PubMed:11247751 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/11247751","sourcedb":"PubMed","sourceid":"11247751","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/11247751","text":"Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection: the signaling module hypothesis.\nThe characterization of biological processes on the basis of alterations in the cellular proteins, or \"proteomic\" analysis, is a powerful approach that may be adopted to decipher the signaling mechanisms that underlie various pathophysiological conditions, such as ischemic heart disease. This review represents a prospectus for the implementation of proteomic analyses to delineate the myocardial intracellular signaling events that evoke cardioprotection against ischemic injury. In concert with this, the manifestation of a protective phenotype has recently been shown to involve dynamic modulation of protein kinase C-epsilon (PKC epsilon) signaling complexes (Ping P, Zhang J, Pierce WM Jr, and Bolli R. Circ Res 88: 59--62, 2001). Accordingly, \"the signaling module hypothesis\" is formulated as a plausible mechanism by which multipurpose stress-activated proteins and signaling kinases may function collectively to facilitate the genesis of cardioprotection.","tracks":[]}