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PubMed:11297520 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-234 Sentence denotes Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
T2 235-370 Sentence denotes Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased risk of developing tumors in those affected.
T3 371-467 Sentence denotes The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor.
T4 468-531 Sentence denotes The mechanism by which LKB1 is regulated in cells is not known.
T5 532-732 Sentence denotes Here, we demonstrate that stimulation of Rat-2 or embryonic stem cells with activators of ERK1/2 or of cAMP-dependent protein kinase induced phosphorylation of endogenously expressed LKB1 at Ser(431).
T6 733-995 Sentence denotes We present pharmacological and genetic evidence that p90(RSK) mediated this phosphorylation in response to agonists that activate ERK1/2 and that cAMP-dependent protein kinase mediated this phosphorylation in response to agonists that activate adenylate cyclase.
T7 996-1183 Sentence denotes Ser(431) of LKB1 lies adjacent to a putative prenylation motif, and we demonstrate that full-length LKB1 expressed in 293 cells was prenylated by addition of a farnesyl group to Cys(433).
T8 1184-1339 Sentence denotes Our data suggest that phosphorylation of LKB1 at Ser(431) does not affect farnesylation and that farnesylation does not affect phosphorylation at Ser(431).
T9 1340-1530 Sentence denotes Phosphorylation of LKB1 at Ser(431) did not alter the activity of LKB1 to phosphorylate itself or the tumor suppressor protein p53 or alter the amount of LKB1 associated with cell membranes.
T10 1531-1757 Sentence denotes The reintroduction of wild-type LKB1 into a cancer cell line that lacks LKB1 suppressed growth, but mutants of LKB1 in which Ser(431) was mutated to Ala to prevent phosphorylation of LKB1 were ineffective in inhibiting growth.
T11 1758-1861 Sentence denotes In contrast, a mutant of LKB1 that cannot be prenylated was still able to suppress the growth of cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 592-602 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T2 592-596 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20039336 733-993 kin(p(MGI:Rps6ka1)) increases p(MGI:Stk11,pmod(P,S,431)) denotes We present pharmacological and genetic evidence that p90(RSK) mediated this phosphorylation in response to agonists that activate ERK1/2 and that cAMP-dependent protein kinase mediated this phosphorylation in response to agonists that activate adenylate cyclas
BEL:20039468 1531-1756 kin(p(MGI:Stk11)) decreases bp(GOBP:"cell proliferation") denotes The reintroduction of wild-type LKB1 into a cancer cell line that lacks LKB1 suppressed growth, but mutants of LKB1 in which Ser(431) was mutated to Ala to prevent phosphorylation of LKB1 were ineffective in inhibiting growth
BEL:20016440 1531-1756 p(MGI:Stk11,pmod(P,S,431)) decreases bp(GOBP:"cell proliferation") denotes The reintroduction of wild-type LKB1 into a cancer cell line that lacks LKB1 suppressed growth, but mutants of LKB1 in which Ser(431) was mutated to Ala to prevent phosphorylation of LKB1 were ineffective in inhibiting growth
BEL:20016442 1531-1756 p(MGI:Stk11,pmod(P,S,431)) directlyIncreases kin(p(MGI:Stk11)) denotes The reintroduction of wild-type LKB1 into a cancer cell line that lacks LKB1 suppressed growth, but mutants of LKB1 in which Ser(431) was mutated to Ala to prevent phosphorylation of LKB1 were ineffective in inhibiting growth

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1563-1567 gene:6794 denotes LKB1
T1 1575-1581 disease:C0006826 denotes cancer
T2 1563-1567 gene:6794 denotes LKB1
T3 1575-1581 disease:C1306459 denotes cancer
R1 T0 T1 associated_with LKB1,cancer
R2 T2 T3 associated_with LKB1,cancer

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 592-602 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 63-69 Phenotype denotes cancer HP:0002664
T2 274-280 Phenotype denotes cancer HP:0002664
T3 450-455 Phenotype denotes tumor HP:0002664
T4 1442-1447 Phenotype denotes tumor HP:0002664
T5 1575-1581 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 63-69 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 235-257 Disease denotes Peutz-Jeghers syndrome http://purl.obolibrary.org/obo/MONDO_0008280
T3 264-289 Disease denotes inherited cancer syndrome http://purl.obolibrary.org/obo/MONDO_0015356
T4 345-351 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T5 450-455 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1442-1447 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 1575-1581 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 592-602 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 1515-1529 Body_part denotes cell membranes http://purl.obolibrary.org/obo/GO_0005886

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 582-602 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T2 1575-1586 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064