PubMed:11278270
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-143 | Sentence | denotes | Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. |
| T2 | 144-419 | Sentence | denotes | Peroxisome proliferator-activated receptor-gamma (PPARgamma) has been shown to play an important role in the regulation of expression of a subclass of adipocyte genes and to serve as the molecular target of the thiazolidinedione (TZD) and certain non-TZD antidiabetic agents. |
| T3 | 420-579 | Sentence | denotes | Hypercorticosteroidism leads to insulin resistance, a variety of metabolic dysfunctions typically seen in diabetes, and hypertrophy of visceral adipose tissue. |
| T4 | 580-831 | Sentence | denotes | In adipocytes, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) converts inactive cortisone into the active glucocorticoid cortisol and thereby plays an important role in regulating the actions of corticosteroids in adipose tissue. |
| T5 | 832-958 | Sentence | denotes | Here, we show that both TZD and non-TZD PPARgamma agonists markedly reduced 11beta-HSD-1 gene expression in 3T3-L1 adipocytes. |
| T6 | 959-1080 | Sentence | denotes | This diminution correlated with a significant decrease in the ability of the adipocytes to convert cortisone to cortisol. |
| T7 | 1081-1357 | Sentence | denotes | The half-maximal inhibition of 11beta-HSD-1 mRNA expression by the TZD, rosiglitazone, occurred at a concentration that was similar to its K(d) for binding PPARgamma and EC(50) for inducing adipocyte differentiation thereby indicating that this action was PPARgamma-dependent. |
| T8 | 1358-1568 | Sentence | denotes | The time required for the inhibitory action of the TZD was markedly greater for 11beta-HSD-1 gene expression than for leptin, suggesting that these genes may be down-regulated by different molecular mechanisms. |
| T9 | 1569-1923 | Sentence | denotes | Furthermore, whereas regulation of PPARgamma-inducible genes such as phosphoenolpyruvate carboxykinase was maintained when cellular protein synthesis was abrogated, PPARgamma agonist inhibition of 11beta-HSD-1 and leptin gene expression was ablated, thereby supporting the conclusion that PPARgamma affects the down-regulation of 11beta-HSD-1 indirectly. |
| T10 | 1924-2040 | Sentence | denotes | Finally, treatment of diabetic db/db mice with rosiglitazone inhibited expression of 11beta-HSD-1 in adipose tissue. |
| T11 | 2041-2146 | Sentence | denotes | This decrease in enzyme expression correlated with a significant decline in plasma corticosterone levels. |
| T12 | 2147-2344 | Sentence | denotes | In sum, these data indicate that some of the beneficial effects of PPARgamma antidiabetic agents may result, at least in part, from the down-regulation of 11beta-HSD-1 expression in adipose tissue. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 564-578 | http://purl.obolibrary.org/obo/MAT_0000015 | denotes | adipose tissue |
| T2 | 816-830 | http://purl.obolibrary.org/obo/MAT_0000015 | denotes | adipose tissue |
| T3 | 2025-2039 | http://purl.obolibrary.org/obo/MAT_0000015 | denotes | adipose tissue |
| T4 | 2329-2343 | http://purl.obolibrary.org/obo/MAT_0000015 | denotes | adipose tissue |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 580-831 | cat(p(MGI:Hsd11b1)) directlyIncreases rxn(reactants(a(CHEBI:cortisone)),products(a(CHEBI:cortisol))) | denotes | In adipocytes, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) converts inactive cortisone into the active glucocorticoid cortisol and thereby plays an important role in regulating the actions of corticosteroids in adipose tissue. |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000288 | 580-831 | cat(p(MGI:Hsd11b1)) directlyIncreases rxn(reactants(a(CHEBI:cortisone)),products(a(CHEBI:cortisol))) | denotes | In adipocytes, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) converts inactive cortisone into the active glucocorticoid cortisol and thereby plays an important role in regulating the actions of corticosteroids in adipose tissue. |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 452-470 | Phenotype | denotes | insulin resistance | HP:0000855 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 526-534 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 1961-1965 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 65-74 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T2 | 295-304 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T3 | 555-578 | Body_part | denotes | visceral adipose tissue | http://purl.obolibrary.org/obo/UBERON_0014454 |
| T4 | 583-593 | Body_part | denotes | adipocytes | http://purl.obolibrary.org/obo/CL_0000136 |
| T5 | 816-830 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T6 | 947-957 | Body_part | denotes | adipocytes | http://purl.obolibrary.org/obo/CL_0000136 |
| T7 | 1036-1046 | Body_part | denotes | adipocytes | http://purl.obolibrary.org/obo/CL_0000136 |
| T8 | 1271-1280 | Body_part | denotes | adipocyte | http://purl.obolibrary.org/obo/CL_0000136 |
| T9 | 2025-2039 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T10 | 2117-2123 | Body_part | denotes | plasma | http://purl.obolibrary.org/obo/UBERON_0001969 |
| T11 | 2329-2343 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 564-578 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/MAT_0000015 |
| T2 | 816-830 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/MAT_0000015 |
| T3 | 2025-2039 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/MAT_0000015 |
| T4 | 2329-2343 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/MAT_0000015 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 65-74 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |
| T2 | 295-304 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |
| T3 | 583-593 | Cell | denotes | adipocytes | http://purl.obolibrary.org/obo/CL:0000136 |
| T4 | 947-957 | Cell | denotes | adipocytes | http://purl.obolibrary.org/obo/CL:0000136 |
| T5 | 1036-1046 | Cell | denotes | adipocytes | http://purl.obolibrary.org/obo/CL:0000136 |
| T6 | 1271-1280 | Cell | denotes | adipocyte | http://purl.obolibrary.org/obo/CL:0000136 |