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PubMed:11261840 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
TextSentencer_T2 133-263 Sentence denotes The modulation of GnT-V activity by signaling molecules in PI-3-K/PKB pathway in human hepatocarcinoma cell line 7721 was studied.
TextSentencer_T3 264-491 Sentence denotes GnT-V activity was determined after the transfection of sense or antisense cDNA of PKB into the cells, as well as the addition of activators, specific inhibitors, and the antibodies to the enzyme assay system or culture medium.
TextSentencer_T4 492-644 Sentence denotes It was found that the basal activity of GnT-V was up regulated by the sense and down regulated by the antisense cDNA of PKB transfected into 7721 cells.
TextSentencer_T5 645-882 Sentence denotes GnT-V was activated by PIP2, PIP3 or GTPgamma[S] added to the assay system, and the activation of PIP2 or GTPgamma[S] was abolished by LY2940002, a specific inhibitor of PI-3-K, but the activation of PIP3 was not attenuated by LY2940002.
TextSentencer_T6 883-1011 Sentence denotes In addition, GnT-V activity in cultured parental or H-ras transfected cells was inhibited by the antibody against PKB or PI-3-K.
TextSentencer_T7 1012-1115 Sentence denotes These findings demonstrated the involvement of PI-3-K/PKB signaling pathway in the regulation of GnT-V.
TextSentencer_T8 1116-1348 Sentence denotes Moreover, ET18-OCH3, an inhibitor of Raf translocation and PI-PLC enzyme, which produces the activator of PKC, as well as the antibodies against Raf-1 or MEK also inhibited GnT-V activity in the parental and H-ras transfected cells.
TextSentencer_T9 1349-1448 Sentence denotes The inhibitory rates, however, were less in the transfected cells than those in the parental cells.
TextSentencer_T10 1449-1645 Sentence denotes These results reveal that in parental and H-ras transfected 7721 cells, the basal activity of GnT-V is also regulated by the Ras/Raf-1/MEK/MAPK cascade in addition to PI-3-K/PKB signaling pathway.
TextSentencer_T11 1646-1857 Sentence denotes The significance of these two pathways in the regulation of GnT-V and their relations to the activation of PKC previously reported by our laboratory (Ju TZ et al., 1995 Glyconjugate J 12, 767-772) was discussed.
T1 0-132 Sentence denotes Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
T2 133-263 Sentence denotes The modulation of GnT-V activity by signaling molecules in PI-3-K/PKB pathway in human hepatocarcinoma cell line 7721 was studied.
T3 264-491 Sentence denotes GnT-V activity was determined after the transfection of sense or antisense cDNA of PKB into the cells, as well as the addition of activators, specific inhibitors, and the antibodies to the enzyme assay system or culture medium.
T4 492-644 Sentence denotes It was found that the basal activity of GnT-V was up regulated by the sense and down regulated by the antisense cDNA of PKB transfected into 7721 cells.
T5 645-882 Sentence denotes GnT-V was activated by PIP2, PIP3 or GTPgamma[S] added to the assay system, and the activation of PIP2 or GTPgamma[S] was abolished by LY2940002, a specific inhibitor of PI-3-K, but the activation of PIP3 was not attenuated by LY2940002.
T6 883-1011 Sentence denotes In addition, GnT-V activity in cultured parental or H-ras transfected cells was inhibited by the antibody against PKB or PI-3-K.
T7 1012-1115 Sentence denotes These findings demonstrated the involvement of PI-3-K/PKB signaling pathway in the regulation of GnT-V.
T8 1116-1348 Sentence denotes Moreover, ET18-OCH3, an inhibitor of Raf translocation and PI-PLC enzyme, which produces the activator of PKC, as well as the antibodies against Raf-1 or MEK also inhibited GnT-V activity in the parental and H-ras transfected cells.
T9 1349-1448 Sentence denotes The inhibitory rates, however, were less in the transfected cells than those in the parental cells.
T10 1449-1645 Sentence denotes These results reveal that in parental and H-ras transfected 7721 cells, the basal activity of GnT-V is also regulated by the Ras/Raf-1/MEK/MAPK cascade in addition to PI-3-K/PKB signaling pathway.
T11 1646-1857 Sentence denotes The significance of these two pathways in the regulation of GnT-V and their relations to the activation of PKC previously reported by our laboratory (Ju TZ et al., 1995 Glyconjugate J 12, 767-772) was discussed.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 151-156 gene:4249 denotes GnT-V
T1 220-235 disease:C2239176 denotes hepatocarcinoma
T2 199-202 gene:2185 denotes PKB
T3 220-235 disease:C2239176 denotes hepatocarcinoma
T4 199-202 gene:207 denotes PKB
T5 220-235 disease:C2239176 denotes hepatocarcinoma
R1 T0 T1 associated_with GnT-V,hepatocarcinoma
R2 T2 T3 associated_with PKB,hepatocarcinoma
R3 T4 T5 associated_with PKB,hepatocarcinoma

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 104-109 OrganismTaxon denotes human 9606
T2 214-219 OrganismTaxon denotes human 9606

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 18-23 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T2 514-519 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T3 1525-1530 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324