PubMed:11278534
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. |
| T2 | 133-324 | Sentence | denotes | We have cloned, expressed and characterized the gene encoding a ninth member of the mammalian UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) family, termed ppGaNTase-T9. |
| T3 | 325-530 | Sentence | denotes | This type II membrane protein consists of a 9-amino acid N-terminal cytoplasmic region, a 20-amino acid hydrophobic/transmembrane region, a 94-amino acid stem region, and a 480-amino acid conserved region. |
| T4 | 531-669 | Sentence | denotes | Northern blot analysis revealed that the gene encoding this enzyme is expressed in a broadly distributed manner across many adult tissues. |
| T5 | 670-882 | Sentence | denotes | Significant levels of 5- and 4.2-kilobase transcripts were found in rat sublingual gland, testis, small intestine, colon, and ovary, with lesser amounts in heart, brain, spleen, lung, stomach, cervix, and uterus. |
| T6 | 883-1054 | Sentence | denotes | In situ hybridization to mouse embryos (embryonic day 14.5) revealed significant hybridization in the developing mandible, maxilla, intestine, and mesencephalic ventricle. |
| T7 | 1055-1269 | Sentence | denotes | Constructs expressing this gene transiently in COS7 cells resulted in no detectable transferase activity in vitro against a panel of unmodified peptides, including MUC5AC (GTTPSPVPTTSTTSAP) and EA2 (PTTDSTTPAPTTK). |
| T8 | 1270-1473 | Sentence | denotes | However, when incubated with MUC5AC and EA2 glycopeptides (obtained by the prior action of ppGaNTase-T1), additional incorporation of GalNAc was achieved, resulting in new hydroxyamino acid modification. |
| T9 | 1474-1708 | Sentence | denotes | The activity of this glycopeptide transferase is distinguished from that of ppGaNTase-T7 in that it forms a tetra-glycopeptide species from the MUC5AC tri-glycopeptide substrate, whereas ppGaNTase-T7 forms a hexa-glycopeptide species. |
| T10 | 1709-1914 | Sentence | denotes | This isoform thus represents the second example of a glycopeptide transferase and is distinct from the previously identified form in enzymatic activity as well as expression in embryonic and adult tissues. |
| T11 | 1915-2147 | Sentence | denotes | These findings lend further support to the existence of a hierarchical network of differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a role in the various processes governing development. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 479-483 | http://purl.obolibrary.org/obo/MAT_0000239 | denotes | stem |
| T2 | 753-758 | http://purl.obolibrary.org/obo/MAT_0000021 | denotes | gland |
| T3 | 760-766 | http://purl.obolibrary.org/obo/MAT_0000132 | denotes | testis |
| T4 | 768-783 | http://purl.obolibrary.org/obo/MAT_0000047 | denotes | small intestine |
| T5 | 774-783 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | intestine |
| T6 | 785-790 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
| T7 | 826-831 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
| T8 | 833-838 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T9 | 840-846 | http://purl.obolibrary.org/obo/MAT_0000085 | denotes | spleen |
| T10 | 848-852 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T11 | 854-861 | http://purl.obolibrary.org/obo/MAT_0000051 | denotes | stomach |
| T12 | 863-869 | http://purl.obolibrary.org/obo/MAT_0000292 | denotes | cervix |
| T13 | 875-881 | http://purl.obolibrary.org/obo/MAT_0000127 | denotes | uterus |
| T14 | 914-921 | http://purl.obolibrary.org/obo/MAT_0000226 | denotes | embryos |
| T15 | 1015-1024 | http://purl.obolibrary.org/obo/MAT_0000043 | denotes | intestine |
| T16 | 1044-1053 | http://purl.obolibrary.org/obo/MAT_0000497 | denotes | ventricle |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 479-483 | Body_part | denotes | stem | http://purl.obolibrary.org/obo/MAT_0000239 |
| T2 | 753-758 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/MAT_0000021 |
| T3 | 760-766 | Body_part | denotes | testis | http://purl.obolibrary.org/obo/MAT_0000132 |
| T4 | 768-783 | Body_part | denotes | small intestine | http://purl.obolibrary.org/obo/MAT_0000047 |
| T5 | 785-790 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T6 | 826-831 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T7 | 833-838 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 840-846 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
| T9 | 848-852 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T10 | 854-861 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/MAT_0000051 |
| T11 | 863-869 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/MAT_0000292 |
| T12 | 875-881 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/MAT_0000127 |
| T13 | 914-921 | Body_part | denotes | embryos | http://purl.obolibrary.org/obo/MAT_0000226 |
| T14 | 1015-1024 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/MAT_0000043 |
| T15 | 1044-1053 | Body_part | denotes | ventricle | http://purl.obolibrary.org/obo/MAT_0000497 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 863-869 | Disease | denotes | cervix | http://purl.obolibrary.org/obo/MONDO_0021230 |
| T2 | 1249-1252 | Disease | denotes | EA2 | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T3 | 1310-1313 | Disease | denotes | EA2 | http://purl.obolibrary.org/obo/MONDO_0007163 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1404-1410 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 863-869 | Disease | denotes | cervix | http://purl.obolibrary.org/obo/MONDO_0021230 |
| T2 | 1249-1252 | Disease | denotes | EA2 | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T3 | 1310-1313 | Disease | denotes | EA2 | http://purl.obolibrary.org/obo/MONDO_0007163 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 738-741 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 908-913 | OrganismTaxon | denotes | mouse | 10088|10090 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 338-346 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 393-411 | Body_part | denotes | cytoplasmic region | http://purl.obolibrary.org/obo/GO_0099568 |
| T5 | 441-454 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T6 | 742-758 | Body_part | denotes | sublingual gland | http://purl.obolibrary.org/obo/UBERON_0001832 |
| T7 | 760-766 | Body_part | denotes | testis | http://purl.obolibrary.org/obo/UBERON_0000473 |
| T8 | 768-783 | Body_part | denotes | small intestine | http://purl.obolibrary.org/obo/UBERON_0002108 |
| T9 | 785-790 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T10 | 796-801 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T11 | 826-831 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T15 | 833-838 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T17 | 840-846 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T18 | 848-852 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T19 | 854-861 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/UBERON_0000945 |
| T20 | 863-869 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/UBERON_0000002 |
| T21 | 875-881 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/UBERON_0000995|http://purl.obolibrary.org/obo/UBERON_0006834 |
| T23 | 996-1004 | Body_part | denotes | mandible | http://purl.obolibrary.org/obo/UBERON_0001684|http://purl.obolibrary.org/obo/UBERON_0003278 |
| T25 | 1006-1013 | Body_part | denotes | maxilla | http://purl.obolibrary.org/obo/UBERON_0002397 |
| T26 | 1015-1024 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T27 | 1030-1053 | Body_part | denotes | mesencephalic ventricle | http://purl.obolibrary.org/obo/UBERON_0002289 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 479-483 | Body_part | denotes | stem | http://purl.obolibrary.org/obo/MAT_0000239 |
| T2 | 753-758 | Body_part | denotes | gland | http://purl.obolibrary.org/obo/MAT_0000021 |
| T3 | 760-766 | Body_part | denotes | testis | http://purl.obolibrary.org/obo/MAT_0000132 |
| T4 | 768-783 | Body_part | denotes | small intestine | http://purl.obolibrary.org/obo/MAT_0000047 |
| T5 | 785-790 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T6 | 826-831 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T7 | 833-838 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 840-846 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/MAT_0000085 |
| T9 | 848-852 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T10 | 854-861 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/MAT_0000051 |
| T11 | 863-869 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/MAT_0000292 |
| T12 | 875-881 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/MAT_0000127 |
| T13 | 914-921 | Body_part | denotes | embryos | http://purl.obolibrary.org/obo/MAT_0000226 |
| T14 | 1015-1024 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/MAT_0000043 |
| T15 | 1044-1053 | Body_part | denotes | ventricle | http://purl.obolibrary.org/obo/MAT_0000497 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. |
| T2 | 133-324 | Sentence | denotes | We have cloned, expressed and characterized the gene encoding a ninth member of the mammalian UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) family, termed ppGaNTase-T9. |
| T3 | 325-530 | Sentence | denotes | This type II membrane protein consists of a 9-amino acid N-terminal cytoplasmic region, a 20-amino acid hydrophobic/transmembrane region, a 94-amino acid stem region, and a 480-amino acid conserved region. |
| T4 | 531-669 | Sentence | denotes | Northern blot analysis revealed that the gene encoding this enzyme is expressed in a broadly distributed manner across many adult tissues. |
| T5 | 670-882 | Sentence | denotes | Significant levels of 5- and 4.2-kilobase transcripts were found in rat sublingual gland, testis, small intestine, colon, and ovary, with lesser amounts in heart, brain, spleen, lung, stomach, cervix, and uterus. |
| T6 | 883-1054 | Sentence | denotes | In situ hybridization to mouse embryos (embryonic day 14.5) revealed significant hybridization in the developing mandible, maxilla, intestine, and mesencephalic ventricle. |
| T7 | 1055-1269 | Sentence | denotes | Constructs expressing this gene transiently in COS7 cells resulted in no detectable transferase activity in vitro against a panel of unmodified peptides, including MUC5AC (GTTPSPVPTTSTTSAP) and EA2 (PTTDSTTPAPTTK). |
| T8 | 1270-1473 | Sentence | denotes | However, when incubated with MUC5AC and EA2 glycopeptides (obtained by the prior action of ppGaNTase-T1), additional incorporation of GalNAc was achieved, resulting in new hydroxyamino acid modification. |
| T9 | 1474-1708 | Sentence | denotes | The activity of this glycopeptide transferase is distinguished from that of ppGaNTase-T7 in that it forms a tetra-glycopeptide species from the MUC5AC tri-glycopeptide substrate, whereas ppGaNTase-T7 forms a hexa-glycopeptide species. |
| T10 | 1709-1914 | Sentence | denotes | This isoform thus represents the second example of a glycopeptide transferase and is distinct from the previously identified form in enzymatic activity as well as expression in embryonic and adult tissues. |
| T11 | 1915-2147 | Sentence | denotes | These findings lend further support to the existence of a hierarchical network of differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a role in the various processes governing development. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-132 | Sentence | denotes | Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. |
| T2 | 133-324 | Sentence | denotes | We have cloned, expressed and characterized the gene encoding a ninth member of the mammalian UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) family, termed ppGaNTase-T9. |
| T3 | 325-530 | Sentence | denotes | This type II membrane protein consists of a 9-amino acid N-terminal cytoplasmic region, a 20-amino acid hydrophobic/transmembrane region, a 94-amino acid stem region, and a 480-amino acid conserved region. |
| T4 | 531-669 | Sentence | denotes | Northern blot analysis revealed that the gene encoding this enzyme is expressed in a broadly distributed manner across many adult tissues. |
| T5 | 670-882 | Sentence | denotes | Significant levels of 5- and 4.2-kilobase transcripts were found in rat sublingual gland, testis, small intestine, colon, and ovary, with lesser amounts in heart, brain, spleen, lung, stomach, cervix, and uterus. |
| T6 | 883-1054 | Sentence | denotes | In situ hybridization to mouse embryos (embryonic day 14.5) revealed significant hybridization in the developing mandible, maxilla, intestine, and mesencephalic ventricle. |
| T7 | 1055-1269 | Sentence | denotes | Constructs expressing this gene transiently in COS7 cells resulted in no detectable transferase activity in vitro against a panel of unmodified peptides, including MUC5AC (GTTPSPVPTTSTTSAP) and EA2 (PTTDSTTPAPTTK). |
| T8 | 1270-1473 | Sentence | denotes | However, when incubated with MUC5AC and EA2 glycopeptides (obtained by the prior action of ppGaNTase-T1), additional incorporation of GalNAc was achieved, resulting in new hydroxyamino acid modification. |
| T9 | 1474-1708 | Sentence | denotes | The activity of this glycopeptide transferase is distinguished from that of ppGaNTase-T7 in that it forms a tetra-glycopeptide species from the MUC5AC tri-glycopeptide substrate, whereas ppGaNTase-T7 forms a hexa-glycopeptide species. |
| T10 | 1709-1914 | Sentence | denotes | This isoform thus represents the second example of a glycopeptide transferase and is distinct from the previously identified form in enzymatic activity as well as expression in embryonic and adult tissues. |
| T11 | 1915-2147 | Sentence | denotes | These findings lend further support to the existence of a hierarchical network of differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a role in the various processes governing development. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1404-1410 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 738-741 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 908-913 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 338-346 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T4 | 393-411 | Body_part | denotes | cytoplasmic region | http://purl.obolibrary.org/obo/GO_0099568 |
| T5 | 441-454 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T6 | 742-758 | Body_part | denotes | sublingual gland | http://purl.obolibrary.org/obo/UBERON_0001832 |
| T7 | 760-766 | Body_part | denotes | testis | http://purl.obolibrary.org/obo/UBERON_0000473 |
| T8 | 768-783 | Body_part | denotes | small intestine | http://purl.obolibrary.org/obo/UBERON_0002108 |
| T9 | 785-790 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T10 | 796-801 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T11 | 826-831 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T15 | 833-838 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T17 | 840-846 | Body_part | denotes | spleen | http://purl.obolibrary.org/obo/UBERON_0002106 |
| T18 | 848-852 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T19 | 854-861 | Body_part | denotes | stomach | http://purl.obolibrary.org/obo/UBERON_0000945 |
| T20 | 863-869 | Body_part | denotes | cervix | http://purl.obolibrary.org/obo/UBERON_0000002 |
| T21 | 875-881 | Body_part | denotes | uterus | http://purl.obolibrary.org/obo/UBERON_0000995|http://purl.obolibrary.org/obo/UBERON_0006834 |
| T23 | 996-1004 | Body_part | denotes | mandible | http://purl.obolibrary.org/obo/UBERON_0001684|http://purl.obolibrary.org/obo/UBERON_0003278 |
| T25 | 1006-1013 | Body_part | denotes | maxilla | http://purl.obolibrary.org/obo/UBERON_0002397 |
| T26 | 1015-1024 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T27 | 1030-1053 | Body_part | denotes | mesencephalic ventricle | http://purl.obolibrary.org/obo/UBERON_0002289 |