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PubMed:11243852 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-164 Sentence denotes Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells.
TextSentencer_T2 165-272 Sentence denotes Monocyte adhesion to the endothelium via adhesion molecules is one of the earliest events in atherogenesis.
TextSentencer_T3 273-422 Sentence denotes It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) plays a very important role in the recruitment of monocytes in atherosclerosis.
TextSentencer_T4 423-591 Sentence denotes The aim of our study was to evaluate whether hematein can influence the expression of VCAM-1 and the transcription of nuclear factor-kappaB (NF-kappaB)-dependent genes.
TextSentencer_T5 592-730 Sentence denotes Immunohistochemistry revealed that mouse aortic artery endothelial cells express VCAM-1 after feeding a high cholesterol diet for 8 weeks.
TextSentencer_T6 731-864 Sentence denotes Hematein dose dependently suppressed TNF-alpha-induced VCAM-1 in both surface (30.8%) and soluble protein (65%) production in HUVECs.
TextSentencer_T7 865-1037 Sentence denotes The transcription level of VCAM-1 was measured by Northern blot analysis, and decreased VCAM-1 protein expression was associated with a reduction of VCAM-1 mRNA expression.
TextSentencer_T8 1038-1261 Sentence denotes Transient transfection study of NF-kappaB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-kappaB-dependent gene expression and NF-kappaB activation induced by TNF-alpha.
TextSentencer_T9 1262-1416 Sentence denotes Our results suggest that the down-regulation of VCAM-1 expression by hematein may in part be due to the inhibition of NF-kappaB-dependent gene expression.
T1 0-164 Sentence denotes Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells.
T2 165-272 Sentence denotes Monocyte adhesion to the endothelium via adhesion molecules is one of the earliest events in atherogenesis.
T3 273-422 Sentence denotes It has been suggested that vascular cell adhesion molecule-1 (VCAM-1) plays a very important role in the recruitment of monocytes in atherosclerosis.
T4 423-591 Sentence denotes The aim of our study was to evaluate whether hematein can influence the expression of VCAM-1 and the transcription of nuclear factor-kappaB (NF-kappaB)-dependent genes.
T5 592-730 Sentence denotes Immunohistochemistry revealed that mouse aortic artery endothelial cells express VCAM-1 after feeding a high cholesterol diet for 8 weeks.
T6 731-864 Sentence denotes Hematein dose dependently suppressed TNF-alpha-induced VCAM-1 in both surface (30.8%) and soluble protein (65%) production in HUVECs.
T7 865-1037 Sentence denotes The transcription level of VCAM-1 was measured by Northern blot analysis, and decreased VCAM-1 protein expression was associated with a reduction of VCAM-1 mRNA expression.
T8 1038-1261 Sentence denotes Transient transfection study of NF-kappaB promoter construct and electrophoretic mobility shift assay suggested that hematein inhibited both NF-kappaB-dependent gene expression and NF-kappaB activation induced by TNF-alpha.
T9 1262-1416 Sentence denotes Our results suggest that the down-regulation of VCAM-1 expression by hematein may in part be due to the inhibition of NF-kappaB-dependent gene expression.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11243852-2#27#60#gene7412 300-333 gene7412 denotes vascular cell adhesion molecule-1
11243852-2#62#68#gene7412 335-341 gene7412 denotes VCAM-1
11243852-2#133#148#diseaseC0004153 406-421 diseaseC0004153 denotes atherosclerosis
11243852-4#81#87#gene7412 673-679 gene7412 denotes VCAM-1
11243852-4#104#120#diseaseC0020443 696-712 diseaseC0020443 denotes high cholesterol
27#60#gene7412133#148#diseaseC0004153 11243852-2#27#60#gene7412 11243852-2#133#148#diseaseC0004153 associated_with vascular cell adhesion molecule-1,atherosclerosis
62#68#gene7412133#148#diseaseC0004153 11243852-2#62#68#gene7412 11243852-2#133#148#diseaseC0004153 associated_with VCAM-1,atherosclerosis
81#87#gene7412104#120#diseaseC0020443 11243852-4#81#87#gene7412 11243852-4#104#120#diseaseC0020443 associated_with VCAM-1,high cholesterol

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 640-646 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
PD-UBERON-AE-B_T2 190-201 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T48 300-333 gene:7412 denotes vascular cell adhesion molecule-1
T49 406-421 disease:C0004153 denotes atherosclerosis
T50 335-341 gene:7412 denotes VCAM-1
R1 T48 T49 associated_with vascular cell adhesion molecule-1,atherosclerosis
R2 T50 T49 associated_with VCAM-1,atherosclerosis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 190-201 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
PD-UBERON-AE-B_T2 640-646 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery

DisGeNET

Id Subject Object Predicate Lexical cue
T0 300-333 gene:7412 denotes vascular cell adhesion molecule-1
T1 406-421 disease:C0003850 denotes atherosclerosis
T2 300-333 gene:7412 denotes vascular cell adhesion molecule-1
T3 406-421 disease:C0004153 denotes atherosclerosis
T4 335-341 gene:7412 denotes VCAM-1
T5 406-421 disease:C0003850 denotes atherosclerosis
T6 335-341 gene:7412 denotes VCAM-1
T7 406-421 disease:C0004153 denotes atherosclerosis
R1 T0 T1 associated_with vascular cell adhesion molecule-1,atherosclerosis
R2 T2 T3 associated_with vascular cell adhesion molecule-1,atherosclerosis
R3 T4 T5 associated_with VCAM-1,atherosclerosis
R4 T6 T7 associated_with VCAM-1,atherosclerosis