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sentences

Id Subject Object Predicate Lexical cue
T1 0-154 Sentence denotes An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form.
T2 155-270 Sentence denotes The LHX3 LIM homeodomain transcription factor is required for pituitary development and motor neuron specification.
T3 271-370 Sentence denotes The Lhx3 gene encodes two isoforms, LHX3a and LHX3b, that differ in their amino-terminal sequences.
T4 371-499 Sentence denotes Humans and mice with defective Lhx3 genes are deficient in gonadotrope, lactotrope, somatotrope, and thyrotrope pituitary cells.
T5 500-701 Sentence denotes We show that, whereas Lhx3b is highly expressed in these Lhx3-dependent cell types, high levels of Lhx3a expression are restricted to alpha glycoprotein subunit-expressing thyrotropes and gonadotropes.
T6 702-810 Sentence denotes Cross-species comparison reveals the LHX3b-specific domain is more conserved than the LHX3a-specific domain.
T7 811-954 Sentence denotes We demonstrate that the LHX3b-specific domain is a transferable inhibitor that reduces gene activation and DNA binding by homeodomain proteins.
T8 955-1101 Sentence denotes In addition, we identify a novel LHX3 protein (M2-LHX3) and determine that this molecule is generated by an internal translation initiation codon.
T9 1102-1206 Sentence denotes The LHX3a- and LHX3b-specific coding sequences regulate differential usage of this internal start codon.
T10 1207-1305 Sentence denotes Further, we identify the major activation domain of LHX3 in the carboxyl terminus of the molecule.
T11 1306-1396 Sentence denotes M2-LHX3 is active because it retains this domain and binds DNA better than LHX3a or LHX3b.
T12 1397-1478 Sentence denotes Other LIM homeodomain genes, including Lhx4, generate similar truncated proteins.
T13 1479-1581 Sentence denotes These studies describe how transcriptional regulatory genes can generate multiple functional proteins.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 217-226 http://purl.obolibrary.org/obo/MAT_0000077 denotes pituitary
T2 483-492 http://purl.obolibrary.org/obo/MAT_0000077 denotes pituitary

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 52-56 protein denotes LHX3
T2 159-163 protein denotes LHX3
T3 180-200 protein denotes transcription factor
T4 275-279 protein denotes Lhx3
T5 307-312 protein denotes LHX3a
T6 317-322 protein denotes LHX3b
T7 402-406 protein denotes Lhx3
T8 522-527 protein denotes Lhx3b
T9 557-561 protein denotes Lhx3
T10 599-604 protein denotes Lhx3a
T11 739-744 protein denotes LHX3b
T12 788-793 protein denotes LHX3a
T13 835-840 protein denotes LHX3b
T14 988-992 protein denotes LHX3
T15 1002-1009 protein denotes M2-LHX3
T16 1106-1111 protein denotes LHX3a
T17 1117-1122 protein denotes LHX3b
T18 1259-1263 protein denotes LHX3
T19 1306-1313 protein denotes M2-LHX3
T20 1381-1386 protein denotes LHX3a
T21 1390-1395 protein denotes LHX3b
T22 1436-1440 protein denotes Lhx4

PIR-corpus2

Id Subject Object Predicate Lexical cue
T19 1259-1263 protein denotes LHX3
T1 52-72 protein denotes LHX3 LIM homeodomain
T2 159-200 protein denotes LHX3 LIM homeodomain transcription factor
T3 275-279 protein denotes Lhx3
T4 307-312 protein denotes LHX3a
T5 317-322 protein denotes LHX3b
T6 402-406 protein denotes Lhx3
T7 522-527 protein denotes Lhx3b
T8 557-561 protein denotes Lhx3
T9 599-604 protein denotes Lhx3a
T10 634-652 protein denotes alpha glycoprotein
T11 739-744 protein denotes LHX3b
T12 788-793 protein denotes LHX3a
T13 835-840 protein denotes LHX3b
T14 933-953 protein denotes homeodomain proteins
T15 988-1000 protein denotes LHX3 protein
T16 1002-1009 protein denotes M2-LHX3
T17 1106-1111 protein denotes LHX3a
T18 1117-1122 protein denotes LHX3b
T20 1306-1313 protein denotes M2-LHX3
T21 1381-1386 protein denotes LHX3a
T22 1390-1395 protein denotes LHX3b
T23 1403-1418 protein denotes LIM homeodomain
T24 1436-1440 protein denotes Lhx4

PIR-corpus1

Id Subject Object Predicate Lexical cue
T1 52-72 protein denotes LHX3 LIM homeodomain
T2 159-200 protein denotes LHX3 LIM homeodomain transcription factor
T3 307-312 protein denotes LHX3a
T4 317-322 protein denotes LHX3b
T5 522-527 protein denotes Lhx3b
T6 599-604 protein denotes Lhx3a
T7 933-953 protein denotes homeodomain proteins
T8 988-1000 protein denotes LHX3 protein
T9 1002-1009 protein denotes M2-LHX3
T10 1035-1043 protein denotes molecule
T11 1259-1263 protein denotes LHX3
T12 1306-1313 protein denotes M2-LHX3
T13 1381-1386 protein denotes LHX3a
T14 1390-1395 protein denotes LHX3b
T15 1469-1477 protein denotes proteins

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 217-226 Body_part denotes pituitary http://purl.obolibrary.org/obo/MAT_0000077
T2 483-492 Body_part denotes pituitary http://purl.obolibrary.org/obo/MAT_0000077

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 217-226 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T2 483-492 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 382-386 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 217-226 Body_part denotes pituitary http://purl.obolibrary.org/obo/UBERON_0000007
T2 243-255 Body_part denotes motor neuron http://purl.obolibrary.org/obo/CL_0000100
T3 455-466 Body_part denotes somatotrope http://purl.obolibrary.org/obo/CL_0002312
T4 483-492 Body_part denotes pituitary http://purl.obolibrary.org/obo/UBERON_0000007

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 243-255 Cell denotes motor neuron http://purl.obolibrary.org/obo/CL:0000100
T2 249-255 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T3 430-441 Cell denotes gonadotrope http://purl.obolibrary.org/obo/CL:0000437
T4 443-453 Cell denotes lactotrope http://purl.obolibrary.org/obo/CL:0002311
T5 455-466 Cell denotes somatotrope http://purl.obolibrary.org/obo/CL:0002312
T6 472-482 Cell denotes thyrotrope http://purl.obolibrary.org/obo/CL:0000476
T7 672-683 Cell denotes thyrotropes http://purl.obolibrary.org/obo/CL:0000476
T8 688-700 Cell denotes gonadotropes http://purl.obolibrary.org/obo/CL:0000437