PubMed:11201732 JSONTXT

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11201732-0#12#20#gene56729","span":{"begin":431,"end":484},"obj":"gene56729"},{"id":"11201732-0#38#46#diseaseC0011847","span":{"begin":1114,"end":1122},"obj":"diseaseC0011847"},{"id":"11201732-0#38#46#diseaseC0011849","span":{"begin":1114,"end":1122},"obj":"diseaseC0011849"},{"id":"11201732-0#27#34#diseaseC0028754","span":{"begin":1103,"end":1110},"obj":"diseaseC0028754"}],"relations":[{"id":"12#20#gene5672938#46#diseaseC0011847","pred":"associated_with","subj":"11201732-0#12#20#gene56729","obj":"11201732-0#38#46#diseaseC0011847"},{"id":"12#20#gene5672938#46#diseaseC0011849","pred":"associated_with","subj":"11201732-0#12#20#gene56729","obj":"11201732-0#38#46#diseaseC0011849"},{"id":"12#20#gene5672927#34#diseaseC0028754","pred":"associated_with","subj":"11201732-0#12#20#gene56729","obj":"11201732-0#27#34#diseaseC0028754"}],"text":"The hormone resistin links obesity to diabetes.\nDiabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes."}

{"project":"2015-BEL-Sample","denotations":[{"id":"T1","span":{"begin":559,"end":700},"obj":"a(CHEBI:rosiglitazone) decreases sec(p(MGI:Retn))"}],"text":"The hormone resistin links obesity to diabetes.\nDiabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes."}

{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20000264","span":{"begin":559,"end":700},"obj":"path(MESHD:Obesity) increases sec(p(MGI:Retn))"},{"id":"BEL:20000266","span":{"begin":559,"end":700},"obj":"a(CHEBI:rosiglitazone) decreases sec(p(MGI:Retn))"}],"text":"The hormone resistin links obesity to diabetes.\nDiabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":12,"end":20},"obj":"gene:56729"},{"id":"T1","span":{"begin":27,"end":34},"obj":"disease:C0028754"},{"id":"T2","span":{"begin":12,"end":20},"obj":"gene:56729"},{"id":"T3","span":{"begin":38,"end":46},"obj":"disease:C0011847"},{"id":"T4","span":{"begin":12,"end":20},"obj":"gene:56729"},{"id":"T5","span":{"begin":38,"end":46},"obj":"disease:C0011849"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The hormone resistin links obesity to diabetes.\nDiabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes."}