PubMed:11278606
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-20 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 493-504 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T3 | 870-881 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. |
| T2 | 133-275 | Sentence | denotes | Tumor cell adhesion and proteolysis of the extracellular matrix proteins surrounding the cells are tightly linked processes in tumor invasion. |
| T3 | 276-440 | Sentence | denotes | In this study, we sought to identify components of the cell surface of a vertical growth phase melanoma cell line, WM1341D, that mediate invasive cellular behavior. |
| T4 | 441-688 | Sentence | denotes | We determined by antisense inhibition that melanoma chondroitin sulfate proteoglycan (MCSP) and membrane-type 3 matrix metalloproteinase (MT3-MMP) expressed on WM1341D are required for invasion of type I collagen and degradation of type I gelatin. |
| T5 | 689-794 | Sentence | denotes | MT3-MMP co-immunoprecipitated with MCSP in WM1341D melanoma cells cultured on type I collagen or laminin. |
| T6 | 795-1023 | Sentence | denotes | The association between MT3-MMP and MCSP was largely disrupted by removing chondroitin sulfate glycosaminoglycan (CS) from the cell surface, suggesting CS could mediate the association between the two cell surface core proteins. |
| T7 | 1024-1159 | Sentence | denotes | Recombinant MT3-MMP and MT3-MMP from whole cell lysates of WM1341D cells were specifically eluted from CS- conjugated affinity columns. |
| T8 | 1160-1376 | Sentence | denotes | The results indicate that MT3-MMP possesses the potential to promote melanoma invasion and proteolysis and that the formation of a complex between MT3-MMP and MCSP may be a crucial step in activating these processes. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 9-20 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 493-504 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T3 | 870-881 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 9-20 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 493-504 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 870-881 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-8 | Disease | denotes | Melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T2 | 93-101 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T3 | 133-138 | Disease | denotes | Tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 260-265 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T5 | 371-379 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T6 | 484-492 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T7 | 740-748 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T8 | 1229-1237 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 0-8 | Phenotype | denotes | Melanoma | HP:0002861 |
| T2 | 93-101 | Phenotype | denotes | melanoma | HP:0002861 |
| T3 | 133-138 | Phenotype | denotes | Tumor | HP:0002664 |
| T4 | 260-265 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 371-379 | Phenotype | denotes | melanoma | HP:0002861 |
| T6 | 484-492 | Phenotype | denotes | melanoma | HP:0002861 |
| T7 | 740-748 | Phenotype | denotes | melanoma | HP:0002861 |
| T8 | 1229-1237 | Phenotype | denotes | melanoma | HP:0002861 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 9-20 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 493-504 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 870-881 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 0-8 | Phenotype | denotes | Melanoma | HP:0002861 |
| T2 | 93-101 | Phenotype | denotes | melanoma | HP:0002861 |
| T3 | 133-138 | Phenotype | denotes | Tumor | HP:0002664 |
| T4 | 260-265 | Phenotype | denotes | tumor | HP:0002664 |
| T5 | 371-379 | Phenotype | denotes | melanoma | HP:0002861 |
| T6 | 484-492 | Phenotype | denotes | melanoma | HP:0002861 |
| T7 | 740-748 | Phenotype | denotes | melanoma | HP:0002861 |
| T8 | 1229-1237 | Phenotype | denotes | melanoma | HP:0002861 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-20 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 493-504 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 870-881 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 116-122 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T3 | 133-143 | Cell | denotes | Tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T4 | 638-644 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T6 | 673-679 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T8 | 767-773 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 176-196 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 537-545 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/UBERON_0000094 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-8 | Disease | denotes | Melanoma | MONDO:0005105 |
| T2 | 93-101 | Disease | denotes | melanoma | MONDO:0005105 |
| T3 | 133-138 | Disease | denotes | Tumor | MONDO:0005070 |
| T4 | 260-265 | Disease | denotes | tumor | MONDO:0005070 |
| T5 | 371-379 | Disease | denotes | melanoma | MONDO:0005105 |
| T6 | 484-492 | Disease | denotes | melanoma | MONDO:0005105 |
| T7 | 740-748 | Disease | denotes | melanoma | MONDO:0005105 |
| T8 | 1229-1237 | Disease | denotes | melanoma | MONDO:0005105 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 9-20 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 493-504 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 870-881 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 87-92 | Organism | denotes | human | 9606 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-20 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 493-504 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 870-881 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. |
| T2 | 133-275 | Sentence | denotes | Tumor cell adhesion and proteolysis of the extracellular matrix proteins surrounding the cells are tightly linked processes in tumor invasion. |
| T3 | 276-440 | Sentence | denotes | In this study, we sought to identify components of the cell surface of a vertical growth phase melanoma cell line, WM1341D, that mediate invasive cellular behavior. |
| T4 | 441-688 | Sentence | denotes | We determined by antisense inhibition that melanoma chondroitin sulfate proteoglycan (MCSP) and membrane-type 3 matrix metalloproteinase (MT3-MMP) expressed on WM1341D are required for invasion of type I collagen and degradation of type I gelatin. |
| T5 | 689-794 | Sentence | denotes | MT3-MMP co-immunoprecipitated with MCSP in WM1341D melanoma cells cultured on type I collagen or laminin. |
| T6 | 795-1023 | Sentence | denotes | The association between MT3-MMP and MCSP was largely disrupted by removing chondroitin sulfate glycosaminoglycan (CS) from the cell surface, suggesting CS could mediate the association between the two cell surface core proteins. |
| T7 | 1024-1159 | Sentence | denotes | Recombinant MT3-MMP and MT3-MMP from whole cell lysates of WM1341D cells were specifically eluted from CS- conjugated affinity columns. |
| T8 | 1160-1376 | Sentence | denotes | The results indicate that MT3-MMP possesses the potential to promote melanoma invasion and proteolysis and that the formation of a complex between MT3-MMP and MCSP may be a crucial step in activating these processes. |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 176-196 | Body_part | denotes | extracellular matrix | FMA:9672 |
| T2 | 331-343 | Body_part | denotes | cell surface | FMA:67653 |
| T3 | 922-934 | Body_part | denotes | cell surface | FMA:67653 |
| T4 | 996-1008 | Body_part | denotes | cell surface | FMA:67653 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 87-92 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 176-196 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T2 | 537-545 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 116-122 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T3 | 133-143 | Cell | denotes | Tumor cell | http://purl.obolibrary.org/obo/CL:0001063 |
| T4 | 638-644 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T6 | 673-679 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |
| T8 | 767-773 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |