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PubMed:11278581 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1012-1023 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T2 1226-1237 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.
T2 144-383 Sentence denotes Urinary trypsin inhibitor (UTI) forms membrane complexes with UTI-binding proteins (UTI-BPs) and initiates modulation of urokinase-type plasminogen activator (uPA) expression, which results in UTI-mediated suppression of cell invasiveness.
T3 384-731 Sentence denotes It has been established that suppression of uPA expression and invasiveness by UTI is mediated through inhibition of protein kinase C-dependent signaling pathways and that human chondrosarcoma cell line HCS-2/8 expresses two types of UTI-BPs; a 40-kDa UTI-BP (UTI-BP(40)), which is identical to link protein (LP), and a 45-kDa UTI-BP (UTI-BP(45)).
T4 732-810 Sentence denotes Here we characterize binding properties of UTI-BPs.UTI complexes in the cells.
T5 811-957 Sentence denotes In vitro ligand blot, cell binding and competition assays, and Scatchard analyses demonstrate that both UTI-BP(40) and UTI-BP(45) bind (125)I-UTI.
T6 958-1086 Sentence denotes A deglycosylated form of UTI (NG-UTI), from which the chondroitin-sulfate side chain has been removed, binds only to UTI-BP(40).
T7 1087-1306 Sentence denotes Additional experiments, using various reagents to block binding of (125)I-UTI and NG-UTI to the UTI-BP(40) and UTI-BP(45) confirm that the chondroitin sulfate side chain of UTI is required for its binding to UTI-BP(45).
T8 1307-1497 Sentence denotes Analysis of binding of (125)I-UTI and NG-UTI to the cells suggests that low affinity binding sites are the UTI-BP(40) (which can bind NG-UTI), and the high affinity sites are the UTI-BP(45).
T9 1498-1682 Sentence denotes In addition, UTI-induced suppression of phorbol ester stimulated up-regulation of uPA is inhibited by reagents that were shown to prevent binding of UTI to the 40- and 45-kDa proteins.
T10 1683-1767 Sentence denotes We conclude that UTI must bind to both of the UTI-BPs to suppress uPA up-regulation.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1012-1023 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T2 1226-1237 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1012-1023 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin
T2 1226-1237 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 110-124 Phenotype denotes chondrosarcoma HP:0006765
T2 562-576 Phenotype denotes chondrosarcoma HP:0006765

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 110-124 Disease denotes chondrosarcoma http://purl.obolibrary.org/obo/MONDO_0008977
T2 135-138 Disease denotes HCS http://purl.obolibrary.org/obo/MONDO_0011669
T3 171-174 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T4 206-209 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T5 228-231 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T6 303-306 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T7 337-340 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T8 428-431 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T9 463-466 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T10 562-576 Disease denotes chondrosarcoma http://purl.obolibrary.org/obo/MONDO_0008977
T11 587-590 Disease denotes HCS http://purl.obolibrary.org/obo/MONDO_0011669
T12 618-621 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T13 636-639 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T14 644-647 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T15 711-714 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T16 719-722 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T17 775-778 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T18 915-918 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T19 930-933 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T20 953-956 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T21 983-986 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T22 991-994 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T23 1075-1078 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T24 1161-1164 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T25 1172-1175 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T26 1183-1186 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T27 1198-1201 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T28 1260-1263 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T29 1295-1298 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T30 1337-1340 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T31 1348-1351 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T32 1414-1417 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T33 1444-1447 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T34 1486-1489 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T35 1511-1514 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T36 1580-1583 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T37 1647-1650 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T38 1700-1703 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T39 1729-1732 Disease denotes UTI http://purl.obolibrary.org/obo/MONDO_0005247
T40 1749-1752 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1012-1023 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T2 1226-1237 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1012-1023 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1226-1237 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 110-124 Phenotype denotes chondrosarcoma HP:0006765
T2 562-576 Phenotype denotes chondrosarcoma HP:0006765

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 104-109 OrganismTaxon denotes human 9606
T2 556-561 OrganismTaxon denotes human 9606

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 135-138 Cell denotes HCS http://purl.obolibrary.org/obo/CL:0000745
T2 232-235 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748
T3 587-590 Cell denotes HCS http://purl.obolibrary.org/obo/CL:0000745
T4 622-625 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748
T5 1733-1736 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 182-190 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.
T2 144-383 Sentence denotes Urinary trypsin inhibitor (UTI) forms membrane complexes with UTI-binding proteins (UTI-BPs) and initiates modulation of urokinase-type plasminogen activator (uPA) expression, which results in UTI-mediated suppression of cell invasiveness.
T3 384-731 Sentence denotes It has been established that suppression of uPA expression and invasiveness by UTI is mediated through inhibition of protein kinase C-dependent signaling pathways and that human chondrosarcoma cell line HCS-2/8 expresses two types of UTI-BPs; a 40-kDa UTI-BP (UTI-BP(40)), which is identical to link protein (LP), and a 45-kDa UTI-BP (UTI-BP(45)).
T4 732-810 Sentence denotes Here we characterize binding properties of UTI-BPs.UTI complexes in the cells.
T5 811-957 Sentence denotes In vitro ligand blot, cell binding and competition assays, and Scatchard analyses demonstrate that both UTI-BP(40) and UTI-BP(45) bind (125)I-UTI.
T6 958-1086 Sentence denotes A deglycosylated form of UTI (NG-UTI), from which the chondroitin-sulfate side chain has been removed, binds only to UTI-BP(40).
T7 1087-1306 Sentence denotes Additional experiments, using various reagents to block binding of (125)I-UTI and NG-UTI to the UTI-BP(40) and UTI-BP(45) confirm that the chondroitin sulfate side chain of UTI is required for its binding to UTI-BP(45).
T8 1307-1497 Sentence denotes Analysis of binding of (125)I-UTI and NG-UTI to the cells suggests that low affinity binding sites are the UTI-BP(40) (which can bind NG-UTI), and the high affinity sites are the UTI-BP(45).
T9 1498-1682 Sentence denotes In addition, UTI-induced suppression of phorbol ester stimulated up-regulation of uPA is inhibited by reagents that were shown to prevent binding of UTI to the 40- and 45-kDa proteins.
T10 1683-1767 Sentence denotes We conclude that UTI must bind to both of the UTI-BPs to suppress uPA up-regulation.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8.
T2 144-383 Sentence denotes Urinary trypsin inhibitor (UTI) forms membrane complexes with UTI-binding proteins (UTI-BPs) and initiates modulation of urokinase-type plasminogen activator (uPA) expression, which results in UTI-mediated suppression of cell invasiveness.
T3 384-731 Sentence denotes It has been established that suppression of uPA expression and invasiveness by UTI is mediated through inhibition of protein kinase C-dependent signaling pathways and that human chondrosarcoma cell line HCS-2/8 expresses two types of UTI-BPs; a 40-kDa UTI-BP (UTI-BP(40)), which is identical to link protein (LP), and a 45-kDa UTI-BP (UTI-BP(45)).
T4 732-810 Sentence denotes Here we characterize binding properties of UTI-BPs.UTI complexes in the cells.
T5 811-957 Sentence denotes In vitro ligand blot, cell binding and competition assays, and Scatchard analyses demonstrate that both UTI-BP(40) and UTI-BP(45) bind (125)I-UTI.
T6 958-1086 Sentence denotes A deglycosylated form of UTI (NG-UTI), from which the chondroitin-sulfate side chain has been removed, binds only to UTI-BP(40).
T7 1087-1306 Sentence denotes Additional experiments, using various reagents to block binding of (125)I-UTI and NG-UTI to the UTI-BP(40) and UTI-BP(45) confirm that the chondroitin sulfate side chain of UTI is required for its binding to UTI-BP(45).
T8 1307-1497 Sentence denotes Analysis of binding of (125)I-UTI and NG-UTI to the cells suggests that low affinity binding sites are the UTI-BP(40) (which can bind NG-UTI), and the high affinity sites are the UTI-BP(45).
T9 1498-1682 Sentence denotes In addition, UTI-induced suppression of phorbol ester stimulated up-regulation of uPA is inhibited by reagents that were shown to prevent binding of UTI to the 40- and 45-kDa proteins.
T10 1683-1767 Sentence denotes We conclude that UTI must bind to both of the UTI-BPs to suppress uPA up-regulation.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1012-1023 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081
T2 1226-1237 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 110-124 Disease denotes chondrosarcoma MONDO:0008977
T2 562-576 Disease denotes chondrosarcoma MONDO:0008977

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1012-1023 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT
T2 1226-1237 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 104-109 OrganismTaxon denotes human 9606
T2 556-561 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 182-190 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 135-138 Cell denotes HCS http://purl.obolibrary.org/obo/CL:0000745
T2 232-235 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748
T3 587-590 Cell denotes HCS http://purl.obolibrary.org/obo/CL:0000745
T4 622-625 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748
T5 1733-1736 Cell denotes BPs http://purl.obolibrary.org/obo/CL:0000748