PubMed:11384981
Annnotations
Glycosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1863-1870 | Cell | denotes | B-cells | http://purl.obolibrary.org/obo/CL:0000236 |
| T2 | 1890-1915 | Cell | denotes | cerebellar Purkinje cells | http://purl.obolibrary.org/obo/CL:0000121 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 451-454 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T2 | 477-480 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T3 | 655-658 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T4 | 784-787 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T5 | 927-930 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T6 | 972-989 | Glycan_Motif | denotes | lactosyl ceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT |
| T9 | 1052-1055 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T10 | 1194-1197 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T11 | 1357-1360 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T12 | 1396-1415 | Glycan_Motif | denotes | N-acetyllactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO |
| T13 | 1484-1487 | Glycan_Motif | denotes | GM1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI |
| T15 | 1493-1497 | Glycan_Motif | denotes | GD1b | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G97612UN|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G37184KW |
| T17 | 1556-1559 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T18 | 1679-1682 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
| T19 | 1942-1947 | Glycan_Motif | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54406UD |
| T20 | 1998-2001 | Glycan_Motif | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G06239NA |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-183 | Sentence | denotes | Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. |
| T2 | 184-304 | Sentence | denotes | The distinction between the different classes of glycolipids is conditioned by the action of specific core transferases. |
| T3 | 305-472 | Sentence | denotes | The entry point for lacto-series glycolipids is catalyzed by the beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide (Lc3) synthase enzyme. |
| T4 | 473-588 | Sentence | denotes | The Lc3 synthase activity has been shown to be regulated during development, especially during brain morphogenesis. |
| T5 | 589-675 | Sentence | denotes | Here, we report the molecular cloning of a mouse gene encoding an Lc3 synthase enzyme. |
| T6 | 676-779 | Sentence | denotes | The mouse cDNA included an open reading frame of 1131 base pairs encoding a protein of 376 amino acids. |
| T7 | 780-922 | Sentence | denotes | The Lc3 synthase protein shared several structural motifs previously identified in the members of the beta1,3 glycosyltransferase superfamily. |
| T8 | 923-1010 | Sentence | denotes | The Lc3 synthase enzyme efficiently utilized the lactosyl ceramide glycolipid acceptor. |
| T9 | 1011-1286 | Sentence | denotes | The identity of the reaction products of Lc3 synthase-transfected CHOP2/1 cells was confirmed by thin-layer chromatography immunostaining using antibodies TE-8 and 1B2 that recognize Lc3 and Gal(beta1,4)GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide (nLc4) structures, respectively. |
| T10 | 1287-1545 | Sentence | denotes | In addition to the initiating activity for lacto-chain synthesis, the Lc3 synthase could extend the terminal N-acetyllactosamine unit of nLc4 and also had a broad specificity for gangliosides GA1, GM1, and GD1b to generate neolacto-ganglio hybrid structures. |
| T11 | 1546-1624 | Sentence | denotes | The mouse Lc3 synthase gene was mainly expressed during embryonic development. |
| T12 | 1625-1808 | Sentence | denotes | In situ hybridization analysis revealed that that the Lc3 synthase was expressed in most tissues at embryonic day 11 with elevated expression in the developing central nervous system. |
| T13 | 1809-1959 | Sentence | denotes | Postnatally, the expression was restricted to splenic B-cells, the placenta, and cerebellar Purkinje cells where it colocalized with HNK-1 reactivity. |
| T14 | 1960-2091 | Sentence | denotes | These data support a key role for the Lc3 synthase in regulating neolacto-series glycolipid synthesis during embryonic development. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 451-454 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T2 | 477-480 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T3 | 655-658 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T4 | 784-787 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T5 | 927-930 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T6 | 972-989 | https://glytoucan.org/Structures/Glycans/G20420WT | denotes | lactosyl ceramide |
| T7 | 972-989 | https://glytoucan.org/Structures/Glycans/G74621DY | denotes | lactosyl ceramide |
| T8 | 972-989 | https://glytoucan.org/Structures/Glycans/G84224TW | denotes | lactosyl ceramide |
| T9 | 1052-1055 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T10 | 1194-1197 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T11 | 1357-1360 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T12 | 1396-1415 | https://glytoucan.org/Structures/Glycans/G00055MO | denotes | N-acetyllactosamine |
| T13 | 1484-1487 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T14 | 1484-1487 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T15 | 1493-1497 | https://glytoucan.org/Structures/Glycans/G37184KW | denotes | GD1b |
| T16 | 1493-1497 | https://glytoucan.org/Structures/Glycans/G97612UN | denotes | GD1b |
| T17 | 1556-1559 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T18 | 1679-1682 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
| T19 | 1942-1947 | https://glytoucan.org/Structures/Glycans/G54406UD | denotes | HNK-1 |
| T20 | 1998-2001 | https://glytoucan.org/Structures/Glycans/G06239NA | denotes | Lc3 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 972-989 | http://www.glycoepitope.jp/epitopes/EP0078 | denotes | lactosyl ceramide |
| T2 | 1175-1178 | http://www.glycoepitope.jp/epitopes/AN0389 | denotes | 1B2 |
| T3 | 1484-1487 | http://www.glycoepitope.jp/epitopes/EP0050 | denotes | GM1 |
| T4 | 1493-1497 | http://www.glycoepitope.jp/epitopes/EP0059 | denotes | GD1b |
| T5 | 1942-1947 | http://www.glycoepitope.jp/epitopes/EP0001 | denotes | HNK-1 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 568-573 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T2 | 1785-1807 | http://purl.obolibrary.org/obo/MAT_0000457 | denotes | central nervous system |
| T3 | 1793-1807 | http://purl.obolibrary.org/obo/MAT_0000026 | denotes | nervous system |
| T4 | 1876-1884 | http://purl.obolibrary.org/obo/MAT_0000279 | denotes | placenta |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 19-110 | protein | denotes | beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase |
| T2 | 291-303 | protein | denotes | transferases |
| T3 | 370-464 | protein | denotes | beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide (Lc3) synthase |
| T4 | 477-489 | protein | denotes | Lc3 synthase |
| T5 | 655-667 | protein | denotes | Lc3 synthase |
| T6 | 784-796 | protein | denotes | Lc3 synthase |
| T7 | 882-921 | protein | denotes | beta1,3 glycosyltransferase superfamily |
| T8 | 927-939 | protein | denotes | Lc3 synthase |
| T9 | 1052-1064 | protein | denotes | Lc3 synthase |
| T10 | 1357-1369 | protein | denotes | Lc3 synthase |
| T11 | 1556-1568 | protein | denotes | Lc3 synthase |
| T12 | 1679-1691 | protein | denotes | Lc3 synthase |
| T13 | 1942-1947 | protein | denotes | HNK-1 |
| T14 | 1998-2010 | protein | denotes | Lc3 synthase |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 499-502 | https://acgg.asia/db/ggdb/info/gg135 | denotes | has |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 60-66 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 410-416 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T3 | 1214-1220 | chem:24139 | denotes | GlcNAc |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1479-1482 | Disease | denotes | GA1 | http://purl.obolibrary.org/obo/MONDO_0009281 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 568-573 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 1785-1807 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/MAT_0000457 |
| T3 | 1876-1884 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/MAT_0000279 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 451-454 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T2 | 477-480 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T3 | 655-658 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T4 | 784-787 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T5 | 927-930 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T6 | 1052-1055 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T7 | 1194-1197 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T8 | 1255-1259 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T9 | 1357-1360 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T10 | 1424-1428 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T11 | 1484-1487 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T12 | 1493-1497 | Glycan | denotes | GD1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G37184KW |
| T13 | 1556-1559 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T14 | 1679-1682 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
| T15 | 1942-1947 | Glycan | denotes | HNK-1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54406UD |
| T16 | 1998-2001 | Glycan | denotes | Lc3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G06239NA |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 13-18 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 632-637 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T5 | 680-685 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T7 | 1550-1555 | OrganismTaxon | denotes | mouse | 10088|10090 |
Glycosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 972-989 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | lactosyl ceramide | http://www.glycoepitope.jp/epitopes/EP0078 |
| T2 | 1175-1178 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 1B2 | http://www.glycoepitope.jp/epitopes/AN0389 |
| T3 | 1484-1487 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T4 | 1493-1497 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GD1b | http://www.glycoepitope.jp/epitopes/EP0059 |
| T5 | 1942-1947 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | HNK-1 | http://www.glycoepitope.jp/epitopes/EP0001 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 568-573 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 1113-1118 | Body_part | denotes | layer | http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303 |
| T5 | 1785-1807 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T6 | 1876-1884 | Body_part | denotes | placenta | http://purl.obolibrary.org/obo/UBERON_0001987 |
| T7 | 1890-1915 | Body_part | denotes | cerebellar Purkinje cells | http://purl.obolibrary.org/obo/CL_0000121 |