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PubMed:11279154 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 345-354 Body_part denotes myoblasts http://purl.obolibrary.org/obo/CL_0000056
T2 1540-1555 Body_part denotes skeletal muscle http://purl.obolibrary.org/obo/UBERON_0001134|http://purl.obolibrary.org/obo/UBERON_0014892|http://purl.obolibrary.org/obo/UBERON_0014895

sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Role of intronic E- and N-box motifs in the transcriptional induction of the acetylcholinesterase gene during myogenic differentiation.
T2 136-274 Sentence denotes In this study, we examined whether an intronic N-box motif is involved in the expression of acetylcholinesterase (AChE) during myogenesis.
T3 275-411 Sentence denotes We determined that AChE transcripts are barely detectable in cultured myoblasts and that their levels increase dramatically in myotubes.
T4 412-551 Sentence denotes Nuclear run-on assays revealed that this increase was accompanied by a parallel induction in the transcriptional activity of the AChE gene.
T5 552-675 Sentence denotes These changes in transcription were also observed in transfection experiments using AChE promoter-reporter gene constructs.
T6 676-809 Sentence denotes Mutation of the intronic N-box at position +755 base pairs (bp) reduced by more than 70% expression of the reporter gene in myotubes.
T7 810-944 Sentence denotes Disruption of an adjacent E-box, at position +767 bp, also reduced expression of the reporter gene following myogenic differentiation.
T8 945-1154 Sentence denotes Co-transfection experiments using AChE promoter-reporter gene constructs and a myogenin expression vector showed that expression of this regulatory factor increased expression of the reporter gene in myotubes.
T9 1155-1323 Sentence denotes Although the AChE promoter contains multiple E-boxes, mutation of this intronic one was sufficient to prevent the myogenin-induced increase in reporter gene expression.
T10 1324-1556 Sentence denotes Together, these results indicate that changes in AChE gene transcription occur during myogenesis and highlight the contribution of the intronic N- and E-box motifs in the developmental regulation of the AChE gene in skeletal muscle.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1540-1555 http://purl.obolibrary.org/obo/MAT_0000302 denotes skeletal muscle
T2 1549-1555 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 402-410 http://purl.obolibrary.org/obo/CL_0002372 denotes myotubes
T2 525-533 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 800-808 http://purl.obolibrary.org/obo/CL_0002372 denotes myotubes
T4 1145-1153 http://purl.obolibrary.org/obo/CL_0002372 denotes myotubes

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1033-1050 OrganismTaxon denotes expression vector NCBItxid:81076

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20066112 945-1152 tscript(p(HGNC:MYOG)) increases r(HGNC:ACHE) denotes Co-transfection experiments using AChE promoter-reporter gene constructs and a myogenin expression vector showed that expression of this regulatory factor increased expression of the reporter gene in myotube