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c_corpus

Id Subject Object Predicate Lexical cue
T1 24-30 UBERON:0027368 denotes matrix
T2 24-49 D020782 denotes matrix metalloproteinases
T4 53-71 D015427 denotes reperfusion injury
T5 53-71 D015427 denotes reperfusion injury
T6 72-78 PR:P21643 denotes to rat
T7 75-78 10116 denotes rat
T11 75-78 D051381 denotes rat
T12 79-84 UBERON:6110636 denotes brain
T13 79-84 UBERON:0000955 denotes brain
T14 100-103 CHEBI:340824 denotes MMP
T17 100-103 CHEBI:59761 denotes MMP
T18 100-105 PR:P50282 denotes MMP-9
T19 100-105 PR:P14780 denotes MMP-9
T20 100-105 P14780 denotes MMP-9
T21 100-105 PR:P41245 denotes MMP-9
T22 100-105 P41246 denotes MMP-9
T23 100-105 P41245 denotes MMP-9
T24 100-105 PR:P52176 denotes MMP-9
T25 100-105 P50282 denotes MMP-9
T27 100-105 PR:000010491 denotes MMP-9
T28 100-105 P52176 denotes MMP-9
T29 100-105 O18733 denotes MMP-9
T26 100-105 GO:0004229 denotes MMP-9
T31 116-127 GO:0004248 denotes stromelysin
T33 116-129 P28863 denotes stromelysin-1
T34 116-129 P08254 denotes stromelysin-1
T35 116-129 Q28397 denotes stromelysin-1
T36 116-129 Q6Y4Q5 denotes stromelysin-1
T37 116-129 P28862 denotes stromelysin-1
T38 116-129 PR:000010488 denotes stromelysin-1
T39 116-129 P03957 denotes stromelysin-1
T32 116-129 D019278 denotes stromelysin-1
T40 134-143 CL:0000129 denotes microglia
T41 186-205 UBERON:0000120 denotes blood-brain barrier
T44 207-210 UBERON:0000120 denotes BBB
T45 213-238 D020782 denotes Matrix metalloproteinases
T47 240-244 D020782 denotes MMPs
T48 270-277 UBERON:0004111 denotes opening
T49 285-288 UBERON:0000120 denotes BBB
T50 300-321 GO:0051641 denotes cellular localization
T52 409-430 GO:0051641 denotes cellular localization
T54 438-442 D020782 denotes MMPs
T56 457-460 PR:P63003-1 denotes rat
T57 457-460 PR:Q2G0B1 denotes rat
T58 457-460 PR:Q8VHJ4 denotes rat
T55 457-460 10116 denotes rat
T59 457-460 D051381 denotes rat
T60 461-466 UBERON:6110636 denotes brain
T61 461-466 UBERON:0000955 denotes brain
T62 513-544 D011918 denotes Spontaneously hypertensive rats
T66 540-549 D011918 denotes rats (SHR
T67 546-549 PR:Q9SZF7 denotes SHR
T68 560-563 CVCL_E777 denotes min
T69 564-586 UBERON:0001627 denotes middle cerebral artery
T70 564-596 D020244 denotes middle cerebral artery occlusion
T71 564-596 D020244 denotes middle cerebral artery occlusion
T76 699-709 D000906 denotes antibodies
T79 713-725 P08253 denotes gelatinase A
T80 713-725 Q90611 denotes gelatinase A
T82 713-725 PR:000010479 denotes gelatinase A
T83 713-725 P33436 denotes gelatinase A
T84 713-725 P33434 denotes gelatinase A
T85 713-725 P50757 denotes gelatinase A
T81 713-725 D020778 denotes gelatinase A
T86 727-730 CHEBI:340824 denotes MMP
T89 727-730 CHEBI:59761 denotes MMP
T90 727-732 PR:P08253 denotes MMP-2
T91 727-732 Q9GLE5 denotes MMP-2
T92 727-732 P08253 denotes MMP-2
T93 727-732 Q90611 denotes MMP-2
T95 727-732 PR:Q8MPP3 denotes MMP-2
T96 727-732 P33436 denotes MMP-2
T97 727-732 PR:Q90611 denotes MMP-2
T98 727-732 PR:P33436 denotes MMP-2
T99 727-732 PR:000010479 denotes MMP-2
T100 727-732 PR:P33434 denotes MMP-2
T101 727-732 P33434 denotes MMP-2
T102 727-732 P50757 denotes MMP-2
T94 727-732 GO:0004228 denotes MMP-2
T104 735-746 GO:0004248 denotes stromelysin
T106 735-748 P28863 denotes stromelysin-1
T107 735-748 P08254 denotes stromelysin-1
T108 735-748 Q28397 denotes stromelysin-1
T109 735-748 Q6Y4Q5 denotes stromelysin-1
T110 735-748 P28862 denotes stromelysin-1
T111 735-748 PR:000010488 denotes stromelysin-1
T112 735-748 P03957 denotes stromelysin-1
T105 735-748 D019278 denotes stromelysin-1
T113 747-753 PR:O23507 denotes 1 (MMP
T114 750-753 CHEBI:340824 denotes MMP
T117 750-753 CHEBI:59761 denotes MMP
T118 750-755 P28863 denotes MMP-3
T119 750-755 P08254 denotes MMP-3
T120 750-755 Q28397 denotes MMP-3
T121 750-755 PR:P08254 denotes MMP-3
T122 750-755 PR:P03957 denotes MMP-3
T123 750-755 Q6Y4Q5 denotes MMP-3
T124 750-755 P28862 denotes MMP-3
T126 750-755 PR:000010488 denotes MMP-3
T127 750-755 PR:P28862 denotes MMP-3
T128 750-755 P03957 denotes MMP-3
T125 750-755 GO:0004248 denotes MMP-3
T132 762-774 P14780 denotes gelatinase B
T133 762-774 P41246 denotes gelatinase B
T134 762-774 P41245 denotes gelatinase B
T135 762-774 P50282 denotes gelatinase B
T136 762-774 PR:000010491 denotes gelatinase B
T137 762-774 P52176 denotes gelatinase B
T138 762-774 O18733 denotes gelatinase B
T131 762-774 D020780 denotes gelatinase B
T139 776-779 CHEBI:340824 denotes MMP
T142 776-779 CHEBI:59761 denotes MMP
T143 776-781 PR:P50282 denotes MMP-9
T144 776-781 PR:P14780 denotes MMP-9
T145 776-781 P14780 denotes MMP-9
T146 776-781 PR:P41245 denotes MMP-9
T147 776-781 P41246 denotes MMP-9
T148 776-781 P41245 denotes MMP-9
T149 776-781 PR:P52176 denotes MMP-9
T150 776-781 P50282 denotes MMP-9
T152 776-781 PR:000010491 denotes MMP-9
T153 776-781 P52176 denotes MMP-9
T154 776-781 O18733 denotes MMP-9
T151 776-781 GO:0004229 denotes MMP-9
T155 784-788 C005703 denotes Sham
T156 784-788 C005703 denotes Sham
T157 784-788 CHEBI:45615 denotes Sham
T158 806-810 10118 denotes rats
T159 806-810 10116 denotes rats
T160 806-810 D051381 denotes rats
T161 818-821 CHEBI:340824 denotes MMP
T164 818-821 CHEBI:59761 denotes MMP
T165 818-823 PR:P08253 denotes MMP-2
T166 818-823 Q9GLE5 denotes MMP-2
T167 818-823 P08253 denotes MMP-2
T168 818-823 Q90611 denotes MMP-2
T170 818-823 PR:Q8MPP3 denotes MMP-2
T171 818-823 P33436 denotes MMP-2
T172 818-823 PR:Q90611 denotes MMP-2
T173 818-823 PR:P33436 denotes MMP-2
T174 818-823 PR:000010479 denotes MMP-2
T175 818-823 PR:P33434 denotes MMP-2
T176 818-823 P33434 denotes MMP-2
T177 818-823 P50757 denotes MMP-2
T169 818-823 GO:0004228 denotes MMP-2
T178 853-862 UBERON:0004529 denotes processes
T179 871-884 UBERON:0004537 denotes blood vessels
T180 924-927 CHEBI:340824 denotes MMP
T183 924-927 CHEBI:59761 denotes MMP
T184 924-929 PR:P08253 denotes MMP-2
T185 924-929 Q9GLE5 denotes MMP-2
T186 924-929 P08253 denotes MMP-2
T187 924-929 Q90611 denotes MMP-2
T189 924-929 PR:Q8MPP3 denotes MMP-2
T190 924-929 P33436 denotes MMP-2
T191 924-929 PR:Q90611 denotes MMP-2
T192 924-929 PR:P33436 denotes MMP-2
T193 924-929 PR:000010479 denotes MMP-2
T194 924-929 PR:P33434 denotes MMP-2
T195 924-929 P33434 denotes MMP-2
T196 924-929 P50757 denotes MMP-2
T188 924-929 GO:0004228 denotes MMP-2
T198 973-977 CVCL_8262 denotes 24 h
T199 999-1002 CHEBI:340824 denotes MMP
T202 999-1002 CHEBI:59761 denotes MMP
T203 999-1004 P28863 denotes MMP-3
T204 999-1004 P08254 denotes MMP-3
T205 999-1004 Q28397 denotes MMP-3
T206 999-1004 PR:P08254 denotes MMP-3
T207 999-1004 PR:P03957 denotes MMP-3
T208 999-1004 Q6Y4Q5 denotes MMP-3
T209 999-1004 P28862 denotes MMP-3
T211 999-1004 PR:000010488 denotes MMP-3
T212 999-1004 PR:P28862 denotes MMP-3
T213 999-1004 P03957 denotes MMP-3
T210 999-1004 GO:0004248 denotes MMP-3
T214 1009-1012 CHEBI:340824 denotes MMP
T217 1009-1012 CHEBI:59761 denotes MMP
T218 1009-1014 PR:P50282 denotes MMP-9
T219 1009-1014 PR:P14780 denotes MMP-9
T220 1009-1014 P14780 denotes MMP-9
T221 1009-1014 PR:P41245 denotes MMP-9
T222 1009-1014 P41246 denotes MMP-9
T223 1009-1014 P41245 denotes MMP-9
T224 1009-1014 PR:P52176 denotes MMP-9
T225 1009-1014 P50282 denotes MMP-9
T227 1009-1014 PR:000010491 denotes MMP-9
T228 1009-1014 P52176 denotes MMP-9
T229 1009-1014 O18733 denotes MMP-9
T226 1009-1014 GO:0004229 denotes MMP-9
T230 1025-1028 CHEBI:340824 denotes MMP
T233 1025-1028 CHEBI:59761 denotes MMP
T234 1025-1030 P28863 denotes MMP-3
T235 1025-1030 P08254 denotes MMP-3
T236 1025-1030 Q28397 denotes MMP-3
T237 1025-1030 PR:P08254 denotes MMP-3
T238 1025-1030 PR:P03957 denotes MMP-3
T239 1025-1030 Q6Y4Q5 denotes MMP-3
T240 1025-1030 P28862 denotes MMP-3
T242 1025-1030 PR:000010488 denotes MMP-3
T243 1025-1030 PR:P28862 denotes MMP-3
T244 1025-1030 P03957 denotes MMP-3
T241 1025-1030 GO:0004248 denotes MMP-3
T245 1049-1068 CL:0002629 denotes activated microglia
T247 1070-1075 CVCL_J194 denotes Ox-42
T248 1108-1111 CHEBI:340824 denotes MMP
T251 1108-1111 CHEBI:59761 denotes MMP
T252 1108-1113 PR:P50282 denotes MMP-9
T253 1108-1113 PR:P14780 denotes MMP-9
T254 1108-1113 P14780 denotes MMP-9
T255 1108-1113 PR:P41245 denotes MMP-9
T256 1108-1113 P41246 denotes MMP-9
T257 1108-1113 P41245 denotes MMP-9
T258 1108-1113 PR:P52176 denotes MMP-9
T259 1108-1113 P50282 denotes MMP-9
T261 1108-1113 PR:000010491 denotes MMP-9
T262 1108-1113 P52176 denotes MMP-9
T263 1108-1113 O18733 denotes MMP-9
T260 1108-1113 GO:0004229 denotes MMP-9
T264 1144-1148 CHEBI:13359 denotes h in
T269 1219-1222 CHEBI:340824 denotes MMP
T272 1219-1222 CHEBI:59761 denotes MMP
T273 1219-1224 PR:P08253 denotes MMP-2
T274 1219-1224 Q9GLE5 denotes MMP-2
T275 1219-1224 P08253 denotes MMP-2
T276 1219-1224 Q90611 denotes MMP-2
T278 1219-1224 PR:Q8MPP3 denotes MMP-2
T279 1219-1224 P33436 denotes MMP-2
T280 1219-1224 PR:Q90611 denotes MMP-2
T281 1219-1224 PR:P33436 denotes MMP-2
T282 1219-1224 PR:000010479 denotes MMP-2
T283 1219-1224 PR:P33434 denotes MMP-2
T284 1219-1224 P33434 denotes MMP-2
T285 1219-1224 P50757 denotes MMP-2
T277 1219-1224 GO:0004228 denotes MMP-2
T286 1286-1290 GO:0019013 denotes core
T289 1321-1324 PR:O04529 denotes MMP
T287 1321-1324 CHEBI:340824 denotes MMP
T290 1321-1324 CHEBI:59761 denotes MMP
T288 1321-1324 GO:0004235 denotes MMP
T291 1338-1356 CHEBI:89981 denotes lipopolysaccharide
T292 1338-1356 CHEBI:16412 denotes lipopolysaccharide
T294 1358-1361 PR:Q9QUK6 denotes LPS
T296 1358-1361 PR:000001155 denotes LPS
T293 1358-1361 CHEBI:89981 denotes LPS
T297 1358-1361 CHEBI:52603 denotes LPS
T298 1358-1361 CHEBI:16412 denotes LPS
T295 1358-1361 C536528 denotes LPS
T299 1374-1383 CL:0000127 denotes astrocyte
T300 1388-1397 CL:0000129 denotes microglia
T301 1460-1463 CHEBI:340824 denotes MMP
T304 1460-1463 CHEBI:59761 denotes MMP
T305 1460-1465 PR:P08253 denotes MMP-2
T306 1460-1465 Q9GLE5 denotes MMP-2
T307 1460-1465 P08253 denotes MMP-2
T308 1460-1465 Q90611 denotes MMP-2
T310 1460-1465 PR:Q8MPP3 denotes MMP-2
T311 1460-1465 P33436 denotes MMP-2
T312 1460-1465 PR:Q90611 denotes MMP-2
T313 1460-1465 PR:P33436 denotes MMP-2
T314 1460-1465 PR:000010479 denotes MMP-2
T315 1460-1465 PR:P33434 denotes MMP-2
T316 1460-1465 P33434 denotes MMP-2
T317 1460-1465 P50757 denotes MMP-2
T309 1460-1465 GO:0004228 denotes MMP-2
T318 1472-1481 CL:0000129 denotes microglia
T319 1514-1517 CHEBI:340824 denotes MMP
T322 1514-1517 CHEBI:59761 denotes MMP
T323 1514-1519 PR:P50282 denotes MMP-9
T324 1514-1519 PR:P14780 denotes MMP-9
T325 1514-1519 P14780 denotes MMP-9
T326 1514-1519 PR:P41245 denotes MMP-9
T327 1514-1519 P41246 denotes MMP-9
T328 1514-1519 P41245 denotes MMP-9
T329 1514-1519 PR:P52176 denotes MMP-9
T330 1514-1519 P50282 denotes MMP-9
T332 1514-1519 PR:000010491 denotes MMP-9
T333 1514-1519 P52176 denotes MMP-9
T334 1514-1519 O18733 denotes MMP-9
T331 1514-1519 GO:0004229 denotes MMP-9
T335 1543-1546 CHEBI:340824 denotes MMP
T338 1543-1546 CHEBI:59761 denotes MMP
T339 1543-1548 P28863 denotes MMP-3
T340 1543-1548 P08254 denotes MMP-3
T341 1543-1548 Q28397 denotes MMP-3
T342 1543-1548 PR:P08254 denotes MMP-3
T343 1543-1548 PR:P03957 denotes MMP-3
T344 1543-1548 Q6Y4Q5 denotes MMP-3
T345 1543-1548 P28862 denotes MMP-3
T347 1543-1548 PR:000010488 denotes MMP-3
T348 1543-1548 PR:P28862 denotes MMP-3
T349 1543-1548 P03957 denotes MMP-3
T346 1543-1548 GO:0004248 denotes MMP-3
T352 1613-1616 PR:O04529 denotes MMP
T350 1613-1616 CHEBI:340824 denotes MMP
T353 1613-1616 CHEBI:59761 denotes MMP
T351 1613-1616 GO:0004235 denotes MMP
T354 1617-1626 CHEBI:35222 denotes inhibitor
T355 1628-1635 C101468 denotes BB-1101
T356 1628-1635 C101468 denotes BB-1101
T357 1663-1666 CHEBI:340824 denotes MMP
T360 1663-1666 CHEBI:59761 denotes MMP
T361 1663-1668 PR:P08253 denotes MMP-2
T362 1663-1668 Q9GLE5 denotes MMP-2
T363 1663-1668 P08253 denotes MMP-2
T364 1663-1668 Q90611 denotes MMP-2
T366 1663-1668 PR:Q8MPP3 denotes MMP-2
T367 1663-1668 P33436 denotes MMP-2
T368 1663-1668 PR:Q90611 denotes MMP-2
T369 1663-1668 PR:P33436 denotes MMP-2
T370 1663-1668 PR:000010479 denotes MMP-2
T371 1663-1668 PR:P33434 denotes MMP-2
T372 1663-1668 P33434 denotes MMP-2
T373 1663-1668 P50757 denotes MMP-2
T365 1663-1668 GO:0004228 denotes MMP-2
T374 1673-1676 CHEBI:340824 denotes MMP
T377 1673-1676 CHEBI:59761 denotes MMP
T378 1673-1678 PR:P50282 denotes MMP-9
T379 1673-1678 PR:P14780 denotes MMP-9
T380 1673-1678 P14780 denotes MMP-9
T381 1673-1678 PR:P41245 denotes MMP-9
T382 1673-1678 P41246 denotes MMP-9
T383 1673-1678 P41245 denotes MMP-9
T384 1673-1678 PR:P52176 denotes MMP-9
T385 1673-1678 P50282 denotes MMP-9
T387 1673-1678 PR:000010491 denotes MMP-9
T388 1673-1678 P52176 denotes MMP-9
T389 1673-1678 O18733 denotes MMP-9
T386 1673-1678 GO:0004229 denotes MMP-9
T391 1682-1685 PR:Q9QUK6 denotes LPS
T393 1682-1685 PR:000001155 denotes LPS
T390 1682-1685 CHEBI:89981 denotes LPS
T394 1682-1685 CHEBI:52603 denotes LPS
T395 1682-1685 CHEBI:16412 denotes LPS
T392 1682-1685 C536528 denotes LPS
T396 1727-1730 CHEBI:340824 denotes MMP
T399 1727-1730 CHEBI:59761 denotes MMP
T400 1727-1732 PR:P08253 denotes MMP-2
T401 1727-1732 Q9GLE5 denotes MMP-2
T402 1727-1732 P08253 denotes MMP-2
T403 1727-1732 Q90611 denotes MMP-2
T405 1727-1732 PR:Q8MPP3 denotes MMP-2
T406 1727-1732 P33436 denotes MMP-2
T407 1727-1732 PR:Q90611 denotes MMP-2
T408 1727-1732 PR:P33436 denotes MMP-2
T409 1727-1732 PR:000010479 denotes MMP-2
T410 1727-1732 PR:P33434 denotes MMP-2
T411 1727-1732 P33434 denotes MMP-2
T412 1727-1732 P50757 denotes MMP-2
T404 1727-1732 GO:0004228 denotes MMP-2
T413 1793-1801 D007511 denotes ischemia
T414 1793-1801 D007511 denotes ischemia
T415 1802-1805 CHEBI:340824 denotes MMP
T418 1802-1805 CHEBI:59761 denotes MMP
T419 1802-1807 PR:P50282 denotes MMP-9
T420 1802-1807 PR:P14780 denotes MMP-9
T421 1802-1807 P14780 denotes MMP-9
T422 1802-1807 PR:P41245 denotes MMP-9
T423 1802-1807 P41246 denotes MMP-9
T424 1802-1807 P41245 denotes MMP-9
T425 1802-1807 PR:P52176 denotes MMP-9
T426 1802-1807 P50282 denotes MMP-9
T428 1802-1807 PR:000010491 denotes MMP-9
T429 1802-1807 P52176 denotes MMP-9
T430 1802-1807 O18733 denotes MMP-9
T427 1802-1807 GO:0004229 denotes MMP-9
T431 1812-1815 CHEBI:340824 denotes MMP
T434 1812-1815 CHEBI:59761 denotes MMP
T435 1812-1817 P28863 denotes MMP-3
T436 1812-1817 P08254 denotes MMP-3
T437 1812-1817 Q28397 denotes MMP-3
T438 1812-1817 PR:P08254 denotes MMP-3
T439 1812-1817 PR:P03957 denotes MMP-3
T440 1812-1817 Q6Y4Q5 denotes MMP-3
T441 1812-1817 P28862 denotes MMP-3
T443 1812-1817 PR:000010488 denotes MMP-3
T444 1812-1817 PR:P28862 denotes MMP-3
T445 1812-1817 P03957 denotes MMP-3
T442 1812-1817 GO:0004248 denotes MMP-3
T446 1832-1835 CHEBI:340824 denotes MMP
T449 1832-1835 CHEBI:59761 denotes MMP
T450 1832-1837 P28863 denotes MMP-3
T451 1832-1837 P08254 denotes MMP-3
T452 1832-1837 Q28397 denotes MMP-3
T453 1832-1837 PR:P08254 denotes MMP-3
T454 1832-1837 PR:P03957 denotes MMP-3
T455 1832-1837 Q6Y4Q5 denotes MMP-3
T456 1832-1837 P28862 denotes MMP-3
T458 1832-1837 PR:000010488 denotes MMP-3
T459 1832-1837 PR:P28862 denotes MMP-3
T460 1832-1837 P03957 denotes MMP-3
T457 1832-1837 GO:0004248 denotes MMP-3
T461 1841-1850 CL:0000129 denotes microglia
T462 1881-1889 C120487 denotes proMMP-9
T463 1942-1946 D020782 denotes MMPs
T464 1962-1971 CL:0000129 denotes microglia
T465 2002-2015 UBERON:0004537 denotes blood vessels
T466 2065-2068 UBERON:0000120 denotes BBB

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-161 DRI_Background denotes Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures.
T2 162-212 DRI_Unspecified denotes Reperfusion damages the blood-brain barrier (BBB).
T3 213-362 DRI_Approach denotes Matrix metalloproteinases (MMPs) are associated with the opening of the BBB, but their cellular localization and activation mechanisms are uncertain.
T4 363-512 DRI_Approach denotes We used immunohistochemistry to determine the cellular localization of the MMPs in reperfused rat brain, and cell cultures to study their activation.
T5 513-658 DRI_Background denotes Spontaneously hypertensive rats (SHR) had a 90 min middle cerebral artery occlusion (MCAO) followed by reperfusion for times from 3 h to 21 days.
T6 659-783 DRI_Approach denotes Frozen sections were immunostained with antibodies to gelatinase A (MMP-2), stromelysin-1 (MMP-3), and gelatinase B (MMP-9).
T7 784-817 DRI_Background denotes Sham-operated control rats showed
T8 818-838 Token_Label.OUTSIDE denotes MMP-2 immunostaining
T9 839-885 DRI_Background denotes in astrocytic processes next to blood vessels.
T10 886-923 DRI_Background denotes After 3 h of the onset of reperfusion
T11 924-944 Token_Label.OUTSIDE denotes MMP-2 immunostaining
T12 945-969 DRI_Background denotes increased in astrocytes.
T13 970-1024 DRI_Unspecified denotes At 24 h immunoreactivity for MMP-3 and MMP-9 appeared.
T14 1025-1030 REPLACED denotes MMP-3
T15 1031-1043 Token_Label.OUTSIDE denotes co-localized
T16 1044-1107 DRI_Unspecified denotes with activated microglia (Ox-42+) and ischemic neurons (NeuN+).
T17 1108-1113 REPLACED denotes MMP-9
T18 1114-1128 Token_Label.OUTSIDE denotes immunostaining
T19 1129-1193 DRI_Approach denotes was seen at 48 h in endothelial cells, neutrophils, and neurons.
T20 1194-1291 DRI_Background denotes At 5 and 21 days intense MMP-2 staining was seen in reactive astrocytes around the ischemic core.
T21 1292-1407 DRI_Background denotes Studies of activation of the MMP were done in lipopolysaccharide (LPS)-stimulated astrocyte and microglia cultures.
T22 1408-1466 DRI_Background denotes Stimulated astrocytes produced an activated form of MMP-2.
T23 1467-1520 DRI_Background denotes When microglia were stimulated, they activated MMP-9.
T24 1521-1590 DRI_Background denotes Immunostaining showed MMP-3 in cultures of enriched microglial cells.
T25 1591-1710 DRI_Outcome denotes The hydroxymate-type, MMP inhibitor, BB-1101, blocked the activation of MMP-2 and MMP-9 by LPS in mixed glial cultures.
T26 1711-1831 DRI_Challenge denotes We propose that MMP-2 is normally present in astrocytic end feet, and that during ischemia MMP-9 and MMP-3 are produced.
T27 1832-1890 DRI_Approach denotes MMP-3 in microglia/macrophages may be activating proMMP-9.
T28 1891-2069 DRI_Outcome denotes Our results show that a differential expression of MMPs by astrocytes, microglia, and endothelial cells at the blood vessels is involved in the proteolytic disruption of the BBB.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 213-362 DRI_Approach denotes Matrix metalloproteinases (MMPs) are associated with the opening of the BBB, but their cellular localization and activation mechanisms are uncertain.
T2 363-512 DRI_Approach denotes We used immunohistochemistry to determine the cellular localization of the MMPs in reperfused rat brain, and cell cultures to study their activation.
T3 513-658 DRI_Background denotes Spontaneously hypertensive rats (SHR) had a 90 min middle cerebral artery occlusion (MCAO) followed by reperfusion for times from 3 h to 21 days.
T4 659-783 DRI_Approach denotes Frozen sections were immunostained with antibodies to gelatinase A (MMP-2), stromelysin-1 (MMP-3), and gelatinase B (MMP-9).
T5 784-817 DRI_Background denotes Sham-operated control rats showed
T6 839-885 DRI_Background denotes in astrocytic processes next to blood vessels.
T7 886-923 DRI_Background denotes After 3 h of the onset of reperfusion
T8 945-969 DRI_Background denotes increased in astrocytes.
T9 1025-1030 REPLACED denotes MMP-3
T10 1108-1113 REPLACED denotes MMP-9
T11 1129-1193 DRI_Approach denotes was seen at 48 h in endothelial cells, neutrophils, and neurons.
T12 1194-1291 DRI_Background denotes At 5 and 21 days intense MMP-2 staining was seen in reactive astrocytes around the ischemic core.
T13 1292-1407 DRI_Background denotes Studies of activation of the MMP were done in lipopolysaccharide (LPS)-stimulated astrocyte and microglia cultures.
T14 1408-1466 DRI_Background denotes Stimulated astrocytes produced an activated form of MMP-2.
T15 1467-1520 DRI_Background denotes When microglia were stimulated, they activated MMP-9.
T16 1521-1590 DRI_Background denotes Immunostaining showed MMP-3 in cultures of enriched microglial cells.
T17 1591-1710 DRI_Outcome denotes The hydroxymate-type, MMP inhibitor, BB-1101, blocked the activation of MMP-2 and MMP-9 by LPS in mixed glial cultures.
T18 1711-1831 DRI_Challenge denotes We propose that MMP-2 is normally present in astrocytic end feet, and that during ischemia MMP-9 and MMP-3 are produced.
T19 1832-1890 DRI_Approach denotes MMP-3 in microglia/macrophages may be activating proMMP-9.
T20 1891-2069 DRI_Outcome denotes Our results show that a differential expression of MMPs by astrocytes, microglia, and endothelial cells at the blood vessels is involved in the proteolytic disruption of the BBB.