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PubMed:11447138 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 235-250 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose beta1
T2 253-274 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T3 830-840 https://glytoucan.org/Structures/Glycans/G00031MO denotes TF antigen

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 235-250 Glycan_Motif denotes galactose beta1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT
T2 253-274 Glycan_Motif denotes N-acetylgalactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB
T3 830-840 Glycan_Motif denotes TF antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
TextSentencer_T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
TextSentencer_T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
TextSentencer_T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
TextSentencer_T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
TextSentencer_T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
TextSentencer_T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
TextSentencer_T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
TextSentencer_T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
TextSentencer_T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
TextSentencer_T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
TextSentencer_T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.
T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.
T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 235-250 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose beta1
T2 253-274 https://glytoucan.org/Structures/Glycans/G27025MB denotes N-acetylgalactosamine
T3 830-840 https://glytoucan.org/Structures/Glycans/G00031MO denotes TF antigen

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 214-219 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 214-219 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 293-298 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T5 520-525 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T6 1194-1199 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T7 1342-1347 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T8 1428-1433 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T9 1577-1582 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.
T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 844-857 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC725 denotes Streptococcus
_T2 844-868 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC672 denotes Streptococcus pneumoniae
_T3 844-868 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC061 denotes Streptococcus pneumoniae
_T4 844-868 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC707 denotes Streptococcus pneumoniae
_T5 844-868 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC530 denotes Streptococcus pneumoniae
_T6 844-868 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC115,LEC118,LEC374,LEC408,LEC423,LEC435,LEC440,LEC557,LEC639 denotes Streptococcus pneumoniae

ICD10

Id Subject Object Predicate Lexical cue
T1 858-868 http://purl.bioontology.org/ontology/ICD10/J18.9 denotes pneumoniae

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-12 FMAID:200942 denotes Cell surface
_T2 0-12 FMAID:212684 denotes Cell surface
_T3 5-12 FMAID:50594 denotes surface
_T4 5-12 FMAID:146300 denotes surface
_T5 55-60 FMAID:14543 denotes colon
_T6 55-60 FMAID:104231 denotes colon
_T7 214-219 FMAID:256053 denotes blood
_T8 235-244 FMAID:196789 denotes galactose
_T9 235-244 FMAID:82794 denotes galactose
_T10 253-274 FMAID:82786 denotes N-acetylgalactosamine
_T11 253-274 FMAID:196780 denotes N-acetylgalactosamine
_T12 293-298 FMAID:104231 denotes colon
_T13 293-298 FMAID:14543 denotes colon
_T14 422-443 FMAID:210229 denotes colorectal epithelium
_T15 422-443 FMAID:108416 denotes colorectal epithelium
_T16 433-443 FMAID:69064 denotes epithelium
_T17 433-443 FMAID:169643 denotes epithelium
_T18 433-443 FMAID:256071 denotes epithelium
_T19 433-443 FMAID:69065 denotes epithelium
_T20 433-443 FMAID:169642 denotes epithelium
_T21 461-473 FMAID:200942 denotes cell surface
_T22 461-473 FMAID:212684 denotes cell surface
_T23 466-473 FMAID:50594 denotes surface
_T24 466-473 FMAID:146300 denotes surface
_T25 488-500 FMAID:62925 denotes glycoprotein
_T26 488-500 FMAID:167256 denotes glycoprotein
_T27 520-525 FMAID:14543 denotes colon
_T28 520-525 FMAID:104231 denotes colon
_T29 533-538 FMAID:169002 denotes cells
_T30 533-538 FMAID:68646 denotes cells
_T31 533-551 FMAID:200942 denotes cells were surface
_T32 544-551 FMAID:146300 denotes surface
_T33 544-551 FMAID:50594 denotes surface
_T34 648-656 FMAID:67257 denotes Proteins
_T35 648-656 FMAID:165447 denotes Proteins
_T36 880-905 FMAID:196780 denotes N-acetylgalactosaminidase
_T37 880-905 FMAID:82786 denotes N-acetylgalactosaminidase
_T38 906-919 FMAID:188924 denotes substantially
_T39 1036-1062 FMAID:196780 denotes N-acetylgalactosaminealpha
_T40 1036-1062 FMAID:82786 denotes N-acetylgalactosaminealpha
_T41 1107-1112 FMAID:68646 denotes cells
_T42 1107-1112 FMAID:169002 denotes cells
_T43 1194-1199 FMAID:14543 denotes colon
_T44 1194-1199 FMAID:104231 denotes colon
_T45 1207-1213 FMAID:256050 denotes tissue
_T46 1326-1338 FMAID:167256 denotes glycoprotein
_T47 1326-1338 FMAID:62925 denotes glycoprotein
_T48 1342-1347 FMAID:14543 denotes colon
_T49 1342-1347 FMAID:104231 denotes colon
_T50 1355-1360 FMAID:169002 denotes cells
_T51 1355-1360 FMAID:68646 denotes cells
_T52 1428-1433 FMAID:14543 denotes colon
_T53 1428-1433 FMAID:104231 denotes colon
_T54 1458-1463 FMAID:93675 denotes bowel
_T55 1472-1478 FMAID:256050 denotes tissue
_T56 1506-1512 FMAID:261267 denotes mucosa
_T57 1506-1512 FMAID:85355 denotes mucosa
_T58 1577-1582 FMAID:14543 denotes colon
_T59 1577-1582 FMAID:104231 denotes colon
_T60 1607-1612 FMAID:93675 denotes bowel
_T61 1652-1664 FMAID:197276 denotes carbohydrate
_T62 1652-1664 FMAID:82737 denotes carbohydrate

uniprot-human

Id Subject Object Predicate Lexical cue
T1 137-141 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T2 795-799 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T3 1270-1274 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T4 1370-1374 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T5 1694-1698 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T6 1786-1790 http://www.uniprot.org/uniprot/Q9UCB0 denotes CD44
T7 175-177 http://www.uniprot.org/uniprot/P02787 denotes TF
T8 342-344 http://www.uniprot.org/uniprot/P02787 denotes TF
T9 474-476 http://www.uniprot.org/uniprot/P02787 denotes TF
T10 830-832 http://www.uniprot.org/uniprot/P02787 denotes TF
T11 1674-1676 http://www.uniprot.org/uniprot/P02787 denotes TF
T12 175-177 http://www.uniprot.org/uniprot/P13726 denotes TF
T13 342-344 http://www.uniprot.org/uniprot/P13726 denotes TF
T14 474-476 http://www.uniprot.org/uniprot/P13726 denotes TF
T15 830-832 http://www.uniprot.org/uniprot/P13726 denotes TF
T16 1674-1676 http://www.uniprot.org/uniprot/P13726 denotes TF
T17 874-905 http://www.uniprot.org/uniprot/P17050 denotes alpha-N-acetylgalactosaminidase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 137-141 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T2 795-799 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T3 1270-1274 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T4 1370-1374 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T5 1694-1698 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T6 1786-1790 http://www.uniprot.org/uniprot/Q62409 denotes CD44
T7 175-177 http://www.uniprot.org/uniprot/P20352 denotes TF
T8 342-344 http://www.uniprot.org/uniprot/P20352 denotes TF
T9 474-476 http://www.uniprot.org/uniprot/P20352 denotes TF
T10 830-832 http://www.uniprot.org/uniprot/P20352 denotes TF
T11 1674-1676 http://www.uniprot.org/uniprot/P20352 denotes TF
T12 874-905 http://www.uniprot.org/uniprot/Q9QWR8 denotes alpha-N-acetylgalactosaminidase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 61-67 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 220-225 http://purl.bioontology.org/ontology/STY/T096 denotes group
T3 299-305 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T4 526-532 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T5 533-538 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 844-857 http://purl.bioontology.org/ontology/NCBITAXON/1306 denotes Streptococcus
T7 844-857 http://purl.bioontology.org/ontology/NCBITAXON/1301 denotes Streptococcus
T8 844-857 http://purl.bioontology.org/ontology/NCBITAXON/155680 denotes Streptococcus
T9 844-868 http://purl.bioontology.org/ontology/NCBITAXON/257758 denotes Streptococcus pneumoniae
T10 844-868 http://purl.bioontology.org/ontology/NCBITAXON/1313 denotes Streptococcus pneumoniae
T11 1107-1112 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T12 1200-1206 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T13 1207-1213 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T14 1348-1354 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T15 1355-1360 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T16 1434-1440 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T17 1472-1478 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T18 1583-1589 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T19 1739-1745 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer

GO-BP

Id Subject Object Predicate Lexical cue
T1 118-124 http://purl.obolibrary.org/obo/GO_0045292 denotes splice
T2 776-782 http://purl.obolibrary.org/obo/GO_0045292 denotes splice
T3 1397-1403 http://purl.obolibrary.org/obo/GO_0045292 denotes splice
T4 1699-1705 http://purl.obolibrary.org/obo/GO_0045292 denotes splice
T5 1791-1799 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T6 1014-1020 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T7 1025-1031 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T8 1681-1687 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T9 1768-1781 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 331-338 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 932-939 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1318-1325 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 331-338 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 932-939 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 1318-1325 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 331-338 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T8 932-939 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T9 1318-1325 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 331-338 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11 932-939 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12 1318-1325 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13 331-344 http://purl.obolibrary.org/obo/GO_0008134 denotes binding of TF
T14 1318-1338 http://purl.obolibrary.org/obo/GO_0001948 denotes binding glycoprotein

GO-CC

Id Subject Object Predicate Lexical cue
T1 0-4 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T2 461-465 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 533-538 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 1107-1112 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 1355-1360 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 0-12 http://purl.obolibrary.org/obo/GO_0009986 denotes Cell surface
T7 461-473 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T2 293-298 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T3 520-525 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T4 1194-1199 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T5 1342-1347 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T6 1428-1433 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T7 1577-1582 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T8 214-219 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9 433-443 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T10 1207-1213 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T11 1472-1478 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T12 1506-1512 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 44-51 http://edamontology.org/topic_2830 denotes antigen
T2 61-67 http://edamontology.org/topic_2640 denotes cancer
T3 226-233 http://edamontology.org/topic_2830 denotes antigen
T4 299-305 http://edamontology.org/topic_2640 denotes cancer
T5 526-532 http://edamontology.org/topic_2640 denotes cancer
T6 648-656 http://edamontology.org/topic_0078 denotes Proteins
T7 833-840 http://edamontology.org/topic_2830 denotes antigen
T8 950-968 http://edamontology.org/topic_3557 denotes Immunoprecipitated
T9 1200-1206 http://edamontology.org/topic_2640 denotes cancer
T10 1348-1354 http://edamontology.org/topic_2640 denotes cancer
T11 1434-1440 http://edamontology.org/topic_2640 denotes cancer
T12 1464-1471 http://edamontology.org/topic_0634 denotes disease
T13 1583-1589 http://edamontology.org/topic_2640 denotes cancer
T14 1613-1620 http://edamontology.org/topic_0634 denotes disease
T15 1652-1664 http://edamontology.org/topic_0152 denotes carbohydrate
T16 1665-1673 http://edamontology.org/topic_2830 denotes antigens
T17 1739-1745 http://edamontology.org/topic_2640 denotes cancer

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 96-117 http://edamontology.org/data_1519 denotes high molecular weight
T2 445-456 http://edamontology.org/data_0977 denotes To identify
T3 445-456 http://edamontology.org/data_2576 denotes To identify
T4 448-456 http://edamontology.org/data_2611 denotes identify
T5 448-456 http://edamontology.org/data_0842 denotes identify
T6 648-656 http://edamontology.org/format_1208 denotes Proteins
T7 648-656 http://edamontology.org/data_1467 denotes Proteins
T8 720-730 http://edamontology.org/data_2611 denotes identified
T9 720-730 http://edamontology.org/data_0842 denotes identified
T10 754-775 http://edamontology.org/data_1519 denotes high molecular weight
T11 1261-1269 http://edamontology.org/operation_3435 denotes standard
T12 1282-1286 http://edamontology.org/data_0006 denotes data
T13 1375-1396 http://edamontology.org/data_1519 denotes high molecular weight
T14 1499-1505 http://edamontology.org/operation_3435 denotes normal
T15 1815-1824 http://edamontology.org/operation_3465 denotes correlate

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11447138-0#137#141#gene960 137-141 gene960 denotes CD44
11447138-0#55#67#diseaseC0007102 55-67 diseaseC0007102 denotes colon cancer
11447138-0#55#67#diseaseC0699790 55-67 diseaseC0699790 denotes colon cancer
11447138-10#8#12#gene960 1370-1374 gene960 denotes CD44
11447138-10#83#109#diseaseC0021390 1445-1471 diseaseC0021390 denotes inflammatory bowel disease
11447138-10#232#258#diseaseC0021390 1594-1620 diseaseC0021390 denotes inflammatory bowel disease
137#141#gene96055#67#diseaseC0007102 11447138-0#137#141#gene960 11447138-0#55#67#diseaseC0007102 associated_with CD44,colon cancer
137#141#gene96055#67#diseaseC0699790 11447138-0#137#141#gene960 11447138-0#55#67#diseaseC0699790 associated_with CD44,colon cancer
8#12#gene96083#109#diseaseC0021390 11447138-10#8#12#gene960 11447138-10#83#109#diseaseC0021390 associated_with CD44,inflammatory bowel disease
8#12#gene960232#258#diseaseC0021390 11447138-10#8#12#gene960 11447138-10#232#258#diseaseC0021390 associated_with CD44,inflammatory bowel disease

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 55-60 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T2 214-219 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 214-219 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 293-298 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T5 520-525 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T6 1194-1199 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T7 1342-1347 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T8 1428-1433 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T9 1577-1582 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 214-225 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 390-393 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T2 593-596 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T3 928-931 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T4 1080-1083 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T5 1231-1234 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T6 1314-1317 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T7 1559-1562 https://acgg.asia/db/lfdb/LfDB0172 denotes PNA
Lectin_T8 1021-1023 https://acgg.asia/db/lfdb/LfDB0021 denotes Tn
Lectin_T9 1688-1690 https://acgg.asia/db/lfdb/LfDB0021 denotes Tn

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 552-559 id denotes labeled

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1506-1512 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
PD-UBERON-AE-B_T2 1207-1213 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1472-1478 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 214-219 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T5 433-443 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
PD-UBERON-AE-B_T6 55-60 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T7 293-298 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T8 520-525 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T9 1194-1199 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T10 1342-1347 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T11 1428-1433 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T12 1577-1582 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1244-1249 gene:960 denotes CD44v
T1 1194-1206 disease:C0007102 denotes colon cancer
T2 1244-1249 gene:960 denotes CD44v
T3 1194-1206 disease:C0699790 denotes colon cancer
T4 1270-1274 gene:960 denotes CD44
T5 1194-1206 disease:C0007102 denotes colon cancer
T6 1270-1274 gene:960 denotes CD44
T7 1194-1206 disease:C0699790 denotes colon cancer
T8 1297-1302 gene:960 denotes CD44v
T9 1342-1354 disease:C0007102 denotes colon cancer
T10 1297-1302 gene:960 denotes CD44v
T11 1342-1354 disease:C0699790 denotes colon cancer
R1 T0 T1 associated_with CD44v,colon cancer
R2 T2 T3 associated_with CD44v,colon cancer
R3 T4 T5 associated_with CD44,colon cancer
R4 T6 T7 associated_with CD44,colon cancer
R5 T8 T9 associated_with CD44v,colon cancer
R6 T10 T11 associated_with CD44v,colon cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 55-67 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T2 293-305 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T3 310-317 Disease denotes colitis http://purl.obolibrary.org/obo/MONDO_0005292
T4 520-532 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T5 844-868 Disease denotes Streptococcus pneumoniae http://purl.obolibrary.org/obo/MONDO_0005972
T6 1194-1206 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T7 1342-1354 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T8 1428-1440 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T9 1445-1471 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T10 1577-1589 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T11 1594-1620 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T12 1739-1745 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 55-60 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T2 214-219 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T4 293-298 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T5 520-525 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T6 1194-1199 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T7 1342-1347 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T8 1428-1433 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526
T9 1577-1582 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

Lectin-carbogrove

Id Subject Object Predicate Lexical cue
T1 371-388 GL_000456 denotes peanut agglutinin
T2 390-393 GL_000456 denotes PNA
T3 593-596 GL_000456 denotes PNA
T4 928-931 GL_000456 denotes PNA
T5 1080-1083 GL_000456 denotes PNA
T6 1231-1234 GL_000456 denotes PNA
T7 1314-1317 GL_000456 denotes PNA
T8 1559-1562 GL_000456 denotes PNA

Lectin-Jamboree

Id Subject Object Predicate Lexical cue
T1 354-361 lectin denotes lectins

Lectin-Jamboree-small

Id Subject Object Predicate Lexical cue glycosmos_id
T1 390-393 Lectin denotes PNA GL_000456
T2 593-596 Lectin denotes PNA GL_000456
T3 928-931 Lectin denotes PNA GL_000456
T4 1080-1083 Lectin denotes PNA GL_000456
T5 1231-1234 Lectin denotes PNA GL_000456
T6 1314-1317 Lectin denotes PNA GL_000456
T7 1559-1562 Lectin denotes PNA GL_000456

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-142 Sentence denotes Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44.
T2 143-318 Sentence denotes Increased mucosal expression of TF, the Thomsen-Friedenreich oncofetal blood group antigen (galactose beta1-3 N-acetylgalactosamine alpha-) occurs in colon cancer and colitis.
T3 319-444 Sentence denotes This allows binding of TF-specific lectins, such as peanut agglutinin (PNA), which is mitogenic to the colorectal epithelium.
T4 445-647 Sentence denotes To identify the cell surface TF-expressing glycoprotein(s), HT29 and Caco2 colon cancer cells were surface-labeled with Na[(125)I] and subjected to PNA-agarose affinity purification and electrophoresis.
T5 648-808 Sentence denotes Proteins, approximately 110-180 kDa, present in HT29 but not Caco2 were identified by Western blotting as high molecular weight splice variants of CD44 (CD44v).
T6 809-949 Sentence denotes Selective removal of TF antigen by Streptococcus pneumoniae endo-alpha-N-acetylgalactosaminidase substantially reduced PNA binding to CD44v.
T7 950-1065 Sentence denotes Immunoprecipitated CD44v from HT29 cell extracts also expressed sialyl-Tn (sialyl 2-6 N-acetylgalactosaminealpha-).
T8 1066-1190 Sentence denotes Incubation of PNA 15 microg/ml with HT29 cells caused no additional proliferative effect in the presence of anti-CD44v6 mAb.
T9 1191-1275 Sentence denotes In colon cancer tissue extracts (N = 3) PNA bound to CD44v but not to standard CD44.
T10 1276-1361 Sentence denotes These data show that CD44v is a major PNA-binding glycoprotein in colon cancer cells.
T11 1362-1621 Sentence denotes Because CD44 high molecular weight splice variants are present in colon cancer and inflammatory bowel disease tissue but are absent from normal mucosa, these results may also explain the increased PNA reactivity in colon cancer and inflammatory bowel disease.
T12 1622-1861 Sentence denotes The coexpression of oncofetal carbohydrate antigens TF and sialyl-Tn on CD44 splice variants provides a link between cancer-associated changes in glycosylation and CD44 splicing, both of which correlate with increased metastatic potential.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 844-868 OrganismTaxon denotes Streptococcus pneumoniae 1313

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 55-60 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T2 214-219 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 293-298 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T4 433-443 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T5 520-525 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T6 1194-1199 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T7 1207-1213 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 1342-1347 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T9 1428-1433 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T10 1458-1463 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T11 1472-1478 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T12 1506-1512 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T13 1577-1582 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T14 1607-1612 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 55-67 Phenotype denotes colon cancer HP:0003003
T2 293-305 Phenotype denotes colon cancer HP:0003003
T3 310-317 Phenotype denotes colitis HP:0002583
T4 520-532 Phenotype denotes colon cancer HP:0003003
T5 858-868 Phenotype denotes pneumoniae HP:0002090
T6 1194-1206 Phenotype denotes colon cancer HP:0003003
T7 1342-1354 Phenotype denotes colon cancer HP:0003003
T8 1428-1440 Phenotype denotes colon cancer HP:0003003
T9 1445-1471 Phenotype denotes inflammatory bowel disease HP:0002037
T10 1577-1589 Phenotype denotes colon cancer HP:0003003
T11 1594-1620 Phenotype denotes inflammatory bowel disease HP:0002037
T12 1739-1745 Phenotype denotes cancer HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 526-538 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 1348-1360 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064