PubMed:11434510
Annnotations
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 51-53 | gene:5551 | denotes | P1 |
T1 | 91-106 | disease:C0376358 | denotes | prostate cancer |
T2 | 51-53 | gene:5551 | denotes | P1 |
T3 | 91-106 | disease:C0600139 | denotes | prostate cancer |
T4 | 419-825 | gene:2950 | denotes | GSTs have been consistently implicated as cancer susceptibility genes in this context. The GST supergene family includes several loci with well characterized polymorphisms. Approximately 50% of the Caucasian population are homozygous for deletions in GSTM1 and approximately 20% are homozygous for deletions in GSTT1, resulting in conjugation deficiency of mutagenic electrophiles to glutathione. The GSTP1 |
T5 | 1039-1046 | disease:C0006826 | denotes | cancers |
T6 | 1089-1092 | gene:373156 | denotes | GST |
T7 | 1123-1138 | disease:C0376358 | denotes | prostate cancer |
T8 | 1089-1092 | gene:373156 | denotes | GST |
T9 | 1123-1138 | disease:C0600139 | denotes | prostate cancer |
T10 | 1089-1092 | gene:133482 | denotes | GST |
T11 | 1123-1138 | disease:C0376358 | denotes | prostate cancer |
T12 | 1089-1092 | gene:133482 | denotes | GST |
T13 | 1123-1138 | disease:C0600139 | denotes | prostate cancer |
R1 | T0 | T1 | associated_with | P1,prostate cancer |
R2 | T2 | T3 | associated_with | P1,prostate cancer |
R3 | T4 | T5 | associated_with | "GSTs have been consistently implicated as cancer susceptibility genes in this context. The GST supergene family includes several loci with well characterized polymorphisms. Approximately 50% of the Caucasian population are homozygous for deletions in GSTM1 and approximately 20% are homozygous for deletions in GSTT1, resulting in conjugation deficiency of mutagenic electrophiles to glutathione. The GSTP1",cancers |
R4 | T6 | T7 | associated_with | GST,prostate cancer |
R5 | T8 | T9 | associated_with | GST,prostate cancer |
R6 | T10 | T11 | associated_with | GST,prostate cancer |
R7 | T12 | T13 | associated_with | GST,prostate cancer |