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PubMed:11144036 JSONTXT

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PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 0-26 HP:0002044 denotes Zollinger-Ellison syndrome
AB1 147-173 HP:0002044 denotes Zollinger-Ellison syndrome
AB2 691-705 HP:0002027 denotes Abdominal pain
AB3 710-718 HP:0002014 denotes diarrhea
AB4 814-825 HP:0001824 denotes weight loss
AB5 1068-1072 HP:0012531 denotes pain
AB6 1077-1085 HP:0002014 denotes diarrhea
AB7 1296-1316 HP:0002043 denotes esophageal stricture
AB8 1341-1349 HP:0100699 denotes scarring
AB9 1464-1468 HP:0012531 denotes pain
AB10 1507-1522 HP:0000787 denotes nephrolithiasis
AB11 1874-1878 HP:0012531 denotes pain
AB12 1880-1888 HP:0002014 denotes diarrhea
AB13 1890-1901 HP:0001824 denotes weight loss
AB14 1983-2004 HP:0002043 denotes esophageal strictures
AB15 2014-2022 HP:0100699 denotes scarring
AB16 2442-2457 HP:0000787 denotes nephrolithiasis
AB17 2509-2522 HP:0004398 denotes peptic ulcers
AB18 2532-2540 HP:0100699 denotes scarring
AB19 2835-2843 HP:0002014 denotes diarrhea
AB20 3024-3036 HP:0004398 denotes peptic ulcer
AB21 3063-3086 HP:0002020 denotes gastroesophageal reflux
AB22 3131-3139 HP:0002014 denotes diarrhea
AB23 3213-3221 HP:0002014 denotes diarrhea
AB24 3293-3301 HP:0002014 denotes diarrhea
AB25 3312-3331 HP:0004789 denotes lactose intolerance
AB26 3521-3540 HP:0000843 denotes Hyperparathyroidism
AB27 3790-3804 HP:0002027 denotes abdominal pain
AB28 3806-3814 HP:0002014 denotes diarrhea
AB29 3900-3908 HP:0002014 denotes diarrhea
AB30 3967-3978 HP:0001824 denotes weight loss
AB31 3995-4009 HP:0002027 denotes abdominal pain
AB32 4011-4019 HP:0002014 denotes diarrhea

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 0-26 ORDO:913 denotes Zollinger-Ellison syndrome
AB1 147-173 ORDO:913 denotes Zollinger-Ellison syndrome
AB2 242-277 ORDO:652 denotes multiple endocrine neoplasia-type 1
AB3 4082-4092 ORDO:913 denotes gastrinoma
AB4 4369-4379 ORDO:913 denotes Gastrinoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 673-678 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 3567-3573 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-27 Sentence denotes Zollinger-Ellison syndrome.
TextSentencer_T2 28-66 Sentence denotes Clinical presentation in 261 patients.
TextSentencer_T3 67-202 Sentence denotes We prospectively evaluated the initial presenting symptoms in 261 patients with Zollinger-Ellison syndrome (ZES) over a 25-year period.
TextSentencer_T4 203-295 Sentence denotes Twenty-two percent of the patients had multiple endocrine neoplasia-type 1 (MEN-1) with ZES.
TextSentencer_T5 296-428 Sentence denotes Mean age at onset was 41.1 +/- 0.7 years, with MEN-1 patients presenting at a younger age than those with sporadic ZES (p < 0.0001).
TextSentencer_T6 429-518 Sentence denotes Three percent of the patients had onset of the disease < age 20 years, and 7% > 60 years.
TextSentencer_T7 519-591 Sentence denotes A mean delay to diagnosis of 5.2 +/- 0.4 years occurred in all patients.
TextSentencer_T8 592-690 Sentence denotes A shorter duration of symptoms was noted in female patients and in patients with liver metastases.
TextSentencer_T9 691-799 Sentence denotes Abdominal pain and diarrhea were the most common symptoms, present in 75% and 73% of patients, respectively.
TextSentencer_T10 800-929 Sentence denotes Heartburn and weight loss, which were uncommonly reported in early series, were present in 44% and 17% of patients, respectively.
TextSentencer_T11 930-1014 Sentence denotes Gastrointestinal bleeding was the initial presentation in a quarter of the patients.
TextSentencer_T12 1015-1150 Sentence denotes Patients rarely presented with only 1 symptom (11%); pain and diarrhea was the most frequent combination, occurring in 55% of patients.
TextSentencer_T13 1151-1412 Sentence denotes An important presenting sign that should suggest ZES is prominent gastric body folds, which were noted on endoscopy in 94% of patients; however, esophageal stricture and duodenal or pyloric scarring, reported in numerous case reports, were noted in only 4%-10%.
TextSentencer_T14 1413-1523 Sentence denotes Patients with MEN-1 presented less frequently with pain and bleeding and more frequently with nephrolithiasis.
TextSentencer_T15 1524-2024 Sentence denotes Comparing the clinical presentation before the introduction of histamine H2-receptor antagonists (pre-1980, n = 36), after the introduction of histamine H2-receptor antagonists (1981-1989, n = 118), and after the introduction of proton pump inhibitors (PPIs) (> 1990, n = 106) demonstrates no change in age of onset; delay in diagnosis; frequency of pain, diarrhea, weight loss; or frequency of complications of severe peptic disease (bleeding, perforations, esophageal strictures, pyloric scarring).
TextSentencer_T16 2025-2178 Sentence denotes Since the introduction of histamine H2-receptor antagonists, fewer patients had a previous history of gastric acid-reducing surgery or total gastrectomy.
TextSentencer_T17 2179-2266 Sentence denotes Only 1 patient evaluated after 1980 had a total gastrectomy, and this was done in 1977.
TextSentencer_T18 2267-2542 Sentence denotes The location of the primary tumor in general had a minimal effect on the clinical presentation, causing no effect on the age at presentation, delay in diagnosis, frequency of nephrolithiasis, or severity of disease (strictures, perforations, peptic ulcers, pyloric scarring).
TextSentencer_T19 2543-2666 Sentence denotes Disease extent had a minimal effect on symptoms, with only bleeding being more frequent in patients with localized disease.
TextSentencer_T20 2667-2872 Sentence denotes Patients with advanced disease presented at a later age and with a shorter disease history (p = 0.001), were less likely to have MEN-1 (p = 0.0087), and tended to have diarrhea more frequently (p = 0.079).
TextSentencer_T21 2873-2973 Sentence denotes A correct diagnosis of ZES was made by the referring physician initially in only 3% of the patients.
TextSentencer_T22 2974-3145 Sentence denotes The most common misdiagnosis made were idiopathic peptic ulcer disease (71%), idiopathic gastroesophageal reflux disease (GERD) (7%), and chronic idiopathic diarrhea (7%).
TextSentencer_T23 3146-3338 Sentence denotes Other less common misdiagnosis were Crohn disease (2%) and various diarrhea diseases (celiac sprue [3%], irritable bowel syndrome [3%], infectious diarrhea [2%], and lactose intolerance [1%]).
TextSentencer_T24 3339-3520 Sentence denotes Other medical disorders were present in 55% of all patients; patients with sporadic disease had fewer other medical disorders than patients with MEN-1 (45% versus 90%, p < 0.00001).
TextSentencer_T25 3521-3669 Sentence denotes Hyperparathyroidism and a previous history of kidney stones were significantly more frequent in patients with MEN-1 than in those with sporadic ZES.
TextSentencer_T26 3670-3758 Sentence denotes Pulmonary disorders and other malignancies were also more common in patients with MEN-1.
TextSentencer_T27 3759-3950 Sentence denotes These results demonstrate that abdominal pain, diarrhea, and heartburn are the most common presenting symptoms in ZES and that heartburn and diarrhea are more common than previously reported.
TextSentencer_T28 3951-4093 Sentence denotes The presence of weight loss especially with abdominal pain, diarrhea, or heartburn is an important clue suggesting the presence of gastrinoma.
TextSentencer_T29 4094-4237 Sentence denotes The presence of prominent gastric body folds, a clinical sign that has not been appreciated, is another important clue to the diagnosis of ZES.
TextSentencer_T30 4238-4368 Sentence denotes Patients with MEN-1 presented at an earlier age; however, in general, the initial symptoms were similar to patients without MEN-1.
TextSentencer_T31 4369-4450 Sentence denotes Gastrinoma extent and location have minimal effects on the clinical presentation.
TextSentencer_T32 4451-4704 Sentence denotes Overall, neither the introduction of successful antisecretory therapy nor widespread publication about ZES, attempting to increase awareness, has shortened the delay in diagnosis or reduced the incidence of patients presenting with peptic complications.
TextSentencer_T33 4705-4958 Sentence denotes The introduction of successful antisecretory therapy, however, has dramatically decreased the rate of surgery in controlling the acid secretion and likely led to patients presenting with less severe symptoms and fewer complications. (ABSTRACT TRUNCATED)
T1 0-27 Sentence denotes Zollinger-Ellison syndrome.
T2 28-66 Sentence denotes Clinical presentation in 261 patients.
T3 67-202 Sentence denotes We prospectively evaluated the initial presenting symptoms in 261 patients with Zollinger-Ellison syndrome (ZES) over a 25-year period.
T4 203-295 Sentence denotes Twenty-two percent of the patients had multiple endocrine neoplasia-type 1 (MEN-1) with ZES.
T5 296-428 Sentence denotes Mean age at onset was 41.1 +/- 0.7 years, with MEN-1 patients presenting at a younger age than those with sporadic ZES (p < 0.0001).
T6 429-518 Sentence denotes Three percent of the patients had onset of the disease < age 20 years, and 7% > 60 years.
T7 519-591 Sentence denotes A mean delay to diagnosis of 5.2 +/- 0.4 years occurred in all patients.
T8 592-690 Sentence denotes A shorter duration of symptoms was noted in female patients and in patients with liver metastases.
T9 691-799 Sentence denotes Abdominal pain and diarrhea were the most common symptoms, present in 75% and 73% of patients, respectively.
T10 800-929 Sentence denotes Heartburn and weight loss, which were uncommonly reported in early series, were present in 44% and 17% of patients, respectively.
T11 930-1014 Sentence denotes Gastrointestinal bleeding was the initial presentation in a quarter of the patients.
T12 1015-1150 Sentence denotes Patients rarely presented with only 1 symptom (11%); pain and diarrhea was the most frequent combination, occurring in 55% of patients.
T13 1151-1412 Sentence denotes An important presenting sign that should suggest ZES is prominent gastric body folds, which were noted on endoscopy in 94% of patients; however, esophageal stricture and duodenal or pyloric scarring, reported in numerous case reports, were noted in only 4%-10%.
T14 1413-1523 Sentence denotes Patients with MEN-1 presented less frequently with pain and bleeding and more frequently with nephrolithiasis.
T15 1524-2024 Sentence denotes Comparing the clinical presentation before the introduction of histamine H2-receptor antagonists (pre-1980, n = 36), after the introduction of histamine H2-receptor antagonists (1981-1989, n = 118), and after the introduction of proton pump inhibitors (PPIs) (> 1990, n = 106) demonstrates no change in age of onset; delay in diagnosis; frequency of pain, diarrhea, weight loss; or frequency of complications of severe peptic disease (bleeding, perforations, esophageal strictures, pyloric scarring).
T16 2025-2178 Sentence denotes Since the introduction of histamine H2-receptor antagonists, fewer patients had a previous history of gastric acid-reducing surgery or total gastrectomy.
T17 2179-2266 Sentence denotes Only 1 patient evaluated after 1980 had a total gastrectomy, and this was done in 1977.
T18 2267-2542 Sentence denotes The location of the primary tumor in general had a minimal effect on the clinical presentation, causing no effect on the age at presentation, delay in diagnosis, frequency of nephrolithiasis, or severity of disease (strictures, perforations, peptic ulcers, pyloric scarring).
T19 2543-2666 Sentence denotes Disease extent had a minimal effect on symptoms, with only bleeding being more frequent in patients with localized disease.
T20 2667-2872 Sentence denotes Patients with advanced disease presented at a later age and with a shorter disease history (p = 0.001), were less likely to have MEN-1 (p = 0.0087), and tended to have diarrhea more frequently (p = 0.079).
T21 2873-2973 Sentence denotes A correct diagnosis of ZES was made by the referring physician initially in only 3% of the patients.
T22 2974-3145 Sentence denotes The most common misdiagnosis made were idiopathic peptic ulcer disease (71%), idiopathic gastroesophageal reflux disease (GERD) (7%), and chronic idiopathic diarrhea (7%).
T23 3146-3338 Sentence denotes Other less common misdiagnosis were Crohn disease (2%) and various diarrhea diseases (celiac sprue [3%], irritable bowel syndrome [3%], infectious diarrhea [2%], and lactose intolerance [1%]).
T24 3339-3520 Sentence denotes Other medical disorders were present in 55% of all patients; patients with sporadic disease had fewer other medical disorders than patients with MEN-1 (45% versus 90%, p < 0.00001).
T25 3521-3669 Sentence denotes Hyperparathyroidism and a previous history of kidney stones were significantly more frequent in patients with MEN-1 than in those with sporadic ZES.
T26 3670-3758 Sentence denotes Pulmonary disorders and other malignancies were also more common in patients with MEN-1.
T27 3759-3950 Sentence denotes These results demonstrate that abdominal pain, diarrhea, and heartburn are the most common presenting symptoms in ZES and that heartburn and diarrhea are more common than previously reported.
T28 3951-4093 Sentence denotes The presence of weight loss especially with abdominal pain, diarrhea, or heartburn is an important clue suggesting the presence of gastrinoma.
T29 4094-4237 Sentence denotes The presence of prominent gastric body folds, a clinical sign that has not been appreciated, is another important clue to the diagnosis of ZES.
T30 4238-4368 Sentence denotes Patients with MEN-1 presented at an earlier age; however, in general, the initial symptoms were similar to patients without MEN-1.
T31 4369-4450 Sentence denotes Gastrinoma extent and location have minimal effects on the clinical presentation.
T32 4451-4704 Sentence denotes Overall, neither the introduction of successful antisecretory therapy nor widespread publication about ZES, attempting to increase awareness, has shortened the delay in diagnosis or reduced the incidence of patients presenting with peptic complications.
T33 4705-4958 Sentence denotes The introduction of successful antisecretory therapy, however, has dramatically decreased the rate of surgery in controlling the acid secretion and likely led to patients presenting with less severe symptoms and fewer complications. (ABSTRACT TRUNCATED)

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 673-678 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 3567-3573 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney