
| T9 | 1489-1553 | Sentence | denotes | Northern blot analysis reveals a single 2.4-kilobase transcript. |
| T10 | 1554-1694 | Sentence | denotes | D4ST-1 message is expressed in virtually all tissues at some level but is most highly expressed in pituitary, placenta, uterus, and thyroid. |
| T11 | 1695-1886 | Sentence | denotes | The properties of D4ST-1 indicate that sulfation of the GalNAc moieties in dermatan is mediated by a distinct GalNAc-4-O-sulfotransferase and occurs following epimerization of GlcUA to IdoUA. |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 444-455 | Body_part | denotes | cytoplasmic | FMA:66835 |
| T2 | 1471-1481 | Body_part | denotes | chromosome | FMA:67093 |
| T3 | 1599-1606 | Body_part | denotes | tissues | FMA:9637 |
| T4 | 1653-1662 | Body_part | denotes | pituitary | FMA:13889 |
| T5 | 1664-1672 | Body_part | denotes | placenta | FMA:0329329|FMA:63934 |
| T7 | 1674-1680 | Body_part | denotes | uterus | FMA:17558 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1653-1662 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 1664-1672 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
| T3 | 1674-1680 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/MAT_0000127 |
| T4 | 1686-1693 | Body_part | denotes | thyroid | http://purl.obolibrary.org/obo/MAT_0000081 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1465-1470 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 387-395 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 444-455 | Body_part | denotes | cytoplasmic | http://purl.obolibrary.org/obo/GO_0005737 |
| T5 | 1471-1481 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
| T6 | 1653-1662 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T7 | 1664-1672 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T8 | 1674-1680 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/UBERON_0000995|http://purl.obolibrary.org/obo/UBERON_0006834 |
| T10 | 1686-1693 | Body_part | denotes | thyroid | http://purl.obolibrary.org/obo/UBERON_0002046 |