> top > docs > PubMed:11317354 > annotations

PubMed:11317354 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 130-338 DRI_Background denotes DNA mismatch repair is of considerable scientific and medical importance because of its essential role in maintaining genomic integrity, and its association with hereditary non-polyposis colon cancer (HNPCC).
T2 339-470 DRI_Background denotes Germline mutations in five mismatch repair genes (MLH1, MSH2, PMS1, PMS2, and MSH6) have been associated with HNPCC susceptibility.
T3 471-545 DRI_Approach denotes Our laboratory recently identified MLH3, a novel DNA mismatch repair gene.
T4 546-717 DRI_Approach denotes We screened the MLH3 coding sequence in 60 probands with increased genetic risk factors for colorectal cancer susceptibility and no mutations in the other candidate genes.
T5 718-765 DRI_Approach denotes No definite MLH3 germline mutations were found.
T6 766-903 DRI_Approach denotes We subsequently screened 36 colon tumors, and discovered an appreciable frequency of somatic MLH3 coding mutations in MSI-H tumors (25%).
T7 904-972 DRI_Outcome denotes In four of six tumors, evidence of biallelic inactivation was noted.
T8 973-1108 DRI_Background denotes Furthermore, MLH3 nonsense mutations were identified in two of 12 microsatellite stable (MSS) tumors with 14q24 loss of heterozygosity.
T9 1109-1338 DRI_Outcome denotes While our analyses do not exclude the existence of germline MLH3 mutations in patients with increased genetic risk factors for colorectal cancer susceptibility, they suggest such mutations are uncommon in this patient population.
T10 1339-1508 DRI_Outcome denotes The finding of an appreciable frequency of somatic MLH3 mutations is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis.

c_corpus

Id Subject Object Predicate Lexical cue
T1 21-29 SO:0000109 denotes mutation
T4 46-49 SO:0000352 denotes DNA
T3 46-49 CHEBI:16991 denotes DNA
T5 46-49 D004247 denotes DNA
T2 46-49 GO:0005574 denotes DNA
T6 50-65 GO:0006298 denotes mismatch repair
T7 66-70 SO:0000704 denotes gene
T8 71-75 PR:F4JN26 denotes MLH3
T9 71-75 PR:Q12083 denotes MLH3
T10 71-75 PR:000010443 denotes MLH3
T11 71-75 PR:Q9UHC1 denotes MLH3
T12 98-106 SO:0000109 denotes mutation
T13 110-128 D015179 denotes colorectal cancers
T14 110-128 D015179 denotes colorectal cancers
T17 134-149 GO:0006298 denotes mismatch repair
T18 317-322 UBERON:0001155 denotes colon
T19 317-329 D003110 denotes colon cancer
T20 317-329 D015179 denotes colon cancer
T21 317-329 D003110 denotes colon cancer
T22 366-381 GO:0006298 denotes mismatch repair
T23 389-393 PR:Q9ZRV4 denotes MLH1
T24 389-393 PR:P38920 denotes MLH1
T25 389-393 PR:Q54KD8 denotes MLH1
T27 389-393 PR:Q9JK91 denotes MLH1
T28 389-393 PR:P97679 denotes MLH1
T29 389-393 PR:Q9P7W6 denotes MLH1
T30 389-393 PR:000010442 denotes MLH1
T31 389-393 PR:P40692 denotes MLH1
T26 389-393 CVCL_G669 denotes MLH1
T33 395-398 CHEBI:16768 denotes MSH
T37 395-398 D009074 denotes MSH
T38 395-398 D009074 denotes MSH
T39 395-399 PR:000010666 denotes MSH2
T40 395-399 PR:P25847 denotes MSH2
T41 395-399 PR:P43246 denotes MSH2
T42 395-399 P22711 denotes MSH2
T43 395-399 PR:P22711 denotes MSH2
T44 395-399 PR:P54275 denotes MSH2
T45 395-399 PR:O74773 denotes MSH2
T46 395-399 PR:P43247 denotes MSH2
T47 395-399 PR:Q553L4 denotes MSH2
T48 395-399 PR:O24617 denotes MSH2
T55 401-405 PR:P14242 denotes PMS1
T56 401-405 PR:000012913 denotes PMS1
T59 401-405 PR:Q941I6 denotes PMS1
T60 401-405 PR:P54280 denotes PMS1
T61 401-405 PR:Q5NC83 denotes PMS1
T62 401-405 PR:P54277 denotes PMS1
T63 401-405 PR:Q54QA0 denotes PMS1
T57 401-405 C102203 denotes PMS1
T58 401-405 C102203 denotes PMS1
T64 407-410 CHEBI:53396 denotes PMS
T67 407-410 CHEBI:53430 denotes PMS
T69 407-410 CHEBI:8055 denotes PMS
T70 407-411 PR:P54279 denotes PMS2
T71 407-411 PR:F1NQJ3 denotes PMS2
T72 407-411 PR:P38920 denotes PMS2
T73 407-411 PR:000012914 denotes PMS2
T74 407-411 PR:P54278 denotes PMS2
T76 417-420 CHEBI:16768 denotes MSH
T80 417-420 D009074 denotes MSH
T81 417-420 D009074 denotes MSH
T82 417-421 PR:P52701 denotes MSH6
T83 417-421 PR:P54276 denotes MSH6
T84 417-421 PR:Q9VUM0 denotes MSH6
T85 417-421 PR:Q55GU9 denotes MSH6
T86 417-421 PR:O04716 denotes MSH6
T87 417-421 PR:Q03834 denotes MSH6
T88 417-421 PR:O74502 denotes MSH6
T89 417-421 PR:000010670 denotes MSH6
T90 455-469 D004198 denotes susceptibility
T91 455-469 D004198 denotes susceptibility
T92 506-510 PR:F4JN26 denotes MLH3
T93 506-510 PR:Q12083 denotes MLH3
T94 506-510 PR:000010443 denotes MLH3
T95 506-510 PR:Q9UHC1 denotes MLH3
T97 520-523 CHEBI:16991 denotes DNA
T99 520-523 D004247 denotes DNA
T98 520-523 SO:0000352 denotes DNA
T96 520-523 GO:0005574 denotes DNA
T100 524-539 GO:0006298 denotes mismatch repair
T101 540-544 SO:0000704 denotes gene
T102 562-566 PR:F4JN26 denotes MLH3
T103 562-566 PR:Q12083 denotes MLH3
T104 562-566 PR:000010443 denotes MLH3
T105 562-566 PR:Q9UHC1 denotes MLH3
T106 567-582 SO:0000316 denotes coding sequence
T108 638-655 D015179 denotes colorectal cancer
T109 638-655 D015179 denotes colorectal cancer
T110 656-670 D004198 denotes susceptibility
T111 656-670 D004198 denotes susceptibility
T112 730-734 PR:F4JN26 denotes MLH3
T113 730-734 PR:Q12083 denotes MLH3
T114 730-734 PR:000010443 denotes MLH3
T115 730-734 PR:Q9UHC1 denotes MLH3
T116 794-799 UBERON:0001155 denotes colon
T117 800-806 D009369 denotes tumors
T118 800-806 D009369 denotes tumors
T119 859-863 PR:F4JN26 denotes MLH3
T120 859-863 PR:Q12083 denotes MLH3
T121 859-863 PR:000010443 denotes MLH3
T122 859-863 PR:Q9UHC1 denotes MLH3
T123 884-887 PR:000006870 denotes MSI
T124 884-887 PR:P70245 denotes MSI
T125 890-896 D009369 denotes tumors
T126 890-896 D009369 denotes tumors
T127 919-925 D009369 denotes tumors
T128 919-925 D009369 denotes tumors
T129 986-990 PR:F4JN26 denotes MLH3
T130 986-990 PR:Q12083 denotes MLH3
T131 986-990 PR:000010443 denotes MLH3
T132 986-990 PR:Q9UHC1 denotes MLH3
T133 991-999 SO:0001587 denotes nonsense
T134 991-1009 D018389 denotes nonsense mutations
T135 1039-1053 SO:0000289 denotes microsatellite
T136 1062-1065 PR:000011146 denotes MSS
T137 1062-1065 Q9JMH3 denotes MSS
T138 1062-1065 D013132 denotes MSS
T139 1067-1073 D009369 denotes tumors
T140 1067-1073 D009369 denotes tumors
T141 1085-1107 SO:0001786 denotes loss of heterozygosity
T142 1169-1173 PR:F4JN26 denotes MLH3
T143 1169-1173 PR:Q12083 denotes MLH3
T144 1169-1173 PR:000010443 denotes MLH3
T145 1169-1173 PR:Q9UHC1 denotes MLH3
T146 1236-1253 D015179 denotes colorectal cancer
T147 1236-1253 D015179 denotes colorectal cancer
T148 1254-1268 D004198 denotes susceptibility
T149 1254-1268 D004198 denotes susceptibility
T150 1390-1394 PR:F4JN26 denotes MLH3
T151 1390-1394 PR:Q12083 denotes MLH3
T152 1390-1394 PR:000010443 denotes MLH3
T153 1390-1394 PR:Q9UHC1 denotes MLH3
T154 1449-1453 SO:0000704 denotes gene
T155 1476-1493 D015179 denotes colorectal cancer
T156 1476-1493 D015179 denotes colorectal cancer
T157 1494-1507 D063646 denotes tumorigenesis
T158 1494-1507 D063646 denotes tumorigenesis
T159 1564-1567 UBERON:0035973 denotes Inc

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11317354-0#71#75#gene27030 71-75 gene27030 denotes MLH3
11317354-0#110#128#diseaseC1527249 110-128 diseaseC1527249 denotes colorectal cancers
11317354-10#51#55#gene27030 1390-1394 gene27030 denotes MLH3
11317354-10#137#154#diseaseC0009402 1476-1493 diseaseC0009402 denotes colorectal cancer
11317354-10#155#168#diseaseC0596263 1494-1507 diseaseC0596263 denotes tumorigenesis
11317354-8#13#17#gene27030 986-990 gene27030 denotes MLH3
11317354-8#89#92#diseaseC0024814 1062-1065 diseaseC0024814 denotes MSS
71#75#gene27030110#128#diseaseC1527249 11317354-0#71#75#gene27030 11317354-0#110#128#diseaseC1527249 associated_with MLH3,colorectal cancers
51#55#gene27030137#154#diseaseC0009402 11317354-10#51#55#gene27030 11317354-10#137#154#diseaseC0009402 associated_with MLH3,colorectal cancer
51#55#gene27030155#168#diseaseC0596263 11317354-10#51#55#gene27030 11317354-10#155#168#diseaseC0596263 associated_with MLH3,tumorigenesis
13#17#gene2703089#92#diseaseC0024814 11317354-8#13#17#gene27030 11317354-8#89#92#diseaseC0024814 associated_with MLH3,MSS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 71-75 gene:27030 denotes MLH3
T1 110-128 disease:C1527249 denotes colorectal cancers
T2 562-566 gene:27030 denotes MLH3
T3 638-655 disease:C0009402 denotes colorectal cancer
T4 562-566 gene:27030 denotes MLH3
T5 638-655 disease:C1527249 denotes colorectal cancer
T6 1169-1173 gene:27030 denotes MLH3
T7 1236-1253 disease:C1527249 denotes colorectal cancer
T8 1169-1173 gene:27030 denotes MLH3
T9 1236-1253 disease:C0009402 denotes colorectal cancer
R1 T0 T1 associated_with MLH3,colorectal cancers
R2 T2 T3 associated_with MLH3,colorectal cancer
R3 T4 T5 associated_with MLH3,colorectal cancer
R4 T6 T7 associated_with MLH3,colorectal cancer
R5 T8 T9 associated_with MLH3,colorectal cancer