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PubMed:11319227 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 721-728 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Crystal structure of the eosinophil major basic protein at 1.8 A.
T2 66-122 Sentence denotes An atypical lectin with a paradigm shift in specificity.
T3 123-254 Sentence denotes The eosinophil major basic protein (EMBP) is the predominant constituent of the crystalline core of the eosinophil primary granule.
T4 255-376 Sentence denotes EMBP is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases such as asthma.
T5 377-605 Sentence denotes Here we report the crystal structure of EMBP at 1.8 A resolution, and show that it is similar to that of members of the C-type lectin superfamily with which it shares minimal amino acid sequence identity (approximately 15--28%).
T6 606-669 Sentence denotes However, this protein lacks a Ca(2+)/carbohydrate-binding site.
T7 670-729 Sentence denotes Our analysis suggests that EMBP specifically binds heparin.
T8 730-860 Sentence denotes Based on our results, we propose a possible new function for this protein, which is likely to have implications for EMBP function.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 721-728 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 721-728 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 327-339 Disease denotes bronchospasm http://purl.obolibrary.org/obo/MONDO_0001358
T2 343-360 Disease denotes allergic diseases http://purl.obolibrary.org/obo/MONDO_0005271
T3 369-375 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 327-339 Phenotype denotes bronchospasm HP:4000007
T2 369-375 Phenotype denotes asthma HP:0002099

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity.
T2 123-254 Sentence denotes The eosinophil major basic protein (EMBP) is the predominant constituent of the crystalline core of the eosinophil primary granule.
T3 255-376 Sentence denotes EMBP is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases such as asthma.
T4 377-605 Sentence denotes Here we report the crystal structure of EMBP at 1.8 A resolution, and show that it is similar to that of members of the C-type lectin superfamily with which it shares minimal amino acid sequence identity (approximately 15--28%).
T5 606-669 Sentence denotes However, this protein lacks a Ca(2+)/carbohydrate-binding site.
T6 670-729 Sentence denotes Our analysis suggests that EMBP specifically binds heparin.
T7 730-860 Sentence denotes Based on our results, we propose a possible new function for this protein, which is likely to have implications for EMBP function.

Lectin_function

Id Subject Object Predicate Lexical cue
T1 78-84 GX_000027 denotes lectin
T2 78-84 GX_000045 denotes lectin
T3 497-510 GL_000114 denotes C-type lectin
T4 497-510 GL_000115 denotes C-type lectin
T5 504-510 GX_000027 denotes lectin
T6 504-510 GX_000045 denotes lectin

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 25-35 Body_part denotes eosinophil http://purl.obolibrary.org/obo/CL_0017502
T2 127-137 Body_part denotes eosinophil http://purl.obolibrary.org/obo/CL_0017502
T3 227-237 Body_part denotes eosinophil http://purl.obolibrary.org/obo/CL_0017502
T4 238-253 Body_part denotes primary granule http://purl.obolibrary.org/obo/GO_0042582
T5 286-301 Body_part denotes epithelial cell http://purl.obolibrary.org/obo/CL_0000066

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 25-35 Cell denotes eosinophil http://purl.obolibrary.org/obo/CL:0000771
T2 127-137 Cell denotes eosinophil http://purl.obolibrary.org/obo/CL:0000771
T3 227-237 Cell denotes eosinophil http://purl.obolibrary.org/obo/CL:0000771
T4 286-301 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066