> top > docs > PubMed:11439001 > annotations

PubMed:11439001 JSONTXT

Annnotations TAB JSON ListView MergeView

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
11439001-6#131#137#geners72653744 993-999 geners72653744 denotes R1164X
11439001-6#156#165#geners773165722 1018-1027 geners773165722 denotes c.960delC
11439001-6#156#165#geners139211763 1018-1027 geners139211763 denotes c.960delC
11439001-6#156#165#geners72664226 1018-1027 geners72664226 denotes c.960delC
11439001-6#124#129#geners72650700 986-991 geners72650700 denotes R518X
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0033847 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0033847 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0473583 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0473583 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0033847 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0033847 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0473583 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0473583 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0033847 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0033847 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0473583 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0473583 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0033847 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0033847 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0473583 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0473583 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0033847 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0033847 associated_with R1164X,pseudoxanthoma elasticum
131#137#geners72653744275#299#diseaseC0473583 11439001-6#131#137#geners72653744 11439001-6#275#299#diseaseC0473583 associated_with R1164X,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0033847 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0473583 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0033847 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0473583 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0033847 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0473583 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0033847 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0473583 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0033847 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners773165722275#299#diseaseC0473583 11439001-6#156#165#geners773165722 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0033847 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0473583 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0033847 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0473583 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0033847 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0473583 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0033847 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0473583 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0033847 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners139211763275#299#diseaseC0473583 11439001-6#156#165#geners139211763 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0033847 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0473583 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0033847 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0473583 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0033847 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0473583 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0033847 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0473583 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0033847 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0033847 associated_with c.960delC,pseudoxanthoma elasticum
156#165#geners72664226275#299#diseaseC0473583 11439001-6#156#165#geners72664226 11439001-6#275#299#diseaseC0473583 associated_with c.960delC,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0033847 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0033847 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0473583 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0473583 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0033847 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0033847 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0473583 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0473583 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0033847 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0033847 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0473583 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0473583 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0033847 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0033847 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0473583 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0473583 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0033847 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0033847 associated_with R518X,pseudoxanthoma elasticum
124#129#geners72650700275#299#diseaseC0473583 11439001-6#124#129#geners72650700 11439001-6#275#299#diseaseC0473583 associated_with R518X,pseudoxanthoma elasticum

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11439001-0#96#101#gene4363 96-101 gene4363 denotes ABCC1
11439001-0#106#111#gene4629 106-111 gene4629 denotes MYH11
11439001-0#0#24#diseaseC0033847 0-24 diseaseC0033847 denotes Pseudoxanthoma elasticum
11439001-0#0#24#diseaseC0473583 0-24 diseaseC0473583 denotes Pseudoxanthoma elasticum
11439001-0#0#24#diseaseC0033847 0-24 diseaseC0033847 denotes Pseudoxanthoma elasticum
11439001-0#0#24#diseaseC0473583 0-24 diseaseC0473583 denotes Pseudoxanthoma elasticum
11439001-6#180#185#gene368 1042-1047 gene368 denotes ABCC6
11439001-6#187#191#gene368 1049-1053 gene368 denotes MRP6
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0033847 1137-1161 diseaseC0033847 denotes pseudoxanthoma elasticum
11439001-6#275#299#diseaseC0473583 1137-1161 diseaseC0473583 denotes pseudoxanthoma elasticum
96#101#gene43630#24#diseaseC0033847 11439001-0#96#101#gene4363 11439001-0#0#24#diseaseC0033847 associated_with ABCC1,Pseudoxanthoma elasticum
96#101#gene43630#24#diseaseC0473583 11439001-0#96#101#gene4363 11439001-0#0#24#diseaseC0473583 associated_with ABCC1,Pseudoxanthoma elasticum
96#101#gene43630#24#diseaseC0033847 11439001-0#96#101#gene4363 11439001-0#0#24#diseaseC0033847 associated_with ABCC1,Pseudoxanthoma elasticum
96#101#gene43630#24#diseaseC0473583 11439001-0#96#101#gene4363 11439001-0#0#24#diseaseC0473583 associated_with ABCC1,Pseudoxanthoma elasticum
106#111#gene46290#24#diseaseC0033847 11439001-0#106#111#gene4629 11439001-0#0#24#diseaseC0033847 associated_with MYH11,Pseudoxanthoma elasticum
106#111#gene46290#24#diseaseC0473583 11439001-0#106#111#gene4629 11439001-0#0#24#diseaseC0473583 associated_with MYH11,Pseudoxanthoma elasticum
106#111#gene46290#24#diseaseC0033847 11439001-0#106#111#gene4629 11439001-0#0#24#diseaseC0033847 associated_with MYH11,Pseudoxanthoma elasticum
106#111#gene46290#24#diseaseC0473583 11439001-0#106#111#gene4629 11439001-0#0#24#diseaseC0473583 associated_with MYH11,Pseudoxanthoma elasticum
180#185#gene368275#299#diseaseC0033847 11439001-6#180#185#gene368 11439001-6#275#299#diseaseC0033847 associated_with ABCC6,pseudoxanthoma elasticum
180#185#gene368275#299#diseaseC0473583 11439001-6#180#185#gene368 11439001-6#275#299#diseaseC0473583 associated_with ABCC6,pseudoxanthoma elasticum
180#185#gene368275#299#diseaseC0033847 11439001-6#180#185#gene368 11439001-6#275#299#diseaseC0033847 associated_with ABCC6,pseudoxanthoma elasticum
180#185#gene368275#299#diseaseC0473583 11439001-6#180#185#gene368 11439001-6#275#299#diseaseC0473583 associated_with ABCC6,pseudoxanthoma elasticum
187#191#gene368275#299#diseaseC0033847 11439001-6#187#191#gene368 11439001-6#275#299#diseaseC0033847 associated_with MRP6,pseudoxanthoma elasticum
187#191#gene368275#299#diseaseC0473583 11439001-6#187#191#gene368 11439001-6#275#299#diseaseC0473583 associated_with MRP6,pseudoxanthoma elasticum
187#191#gene368275#299#diseaseC0033847 11439001-6#187#191#gene368 11439001-6#275#299#diseaseC0033847 associated_with MRP6,pseudoxanthoma elasticum
187#191#gene368275#299#diseaseC0473583 11439001-6#187#191#gene368 11439001-6#275#299#diseaseC0473583 associated_with MRP6,pseudoxanthoma elasticum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 305-324 HP:0000573 denotes retinal hemorrhages
AB2 337-357 HP:0000608 denotes macular degeneration

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-25 Sentence denotes Pseudoxanthoma elasticum:
TextSentencer_T2 26-112 Sentence denotes Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11.
TextSentencer_T3 113-247 Sentence denotes Pseudoxanthoma elasticum (PXE) is a mendelian disorder characterized by calcification of elastic fibers in skin, arteries, and retina.
TextSentencer_T4 248-358 Sentence denotes It results in dermal lesions, arterial insufficiency and retinal hemorrhages, leading to macular degeneration.
TextSentencer_T5 359-475 Sentence denotes PXE is transmitted either as an autosomal dominant or recessive trait and several sporadic cases have been observed.
TextSentencer_T6 476-551 Sentence denotes Mutations in the ABCC6 gene have been identified very recently in patients.
TextSentencer_T7 552-861 Sentence denotes Here, we report on a large Italian family affected by pseudoxanthoma elasticum for which linkage analysis had pointed to a region encompassing markers D16S3069-D16S405-D16S3103; hemizygosity of marker D16S405 allowed us to detect a submicroscopic deletion of at least 900 kb involving ABCC6, ABCC1, and MYH11.
TextSentencer_T8 862-1162 Sentence denotes Mutation analysis on the other allele of the family, as well as on two additional sporadic cases, revealed nonsense (Y227X, R518X, R1164X) and frame-shift (c.960delC) mutations in ABCC6 (MRP6) further confirming the role of this multi-drug resistance gene in the etiology of pseudoxanthoma elasticum.
TextSentencer_T9 1163-1346 Sentence denotes Furthermore, clinical re-examination of members of the family harboring the deletion led to the detection of additional features, potentially caused by the deletion of the MYH11 gene.
TextSentencer_T10 1347-1425 Sentence denotes In the course of the analysis five nonpathogenic variants were found in ABCC6:
TextSentencer_T11 1426-1486 Sentence denotes 1233T>C, 1245G>A, 1838 T>G (V614A), 1890C>G, and 3506+83C>A.
TextSentencer_T12 1487-1509 Sentence denotes Hum Mutat 18:85, 2001.
T1 0-25 Sentence denotes Pseudoxanthoma elasticum:
T2 26-112 Sentence denotes Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11.
T3 113-247 Sentence denotes Pseudoxanthoma elasticum (PXE) is a mendelian disorder characterized by calcification of elastic fibers in skin, arteries, and retina.
T4 248-358 Sentence denotes It results in dermal lesions, arterial insufficiency and retinal hemorrhages, leading to macular degeneration.
T5 359-475 Sentence denotes PXE is transmitted either as an autosomal dominant or recessive trait and several sporadic cases have been observed.
T6 476-551 Sentence denotes Mutations in the ABCC6 gene have been identified very recently in patients.
T7 552-861 Sentence denotes Here, we report on a large Italian family affected by pseudoxanthoma elasticum for which linkage analysis had pointed to a region encompassing markers D16S3069-D16S405-D16S3103; hemizygosity of marker D16S405 allowed us to detect a submicroscopic deletion of at least 900 kb involving ABCC6, ABCC1, and MYH11.
T8 862-1162 Sentence denotes Mutation analysis on the other allele of the family, as well as on two additional sporadic cases, revealed nonsense (Y227X, R518X, R1164X) and frame-shift (c.960delC) mutations in ABCC6 (MRP6) further confirming the role of this multi-drug resistance gene in the etiology of pseudoxanthoma elasticum.
T9 1163-1346 Sentence denotes Furthermore, clinical re-examination of members of the family harboring the deletion led to the detection of additional features, potentially caused by the deletion of the MYH11 gene.
T10 1347-1425 Sentence denotes In the course of the analysis five nonpathogenic variants were found in ABCC6:
T11 1426-1486 Sentence denotes 1233T>C, 1245G>A, 1838 T>G (V614A), 1890C>G, and 3506+83C>A.
T12 1487-1509 Sentence denotes Hum Mutat 18:85, 2001.

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 226-234 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arteries
PD-UBERON-AE-B_T2 278-286 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 240-246 http://purl.obolibrary.org/obo/UBERON_0000966 denotes retina

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 113-137 ORDO:758 denotes Pseudoxanthoma elasticum
AB2 139-142 ORDO:758 denotes PXE
AB3 359-362 ORDO:758 denotes PXE
AB4 606-630 ORDO:758 denotes pseudoxanthoma elasticum
AB5 1137-1161 ORDO:758 denotes pseudoxanthoma elasticum

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 226-234 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arteries
PD-UBERON-AE-B_T2 278-286 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
PD-UBERON-AE-B_T3 240-246 http://purl.obolibrary.org/obo/UBERON_0000966 denotes retina

DisGeNET

Id Subject Object Predicate Lexical cue
T0 106-111 gene:4629 denotes MYH11
T1 0-24 disease:C0473583 denotes Pseudoxanthoma elasticum
T2 106-111 gene:4629 denotes MYH11
T3 0-24 disease:C0033847 denotes Pseudoxanthoma elasticum
T4 96-101 gene:4363 denotes ABCC1
T5 0-24 disease:C0033847 denotes Pseudoxanthoma elasticum
T6 96-101 gene:4363 denotes ABCC1
T7 0-24 disease:C0473583 denotes Pseudoxanthoma elasticum
T8 837-842 gene:368 denotes ABCC6
T9 606-630 disease:C0033847 denotes pseudoxanthoma elasticum
T10 837-842 gene:368 denotes ABCC6
T11 606-630 disease:C0473583 denotes pseudoxanthoma elasticum
T12 1049-1053 gene:368 denotes MRP6
T13 1137-1161 disease:C0473583 denotes pseudoxanthoma elasticum
T14 1049-1053 gene:368 denotes MRP6
T15 1137-1161 disease:C0033847 denotes pseudoxanthoma elasticum
T16 1042-1047 gene:368 denotes ABCC6
T17 1137-1161 disease:C0473583 denotes pseudoxanthoma elasticum
T18 1042-1047 gene:368 denotes ABCC6
T19 1137-1161 disease:C0033847 denotes pseudoxanthoma elasticum
R1 T0 T1 associated_with MYH11,Pseudoxanthoma elasticum
R2 T2 T3 associated_with MYH11,Pseudoxanthoma elasticum
R3 T4 T5 associated_with ABCC1,Pseudoxanthoma elasticum
R4 T6 T7 associated_with ABCC1,Pseudoxanthoma elasticum
R5 T8 T9 associated_with ABCC6,pseudoxanthoma elasticum
R6 T10 T11 associated_with ABCC6,pseudoxanthoma elasticum
R7 T12 T13 associated_with MRP6,pseudoxanthoma elasticum
R8 T14 T15 associated_with MRP6,pseudoxanthoma elasticum
R9 T16 T17 associated_with ABCC6,pseudoxanthoma elasticum
R10 T18 T19 associated_with ABCC6,pseudoxanthoma elasticum