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PubMed:11161632 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-125 DRI_Outcome denotes Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma.
T2 126-334 DRI_Outcome denotes The effects of selective blockade of group I metabotropic glutamate receptor subtype 1 (mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in vitro and in vivo trauma models.
T3 335-713 DRI_Approach denotes The selective mGluR1 antagonists (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA), 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), and (S)-(+)-alpha-amino-4-carboxy-2-methylbezeneacetic acid (LY367385) provided significant neuroprotection in rat cortical neuronal cultures subjected to mechanical injury, in both pretreatment or posttreatment paradigms.
T4 714-818 DRI_Background denotes Administration of the antagonists also attenuated glutamate-induced neuronal cell death in the cultures.
T5 819-1061 DRI_Background denotes Coapplication of these antagonists with the N-methyl-d-aspartate (NMDA) receptor antagonist (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) had additive neuroprotective effects in glutamate injured cultures.
T6 1062-1235 DRI_Challenge denotes Intracerebroventricular administration of AIDA to rats markedly improved recovery from motor dysfunction after lateral fluid percussion induced traumatic brain injury (TBI).
T7 1236-1351 DRI_Approach denotes Treatment with mGluR1 antagonists also significantly reduced lesion volumes in rats after TBI, as evaluated by MRI.
T8 1352-1558 DRI_Outcome denotes It appears that these compounds mediate their neuroprotective effect through an mGluR1 antagonist action, as demonstrated by inhibition of agonist induced phosphoinositide hydrolysis in our in vitro system.
T9 1559-1723 DRI_Background denotes Moreover, AIDA, CPCCOEt, and LY367385, at concentrations shown to be neuroprotective, had no significant effects on the steady state NMDA evoked whole cell current.
T10 1724-1853 DRI_Approach denotes Taken together, these data suggest that modulation of mGluR1 activity may have substantial therapeutic potential in brain injury.