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PubMed:11278466 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 2-23 Cell denotes pancreatic beta -cell http://purl.obolibrary.org/obo/CL:0000169
T2 82-92 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182
T3 341-350 Cell denotes beta-cell http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T5 473-483 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T7 691-701 Cell denotes beta-cells http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T9 710-719 Cell denotes beta-cell http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639
T11 921-931 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182

sentences

Id Subject Object Predicate Lexical cue
T1 0-170 Sentence denotes A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors.
T2 171-243 Sentence denotes The PDX-1 transcription factor plays a key role in pancreas development.
T3 244-351 Sentence denotes Although expressed in all cells at the early stages, in the adult it is mainly restricted to the beta-cell.
T4 352-618 Sentence denotes To characterize the regulatory elements and potential transcription factors necessary for human PDX-1 gene expression in beta-cells, we constructed a series of 5' and 3' deletion fragments of the 5'-flanking region of the gene, fused to the luciferase reporter gene.
T5 619-794 Sentence denotes In this report, we identify by transient transfections in beta- and non-beta-cells a novel beta-cell-specific distal enhancer element located between -3.7 and -3.45 kilobases.
T6 795-980 Sentence denotes DNase I footprinting analysis revealed two protected regions, one binding the transcription factors SP1 and SP3 and the other hepatocyte nuclear factor 3beta (HNF-3beta) and HNF-1alpha.
T7 981-1129 Sentence denotes Cotransfection experiments suggest that HNF-3beta, HNF-1alpha, and SP1 are positive regulators of the herein-described human PDX-1 enhancer element.
T8 1130-1330 Sentence denotes Furthermore, mutations within each motif abolished the binding of the corresponding factor(s) and dramatically impaired the enhancer activity, therefore suggesting cooperativity between these factors.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 222-230 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas

AnEM_abstracts

Id Subject Object Predicate Lexical cue
T1 2-23 Cell denotes pancreatic beta -cell
T2 222-230 Organ denotes pancreas
T3 270-275 Cell denotes cells
T4 341-350 Cell denotes beta-cell
T5 473-483 Cell denotes beta-cells
T6 677-682 Cell denotes beta-
T7 687-701 Cell denotes non-beta-cells
T8 710-719 Cell denotes beta-cell

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 222-230 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 49-54 OrganismTaxon denotes human 9606
T2 442-447 OrganismTaxon denotes human 9606
T3 1100-1105 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2-23 Body_part denotes pancreatic beta -cell http://purl.obolibrary.org/obo/CL_0000169
T2 82-92 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182
T3 222-230 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T5 341-350 Body_part denotes beta-cell http://purl.obolibrary.org/obo/CL_0000169
T6 710-719 Body_part denotes beta-cell http://purl.obolibrary.org/obo/CL_0000169
T7 921-931 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 222-230 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075